Pathology Presents
Path Presents (Path 520) is a seminar lecture series sponsored the Department of Pathology Graduate Program.
The seminars feature presentations on current research in various areas of experimental pathology by members of the Department Pathology and visiting scientists.
Please contact Steve Berard at 685.0564 or sberard@u.washington.edu if you have any questions about the Path Presents seminar lecture series.
Please check this site for updated Path Presents schedule information.
No upcoming seminars are currently posted.
Recent Pathology Presents
Regulation of Neointimal Hyperplasia by Sphingosine-1-phosphate in Mice
Guenter Daum, Ph.D.
Research Associate Professor
UW Medicine Surgery
University of Washington
Wednesday, June 30, 2010 - 4:30 PM
Health Sciences Center, Turner Auditorium, Rm. D-209
Faculty Sponsor: Chuck Murry, M.D., Ph.D.
Why Attend
Intimal hyperplasia is a severe complication of surgical interventions to restore blood flow. In various models of arterial injury, smooth muscle cell (SMC) proliferation correlates with loss of expression of contractile proteins including smooth muscle alpha actin (SMA). Sphingosine-1-phosphate (S1P) is a phospholipid produced by platelets and other cells in response to injury. In this lecture I will present genetic and biochemical data linking S1P, and its receptors, to the control of smooth muscle migration and proliferation during neointimal formation.
Speaker is a candidate for an adjunct faculty appointment with UW Medicine Pathology
Guenter Daum, Ph.D.
Research Associate Professor
UW Medicine Surgery
University of Washington
Wednesday, June 30, 2010 - 4:30 PM
Health Sciences Center, Turner Auditorium, Rm. D-209
Faculty Sponsor: Chuck Murry, M.D., Ph.D.
Why Attend
Intimal hyperplasia is a severe complication of surgical interventions to restore blood flow. In various models of arterial injury, smooth muscle cell (SMC) proliferation correlates with loss of expression of contractile proteins including smooth muscle alpha actin (SMA). Sphingosine-1-phosphate (S1P) is a phospholipid produced by platelets and other cells in response to injury. In this lecture I will present genetic and biochemical data linking S1P, and its receptors, to the control of smooth muscle migration and proliferation during neointimal formation.
Speaker is a candidate for an adjunct faculty appointment with UW Medicine Pathology
Of Old Mice and Men: Lessons in Comparative Pathology from a Mouse Model of Healthy Aging
Piper M. Treuting, D.V.M., M.S., DACVP
Assistant Professor, UW Comparative Medicine
Chief of UW Comparative Pathology Services
University of Washington
Wednesday, June 9, 2010 - 4:30 PM
Health Sciences Center, K-069
Faculty Sponsor: Suzanne Dintzis, M.D., Ph.D.
Why Attend,
Biomedical research institutions worldwide are literally over run with mice. The majority of extramural NIH funded grants use animals and the overwhelming majority of the research animals are mice. Mouse model development and validation is often performed by a team of scientists including comparative pathologists who understand how research may be impacted by mouse pathobiology such as the interplay of the mouse background strain with genetic manipulations, husbandry, age or commensal organisms. In this seminar, I will present the data generated by the end-of-life pathological analysis of old mice overexpressing mitochondrial-targeted catalase (mCAT) to highlight some of the unique features of mice and mouse-based research including species-specific anatomy and disease spectrum that make mice such useful, yet challenging, human disease models.
Piper M. Treuting, D.V.M., M.S., DACVP
Assistant Professor, UW Comparative Medicine
Chief of UW Comparative Pathology Services
University of Washington
Wednesday, June 9, 2010 - 4:30 PM
Health Sciences Center, K-069
Faculty Sponsor: Suzanne Dintzis, M.D., Ph.D.
Why Attend,
Biomedical research institutions worldwide are literally over run with mice. The majority of extramural NIH funded grants use animals and the overwhelming majority of the research animals are mice. Mouse model development and validation is often performed by a team of scientists including comparative pathologists who understand how research may be impacted by mouse pathobiology such as the interplay of the mouse background strain with genetic manipulations, husbandry, age or commensal organisms. In this seminar, I will present the data generated by the end-of-life pathological analysis of old mice overexpressing mitochondrial-targeted catalase (mCAT) to highlight some of the unique features of mice and mouse-based research including species-specific anatomy and disease spectrum that make mice such useful, yet challenging, human disease models.
The Adventitia: A Novel Hedgehog Signaling Domain and Progenitor Cell Niche in the Vessel Wall
Mark Majesky, Ph.D.
Professor, UW Medicine Pediatrics
Seattle Children's Research Institute
University of Washington
Wednesday, June 2, 2010 - 4:30 PM
Health Sciences Center, K-069
Faculty Sponsor: Stephen M. Schwartz, M.D., Ph.D.
Why Attend
An adventitia surrounds most blood vessels where it functions as a dynamic compartment for cell trafficking into and out of the vessel wall. Adventitial cells regulate vascular growth, remodeling, angiogenesis and defense against infection. Recent studies report unexpected roles for the adventitia insofar as it provides a niche environment for resident vascular stem and progenitor cells. Since all organs contain blood vessels, adventitial stem cells may be important for morphogenesis, repair and disease involving many different tissues and cell types. The roles of sonic hedgehog signaling in vascular development and the origins and fates of vascular progenitor cells will be discussed.
Mark Majesky, Ph.D.
Professor, UW Medicine Pediatrics
Seattle Children's Research Institute
University of Washington
Wednesday, June 2, 2010 - 4:30 PM
Health Sciences Center, K-069
Faculty Sponsor: Stephen M. Schwartz, M.D., Ph.D.
Why Attend
An adventitia surrounds most blood vessels where it functions as a dynamic compartment for cell trafficking into and out of the vessel wall. Adventitial cells regulate vascular growth, remodeling, angiogenesis and defense against infection. Recent studies report unexpected roles for the adventitia insofar as it provides a niche environment for resident vascular stem and progenitor cells. Since all organs contain blood vessels, adventitial stem cells may be important for morphogenesis, repair and disease involving many different tissues and cell types. The roles of sonic hedgehog signaling in vascular development and the origins and fates of vascular progenitor cells will be discussed.
Window of Opportunity: Artificial Cornea Development for Treatable Blindness Worldwide
Tueng Shen
Associate Professor
University of Washington Eye Institute
Wednesday, May 26, 2010 - 4:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Chuck Murry
Why Attend
Treatable blindness, such as cataract and corneal blindness, are already a significant burden on global health and this burden is increasing. The majority of patients with treatable blindness live in the developing world. Common treatments used in developed countries are not viable options in the developing nations due to large discrepancy of health care infrastructure. The research in our laboratory aims to develop innovative solutions that can be applied for the developing world, leveraging cutting edge technology in material science, microelectronics and through collaborations while as the same time, addressing the cost and implementation constraints of the global market. The most recent results of artificial cornea development and drug delivery systems will be presented.
Tueng Shen
Associate Professor
University of Washington Eye Institute
Wednesday, May 26, 2010 - 4:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Chuck Murry
Why Attend
Treatable blindness, such as cataract and corneal blindness, are already a significant burden on global health and this burden is increasing. The majority of patients with treatable blindness live in the developing world. Common treatments used in developed countries are not viable options in the developing nations due to large discrepancy of health care infrastructure. The research in our laboratory aims to develop innovative solutions that can be applied for the developing world, leveraging cutting edge technology in material science, microelectronics and through collaborations while as the same time, addressing the cost and implementation constraints of the global market. The most recent results of artificial cornea development and drug delivery systems will be presented.
Pyroptosis: Coordinated Inflammatory Response
Brad Cookson
Professor
Laboratory Medicine & Microbiology
University of Washington
Wednesday, May 19, 2010 - 4:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Chuck Murry
Why Attend
Eukaryotic cell death is an important and regulated host response, and one outcome is inflammation. We use microbial pathogens as biological probes to query the operation and function(s) of pyroptosis, a caspase-1-dependent pathway of programmed inflammatory cell death. The Greek roots pyro relates to fire or fever and ptosis (to-sis) denotes "a falling" or cell death. Pyroptosis results from the activation of a conserved effector pathway in response to diverse stimuli, with relevance to a variety of diseases in humans in which inflammation plays a central role.
Brad Cookson
Professor
Laboratory Medicine & Microbiology
University of Washington
Wednesday, May 19, 2010 - 4:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Chuck Murry
Why Attend
Eukaryotic cell death is an important and regulated host response, and one outcome is inflammation. We use microbial pathogens as biological probes to query the operation and function(s) of pyroptosis, a caspase-1-dependent pathway of programmed inflammatory cell death. The Greek roots pyro relates to fire or fever and ptosis (to-sis) denotes "a falling" or cell death. Pyroptosis results from the activation of a conserved effector pathway in response to diverse stimuli, with relevance to a variety of diseases in humans in which inflammation plays a central role.
Apoptosis and Autophagy: Neuropathology in the Balance
Kevin Roth, M.D., Ph.D.
Professor and Chair
Department of Pathology
University of Alabama at Birmingham
Wednesday, April 21, 2010 - 4:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Dirk Keene
Why Attend?
Research in my laboratory is focused on the molecular regulation of neuronal cell death. Neuronal cell death occurs both during normal nervous system development and in a variety of neuropathological processes. The two major types of regulated cell death are apoptosis and autophagic cell death. While the processes controlling apoptotic cell death are fairly well characterized, the cellular and molecular regulation of autophagic cell death is poorly understood. We use a variety of in vivo and in vitro model systems to define the key molecules and cellular processes that regulate both apoptotic and autophagic cell death in neural stem cells, neurons and nervous system neoplasms. The long-term goals of my laboratory are to define the interactions between apoptotic and autophagic cell death pathways in the nervous system and to use this information to develop effective neuroprotective strategies to inhibit pathological neuron death and identify novel cell death-inducing compounds for the treatment of malignant glial neoplasms.
Kevin Roth, M.D., Ph.D.
Professor and Chair
Department of Pathology
University of Alabama at Birmingham
Wednesday, April 21, 2010 - 4:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Dirk Keene
Why Attend?
Research in my laboratory is focused on the molecular regulation of neuronal cell death. Neuronal cell death occurs both during normal nervous system development and in a variety of neuropathological processes. The two major types of regulated cell death are apoptosis and autophagic cell death. While the processes controlling apoptotic cell death are fairly well characterized, the cellular and molecular regulation of autophagic cell death is poorly understood. We use a variety of in vivo and in vitro model systems to define the key molecules and cellular processes that regulate both apoptotic and autophagic cell death in neural stem cells, neurons and nervous system neoplasms. The long-term goals of my laboratory are to define the interactions between apoptotic and autophagic cell death pathways in the nervous system and to use this information to develop effective neuroprotective strategies to inhibit pathological neuron death and identify novel cell death-inducing compounds for the treatment of malignant glial neoplasms.
Microbe Hunting in the 21st Century
Ian Lipkin, M.D.
Professor
Departments of Epidemiology, Neurology and Pathology
Columbia University Medical Center
Wednesday, April 14, 2010 - 3:30 PM
Health Sciences Center, Turner Auditorium, Room D-209
Faculty Sponsor: Michael Linden
This is a special Path Presents/Grand Rounds hosted by the Departments of Pathology and Laboratory Medicine.
Please note time and location change.
Ian Lipkin, M.D.
Professor
Departments of Epidemiology, Neurology and Pathology
Columbia University Medical Center
Wednesday, April 14, 2010 - 3:30 PM
Health Sciences Center, Turner Auditorium, Room D-209
Faculty Sponsor: Michael Linden
This is a special Path Presents/Grand Rounds hosted by the Departments of Pathology and Laboratory Medicine.
Please note time and location change.
Severe Gastrointestinal Motility Disorders: Understanding the Underlying Pathology of the Neuromuscular Apparatus of the Gut
Michael Schuffler
Professor
UW Medicine Gastroenterology
University of Washington
Wednesday, April 7, 2010 - 4:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Melissa Upton
Why Attend
Gastrointestinal motility disorders are common and responsible for much pain and suffering. Until relatively recently, little was known about the pathology of these disorders. The experimental approach in humans has consisted mainly of physiologic studies to the exclusion of structure. Because of methodologic limitations and relative lack of interest in the morphology of the human muscularis propria and enteric nervous system, the pathology of these structures has received scant attention. My research focused on the pathology of the enteric nervous system and smooth muscles in patients with motility disorders. My lecture will provide an understanding of this pathology and will suggest an approach that conceivably, could be used in the general pathology department to diagnose these disorders.
Michael Schuffler
Professor
UW Medicine Gastroenterology
University of Washington
Wednesday, April 7, 2010 - 4:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Melissa Upton
Why Attend
Gastrointestinal motility disorders are common and responsible for much pain and suffering. Until relatively recently, little was known about the pathology of these disorders. The experimental approach in humans has consisted mainly of physiologic studies to the exclusion of structure. Because of methodologic limitations and relative lack of interest in the morphology of the human muscularis propria and enteric nervous system, the pathology of these structures has received scant attention. My research focused on the pathology of the enteric nervous system and smooth muscles in patients with motility disorders. My lecture will provide an understanding of this pathology and will suggest an approach that conceivably, could be used in the general pathology department to diagnose these disorders.
Diagnosis and Management of Barrett's Esophagus and its Neoplastic Complications
Robert Odze, M.D., F.R.C.P.C
Professor, Harvard Medical School
Department of Pathology
Brigham and Women's Hospital
Wednesday, March 31, 2010 - 4:30 PM
Health Sciences Center, K-069
Faculty Sponsor: Melissa Upton, M.D.
Why Attend
Adenocarcinoma of the esophagus is rapidly rising in incidence in the Western world, and is caused by Barrett's esophagus. Cancer develops in Barrett's through a metaplasia-dysplasia-carcinoma sequence. There are controversies regarding establishing a diagnosis of Barrett's. The pathogenesis, pathology, natural history, and management of its neoplastic complications are also a subject of controversy. This lecture will focus on new insights, and the pathologic and molecular mechanisms involved, in the development of columnar metaplasia, dysplasia, and carcinoma of the esophagus. This lecture will provide guidelines for pathologists and clinicians who treat patients with this disorder.
Robert Odze, M.D., F.R.C.P.C
Professor, Harvard Medical School
Department of Pathology
Brigham and Women's Hospital
Wednesday, March 31, 2010 - 4:30 PM
Health Sciences Center, K-069
Faculty Sponsor: Melissa Upton, M.D.
Why Attend
Adenocarcinoma of the esophagus is rapidly rising in incidence in the Western world, and is caused by Barrett's esophagus. Cancer develops in Barrett's through a metaplasia-dysplasia-carcinoma sequence. There are controversies regarding establishing a diagnosis of Barrett's. The pathogenesis, pathology, natural history, and management of its neoplastic complications are also a subject of controversy. This lecture will focus on new insights, and the pathologic and molecular mechanisms involved, in the development of columnar metaplasia, dysplasia, and carcinoma of the esophagus. This lecture will provide guidelines for pathologists and clinicians who treat patients with this disorder.
