Pathology Seminars
No upcoming seminars are currently posted.
Recent Pathology Seminars
Motors, Movement, and Malignancy
Steven S. Rosenfeld, M.D., Ph.D.
John and Elizabeth Harris Professor
Director, Division of Neuro-Oncology
Department of Neurology, Columbia University
Monday, July 19, 2010 - 4:30 PM
UWMC, Genome Sciences Building, Foege Auditorium
Faculty Sponsor: Thomas Montine, M.D., Ph.D.
Steven S. Rosenfeld, M.D., Ph.D.
John and Elizabeth Harris