Non-Cell Autonomous Neurodegeneration: A Tale of Two Glia
Gwenn Garden
Associate Professor
UW Medicine Neurology
University of Washington
Wednesday, March 24, 2010 - 4:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Tom Montine
Why Attend
The extra-cellular environment is a critical contributor to the pathogenesis if neurodegenerative diseases. Our laboratory is studying the role of the neural environment in a number of specific neurological diseases including HIV Associated Neurocognitive Disorders (HAND), Alzheimer's disease (AD) and Spinocerebellar Ataxia Type 7 (SCA7). Our overarching hypothesis is that altered regulation of normal glial cell function contributes both actively and passively to eventual neurodegeneration in these diseases. We are evaluating the role of specific molecular regulators of the microglia inflammatory response in HAND and AD with the long term goal of identifying molecular pathways that could serve as therapeutic targets that could develop into disease modifying therapies. In SCA7, a disease caused by inheriting a CAG repeat expansion in the ataxin 7 gene, we have discovered an important role for a specialized cerebellar glial cell, the Bergmann glia. The SCA7 disease gene causes altered Bergmann glia functions that contribute to the eventual degeneration of cerebellar neurons and the neurological symptoms of SCA7.
Gwenn Garden
Associate Professor
UW Medicine Neurology
University of Washington
Wednesday, March 24, 2010 - 4:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Tom Montine
Why Attend
The extra-cellular environment is a critical contributor to the pathogenesis if neurodegenerative diseases. Our laboratory is studying the role of the neural environment in a number of specific neurological diseases including HIV Associated Neurocognitive Disorders (HAND), Alzheimer's disease (AD) and Spinocerebellar Ataxia Type 7 (SCA7). Our overarching hypothesis is that altered regulation of normal glial cell function contributes both actively and passively to eventual neurodegeneration in these diseases. We are evaluating the role of specific molecular regulators of the microglia inflammatory response in HAND and AD with the long term goal of identifying molecular pathways that could serve as therapeutic targets that could develop into disease modifying therapies. In SCA7, a disease caused by inheriting a CAG repeat expansion in the ataxin 7 gene, we have discovered an important role for a specialized cerebellar glial cell, the Bergmann glia. The SCA7 disease gene causes altered Bergmann glia functions that contribute to the eventual degeneration of cerebellar neurons and the neurological symptoms of SCA7.
Natural and Artificial Extra-visual Ocular Photoreception
Russ Van Gelder, M.D., Ph.D.
Professor and Chair
UW Medicine Ophthalmology
University of Washington
Wednesday, March 17, 2010 - 4:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Chuck Murry
Why Attend
In the past ten years, we have come to the realization that the vertebrate eye serves as more than the organ of sight. Additional photoreceptor pathways exist in vertebrate eyes, controlling circadian rhythms, sleep, pupillary light responses, and likely seasonal behavior patterns. These pathways are mediated by novel photopigments including melanopsin and cryptochromes. Examples of recent work in chemically conferring photosensitivity on non-natively photoreceptive cells in the eye will also be discussed.
Russ Van Gelder, M.D., Ph.D.
Professor and Chair
UW Medicine Ophthalmology
University of Washington
Wednesday, March 17, 2010 - 4:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Chuck Murry
Why Attend
In the past ten years, we have come to the realization that the vertebrate eye serves as more than the organ of sight. Additional photoreceptor pathways exist in vertebrate eyes, controlling circadian rhythms, sleep, pupillary light responses, and likely seasonal behavior patterns. These pathways are mediated by novel photopigments including melanopsin and cryptochromes. Examples of recent work in chemically conferring photosensitivity on non-natively photoreceptive cells in the eye will also be discussed.
Microfluidics-assisted Display of Genomic DNA for Analysis of DNA Replication and Repair in Vivo
Julia Sidorova, Ph.D.
Acting Assistant Professor
UW Medicine Pathology
University of Washington
Wednesday, March 3, 2010 - 4:30 PM
Health Sciences Center, K-069
Faculty Sponsor: Ray Monnat
Why Attend?
DNA damage and enzymatic malfunction during DNA replication can be major sources of genomic instability. We focus on the functional analysis of DNA replication and repair under conditions of genotoxic stress as it unravels in living cells. Towards this end we have adapted a microfluidics-assisted approach to displaying individual molecules of genomic DNA on glass surfaces suitable for staining and microscopy. This technology allows us to measure DNA replication and repair in different genetic backgrounds and under different environmental stresses. We will discuss the novel insights we derived into the response of replication to blockage caused by nucleotide starvation, and the roles of the human RecQ helicases, WRN and BLM, in this process.
Julia Sidorova, Ph.D.
Acting Assistant Professor
UW Medicine Pathology
University of Washington
Wednesday, March 3, 2010 - 4:30 PM
Health Sciences Center, K-069
Faculty Sponsor: Ray Monnat
Why Attend?
DNA damage and enzymatic malfunction during DNA replication can be major sources of genomic instability. We focus on the functional analysis of DNA replication and repair under conditions of genotoxic stress as it unravels in living cells. Towards this end we have adapted a microfluidics-assisted approach to displaying individual molecules of genomic DNA on glass surfaces suitable for staining and microscopy. This technology allows us to measure DNA replication and repair in different genetic backgrounds and under different environmental stresses. We will discuss the novel insights we derived into the response of replication to blockage caused by nucleotide starvation, and the roles of the human RecQ helicases, WRN and BLM, in this process.
Mapping Gene Expression in the CNS: Tools and Data from the Allen Institute for Brain Science
Allan Jones, Ph.D.
Chief Scientific Officer
Allen Institute for Brain Science
Wednesday, February 24, 2010 - 4:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Ray Monnat, M.D.
Why Attend?
The Allen Institute for Brain Science is a non-profit research organization dedicated to providing tools and data for the larger research community. Since 2003, the Allen Institute has created a suite of large-scale data efforts along with a web portal to view and analyze the data. These efforts include gene expression atlases of the developing and adult mouse brain and spinal cord, and developing and adult human and non-human primate gene expression studies. The presentation will cover an overview of the Allen Institute, its projects and infrastructure, a look at a few specific examples of gene expression in the mouse and human as they relate to genetic diversity, and introduce some of the new projects on the horizon for the Institute.
Allan Jones, Ph.D.
Chief Scientific Officer
Allen Institute for Brain Science
Wednesday, February 24, 2010 - 4:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Ray Monnat, M.D.
Why Attend?
The Allen Institute for Brain Science is a non-profit research organization dedicated to providing tools and data for the larger research community. Since 2003, the Allen Institute has created a suite of large-scale data efforts along with a web portal to view and analyze the data. These efforts include gene expression atlases of the developing and adult mouse brain and spinal cord, and developing and adult human and non-human primate gene expression studies. The presentation will cover an overview of the Allen Institute, its projects and infrastructure, a look at a few specific examples of gene expression in the mouse and human as they relate to genetic diversity, and introduce some of the new projects on the horizon for the Institute.
Common Disease - Multiple Rare Alleles: Understanding the Genetic Basis of Complex Human Traits
Mary-Claire King
Professor
Medicine & Genome Sciences
University of Washington
Wednesday, February 10, 2010 - 4:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Chuck Murry
Why Attend?
Human disease is characterized by marked genetic heterogeneity, far greater than previously appreciated. Converging evidence for a wide range of common diseases indicates that heterogeneity is important at multiple levels of causation: (1) individually rare mutations collectively play a substantial role in causing complex illnesses; (2) the same gene may harbor many different rare severe mutations (hundreds or even thousands) in unrelated affected individuals; (3) the same mutation may have different effects in different individuals; and (4) mutations in different genes in the same or related pathways may all lead to the same disorder. This degree of allelic, locus, and phenotypic heterogeneity has important implications for gene discovery and for development of molecular treatments and their appropriate use by individual patients.
Mary-Claire King
Professor
Medicine & Genome Sciences
University of Washington
Wednesday, February 10, 2010 - 4:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Chuck Murry
Why Attend?
Human disease is characterized by marked genetic heterogeneity, far greater than previously appreciated. Converging evidence for a wide range of common diseases indicates that heterogeneity is important at multiple levels of causation: (1) individually rare mutations collectively play a substantial role in causing complex illnesses; (2) the same gene may harbor many different rare severe mutations (hundreds or even thousands) in unrelated affected individuals; (3) the same mutation may have different effects in different individuals; and (4) mutations in different genes in the same or related pathways may all lead to the same disorder. This degree of allelic, locus, and phenotypic heterogeneity has important implications for gene discovery and for development of molecular treatments and their appropriate use by individual patients.
RNA-based Molecular Circuitry for Conditional Gene Regulation
Georg Seelig, Ph.D.
Assistant Professor
Electrical Engineering, Computer Science & Engineering
University of Washington
Wednesday, February 3, 2010 - 4:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Ray Monnat
Why Attend?
In the first part of this talk I will review my recent work on DNA nanotechnology. Together with collaborators, I have advanced a general mechanism for implementing molecular computation using nucleic acids. Using DNA strand-displacement reactions as a molecular primitive we have been able to implement feed-forward digital logic circuits and, more recently, have proposed a method for implementing arbitrary chemical reaction kinetics in actual DNA-based chemistry. The circuit design principles that helped to make this circuitry robust and reliable will be useful to the construction of reliable circuitry for gene regulation control. In the second part of this talk I want to review work currently ongoing in my lab. We are interested in building nucleic acid-based sensors, logic gates and actuators that can detect cellular RNA inside living cells and, in response to varying expression patterns, can differentially and autonomously regulate gene expression. These synthetic regulatory elements are in part based on our in vitro DNA circuitry but also take advantage of existing RNA-based regulatory pathways, in particular the microRNA (miRNA) pathway and the RNA interference (RNAi) pathway.
Georg Seelig, Ph.D.
Assistant Professor
Electrical Engineering, Computer Science & Engineering
University of Washington
Wednesday, February 3, 2010 - 4:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Ray Monnat
Why Attend?
In the first part of this talk I will review my recent work on DNA nanotechnology. Together with collaborators, I have advanced a general mechanism for implementing molecular computation using nucleic acids. Using DNA strand-displacement reactions as a molecular primitive we have been able to implement feed-forward digital logic circuits and, more recently, have proposed a method for implementing arbitrary chemical reaction kinetics in actual DNA-based chemistry. The circuit design principles that helped to make this circuitry robust and reliable will be useful to the construction of reliable circuitry for gene regulation control. In the second part of this talk I want to review work currently ongoing in my lab. We are interested in building nucleic acid-based sensors, logic gates and actuators that can detect cellular RNA inside living cells and, in response to varying expression patterns, can differentially and autonomously regulate gene expression. These synthetic regulatory elements are in part based on our in vitro DNA circuitry but also take advantage of existing RNA-based regulatory pathways, in particular the microRNA (miRNA) pathway and the RNA interference (RNAi) pathway.
Imaging Circuit Assembly in the Developing Retina
Rachel Wong
Professor
Department of Biological Structure
University of Washington
Wednesday, January 27, 2010 - 4:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Suzy Dintzis
Why Attend?
Proper functioning of the nervous system requires the formation and maintenance of precise connectivity patterns between neurons. Our laboratory focuses on developmental mechanisms that regulate precision in circuit assembly of retinal neurons. Using live-cell imaging approaches to visualize retinal synaptogenesis under normal or perturbed developmental conditions, we have uncovered unexpected strategies by which neurons establish their mature connectivity patterns.
Rachel Wong
Professor
Department of Biological Structure
University of Washington
Wednesday, January 27, 2010 - 4:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Suzy Dintzis
Why Attend?
Proper functioning of the nervous system requires the formation and maintenance of precise connectivity patterns between neurons. Our laboratory focuses on developmental mechanisms that regulate precision in circuit assembly of retinal neurons. Using live-cell imaging approaches to visualize retinal synaptogenesis under normal or perturbed developmental conditions, we have uncovered unexpected strategies by which neurons establish their mature connectivity patterns.
High Throughput Screening at the UW: RNA Interference and Small Molecule Screens
Carla Grandori and Tom Martins
Research Associate Professors
Quellos High Throughput Screening Core, ISCRM
UW Medicine Pharmacology
Wednesday, January 20, 2010 - 4:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Ray Monnat
Why Attend?
High Throughput Screening (HTS) has revolutionized the way biomedical research can be conducted. Utilizing laboratory automation and robotics, HTS enables scientists to study complex biological systems and identify therapeutic drug candidates in reasonable timeframes that previously were improbable. The Quellos High Throughput Screening Core, located within the UW's Institute for Stem Cell and Regenerative Medicine at the UW School of Medicine campus in the South Lake Union area now provides HTS technology to both the Seattle academic community as well as its Biotech industry. This facility enables both genomic scale RNA interference screens as well as screening of large compound libraries for drug discoveries.
Further Information
Website: www.depts.washington.edu/uwhts/
Contact Info
General Core Facility Contact:
uwhts@uw.edu
For RNA Interference Screening
Carla Grandori; grandc@uw.edu
James Annis; annisj@uw.edu
For Chemical Screening
Tim Martins; tmartins@uw.edu
Carla Grandori and Tom Martins
Research Associate Professors
Quellos High Throughput Screening Core, ISCRM
UW Medicine Pharmacology
Wednesday, January 20, 2010 - 4:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Ray Monnat
Why Attend?
High Throughput Screening (HTS) has revolutionized the way biomedical research can be conducted. Utilizing laboratory automation and robotics, HTS enables scientists to study complex biological systems and identify therapeutic drug candidates in reasonable timeframes that previously were improbable. The Quellos High Throughput Screening Core, located within the UW's Institute for Stem Cell and Regenerative Medicine at the UW School of Medicine campus in the South Lake Union area now provides HTS technology to both the Seattle academic community as well as its Biotech industry. This facility enables both genomic scale RNA interference screens as well as screening of large compound libraries for drug discoveries.
Further Information
Website: www.depts.washington.edu/uwhts/
Contact Info
General Core Facility Contact:
uwhts@uw.edu
For RNA Interference Screening
Carla Grandori; grandc@uw.edu
James Annis; annisj@uw.edu
For Chemical Screening
Tim Martins; tmartins@uw.edu
Functional Genetic Approaches in In Vitro Stem Cell Systems Using RNAi
Patrick Paddison, Ph.D.
Assistant Member
Human Biology Division
Fred Hutchinson Cancer Research Center
Wednesday, January 13, 2010 - 4:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Ray Monnat
Why Attend?
While RNA interference (RNAi) first emerged as a peculiarity of nematodes, the molecular machinery that underlies RNAi is found in virtually every experimental eukaryotic system and has been co-opted in most to trigger gene silencing. RNAi has become a methodology of choice for knocking down gene expression in cultured mammalian cells has delivered new insights into a host of disease-related processes, including concrete information on potential drug targets. Its use has been expanded to in vivo applications in model rodent systems, including the ex vivo manipulation and transplantation of hematopoietic stem cells. Dr. Paddison's group focuses on applications of genome-scale RNAi libraries in embryonic, adult and cancer stem cell systems to reveal genes responsible for self-renewal, differentiation, and cancer homeostasis.
Patrick Paddison, Ph.D.
Assistant Member
Human Biology Division
Fred Hutchinson Cancer Research Center
Wednesday, January 13, 2010 - 4:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Ray Monnat
Why Attend?
While RNA interference (RNAi) first emerged as a peculiarity of nematodes, the molecular machinery that underlies RNAi is found in virtually every experimental eukaryotic system and has been co-opted in most to trigger gene silencing. RNAi has become a methodology of choice for knocking down gene expression in cultured mammalian cells has delivered new insights into a host of disease-related processes, including concrete information on potential drug targets. Its use has been expanded to in vivo applications in model rodent systems, including the ex vivo manipulation and transplantation of hematopoietic stem cells. Dr. Paddison's group focuses on applications of genome-scale RNAi libraries in embryonic, adult and cancer stem cell systems to reveal genes responsible for self-renewal, differentiation, and cancer homeostasis.
PET Imaging Tumor Phenotype in Sarcomas
Janet Eary, M.D.
Associate Professor
Department of Nuclear Medicine
University of Washington
Wednesday, January 6, 2010 - 4:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Ray Monnat
Why Attend?
Molecular Imaging techniques have made significant advances in ability to determine tissue specific biological characteristics quantitatively and non-invasively. PET Imaging is among the most sophisticated of these imaging techniques. PET Imaging uses imaging agents labeled with positron emitters and a special positron imaging device. Our UW group has pioneered development and imaging with new agents that report on tissue perfusion, hypoxia, cell proliferation, multiple drug resistance, receptor status, and many others for applications in cancer and several diseases. Sarcoma is a complex malignancy with a wide range of presentations and clinical behavior. In this seminar, molecular imaging in the example of sarcomas will be presented to highlight basic ideas in understanding the disease process in translational clinical studies.
Janet Eary is a Professor of Radiology in the Division of Nuclear Medicine. She has a joint appointment in Orthopedics and has an adjunct appointment in Pathology. She has pioneered a number of translational studies in Molecular Imaging, high dose radionuclide therapy, and is an expert in imaging clinical trials. Her current research is focused on the use of molecular imaging to stratify outcome risk in cancer patients, and advanced image analysis algorithm development and validation. She enjoys collaborations with investigators from many different disciplines.
Janet Eary, M.D.
Associate Professor
Department of Nuclear Medicine
University of Washington
Wednesday, January 6, 2010 - 4:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Ray Monnat
Why Attend?
Molecular Imaging techniques have made significant advances in ability to determine tissue specific biological characteristics quantitatively and non-invasively. PET Imaging is among the most sophisticated of these imaging techniques. PET Imaging uses imaging agents labeled with positron emitters and a special positron imaging device. Our UW group has pioneered development and imaging with new agents that report on tissue perfusion, hypoxia, cell proliferation, multiple drug resistance, receptor status, and many others for applications in cancer and several diseases. Sarcoma is a complex malignancy with a wide range of presentations and clinical behavior. In this seminar, molecular imaging in the example of sarcomas will be presented to highlight basic ideas in understanding the disease process in translational clinical studies.
Janet Eary is a Professor of Radiology in the Division of Nuclear Medicine. She has a joint appointment in Orthopedics and has an adjunct appointment in Pathology. She has pioneered a number of translational studies in Molecular Imaging, high dose radionuclide therapy, and is an expert in imaging clinical trials. Her current research is focused on the use of molecular imaging to stratify outcome risk in cancer patients, and advanced image analysis algorithm development and validation. She enjoys collaborations with investigators from many different disciplines.
Stimulating Myocardial Regeneration with Cardiomyocyte Proliferation Factors
Bernhard Kuhn, M.D.
Associate Professor
Department of Cardiology
Children's Hospital Boston
Wednesday, December 16, 2009 - 4:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Chuck Murry
Why Attend?
Dr. Bernhard Kuhn is a physician-scientist with special interests in cardiac regeneration. He received his medical and graduate degrees from the Freie Universitat in Berlin, Germany, in 1999. Dr. Kuhn completed a residency in pediatrics at Yale in 2002 and a clinical and research fellowship in pediatric cardiology at Children's Hospital Boston in 2007. He is Assistant Professor of Pediatrics at Harvard Medical School. Dr. Kuhn's honors include the Young Investigator Award of the American College of Cardiology (Pathology and Physiology) in 2007.
Dr. Kuhn's laboratory at Children's Hospital Boston studies the mechanisms of heart muscle cell proliferation during development and in adult life with the goal of stimulating this process for treating heart failure. Researchers in Dr. Kuhn's laboratory have extensively studied two extracellular factors that stimulate heart muscle cell proliferation and promote heart muscle regeneration: a peptide of periostin, a component of the extracellular matrix, and neuregulin1, a growth factor. Dr. Kuhn's research may provide new regenerative strategies for the treatment of heart failure.
Bernhard Kuhn, M.D.
Associate Professor
Department of Cardiology
Children's Hospital Boston
Wednesday, December 16, 2009 - 4:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Chuck Murry
Why Attend?
Dr. Bernhard Kuhn is a physician-scientist with special interests in cardiac regeneration. He received his medical and graduate degrees from the Freie Universitat in Berlin, Germany, in 1999. Dr. Kuhn completed a residency in pediatrics at Yale in 2002 and a clinical and research fellowship in pediatric cardiology at Children's Hospital Boston in 2007. He is Assistant Professor of Pediatrics at Harvard Medical School. Dr. Kuhn's honors include the Young Investigator Award of the American College of Cardiology (Pathology and Physiology) in 2007.
Dr. Kuhn's laboratory at Children's Hospital Boston studies the mechanisms of heart muscle cell proliferation during development and in adult life with the goal of stimulating this process for treating heart failure. Researchers in Dr. Kuhn's laboratory have extensively studied two extracellular factors that stimulate heart muscle cell proliferation and promote heart muscle regeneration: a peptide of periostin, a component of the extracellular matrix, and neuregulin1, a growth factor. Dr. Kuhn's research may provide new regenerative strategies for the treatment of heart failure.
Nuclear Architecture and Aging
Tom Misteli, Ph.D.
Senior Investigator
Cell Biology of Genomes
National Cancer Institute, NIH
Wednesday, December 9, 2009 - 4:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Chuck Murry
Why Attend?
Who doesn't care, and at times worry, about aging? Yet, the molecular basis of human aging is one of the least understood fundamental biological processes. A multitude of diverse mechanisms and pathways have been suggested to cause aging. While aging can be readily experimentally studied using animal models, the mechanisms of human aging are more difficult to ascertain. A promising approach is the molecular and cellular interrogation of naturally occurring human pre-mature aging disorders. The most severe premature aging disease is Hutchinson-Gilford Progeria Syndrome. Remarkably, this disease is caused by mutations in a gene encoding major architectural proteins of the cell nucleus. We have analyzed the causes of cellular and organismal defects in this disease and shown that the HGPS mechanisms are also relevant for normal aging. The insights form this rare human disease reveals an intricate interplay between nuclear architecture, stem cell biology and aging.
Tom Misteli is a Senior Investigator at the National Cancer Institute, NIH. He has pioneered the field of genome cell biology by developing imaging approaches to study genomes and gene expression in living cells. His laboratory aims to uncover fundamental principles of higher order genome organization and to apply this knowledge to the development of novel diagnostic and therapeutic strategies for cancer and aging. He has received numerous international awards. He is the Editor-in-Chief of The Journal of Cell Biology and of Current Opinion in Cell Biology.
Tom Misteli, Ph.D.
Senior Investigator
Cell Biology of Genomes
National Cancer Institute, NIH
Wednesday, December 9, 2009 - 4:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Chuck Murry
Why Attend?
Who doesn't care, and at times worry, about aging? Yet, the molecular basis of human aging is one of the least understood fundamental biological processes. A multitude of diverse mechanisms and pathways have been suggested to cause aging. While aging can be readily experimentally studied using animal models, the mechanisms of human aging are more difficult to ascertain. A promising approach is the molecular and cellular interrogation of naturally occurring human pre-mature aging disorders. The most severe premature aging disease is Hutchinson-Gilford Progeria Syndrome. Remarkably, this disease is caused by mutations in a gene encoding major architectural proteins of the cell nucleus. We have analyzed the causes of cellular and organismal defects in this disease and shown that the HGPS mechanisms are also relevant for normal aging. The insights form this rare human disease reveals an intricate interplay between nuclear architecture, stem cell biology and aging.
Tom Misteli is a Senior Investigator at the National Cancer Institute, NIH. He has pioneered the field of genome cell biology by developing imaging approaches to study genomes and gene expression in living cells. His laboratory aims to uncover fundamental principles of higher order genome organization and to apply this knowledge to the development of novel diagnostic and therapeutic strategies for cancer and aging. He has received numerous international awards. He is the Editor-in-Chief of The Journal of Cell Biology and of Current Opinion in Cell Biology.
Evidence Based Management of Liver Cancer: Integration of Research and Clinical Decision Making
Jordi Bruix, M.D.
Associate Professor
Director, Liver Cancer Group
University of Barcelona
Wednesday, December 2, 2009 - 4:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Jean Campbell
Why Attend?
Hepatocellular Carcinoma (HCC) is one of the major causes of cancer related death and its incidence is growing worldwide. Treatment of HCC, particularly, the advanced stage disease, is limited and not curative. The combination of these factors has fueled a growing interest in this disease priming research in both its pathogenesis and clinical management. Dr. Jordi Bruix, leader of the Barcelona Clinic Liver Cancer (BCLC) group at the University of Barcelona, has made key contributions in both areas, with a major emphasis on the development of criteria that allow an evidence-based management from diagnosis to therapy. In addition, Dr. Bruix's group through several international collaborations has provided new insight into the molecular profiling of this neoplasm.
Dr. Bruix will discuss his recent work with the phase 3 sorafenib "SHARP" trial, the first successful treatment of advanced-stage HCC and share his critical insight on the implications of recent studies translational studies on the future of HCC research and clinical practice.
Jordi Bruix, M.D.
Associate Professor
Director, Liver Cancer Group
University of Barcelona
Wednesday, December 2, 2009 - 4:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Jean Campbell
Why Attend?
Hepatocellular Carcinoma (HCC) is one of the major causes of cancer related death and its incidence is growing worldwide. Treatment of HCC, particularly, the advanced stage disease, is limited and not curative. The combination of these factors has fueled a growing interest in this disease priming research in both its pathogenesis and clinical management. Dr. Jordi Bruix, leader of the Barcelona Clinic Liver Cancer (BCLC) group at the University of Barcelona, has made key contributions in both areas, with a major emphasis on the development of criteria that allow an evidence-based management from diagnosis to therapy. In addition, Dr. Bruix's group through several international collaborations has provided new insight into the molecular profiling of this neoplasm.
Dr. Bruix will discuss his recent work with the phase 3 sorafenib "SHARP" trial, the first successful treatment of advanced-stage HCC and share his critical insight on the implications of recent studies translational studies on the future of HCC research and clinical practice.
Alpha-catenin in Tissue Morphogenesis, Organ Maintenance and Cancer
Valera Vasioukhin
Associate Member
Fred Hutchinson Cancer Research Center
Wednesday, November 18, 2009 - 4:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Ray Monnat
Why Attend?
Cadherin-catenin-mediated intercellular adhesion is necessary for the assembly of individual cells into multicellular organisms. Intriguingly, in addition to maintaining intercellular adhesion, cadherin-catenin proteins are also linked to several major developmental signaling pathways. This seminar will discuss our findings on the role and mechanisms of alpha-catenin in mammalian tissue morphogenesis, organ maintenance and cancer.
Valera Vasioukhin
Associate Member
Fred Hutchinson Cancer Research Center
Wednesday, November 18, 2009 - 4:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Ray Monnat
Why Attend?
Cadherin-catenin-mediated intercellular adhesion is necessary for the assembly of individual cells into multicellular organisms. Intriguingly, in addition to maintaining intercellular adhesion, cadherin-catenin proteins are also linked to several major developmental signaling pathways. This seminar will discuss our findings on the role and mechanisms of alpha-catenin in mammalian tissue morphogenesis, organ maintenance and cancer.
Merkel Cell Carcinoma and a New Polyomavirus: Mechanisms of Immune Escape by an Often-lethal Skin Malignancy
Paul Nghiem, M.D., Ph.D.
Associate Professor
UW Medicine Dermatology and Pathology
Wednesday, November 4, 2009 - 4:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Suzy Dintzis
Why Attend?
Merkel cell carcinoma (MCC) is a neuroendocrine skin cancer associated with advanced age, UV exposure and a new human polyomavirus (integrated in 80% of MCCs). Although 10% of MCC patients are profoundly immune suppressed, 90% have apparently normal immunity. Using genome-wide studies of MCC tumors, we found clues as to immune evasion mechanisms in use by this cancer and associated with outcomes. Using IHC studies on validation sets, we have found evidence of profound intra-tumoral immune suppression in many cases associated with poor outcomes. In contrast, outcomes are excellent in cases with evidence of immune recognition of this tumor. These insights are leading to potential new prognostic tests and translational studies designed to activate immune recognition of this highly antigenic tumor that is currently lethal in about 40% of cases.
Paul Nghiem received his undergraduate degree from Harvard, MD & PhD from Stanford, trained in medicine (Brigham & Women's), dermatology (MGH) and post-doctoral fellowship (Stuart Schreiber's lab in Harvard Chemistry). He moved to Seattle in 2006 and is an Associate Professor of Medicine/Dermatology and Pathology (Adjunct) at UW, and Affiliate Investigator at Fred Hutchinson. He sees patients at the Seattle Cancer Care Alliance and his research lab is at SLU.
Paul Nghiem, M.D., Ph.D.
Associate Professor
UW Medicine Dermatology and Pathology
Wednesday, November 4, 2009 - 4:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Suzy Dintzis
Why Attend?
Merkel cell carcinoma (MCC) is a neuroendocrine skin cancer associated with advanced age, UV exposure and a new human polyomavirus (integrated in 80% of MCCs). Although 10% of MCC patients are profoundly immune suppressed, 90% have apparently normal immunity. Using genome-wide studies of MCC tumors, we found clues as to immune evasion mechanisms in use by this cancer and associated with outcomes. Using IHC studies on validation sets, we have found evidence of profound intra-tumoral immune suppression in many cases associated with poor outcomes. In contrast, outcomes are excellent in cases with evidence of immune recognition of this tumor. These insights are leading to potential new prognostic tests and translational studies designed to activate immune recognition of this highly antigenic tumor that is currently lethal in about 40% of cases.
Paul Nghiem received his undergraduate degree from Harvard, MD & PhD from Stanford, trained in medicine (Brigham & Women's), dermatology (MGH) and post-doctoral fellowship (Stuart Schreiber's lab in Harvard Chemistry). He moved to Seattle in 2006 and is an Associate Professor of Medicine/Dermatology and Pathology (Adjunct) at UW, and Affiliate Investigator at Fred Hutchinson. He sees patients at the Seattle Cancer Care Alliance and his research lab is at SLU.
The Amazing Liver: New Perspectives on Regeneration and Cancer
Nelson Fausto, M.D.
Professor and Chair
UW Medicine Pathology
Wednesday, October 21, 2009 - 4:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Chuck Murry
Why Attend?
Most amphibians and fish can regenerate body parts, but mammals have lost this capacity. A question to be asked is "if they can do it, why cant we." Although we do not have clear answers to this question, the liver is a "yes we can" exception. The mechanisms of liver regeneration in mice and humans are complex and involve an initial priming phase in which hepatocytes respond to components of the innate immune system, enter the cell cycle and become sensitive to the effect of growth factors. In a second phase, hepatocytes progress through the cell cycle under growth factor stimulation, and after passing a restriction point, no longer require external proliferative stimuli. Understanding the cellular and molecular mechanisms of liver regeneration is important both because of its scientific interest but also because it has direct applicability to clinical practice, particularly in liver transplantation. Remarkably, liver regeneration even if repeated does not lead to carcinogenesis. New findings on liver cancer show that the liver stroma plays an essential role in the development of liver tumors, through the regulation of angiogenesis and the production of growth factors required for hepatocyte replication. Cancer development involves the close interaction between the stroma and hepatocytes.
Nelson Fausto, M.D.
Professor and Chair
UW Medicine Pathology
Wednesday, October 21, 2009 - 4:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Chuck Murry
Why Attend?
Most amphibians and fish can regenerate body parts, but mammals have lost this capacity. A question to be asked is "if they can do it, why cant we." Although we do not have clear answers to this question, the liver is a "yes we can" exception. The mechanisms of liver regeneration in mice and humans are complex and involve an initial priming phase in which hepatocytes respond to components of the innate immune system, enter the cell cycle and become sensitive to the effect of growth factors. In a second phase, hepatocytes progress through the cell cycle under growth factor stimulation, and after passing a restriction point, no longer require external proliferative stimuli. Understanding the cellular and molecular mechanisms of liver regeneration is important both because of its scientific interest but also because it has direct applicability to clinical practice, particularly in liver transplantation. Remarkably, liver regeneration even if repeated does not lead to carcinogenesis. New findings on liver cancer show that the liver stroma plays an essential role in the development of liver tumors, through the regulation of angiogenesis and the production of growth factors required for hepatocyte replication. Cancer development involves the close interaction between the stroma and hepatocytes.
MicroRNAs as Blood-based Cancer Biomarkers
Muneesh Tewari, MD, PhD
Assistant Member
Human Biology
Fred Hutchinson Cancer Research Center
Wednesday, June 3, 2009 - 4:30 PM
Health Sciences Center, K-069
Faculty Sponsor: Ray Monnat, M.D.
Why Attend?
MicroRNAs are small (~22 nt) non-protein-encoding RNAs that regulate target messenger RNAs via sequence-specific base-pairing interactions. MicroRNAs play important roles in diverse biological contexts and disease states. In cancer tissues, alterations in microRNA expression have been shown to be useful biomarkers for disease classification and prognosis. Recently, microRNAs were found to be released by tumor cells into the blood in a cell-free form where they may be useful as blood-based biomarkers for cancer and potentially other diseases. Dr. Tewari will discuss these results and ongoing work in his lab on circulating microRNAs as potential blood-based biomarkers for human cancer.
Dr. Tewari earned a B.A. in Biochemistry from Case Western Reserve University and M.D. and Ph.D. degrees from the University of Michigan. After completing clinical training in Internal Medicine and Medical Oncology, he pursued postdoctoral training in systems biology of genetic and protein interaction networks at Dana-Farber Cancer Institute and Harvard Medical School. Since 2005 he has been on the faculty at the Fred Hutchinson Cancer Research Center, where he is currently an Assistant Member in the Human Biology and Clinical Research Divisions.
Muneesh Tewari, MD, PhD
Assistant Member
Human Biology
Fred Hutchinson Cancer Research Center
Wednesday, June 3, 2009 - 4:30 PM
Health Sciences Center, K-069
Faculty Sponsor: Ray Monnat, M.D.
Why Attend?
MicroRNAs are small (~22 nt) non-protein-encoding RNAs that regulate target messenger RNAs via sequence-specific base-pairing interactions. MicroRNAs play important roles in diverse biological contexts and disease states. In cancer tissues, alterations in microRNA expression have been shown to be useful biomarkers for disease classification and prognosis. Recently, microRNAs were found to be released by tumor cells into the blood in a cell-free form where they may be useful as blood-based biomarkers for cancer and potentially other diseases. Dr. Tewari will discuss these results and ongoing work in his lab on circulating microRNAs as potential blood-based biomarkers for human cancer.
Dr. Tewari earned a B.A. in Biochemistry from Case Western Reserve University and M.D. and Ph.D. degrees from the University of Michigan. After completing clinical training in Internal Medicine and Medical Oncology, he pursued postdoctoral training in systems biology of genetic and protein interaction networks at Dana-Farber Cancer Institute and Harvard Medical School. Since 2005 he has been on the faculty at the Fred Hutchinson Cancer Research Center, where he is currently an Assistant Member in the Human Biology and Clinical Research Divisions.
Pancreatic Cancer: Genes to Patients
Ralph Hruban, MD
Professor
Pathology/Oncology
John Hopkins University
Wednesday, May 27, 2009 - 4:30 PM
Health Science Center, K-069
Faculty Sponsor: Ray Monnat, M.D.
Why Attend?
Pancreatic cancer is the 4th leading cause of cancer deaths in the United States. Dr. Hruban has been a leader in integrating clinico-pathologic and molecular analyses of human cancer with a special interest in pancreatic carcinoma. Dr. Hruban's research over the past decade has focused on identifying specific genes, mutations and epigenetic profiles that may be determinants of pancreatic cancer risk and progression, and may provide novel insights to improve cancer diagnosis and therapy. His talk will focus on integrating these new data to improve the care of individuals with pancreatic cancer and their families.
Ralph H. Hruban is a Professor of Pathology and Oncology at The Johns Hopkins University School of Medicine. He received his M.D. and completed Residency training at Johns Hopkins, did Fellowship training at Memorial Sloan-Kettering Cancer Center in New York and then returned to Baltimore to join the Johns Hopkins faculty in 1990. Dr. Hruban is currently the Director of The Sol Goldman Pancreatic Cancer Research Center, and Director of the Division of Gastrointestinal/Liver Pathology at Johns Hopkins. In addition to his research Dr. Hruban helped create the Johns Hopkins Pancreatic Cancer Web site (http://pathology.jhu.edu/pancreas), serves on the Scientific Advisory Board of PanCAN and is a Board member or Director at the Monastra, Rolfe and Lustgarten Foundations that are all focused on pancreatic cancer.
Ralph Hruban, MD
Professor
Pathology/Oncology
John Hopkins University
Wednesday, May 27, 2009 - 4:30 PM
Health Science Center, K-069
Faculty Sponsor: Ray Monnat, M.D.
Why Attend?
Pancreatic cancer is the 4th leading cause of cancer deaths in the United States. Dr. Hruban has been a leader in integrating clinico-pathologic and molecular analyses of human cancer with a special interest in pancreatic carcinoma. Dr. Hruban's research over the past decade has focused on identifying specific genes, mutations and epigenetic profiles that may be determinants of pancreatic cancer risk and progression, and may provide novel insights to improve cancer diagnosis and therapy. His talk will focus on integrating these new data to improve the care of individuals with pancreatic cancer and their families.
Ralph H. Hruban is a Professor of Pathology and Oncology at The Johns Hopkins University School of Medicine. He received his M.D. and completed Residency training at Johns Hopkins, did Fellowship training at Memorial Sloan-Kettering Cancer Center in New York and then returned to Baltimore to join the Johns Hopkins faculty in 1990. Dr. Hruban is currently the Director of The Sol Goldman Pancreatic Cancer Research Center, and Director of the Division of Gastrointestinal/Liver Pathology at Johns Hopkins. In addition to his research Dr. Hruban helped create the Johns Hopkins Pancreatic Cancer Web site (http://pathology.jhu.edu/pancreas), serves on the Scientific Advisory Board of PanCAN and is a Board member or Director at the Monastra, Rolfe and Lustgarten Foundations that are all focused on pancreatic cancer.
Improving Cancer Gene Therapy: Molecular Evolution and the Search for Super Suicide Genes
Margaret Black, Ph.D.
Associate Professor
Pharmaceutical Sciences
Washington State University
Wednesday, May 20, 2009 - 4:30 PM
Health Sciences Center, K-069
Faculty Sponsor: Larry Loeb, M.D., Ph.D.
Why Attend?
Suicide gene therapy employs nucleotide metabolizing enzymes to convert prodrugs to cytotoxic agents as a means to localize toxicity to tumors. Several enzymes involved in pyrimidine and purine anabolism are being exploited as suicide enzymes in combination with pharmacologically relevant analogs. The poor activity the enzymes display towards their respective prodrugs limits the overall therapeutic potential of suicide gene therapy. Dr. Black will discuss molecular engineering methods her lab is using to achieve a more potent cancer cell killing effect.
Dr. Black earned a B.A. in Biology from the University of California, Santa Cruz, and a M.A. in Microbiology from the University of California, Davis and a Ph.D. in Microbiology from Oregon State University. After completion of a postdoctoral fellowship at the University of Washington, she worked at Darwin Molecular Corp. for several years. Since 1998 she has been on the faculty at Washington State University (WSU) in the Department of Pharmaceutical Sciences. Dr. Black is currently the J. Roberts and Marcia Fosberg Distinguished Professor of Pharmacy and is Director of the Pharmacology/Toxicology Graduate Program at WSU.
Margaret Black, Ph.D.
Associate Professor
Pharmaceutical Sciences
Washington State University
Wednesday, May 20, 2009 - 4:30 PM
Health Sciences Center, K-069
Faculty Sponsor: Larry Loeb, M.D., Ph.D.
Why Attend?
Suicide gene therapy employs nucleotide metabolizing enzymes to convert prodrugs to cytotoxic agents as a means to localize toxicity to tumors. Several enzymes involved in pyrimidine and purine anabolism are being exploited as suicide enzymes in combination with pharmacologically relevant analogs. The poor activity the enzymes display towards their respective prodrugs limits the overall therapeutic potential of suicide gene therapy. Dr. Black will discuss molecular engineering methods her lab is using to achieve a more potent cancer cell killing effect.
Dr. Black earned a B.A. in Biology from the University of California, Santa Cruz, and a M.A. in Microbiology from the University of California, Davis and a Ph.D. in Microbiology from Oregon State University. After completion of a postdoctoral fellowship at the University of Washington, she worked at Darwin Molecular Corp. for several years. Since 1998 she has been on the faculty at Washington State University (WSU) in the Department of Pharmaceutical Sciences. Dr. Black is currently the J. Roberts and Marcia Fosberg Distinguished Professor of Pharmacy and is Director of the Pharmacology/Toxicology Graduate Program at WSU.
Signaling Networks in Vascular Morphogenesis and Homeostasis
Luisa Iruela-Arispe, PhD
Professor
Molecular, Cell and Developmental Biology
UCLA
Wednesday, May 13, 2009 - 4:30 PM
Health Sciences Center, K-069
Faculty Sponsor: Charles Murry, M.D., Ph.D.
Why Attend?
Our understanding of vascular fibrosis is limited, particularly at the molecular level. This seminar will discuss how specific molecular alterations in the tunica media result in progressive loss of smooth muscle, expansion of the tunica adventitia and vascular fibrosis. Luisa Iruela-Arispe is currently Professor in the Department of Molecular, Cell and Developmental Biology. She earned her Ph.D. in 1989 from the University of Sao Paulo in Brazil in 1989, but performed her thesis in Dr. Helene Sage at the University of Washington (Dept. of Biological Structure). She continued with Dr. Sage to complete post-doctoral training for four additional years. In 1994, she became Assistant Professor in the Department of Pathology at Harvard Medical School in 1994 and four years later she moved to UCLA, where she is today. Her research focuses on vascular development and pathology.
Luisa Iruela-Arispe, PhD
Professor
Molecular, Cell and Developmental Biology
UCLA
Wednesday, May 13, 2009 - 4:30 PM
Health Sciences Center, K-069
Faculty Sponsor: Charles Murry, M.D., Ph.D.
Why Attend?
Our understanding of vascular fibrosis is limited, particularly at the molecular level. This seminar will discuss how specific molecular alterations in the tunica media result in progressive loss of smooth muscle, expansion of the tunica adventitia and vascular fibrosis. Luisa Iruela-Arispe is currently Professor in the Department of Molecular, Cell and Developmental Biology. She earned her Ph.D. in 1989 from the University of Sao Paulo in Brazil in 1989, but performed her thesis in Dr. Helene Sage at the University of Washington (Dept. of Biological Structure). She continued with Dr. Sage to complete post-doctoral training for four additional years. In 1994, she became Assistant Professor in the Department of Pathology at Harvard Medical School in 1994 and four years later she moved to UCLA, where she is today. Her research focuses on vascular development and pathology.
Mitochondrial Signaling and Dynamics in Health and Disease
Gyorgy Hajnoczky, PhD
Professor
Pathology, Anatomy & Cell Biology
Jefferson Medical University
Wednesday, May 6, 2009 - 4:30 PM
Health Sciences Center , K-069
Faculty Sponsor: Charles Murry, M.D., Ph.D.
Why Attend?
Emerging evidence supports the broad involvement of mitochondria in cell signaling and dynamics. These functions often depend on mitochondrial sensing and responding to calcium. Mitochondrial calcium uptake controls mitochondrial function and cell signaling, while excessive mitochondrial calcium accumulation has been implicated in various diseases.
Gyorgy Hajnoczky is currently a Professor in the Department of Pathology and Cell Biology at Thomas Jefferson University. He earned his M.D. (1987) and Ph.D. (1993) from Semmelweis Medical University in Hungary. In 1991, he joined the lab of Dr. Andrew Thomas at Thomas Jefferson University as a postdoc. He became an independent investigator and was appointed to Assistant Professor in 1995 and to full Professor in 2002. His research focuses on calcium and mitochondrial biology.
Gyorgy Hajnoczky, PhD
Professor
Pathology, Anatomy & Cell Biology
Jefferson Medical University
Wednesday, May 6, 2009 - 4:30 PM
Health Sciences Center , K-069
Faculty Sponsor: Charles Murry, M.D., Ph.D.
Why Attend?
Emerging evidence supports the broad involvement of mitochondria in cell signaling and dynamics. These functions often depend on mitochondrial sensing and responding to calcium. Mitochondrial calcium uptake controls mitochondrial function and cell signaling, while excessive mitochondrial calcium accumulation has been implicated in various diseases.
Gyorgy Hajnoczky is currently a Professor in the Department of Pathology and Cell Biology at Thomas Jefferson University. He earned his M.D. (1987) and Ph.D. (1993) from Semmelweis Medical University in Hungary. In 1991, he joined the lab of Dr. Andrew Thomas at Thomas Jefferson University as a postdoc. He became an independent investigator and was appointed to Assistant Professor in 1995 and to full Professor in 2002. His research focuses on calcium and mitochondrial biology.
Prognostic & Predictive Factors in Surgical Patholgy - - A Critical Assessment
Mark Wick, MD
Professor
Pathology
Univeristy of Virginia
Friday, May 1, 2009 - 4:30 PM
Health Sciences Center, T-639
Faculty Sponsor: Matthew Yeh, M.D., Ph.D.
Why Attend?
Anatomic pathologists are increasingly being asked to evaluate tissue specimens for a growing number of biologically-relevant genes and gene products. These markers are thought to have importance in either prognosis or choice of therapy. However, relatively little attention has been given to the laboratory control mechanisms for assuring the validity of such analyses, and misconceptions also exist as to how they should be applied. This talk considers those issues.
Mark Wick, MD
Professor
Pathology
Univeristy of Virginia
Friday, May 1, 2009 - 4:30 PM
Health Sciences Center, T-639
Faculty Sponsor: Matthew Yeh, M.D., Ph.D.
Why Attend?
Anatomic pathologists are increasingly being asked to evaluate tissue specimens for a growing number of biologically-relevant genes and gene products. These markers are thought to have importance in either prognosis or choice of therapy. However, relatively little attention has been given to the laboratory control mechanisms for assuring the validity of such analyses, and misconceptions also exist as to how they should be applied. This talk considers those issues.
Deciphering the Hereditary Prion Protein Amyloidoses
Bernardino Ghetti, MD
Professor
Pathology & Lab Medicine
Indiana University
Wednesday, April 22, 2009 - 4:30 PM
Health Science Center, K-069
Faculty Sponsor: Montine
7th Annual Alvord Lecture in Neuropathology
The Alvord Lecture honors the scientific and clinical legacy of Professor Emeritus Ellsworth "Buster" Alvord, M.D., as an important pioneer in the field of neuropathology. Dr. Alvord served as Chief of Neoropathology at the University of Washington from 1960 to 2002.
Bernardino Ghetti, MD
Professor
Pathology & Lab Medicine
Indiana University
Wednesday, April 22, 2009 - 4:30 PM
Health Science Center, K-069
Faculty Sponsor: Montine
7th Annual Alvord Lecture in Neuropathology
The Alvord Lecture honors the scientific and clinical legacy of Professor Emeritus Ellsworth "Buster" Alvord, M.D., as an important pioneer in the field of neuropathology. Dr. Alvord served as Chief of Neoropathology at the University of Washington from 1960 to 2002.
Cellular and Molecular Biology of Natural Killer Cells: From Basic Science to Clinical Implications. A Personal Perspective
Vinay Kumar, MD, PhD
Professor and Chairman
Pathology
University of Chicago Medical School
Wednesday, April 15, 2009 - 4:30 PM
Health Sciences Center, K-069
Faculty Sponsor: UW Medicine Pathology Residents
Why Attend?
Dr Vinay Kumar is the Alice Hogge and Arthur Baer Professor, Chairman of the department of Pathology, and the Executive Vice Dean of the Biologic Sciences Division and Pritzker School of Medicine at the University of Chicago. After completing his medical training in India he completed a combined residency-PhD program at The All India Institute Medical Sciences, New Delhi. Soon thereafter, in 1972, he joined the department of pathology at Boston University School of Medicine, then chaired by Dr Stanley Robbins. In 1982, he moved to UT Southwestern Medical School in Dallas where he was appointed Vernie Stembridge Professor of Pathology in 1992. In 2000 he moved to the University of Chicago to chair the department of Pathology and was named the Executive Vice Dean in 2007.
Dr Kumar has devoted his career to medical education and basic research in immunology. He is the coauthor of Robbins and Cotran Pathologic Basis of Disease and Robbins Basic Pathology, and is currently the senior editor/author of both. These two texts with dozens of translations are the most widely used texts of Pathology worldwide. In 1974, two years after he joined Boston University, he and his colleagues discovered a new class of lymphocytes, later called NK cells, as mediators of resistance to acute leukemia in mice. Since then his laboratory has discovered and defined several NK cell receptors and the pathway of NK cell differentiation from stem cell. These studies have impacted clinical bone marrow transplantation and immunotherapy of tumors.
Vinay Kumar, MD, PhD
Professor and Chairman
Pathology
University of Chicago Medical School
Wednesday, April 15, 2009 - 4:30 PM
Health Sciences Center, K-069
Faculty Sponsor: UW Medicine Pathology Residents
Why Attend?
Dr Vinay Kumar is the Alice Hogge and Arthur Baer Professor, Chairman of the department of Pathology, and the Executive Vice Dean of the Biologic Sciences Division and Pritzker School of Medicine at the University of Chicago. After completing his medical training in India he completed a combined residency-PhD program at The All India Institute Medical Sciences, New Delhi. Soon thereafter, in 1972, he joined the department of pathology at Boston University School of Medicine, then chaired by Dr Stanley Robbins. In 1982, he moved to UT Southwestern Medical School in Dallas where he was appointed Vernie Stembridge Professor of Pathology in 1992. In 2000 he moved to the University of Chicago to chair the department of Pathology and was named the Executive Vice Dean in 2007.
Dr Kumar has devoted his career to medical education and basic research in immunology. He is the coauthor of Robbins and Cotran Pathologic Basis of Disease and Robbins Basic Pathology, and is currently the senior editor/author of both. These two texts with dozens of translations are the most widely used texts of Pathology worldwide. In 1974, two years after he joined Boston University, he and his colleagues discovered a new class of lymphocytes, later called NK cells, as mediators of resistance to acute leukemia in mice. Since then his laboratory has discovered and defined several NK cell receptors and the pathway of NK cell differentiation from stem cell. These studies have impacted clinical bone marrow transplantation and immunotherapy of tumors.
Genomic Dosage Disorders: Diagnostic Insights and Challenges
Nancy Spinner, PhD
Professor
Genetics in Pediatrics
University of Pennsylvania School of Medicine
Wednesday, April 8, 2009 - 4:30 PM
Health Science Center, K-069
Faculty Sponsor: Christine Disteche, Ph.D.
Why Attend?
Cytogenetics is experiencing a Renaissance, lead by the introduction of array based technology. We've been using high density SNP arrays in the both our clinical Cytogenetics (now CytoGenomics) and research laboratories. The combination of genotyping and intensity data in this platform has revealed a new view of the genome in patients with congenital abnormalities. We've identified new mechanisms of disease, shed light on meiotic and mitotic origins of several types of abnormalities, and diagnosed single gene disorders (dominant and recessive), which contribute to the construction of a gene dosage map. Dr. Spinner received her BS from Brandeis University, PhD in Genetics from UC Berkeley and Fellowship training in Genetics and Cytogenetics at The University of Pennsylvania. She is currently on the Faculty at Penn, in the Departments of Pediatrics and Genetics and she is the Director of the Clinical CytoGenomics Laboratory at The Children's Hospital of Philadelphia.
Nancy Spinner, PhD
Professor
Genetics in Pediatrics
University of Pennsylvania School of Medicine
Wednesday, April 8, 2009 - 4:30 PM
Health Science Center, K-069
Faculty Sponsor: Christine Disteche, Ph.D.
Why Attend?
Cytogenetics is experiencing a Renaissance, lead by the introduction of array based technology. We've been using high density SNP arrays in the both our clinical Cytogenetics (now CytoGenomics) and research laboratories. The combination of genotyping and intensity data in this platform has revealed a new view of the genome in patients with congenital abnormalities. We've identified new mechanisms of disease, shed light on meiotic and mitotic origins of several types of abnormalities, and diagnosed single gene disorders (dominant and recessive), which contribute to the construction of a gene dosage map. Dr. Spinner received her BS from Brandeis University, PhD in Genetics from UC Berkeley and Fellowship training in Genetics and Cytogenetics at The University of Pennsylvania. She is currently on the Faculty at Penn, in the Departments of Pediatrics and Genetics and she is the Director of the Clinical CytoGenomics Laboratory at The Children's Hospital of Philadelphia.
Gene Networks as Sensors and Drivers of Disease
Eric Schadt, PhD
Executive Scientific Director
Genetics
Rosetta Inpharmatics LLC
Wednesday, April 1, 2009 - 4:30 PM
Health Sciences Center, K-069
Faculty Sponsor: Ray Monnat, M.D.
Why Attend?
Molecular biology has been remarkably successful at revealing mechanisms and interactions between DNA, RNA, and protein biosynthesis, and is beginning to reveal the inner workings of cells. The genomics revolution has extended this approach by providing new tools to take comprehensive 'snapshots' of the molecular states of cells. These data-rich snapshots have allowed us, in turn, to begin to build whole gene networks that define physiological states, and that link and predict how changes in molecular states alter physiology. Dr. Schadt's talk will describe how whole gene networks are constructed, and how they are being used to gain new insights into the origin of human disease, especially the common diseases that are important causes of premature disability and death.
Dr. Schadt received his B.S. in Applied Mathematics/Computer Science from California Polytechnic State University, his M.A. in Pure Mathematics from UCD, and his Ph.D. in Bio-mathematics from UCLA (requiring Ph.D. candidacy in molecular biology and mathematics). He joined Rosetta in 1999, and formed the Genetics/Systems Biology department at Merck when Rosetta was acquired by Merck in 2001. Dr. Schadt is also a UW Affiliate Associate Professor of Biostatistics, and was recently elected a Fellow to the Institute of Systems and Synthetic Biology at Imperial College, London.
Eric Schadt, PhD
Executive Scientific Director
Genetics
Rosetta Inpharmatics LLC
Wednesday, April 1, 2009 - 4:30 PM
Health Sciences Center, K-069
Faculty Sponsor: Ray Monnat, M.D.
Why Attend?
Molecular biology has been remarkably successful at revealing mechanisms and interactions between DNA, RNA, and protein biosynthesis, and is beginning to reveal the inner workings of cells. The genomics revolution has extended this approach by providing new tools to take comprehensive 'snapshots' of the molecular states of cells. These data-rich snapshots have allowed us, in turn, to begin to build whole gene networks that define physiological states, and that link and predict how changes in molecular states alter physiology. Dr. Schadt's talk will describe how whole gene networks are constructed, and how they are being used to gain new insights into the origin of human disease, especially the common diseases that are important causes of premature disability and death.
Dr. Schadt received his B.S. in Applied Mathematics/Computer Science from California Polytechnic State University, his M.A. in Pure Mathematics from UCD, and his Ph.D. in Bio-mathematics from UCLA (requiring Ph.D. candidacy in molecular biology and mathematics). He joined Rosetta in 1999, and formed the Genetics/Systems Biology department at Merck when Rosetta was acquired by Merck in 2001. Dr. Schadt is also a UW Affiliate Associate Professor of Biostatistics, and was recently elected a Fellow to the Institute of Systems and Synthetic Biology at Imperial College, London.
Genetic and Epigenetic Regulation of Gene Expression in Normal Development and Diseases of Skeletal Muscle
Stephen Tapscott
Member
Divisions of Human Biology and Clinical Research
Fred Hutchinson Cancer Research Center
Wednesday, March 11, 2009 - 4:30 PM
Health Sciences Center, K-069
Faculty Sponsor: Ray Monnat, M.D.
Why Attend?
Skeletal myogenesis is a model system for defining the molecular mechanisms of regulating a complex program of gene expression in a dynamic system. MyoD is a central factor in this program and has been used to elucidate general rules for how complex cellular programs might evolve and achieve predictable complex behaviors. Dr. Tapscott will discuss his work on the regulation of gene expression in normal myogenesis and in rhabdomyosarcomas.
Dr. Tapscott earned his BA at Hampshire College and MD/PhD from the University of Pennsylvania, where he also completed medical inter,ship and neurology residency. He completed postdoctoral training in molecular biology at the Fred Hutchinson Cancer Research Center and has been a faculty member there since 1991.
Stephen Tapscott
Member
Divisions of Human Biology and Clinical Research
Fred Hutchinson Cancer Research Center
Wednesday, March 11, 2009 - 4:30 PM
Health Sciences Center, K-069
Faculty Sponsor: Ray Monnat, M.D.
Why Attend?
Skeletal myogenesis is a model system for defining the molecular mechanisms of regulating a complex program of gene expression in a dynamic system. MyoD is a central factor in this program and has been used to elucidate general rules for how complex cellular programs might evolve and achieve predictable complex behaviors. Dr. Tapscott will discuss his work on the regulation of gene expression in normal myogenesis and in rhabdomyosarcomas.
Dr. Tapscott earned his BA at Hampshire College and MD/PhD from the University of Pennsylvania, where he also completed medical inter,ship and neurology residency. He completed postdoctoral training in molecular biology at the Fred Hutchinson Cancer Research Center and has been a faculty member there since 1991.
Chromatin and G-quadruplex Functions at Telomeres and Beyond
Brad Johnson, MD, PhD
Assistant Professor
Pathology/Lab Medicine
University of Pennsylvania
Wednesday, March 4, 2009 - 4:30 PM
Health Sciences Center, K-069
Faculty Sponsor: Ray Monnat, M.D.
Why Attend?
Telomeres are the physical and functional 'caps' on the ends of chromosomes. Telomere defects are now known to contribute to several degenerative diseases as well as cancer. Dr. Johnson's talk will describe how telomeres are maintained by a combination of chromatin and helicase-dependent recombination pathways. He will also present new evidence for the role of G-quadruplex structures formed by G-rich telomeric DNA in telomere capping and the regulation of transcription.
Dr. Johnson received his BS from Yale, and MD and PhD from Stanford. He did residency training in Clinical Pathology at Brigham and Women's Hospital, and postdoctoral research at MIT before joining the faculty at Penn. Dr. Johnson is currently Assistant Professor of Pathology and Assistant Director of the Clinical Immunology Laboratory at the Hospital of the University of Pennsylvania.
Brad Johnson, MD, PhD
Assistant Professor
Pathology/Lab Medicine
University of Pennsylvania
Wednesday, March 4, 2009 - 4:30 PM
Health Sciences Center, K-069
Faculty Sponsor: Ray Monnat, M.D.
Why Attend?
Telomeres are the physical and functional 'caps' on the ends of chromosomes. Telomere defects are now known to contribute to several degenerative diseases as well as cancer. Dr. Johnson's talk will describe how telomeres are maintained by a combination of chromatin and helicase-dependent recombination pathways. He will also present new evidence for the role of G-quadruplex structures formed by G-rich telomeric DNA in telomere capping and the regulation of transcription.
Dr. Johnson received his BS from Yale, and MD and PhD from Stanford. He did residency training in Clinical Pathology at Brigham and Women's Hospital, and postdoctoral research at MIT before joining the faculty at Penn. Dr. Johnson is currently Assistant Professor of Pathology and Assistant Director of the Clinical Immunology Laboratory at the Hospital of the University of Pennsylvania.
Lost in Translation: Ribosomes in Hematopoiesis
Akiko Shimamura, MD, PhD
Associate Member
Division of Pediatric Hematology/Oncology
Fred Hutchinson Cancer Research Center
Wednesday, February 25, 2009 - 4:30 PM
Health Sciences Center, K-069
Faculty Sponsor: Ray Monnat, M.D.
Why Attend?
Ribosomes have long been considered "housekeeping" organelles whose chief-or sole-function is to translate the information contained in mRNAs into cellular proteins. A surprising recent twist in this story was the identification of ribosomal gene mutations in a group of hematologic disorders characterized by marrow failure and leukemia predisposition. Dr. Shimamura will review the emerging field of ribosomal diseases, and discuss models for disease that arise from ribosomal abnormalities or dysfunction.
Dr. Shimamura received her B.A. from Princeton University and did her M.D. and Ph.D. training at the University of Rochester. She joined the faculty at Harvard after Internship and Residency training at Johns Hopkins, and a Fellowship at the Dana-Farber and Children's Hospital in Boston. She was recruited to the UW in 2007, and is an Associate Member at the Fred Hutchinson in 2008. She directs a research lab at the FHCRC, and is head of the Marrow Failure Clinic at Seattle Children's Hospital.
Akiko Shimamura, MD, PhD
Associate Member
Division of Pediatric Hematology/Oncology
Fred Hutchinson Cancer Research Center
Wednesday, February 25, 2009 - 4:30 PM
Health Sciences Center, K-069
Faculty Sponsor: Ray Monnat, M.D.
Why Attend?
Ribosomes have long been considered "housekeeping" organelles whose chief-or sole-function is to translate the information contained in mRNAs into cellular proteins. A surprising recent twist in this story was the identification of ribosomal gene mutations in a group of hematologic disorders characterized by marrow failure and leukemia predisposition. Dr. Shimamura will review the emerging field of ribosomal diseases, and discuss models for disease that arise from ribosomal abnormalities or dysfunction.
Dr. Shimamura received her B.A. from Princeton University and did her M.D. and Ph.D. training at the University of Rochester. She joined the faculty at Harvard after Internship and Residency training at Johns Hopkins, and a Fellowship at the Dana-Farber and Children's Hospital in Boston. She was recruited to the UW in 2007, and is an Associate Member at the Fred Hutchinson in 2008. She directs a research lab at the FHCRC, and is head of the Marrow Failure Clinic at Seattle Children's Hospital.
Translating Pathways to Pancreatic Cancer
Sunil Hingorani, MD, PhD
Assistant Member
Clinical Research and Public Health Sciences Division
Fred Hutchinson Cancer Research Center
Wednesday, February 18, 2009 - 4:30 PM
Health Sciences Center, K-069
Faculty Sponsor: Ray Monnat, M.D.
Why Attend?
Pancreatic cancer is the 4th leading cause of cancer deaths in the U.S. Recent genomic analyses of this common killer have revealed core signaling pathways that are altered in nearly all pancreatic cancers, and thus are new targets for pancreatic cancer diagnosis and therapy. Dr. Hingorani will discuss these findings, and how mouse models can be used to explore the clinical translation of these exciting new results.
Dr. Hingorani received his B.A., M.D. and Ph.D. from Yale. He did internship, residency and fellowship training in Boston at the Brigham & Women's Hospital, Dana-Farber and M.I.T. before joining the faculty at Penn. He was recruited to the Fred Hutchinson and UW in 2005, where he has a research lab and directs the Pancreatic Cancer Specialty Clinic at the Seattle Cancer Care Alliance.
Sunil Hingorani, MD, PhD
Assistant Member
Clinical Research and Public Health Sciences Division
Fred Hutchinson Cancer Research Center
Wednesday, February 18, 2009 - 4:30 PM
Health Sciences Center, K-069
Faculty Sponsor: Ray Monnat, M.D.
Why Attend?
Pancreatic cancer is the 4th leading cause of cancer deaths in the U.S. Recent genomic analyses of this common killer have revealed core signaling pathways that are altered in nearly all pancreatic cancers, and thus are new targets for pancreatic cancer diagnosis and therapy. Dr. Hingorani will discuss these findings, and how mouse models can be used to explore the clinical translation of these exciting new results.
Dr. Hingorani received his B.A., M.D. and Ph.D. from Yale. He did internship, residency and fellowship training in Boston at the Brigham & Women's Hospital, Dana-Farber and M.I.T. before joining the faculty at Penn. He was recruited to the Fred Hutchinson and UW in 2005, where he has a research lab and directs the Pancreatic Cancer Specialty Clinic at the Seattle Cancer Care Alliance.
Patient-Specific Models of Glioma Growth and Invasion: Predictive Capability and Clinical Utility
Kristin Swanson, PhD
Research Associate Professor, UW Medicine Pathology
Adjunct Associate Research Professor, Applied Mathematics
University of Washington
Wednesday, February 11, 2009 - 4:30 PM
Health Sciences Center, K-069
Faculty Sponsor: Monnat
Kristin Swanson, PhD
Research Associate Professor, UW Medicine Pathology
Adjunct Associate Research Professor, Applied Mathematics
University of Washington
Wednesday, February 11, 2009 - 4:30 PM
Health Sciences Center, K-069
Faculty Sponsor: Monnat
Archaeoctyes: Monocytes as Universal Probes for Disease
Stephen Schwartz, MD, PhD
Professor
Pathology
University of Washington
Wednesday, February 4, 2009 - 4:30 PM
Health Sciences Center, K-069
Faculty Sponsor: Monnat
Stephen Schwartz, MD, PhD
Professor
Pathology
University of Washington
Wednesday, February 4, 2009 - 4:30 PM
Health Sciences Center, K-069
Faculty Sponsor: Monnat
Roles of Transcription in Genomic Stability or Instability
Philip Hanawalt, PhD
Professor
Biological Sciences
Stanford University
Wednesday, January 28, 2009 - 4:30 PM
Health Sciences Center, K-069
Faculty Sponsor: Loeb
Philip Hanawalt, PhD
Professor
Biological Sciences
Stanford University
Wednesday, January 28, 2009 - 4:30 PM
Health Sciences Center, K-069
Faculty Sponsor: Loeb
Studying Hematopoietic Disease with Genetics & Genomics
Yajuan Liu, PhD
Senior Fellow
Medical Genetics
University of Washington
Wednesday, January 21, 2009 - 4:30 PM
Health Science Bldg, K-069
Faculty Sponsor: Dr. Monnat
Yajuan Liu, PhD
Senior Fellow
Medical Genetics
University of Washington
Wednesday, January 21, 2009 - 4:30 PM
Health Science Bldg, K-069
Faculty Sponsor: Dr. Monnat
"Mitotic Reduction Divisions (Somatic Meiosis) in polyploid Hepatocytes"
Markus Grompe, MD
Professor
Molecular & Medical Genetics and Pediatrics
Oregon Health & Science University
Wednesday, December 10, 2008 - 4:30 PM
Health Science Center, K-069
Faculty Sponsor: Dr. Monnat
Markus Grompe, MD
Professor
Molecular & Medical Genetics and Pediatrics
Oregon Health & Science University
Wednesday, December 10, 2008 - 4:30 PM
Health Science Center, K-069
Faculty Sponsor: Dr. Monnat
FEN1 Mutations Result in Autoimmunity, Chronic Inflammation and Cancers
Binghui Shen, PhD
Professor
Radiation Biology
City of Hope
Wednesday, December 3, 2008 - 4:30 PM
Health Sciences Center, K-069
Faculty Sponsor: Dr. Loeb
Binghui Shen, PhD
Professor
Radiation Biology
City of Hope
Wednesday, December 3, 2008 - 4:30 PM
Health Sciences Center, K-069
Faculty Sponsor: Dr. Loeb
“Quantum Dots for Cancer Imaging and Therapeutics”
Xiaohu Gao, PhD
Assistant Professor
Bioengineering
University of Washington
Wednesday, November 19, 2008 - 4:30 PM
Health Science Center, K-069
Faculty Sponsor: Dr. Monnat
Xiaohu Gao, PhD
Assistant Professor
Bioengineering
University of Washington
Wednesday, November 19, 2008 - 4:30 PM
Health Science Center, K-069
Faculty Sponsor: Dr. Monnat
Neuroregeneration in the Cerebral Cortex: Impossible and Crazy?
Robert Hevner, M.D., Ph.D.
Professor
Neurological Surgery, Seattle Children's Hospital; and UW Medicine Pathology
University of Washington
Wednesday, November 12, 2008 - 4:30 PM
Health Science Center, K-069
Faculty Sponsor: Dr. Monnat
Robert Hevner, M.D., Ph.D.
Professor
Neurological Surgery, Seattle Children's Hospital; and UW Medicine Pathology
University of Washington
Wednesday, November 12, 2008 - 4:30 PM
Health Science Center, K-069
Faculty Sponsor: Dr. Monnat
"Pathogenesis of NASH: new insights from mice with metabolic syndrome"
Geoffrey Farrell, MD
Director/Professor
Gastroenterology and Hepatology
Australian National University
Wednesday, November 5, 2008 - 4:30 PM
Health Sciences Center, K-069
Faculty Sponsor: Dr. Matthew Yeh
Geoffrey Farrell, MD
Director/Professor
Gastroenterology and Hepatology
Australian National University
Wednesday, November 5, 2008 - 4:30 PM
Health Sciences Center, K-069
Faculty Sponsor: Dr. Matthew Yeh
"The Instability of Genetic Instability: Pathways Suppressing Mutator Phenotypes in Yeast"
Alan Herr, PhD
Senior Fellow
Pathology
University of Washington
Wednesday, October 29, 2008 - 4:30 PM
Health Sciences Center, K-069
Faculty Sponsor: Dr. Brad Preston
Alan Herr, PhD
Senior Fellow
Pathology
University of Washington
Wednesday, October 29, 2008 - 4:30 PM
Health Sciences Center, K-069
Faculty Sponsor: Dr. Brad Preston
"Control of Cardiovascular Signaling by RGS Proteins"
William Mahoney, PhD
Senior Fellow
Pathology
University of Washington
Wednesday, October 22, 2008 - 4:30 PM
Health Sciences Center, K-069
Faculty Sponsor: Dr. Monnat
William Mahoney, PhD
Senior Fellow
Pathology
University of Washington
Wednesday, October 22, 2008 - 4:30 PM
Health Sciences Center, K-069
Faculty Sponsor: Dr. Monnat
Exploring the Interface Between Glial Progenitors and Gliomas
Peter Canoll, MD, PhD
Assistant Professor
Department of Clinical Pathology
Columbia University
Wednesday, October 15, 2008 - 4:30 PM
Health Sciences Center, K-069
Faculty Sponsor: Dr. Tom Montine
Peter Canoll, MD, PhD
Assistant Professor
Department of Clinical Pathology
Columbia University
Wednesday, October 15, 2008 - 4:30 PM
Health Sciences Center, K-069
Faculty Sponsor: Dr. Tom Montine
Pancreatic Cancer: Emerging Ideas About How the Cancer Forms
Teri Brentnall, MD
Professor
Departments of Medicine and Pathology
University of Washington
Wednesday, October 1, 2008 - 4:30 PM
Health Sciences Center, K-069
Faculty Sponsor: Dr. Rabinovitch
Teri Brentnall, MD
Professor
Departments of Medicine and Pathology
University of Washington
Wednesday, October 1, 2008 - 4:30 PM
Health Sciences Center, K-069
Faculty Sponsor: Dr. Rabinovitch
The Blood Brain Barrier in Parkinson's disease: Old Foe or New Friend
Dr. Paul Carvey
Dean
Rush Medical School
Wednesday, February 20, 2008 - 4:30 AM
Health Sciences Building, T639
Faculty Sponsor: Dr. Zhang
Dr. Paul Carvey
Dean
Rush Medical School
Wednesday, February 20, 2008 - 4:30 AM
Health Sciences Building, T639
Faculty Sponsor: Dr. Zhang
Roles of cytokines in regulation of bone mass
Brendan Boyce
Director of Surgical Pathology
Department of Pathology and Laboratory Medicine
University of Rochester Medical Center in New York
Wednesday, June 6, 2007 - 4:30 PM
HSC, K-069
Faculty Sponsor: Dr. Larry True
Brendan Boyce
Director of Surgical Pathology
Department of Pathology and Laboratory Medicine
University of Rochester Medical Center in New York
Wednesday, June 6, 2007 - 4:30 PM
HSC, K-069
Faculty Sponsor: Dr. Larry True
Membrane Electroporation for Cancer Therapies and Direct Gene Electrotherapy
Dr. Eberhard Neumann
Bielefeld, Germany
Department of Chemistry
University of Bielefeld
Wednesday, May 30, 2007 - 4:30 PM
HSC, K-069
Faculty Sponsor: Dr. Lawrence Loeb
International speaker from Germany
Dr. Eberhard Neumann
Bielefeld, Germany
Department of Chemistry
University of Bielefeld
Wednesday, May 30, 2007 - 4:30 PM
HSC, K-069
Faculty Sponsor: Dr. Lawrence Loeb
International speaker from Germany
PathPresents: Molecular Diagnosis of Limb-Girdle and Congenital Muscular Dystrophies
Steven A. Moore, M.D., Ph.D.
Co-Director
Wellstone Muscular Dystrophy Research Center
University of Iowa
Wednesday, March 14, 2007 - 4:30 PM
HSC, K-069
Faculty Sponsor: Dr. Hevner
Sponsored by PathPresents.
Steven A. Moore, M.D., Ph.D.
Co-Director
Wellstone Muscular Dystrophy Research Center
University of Iowa
Wednesday, March 14, 2007 - 4:30 PM
HSC, K-069
Faculty Sponsor: Dr. Hevner
Sponsored by PathPresents.
Path Presents: The Isoprostanes and Related Compounds as Markers and Mediators of Oxidant Stress in Human Disease: New Insights and Current Controversies.
Jason D. Morrow
F. Tremaine Billings Professor of Medicine and Pharmacology
Chief, Division of Clinical Pharmacology
Vanderbilt University School of Medicine
Wednesday, February 7, 2007 - 4:30 PM
HSC, K-069
Faculty Sponsor: Dr. Thomas Montine
Jason D. Morrow
F. Tremaine Billings Professor of Medicine and Pharmacology
Chief, Division of Clinical Pharmacology
Vanderbilt University School of Medicine
Wednesday, February 7, 2007 - 4:30 PM
HSC, K-069
Faculty Sponsor: Dr. Thomas Montine
Proteomics-Based Strategies to Study Hepatitis C Virus-Related Hepatocellular Carcinoma
Laura Beretta
Associate Member, FHCRC, Affiliate Associate Professor, UW
Pathology
UW - Pathology
Wednesday, June 7, 2006 - 4:00 AM
HSB, K-069
Laura Beretta
Associate Member, FHCRC, Affiliate Associate Professor, UW
Pathology
UW - Pathology
Wednesday, June 7, 2006 - 4:00 AM
HSB, K-069
“Global analysis of X chromosome dosage compensation"
Brian Oliver
Section Chief of Developmental Genomics
National Institutes of Health, Bethesda, MD
Wednesday, May 10, 2006 - 4:30 PM
HSB, K-069
Faculty Sponsor: Christine Disteche
Brian Oliver
Section Chief of Developmental Genomics
National Institutes of Health, Bethesda, MD
Wednesday, May 10, 2006 - 4:30 PM
HSB, K-069
Faculty Sponsor: Christine Disteche
**NOTE SPECIAL TIME 1:30PM** "Zebrafish as a model for Cancer, Pigmentation, and Systems Biology"
Keith Cheng
Jake Gittlen Cancer Research Foundation
Penn State College of Medicine
Wednesday, April 26, 2006 - 1:30 PM
HSB, K-069
Faculty Sponsor: Dr. Loeb
Keith Cheng
Jake Gittlen Cancer Research Foundation
Penn State College of Medicine
Wednesday, April 26, 2006 - 1:30 PM
HSB, K-069
Faculty Sponsor: Dr. Loeb
Tough mice and aging: How to survive with a damaged proteome"
Steve Clarke
Professor
Department of Chemistry and Biochemistry
UCLA
Wednesday, May 4, 2005 - 4:30 PM
health science bldg, K-069
Faculty Sponsor: George Martin
Steve Clarke
Professor
Department of Chemistry and Biochemistry
UCLA
Wednesday, May 4, 2005 - 4:30 PM
health science bldg, K-069
Faculty Sponsor: George Martin
Coenzyme Q and Aging: Dr. Jekyll or Mr. Hyde?
Catherine Clarke
Professor
Dept Chemistry and Biochemistry
UCLA
Wednesday, April 27, 2005 - 4:30 PM
Health Science Bldg, K-069
Faculty Sponsor: Tony Parks
Catherine Clarke
Professor
Dept Chemistry and Biochemistry
UCLA
Wednesday, April 27, 2005 - 4:30 PM
Health Science Bldg, K-069
Faculty Sponsor: Tony Parks
"The liver as a model system for cell growth, proliferation, and carcinogenesis"
Jeffrey Albrecht
Associate Professor
Medicine
University of Minnesota
Wednesday, March 9, 2005 - 4:30 PM
Health Science Bldg, K-069
Faculty Sponsor: Tony Parks
Jeffrey Albrecht
Associate Professor
Medicine
University of Minnesota
Wednesday, March 9, 2005 - 4:30 PM
Health Science Bldg, K-069
Faculty Sponsor: Tony Parks
Recombomice" Shed Light on Homologous Recombination in Mammals
Bevin Engelward, Sc.D.
Associate Professor of Molecular Toxicology
Biological Engineering Division
MIT
Wednesday, March 2, 2005 - 4:30 PM
Health Science Bldg, K-069
Faculty Sponsor: Ray Monnat
Bevin Engelward, Sc.D.
Associate Professor of Molecular Toxicology
Biological Engineering Division
MIT
Wednesday, March 2, 2005 - 4:30 PM
Health Science Bldg, K-069
Faculty Sponsor: Ray Monnat
"DNA Repair: Winning the Race with Replication"
Dr. John Heddle
Professor Emeritus & Senior Scholar
Department of Biology
York University, Toronto, Canada
Wednesday, February 16, 2005 - 4:30 PM
Health Science Bldg, K-069
Faculty Sponsor: Dr. Loeb
Dr. John Heddle
Professor Emeritus & Senior Scholar
Department of Biology
York University, Toronto, Canada
Wednesday, February 16, 2005 - 4:30 PM
Health Science Bldg, K-069
Faculty Sponsor: Dr. Loeb
Unrepaired G1 DNA breaks can transit S-phase for repair by homologous recombination
Dr Yannick Saintigny
Wednesday, January 12, 2005 - 4:30 PM
Health Sciences Center, T-747
Faculty Sponsor: Dr. Ray Monnat
Dr Yannick Saintigny
Wednesday, January 12, 2005 - 4:30 PM
Health Sciences Center, T-747
Faculty Sponsor: Dr. Ray Monnat
"Genome Maintenance, Telomeres and RecQ Helicases"
Dr. Judith Campisi
Professor
Lawrence Berkeley Laboratory, Center on the Economics and Demography of Aging
University of California, Berkeley
Wednesday, January 5, 2005 - 3:00 PM
HSB, K-069
Faculty Sponsor: Dr. Rabinovitch
Dr. Judith Campisi
Professor
Lawrence Berkeley Laboratory, Center on the Economics and Demography of Aging
University of California, Berkeley
Wednesday, January 5, 2005 - 3:00 PM
HSB, K-069
Faculty Sponsor: Dr. Rabinovitch
Defective DNA Damage Responses and Neurodegeneration and Brain Tumors."
Peter McKinnon, Ph.D.
Dept of Genetics,St. Jude Children's Research Hospital, Memphis, TN
Pathology
University of Washington
Wednesday, December 8, 2004 - 4:30 PM
HSB, K-069
Faculty Sponsor: Ray Monnat
Peter McKinnon, Ph.D.
Dept of Genetics,St. Jude Children's Research Hospital, Memphis, TN
Pathology
University of Washington
Wednesday, December 8, 2004 - 4:30 PM
HSB, K-069
Faculty Sponsor: Ray Monnat
The collagen VI muscular dystrophies: new insights into their molecular pathology and genetic basis
Shireen Lamande
Departmenet of Pediatrics
University of Melbourne, Australia
Wednesday, November 17, 2004 - 4:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Peter Byers
Shireen Lamande
Departmenet of Pediatrics
University of Melbourne, Australia
Wednesday, November 17, 2004 - 4:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Peter Byers
The Molecular Architecture of Signal Transduction Complexes
John D. Scott
Scientist
Oregon Health Sciences University
Wednesday, October 20, 2004 - 4:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Stephen Schwartz
John D. Scott
Scientist
Oregon Health Sciences University
Wednesday, October 20, 2004 - 4:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Stephen Schwartz
Imaging of Angiogenesis & Lymphangiogenesis in Mouse Models of Disease
Donald McDonald
Professor of Anatomy
University of California, San Francisco
Wednesday, October 6, 2004 - 4:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Stephen Schwartz
Donald McDonald
Professor of Anatomy
University of California, San Francisco
Wednesday, October 6, 2004 - 4:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Stephen Schwartz
Evolving Concepts in Soft Tissue Neoplasia
Christopher Fletcher
Professor and Director of Surgical Pathology
Brigham & Women's Hospital
Boston, MA
Wednesday, September 22, 2004 - 4:30 PM
Health Sciences Center, Room T-733
Faculty Sponsor: Dr. Brian Rubin
Christopher Fletcher
Professor and Director of Surgical Pathology
Brigham & Women's Hospital
Boston, MA
Wednesday, September 22, 2004 - 4:30 PM
Health Sciences Center, Room T-733
Faculty Sponsor: Dr. Brian Rubin
Seminar Title: TBA
Paul DiCorleto
Director
Lerner Institute
Cleveland Clinic
Wednesday, July 14, 2004 - 4:30 PM
Health Sciences Center, K-069
Faculty Sponsor: Dr. Dan Bowen-Pope
Paul DiCorleto
Director
Lerner Institute
Cleveland Clinic
Wednesday, July 14, 2004 - 4:30 PM
Health Sciences Center, K-069
Faculty Sponsor: Dr. Dan Bowen-Pope
Cardiomyopathy of Dystrophy: Primary Mechanisms and Experimental Therapeutics
Joseph Metzger
Professor
Departments of Physiology and Internal Medicine
University of Michigan
Tuesday, July 13, 2004 - 4:30 PM
Health Sciences Center, Room K-069
Joseph Metzger
Professor
Departments of Physiology and Internal Medicine
University of Michigan
Tuesday, July 13, 2004 - 4:30 PM
Health Sciences Center, Room K-069
Regulation of Cell Growth and Cell Size by the TSC-mTOR Pathway
Kun-Liang Guan
Professor
Department of Biological Chemistry
University of Michigan
Monday, July 12, 2004 - 4:30 PM
Health Sciences Center, K-069
Kun-Liang Guan
Professor
Department of Biological Chemistry
University of Michigan
Monday, July 12, 2004 - 4:30 PM
Health Sciences Center, K-069
Progression vs Regression of Chronic Kidney Disease: Fact or Fantasy
Agnos Fogo
Professor
Department of Pathology
Vanderbilt University
Thursday, June 17, 2004 - 10:30 AM
Health Sciences Center, Room T-747
Faculty Sponsor: Dr. Charles Alpers
Agnos Fogo
Professor
Department of Pathology
Vanderbilt University
Thursday, June 17, 2004 - 10:30 AM
Health Sciences Center, Room T-747
Faculty Sponsor: Dr. Charles Alpers
Perlecan Heparan Sulfate in the Control of Vascular Smooth Muscle Cell Proliferation During Development and Disease
Mary Wiser-Evans
Assistant Professor
Departments of Pediatrics and Cell and Developmental Biology
University of Colorado
Tuesday, June 8, 2004 - 4:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Michael Reidy
Mary Wiser-Evans
Assistant Professor
Departments of Pediatrics and Cell and Developmental Biology
University of Colorado
Tuesday, June 8, 2004 - 4:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Michael Reidy
Pleiotropic Effects of HDL and Lysophospholipids in the Vasculature and Heart
Bodo Levkau
Professor
Institute of Pathophysiology
University of Essen
Monday, June 7, 2004 - 4:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Elaine Raines
Bodo Levkau
Professor
Institute of Pathophysiology
University of Essen
Monday, June 7, 2004 - 4:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Elaine Raines
Genetics on Embryonic Stem Cells; A Shortcut for Functional Genomics
Andras Nagy
Professor
Department of Molecular and Medical Genetics
University of Toronto
Wednesday, May 26, 2004 - 4:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Dr. Stephen Schwartz
Andras Nagy
Professor
Department of Molecular and Medical Genetics
University of Toronto
Wednesday, May 26, 2004 - 4:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Dr. Stephen Schwartz
Barking Up the Right Vascular Tree with Sphingosine 1-Phosphate
Timothy Hla
Professor of Cell Biology and of Genetics and Developmental Biology
Director, Center for Vascular Biology
University of Connecticut School of Medicine
Thursday, May 20, 2004 - 4:30 PM
Health Sciences Center, Room T-747
Faculty Sponsor: Dr. Michael Reidy
Timothy Hla
Professor of Cell Biology and of Genetics and Developmental Biology
Director, Center for Vascular Biology
University of Connecticut School of Medicine
Thursday, May 20, 2004 - 4:30 PM
Health Sciences Center, Room T-747
Faculty Sponsor: Dr. Michael Reidy
Histone Methyltransferases in Tumor Suppression
Shi Huang
Associate Professor
The Burnham Institute
La Jolla, California
Wednesday, May 19, 2004 - 4:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Dr. Marshall Horwitz
Shi Huang
Associate Professor
The Burnham Institute
La Jolla, California
Wednesday, May 19, 2004 - 4:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Dr. Marshall Horwitz
New Entities in Pediatric Renal Neoplasia
Pedram Argani
Assistant Professor
Department of Pathology
Johns Hopkins University School of Medicine
Wednesday, May 12, 2004 - 4:30 PM
Health Sciences Center, K-069
Faculty Sponsor: Dr. Brian Rubin
Pedram Argani
Assistant Professor
Department of Pathology
Johns Hopkins University School of Medicine
Wednesday, May 12, 2004 - 4:30 PM
Health Sciences Center, K-069
Faculty Sponsor: Dr. Brian Rubin
Identification of Therapeutic Targets in Clinical Practice: Lessons Learned from the HER2 Story
Stuart Schnitt
Professor
Department of Pathology
Harvard Medical School
Wednesday, May 5, 2004 - 4:30 PM
Health Sciences Center, K-069
Faculty Sponsor: Dr. Brian Rubin
Stuart Schnitt
Professor
Department of Pathology
Harvard Medical School
Wednesday, May 5, 2004 - 4:30 PM
Health Sciences Center, K-069
Faculty Sponsor: Dr. Brian Rubin
Genetic Basis of Aortic Aneurysms and Dissections
Dianna Milewicz
Professor
Department of Medical Genetics
University of Texas Medical School
Wednesday, April 28, 2004 - 4:30 PM
Health Sciences Center, K-069
Faculty Sponsor: Dr. Eileen Mulvihill
Dianna Milewicz
Professor
Department of Medical Genetics
University of Texas Medical School
Wednesday, April 28, 2004 - 4:30 PM
Health Sciences Center, K-069
Faculty Sponsor: Dr. Eileen Mulvihill
Biological Roles of ADAMTS Metalloproteases
Suneel Apte
Associate Professor
Department of Molecular Medicine
CANCELED
Wednesday, April 21, 2004 - 4:30 PM
Health Sciences Center, K-069
Faculty Sponsor: Dr. Ulrike Schwarze
Suneel Apte
Associate Professor
Department of Molecular Medicine
CANCELED
Wednesday, April 21, 2004 - 4:30 PM
Health Sciences Center, K-069
Faculty Sponsor: Dr. Ulrike Schwarze
The Fragile X Gene: Distinct Molecular and Neuropathologic Mechanisms Give Rise to Two Separate Syndromes
Paul Hagerman
Professor
Department of Biological Chemistry
University of California, Davis
Monday, March 15, 2004 - 4:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Brad Preston and Charles Laird
Paul Hagerman
Professor
Department of Biological Chemistry
University of California, Davis
Monday, March 15, 2004 - 4:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Brad Preston and Charles Laird
Development Gone Awry: Genetics and Pathology of Medulloblastoma
Charles Eberhart
Assistant Professor
Department of Pathology
Johns Hopkins University School of Medicine
Wednesday, March 10, 2004 - 4:30 PM
Health Sciences Center, K-069
Faculty Sponsor: Dr. Tom Montine
Charles Eberhart
Assistant Professor
Department of Pathology
Johns Hopkins University School of Medicine
Wednesday, March 10, 2004 - 4:30 PM
Health Sciences Center, K-069
Faculty Sponsor: Dr. Tom Montine
Vascular Calcification in Chronic Kidney Disease
William G. Goodman
Professor
Department of Medicine
U.C.L.A. School of Medicine
Wednesday, March 3, 2004 - 4:30 PM
Health Sciences Center, K-069
Faculty Sponsor: Dr. Cecilia Giachelli
William G. Goodman
Professor
Department of Medicine
U.C.L.A. School of Medicine
Wednesday, March 3, 2004 - 4:30 PM
Health Sciences Center, K-069
Faculty Sponsor: Dr. Cecilia Giachelli
Utilizing Human Genetics to Understand Vascular Development
Dean Li
Associate Professor
Department of Medicine
University of Utah
Wednesday, February 25, 2004 - 4:30 PM
Health Sciences Center, K-069
Faculty Sponsor: Dr. Stephen Schwartz
Dean Li
Associate Professor
Department of Medicine
University of Utah
Wednesday, February 25, 2004 - 4:30 PM
Health Sciences Center, K-069
Faculty Sponsor: Dr. Stephen Schwartz
Characterization of Cancer-Associated Mutants of DNA Polymerase Beta
Joann Sweasy
Associate Professor
Departments of Therapeutic Radiology and Genetics
Yale University School of Medicine
Wednesday, February 11, 2004 - 4:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Dr. Larry Loeb
Joann Sweasy
Associate Professor
Departments of Therapeutic Radiology and Genetics
Yale University School of Medicine
Wednesday, February 11, 2004 - 4:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Dr. Larry Loeb
Mechanism of Lung Adenocarcinoma Induction by Jaagsiekte Sheep Retrovirus and Parallels with Human Lung Cancer
Dusty Miller
Member, FHCRC
Affiliate Professor, Department of Pathology
University of Washington
Wednesday, January 28, 2004 - 4:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Dr. Tony Parks
Dusty Miller
Member, FHCRC
Affiliate Professor, Department of Pathology
University of Washington
Wednesday, January 28, 2004 - 4:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Dr. Tony Parks
Fundamental Issues in Engineered Vessel Development
Laura Niklason
Assistant Professor
Departments of Biomedical Engineering, Anesthesia and Surgery
Duke University
Friday, January 16, 2004 - 3:30 PM
Health Sciences Center, K-069
Faculty Sponsor: Chuck Murry and Thomas Wight
Laura Niklason
Assistant Professor
Departments of Biomedical Engineering, Anesthesia and Surgery
Duke University
Friday, January 16, 2004 - 3:30 PM
Health Sciences Center, K-069
Faculty Sponsor: Chuck Murry and Thomas Wight
Prelamin A Processing and Progeria
Stephen Young, M.D.
Senior Investigator
Gladstone Institute of Cardiovascular Disease
University of California, San Francisco
Wednesday, December 17, 2003 - 4:30 PM
Health Sciences Center, K-069
Stephen Young, M.D.
Senior Investigator
Gladstone Institute of Cardiovascular Disease
University of California, San Francisco
Wednesday, December 17, 2003 - 4:30 PM
Health Sciences Center, K-069
Translational Control in Macrophage Inflammation
Paul L. Fox
Professor of Molecular Medicine
Department of Cell Biology
The Lerner Research Institute, Cleveland Clinic Foundation
Wednesday, December 3, 2003 - 4:30 PM
Health Sciences Center, K-069
Paul L. Fox
Professor of Molecular Medicine
Department of Cell Biology
The Lerner Research Institute, Cleveland Clinic Foundation
Wednesday, December 3, 2003 - 4:30 PM
Health Sciences Center, K-069
Involvement of IKK Alpha in Rank-Mediated Osteoclastogenesis
Michelle Chaisson
Post-Doctoral Fellow
Amgen, Inc.
Wednesday, November 19, 2003 - 4:30 PM
Health Sciences Center, Room K-069
Michelle Chaisson
Post-Doctoral Fellow
Amgen, Inc.
Wednesday, November 19, 2003 - 4:30 PM
Health Sciences Center, Room K-069
A Murine Model of Intestinal Pseudo-Obstruction
Raj Kapur, M.D., Ph.D.
Associate Professor
Department of Pathology and Department of Laboratories
University of Washington and Children's Hospital and Regional Medical Center
Wednesday, November 5, 2003 - 4:30 PM
Health Sciences Center, Room K-069
Raj Kapur, M.D., Ph.D.
Associate Professor
Department of Pathology and Department of Laboratories
University of Washington and Children's Hospital and Regional Medical Center
Wednesday, November 5, 2003 - 4:30 PM
Health Sciences Center, Room K-069
Many Genes and Many Tumors: Genetics of Uterine Leiomyomata
Cynthia Morton
Professor
Department of Pathology
Brigham and Women's Hospital, Boston, MA
Wednesday, October 8, 2003 - 4:30 PM
Health Sciences Center, Room K-069
Cynthia Morton
Professor
Department of Pathology
Brigham and Women's Hospital, Boston, MA
Wednesday, October 8, 2003 - 4:30 PM
Health Sciences Center, Room K-069
Microscale Systems and Applications for Life-on-a-Chip
Deirdre Meldrum
Professor
Department of Electrical Engineering
University of Washington
Wednesday, June 11, 2003 - 4:30 PM
Health Sciences Center, Room K-069
Deirdre Meldrum
Professor
Department of Electrical Engineering
University of Washington
Wednesday, June 11, 2003 - 4:30 PM
Health Sciences Center, Room K-069
Biotechnology Drug Discovery in the Post-Human Genome Era
Thomas Bumol, Ph.D.
Vice President
Biotechnology Discovery Research
Lilly Research Laboratories
Thursday, June 5, 2003 - 4:30 PM
Health Sciences Center, T-747
Thomas Bumol, Ph.D.
Vice President
Biotechnology Discovery Research
Lilly Research Laboratories
Thursday, June 5, 2003 - 4:30 PM
Health Sciences Center, T-747
Genetic Chemoprotection of Hematopoietic Stem Cells: Implications for the Treatment of Genetic and Malignant Diseases
Hans-Peter Kiem
Associate Member
Fred Hutchinson Cancer Research Center
Wednesday, May 21, 2003 - 4:30 PM
Health Sciences Center, K-069
Hans-Peter Kiem
Associate Member
Fred Hutchinson Cancer Research Center
Wednesday, May 21, 2003 - 4:30 PM
Health Sciences Center, K-069
Cellular Adaptation to Client Protein Load on the Endoplasmic Reticulum
David Ron, M.D.
Professor
Departments of Medicine and Cell Biology
NYU School of Medicine
Wednesday, May 14, 2003 - 4:30 PM
Health Sciences Center, Room K-069
David Ron, M.D.
Professor
Departments of Medicine and Cell Biology
NYU School of Medicine
Wednesday, May 14, 2003 - 4:30 PM
Health Sciences Center, Room K-069
Yeast and Mouse Models for Exploring Telomere Function in Werner Syndrome
Brad Johnson, M.D., Ph.D.
Assistant Professor
Department of Pathology and Laboratory Medicine
University of Pennsylvania
Wednesday, May 7, 2003 - 4:30 PM
Health Sciences Center, Room K-069
Brad Johnson, M.D., Ph.D.
Assistant Professor
Department of Pathology and Laboratory Medicine
University of Pennsylvania
Wednesday, May 7, 2003 - 4:30 PM
Health Sciences Center, Room K-069
Bacteriophages: Natures Self-replicating, Self-limiting Antibiotics
Betty Kutter, Ph.D.
Faculty Member
Department of Biophysics
Evergreen State College
Wednesday, April 30, 2003 - 4:30 PM
HSC, Room K-069
Betty Kutter, Ph.D.
Faculty Member
Department of Biophysics
Evergreen State College
Wednesday, April 30, 2003 - 4:30 PM
HSC, Room K-069
Why Is the Gastric Cardia Such a Big Deal When It Is So Small?
Henry Appelman, M.D.
Professor
Pathology
University of Michigan
Wednesday, April 23, 2003 - 4:30 PM
HSC, Room K-069
Henry Appelman, M.D.
Professor
Pathology
University of Michigan
Wednesday, April 23, 2003 - 4:30 PM
HSC, Room K-069
Discoidin Domain Receptors (DDRS) - Novel Collagen Receptors in the Vascular System
Michelle Bendeck, Ph.D.
Associate Professor
Laboratory Medicine and Pathobiology
University of Toronto
Wednesday, April 16, 2003 - 4:30 PM
HSC, Room K-069
Michelle Bendeck, Ph.D.
Associate Professor
Laboratory Medicine and Pathobiology
University of Toronto
Wednesday, April 16, 2003 - 4:30 PM
HSC, Room K-069
Sex Chromosome Evolution: A Tale of the Smart, Sexy X Chromosome and the Degenerate Y
Jenny Graves
Professor
Comparative Genomics
Australian National University
Wednesday, April 2, 2003 - 4:30 PM
HSC, Room K-069
Jenny Graves
Professor
Comparative Genomics
Australian National University
Wednesday, April 2, 2003 - 4:30 PM
HSC, Room K-069
The Genetics and Biology of Tumor Suppression by p27/Kipl
Chris Kemp, Ph.D.
Affiliate Associate Professor
Department of Pathology
Fred Hutchinson Cancer Research Center
Wednesday, March 26, 2003 - 4:30 PM
HSC, K-069
Chris Kemp, Ph.D.
Affiliate Associate Professor
Department of Pathology
Fred Hutchinson Cancer Research Center
Wednesday, March 26, 2003 - 4:30 PM
HSC, K-069
Array CGH for High Resolution Analysis of Genomic Aberrations
Dan Pinkel, Ph.D.
Professor
Department of Laboratory Medicine
UCSF
Tuesday, February 25, 2003 - 4:30 PM
Health Sciences Center, Room K-069
Dan Pinkel, Ph.D.
Professor
Department of Laboratory Medicine
UCSF
Tuesday, February 25, 2003 - 4:30 PM
Health Sciences Center, Room K-069
Innate Immune Recognition and Response to Microbial Pathogens
Kelly Smith, Ph.D., M.D.
Department of Pathology
University of Washington
Wednesday, February 19, 2003 - 4:30 PM
Health Sciences Center, Room K-069
Kelly Smith, Ph.D., M.D.
Department of Pathology
University of Washington
Wednesday, February 19, 2003 - 4:30 PM
Health Sciences Center, Room K-069
The Role of Proteolysis in the Pathogenesis of Atherosclerosis
Peter Gough
Research Assistant Professor
Department of Pathology
University of Washington
Wednesday, February 12, 2003 - 4:30 PM
Health Sciences Center, Room K-069
Peter Gough
Research Assistant Professor
Department of Pathology
University of Washington
Wednesday, February 12, 2003 - 4:30 PM
Health Sciences Center, Room K-069
Cellular and Molecualr Mechanisms of Diabetes-accelerated Atherosclerosis
Karin Bornfeldt, Ph.D.
Associate Professor
Department of Pathology
University of Washington
Wednesday, February 5, 2003 - 4:30 PM
Health Sciences Center, Room K-069
Karin Bornfeldt, Ph.D.
Associate Professor
Department of Pathology
University of Washington
Wednesday, February 5, 2003 - 4:30 PM
Health Sciences Center, Room K-069
Protein Interactions
Stan Fields, Ph.D.
Professor
Departments of Genome Sciences and Medicine
University of Washington
Tuesday, January 21, 2003 - 4:30 PM
Health Sciences Center, T-747
Stan Fields, Ph.D.
Professor
Departments of Genome Sciences and Medicine
University of Washington
Tuesday, January 21, 2003 - 4:30 PM
Health Sciences Center, T-747
From Gene Expression Patterns to Antibody Diagnostics: A Pharmacogenomics Approach to Cancer Classification and Treatment
Douglas Ross, M.D., Ph.D.
Chief Scientific Officer
Applied Genomics Inc.
Wednesday, December 18, 2002 - 4:30 PM
HSC, K-069
Douglas Ross, M.D., Ph.D.
Chief Scientific Officer
Applied Genomics Inc.
Wednesday, December 18, 2002 - 4:30 PM
HSC, K-069
Development of a Gene Expression Array-Based Diagnostic Tool for Lymphoma
Daniel E. Sabath
Associate Professor
Laboratory Medicine
University of Washington
Wednesday, December 4, 2002 - 4:30 PM
HSC, K-069
Daniel E. Sabath
Associate Professor
Laboratory Medicine
University of Washington
Wednesday, December 4, 2002 - 4:30 PM
HSC, K-069
"Microarray Analysis in Cancer Research: Progress and Promise"
Paul Meltzer, M.D., Ph.D.
Senior Investigator
Cancer Genetics Branch
NIH, National Human Genome Research Institute
Wednesday, November 20, 2002 - 4:30 PM
Health Sciences Center, K-069
Paul Meltzer, M.D., Ph.D.
Senior Investigator
Cancer Genetics Branch
NIH, National Human Genome Research Institute
Wednesday, November 20, 2002 - 4:30 PM
Health Sciences Center, K-069
Molecular Pathology of the Vascular Form of Ehlers-Danlos Syndrome
Ulrike Schwarze, M.D.
Assistant Professor
Department of Pathology
University of Washington
Wednesday, November 13, 2002 - 4:30 PM
Health Sciences Center, K-069
Ulrike Schwarze, M.D.
Assistant Professor
Department of Pathology
University of Washington
Wednesday, November 13, 2002 - 4:30 PM
Health Sciences Center, K-069
Single Cell Proteomics
Norm Dovichi
Professor
Department of Chemistry
University of Washington
Wednesday, November 6, 2002 - 4:30 PM
HSC, K-069
Norm Dovichi
Professor
Department of Chemistry
University of Washington
Wednesday, November 6, 2002 - 4:30 PM
HSC, K-069
DNA Repair Genes Select Stem Cells in Vivo
Stan Gerson, M.D.
Professor and Chief
Hematology/Oncology
Case Western Reserve University
Wednesday, October 30, 2002 - 4:30 PM
HSC, K-069
Stan Gerson, M.D.
Professor and Chief
Hematology/Oncology
Case Western Reserve University
Wednesday, October 30, 2002 - 4:30 PM
HSC, K-069
Multimodality Phenotyping: A Systematic Approach to Understanding Pathogenetic Mechanisms in Cardiovascular Disease
James Scott
Professor
Genetics and Genomics Research Institute
Imperial College of Science
Wednesday, October 16, 2002 - 4:30 PM
Health Sciences Center, K-069
James Scott
Professor
Genetics and Genomics Research Institute
Imperial College of Science
Wednesday, October 16, 2002 - 4:30 PM
Health Sciences Center, K-069
Mouse Models Unravel the p53 Pathway
Gigi Lozano, Ph.D.
Professor and Geneticist
Department of Molecular Genetics
MD Anderson Cancer Center
University of Texas
Wednesday, October 2, 2002 - 4:30 PM
Health Sciences Center, K-069
Gigi Lozano, Ph.D.
Professor and Geneticist
Department of Molecular Genetics
MD Anderson Cancer Center
University of Texas
Wednesday, October 2, 2002 - 4:30 PM
Health Sciences Center, K-069
Cell Growth Survival and Papillogenesis in Ovarian Epithelial Cancer
Santo Nicosia, M.D.
Professor
Interdisciplinary Oncology Program
Moffitt Cancer Center and Research Institute
University of South Florida
Wednesday, July 31, 2002 - 4:30 PM
Health Sciences Center, Room T-747
Santo Nicosia, M.D.
Professor
Interdisciplinary Oncology Program
Moffitt Cancer Center and Research Institute
University of South Florida
Wednesday, July 31, 2002 - 4:30 PM
Health Sciences Center, Room T-747
"Regulation of ErbB Ligand Signaling Networks in Cancer and Diabetes - Role of Ligand Trafficking and Processing"
Peter J. Dempsey, Ph.D.
Principal Scientist
Pacific Northwest Research Institute
Seattle, Washington
Wednesday, June 26, 2002 - 4:30 PM
Health Sciences Center, K-069
Peter J. Dempsey, Ph.D.
Principal Scientist
Pacific Northwest Research Institute
Seattle, Washington
Wednesday, June 26, 2002 - 4:30 PM
Health Sciences Center, K-069
"Neurogenesis and Laminar Fate in the Developing Mouse Cerebral Cortex"
Robert Hevner, M.D., Ph.D.
Assistant Professor
Department of Pathology
University of Washington
Wednesday, June 5, 2002 - 4:30 PM
Health Sciences Building, K-069
Robert Hevner, M.D., Ph.D.
Assistant Professor
Department of Pathology
University of Washington
Wednesday, June 5, 2002 - 4:30 PM
Health Sciences Building, K-069
"Immunohistochemistry in Urologic Tumor Pathology"
Mark Wick, M.D.
Associate Director
Surgical Pathology
University of Virgina Health System
Wednesday, May 29, 2002 - 4:30 PM
Health Sciences Building, K-069
Mark Wick, M.D.
Associate Director
Surgical Pathology
University of Virgina Health System
Wednesday, May 29, 2002 - 4:30 PM
Health Sciences Building, K-069
Membranoproliferative/Cryoglobulinemic (Hepatitis C Associcated) Glomerulonephritis: A Disease of Mice and Men
Charles Alpers, M.D.
Professor
Department of Pathology
University of Washington
Wednesday, May 15, 2002 - 4:30 PM
Health Sciences Center,
Charles Alpers, M.D.
Professor
Department of Pathology
University of Washington
Wednesday, May 15, 2002 - 4:30 PM
Health Sciences Center,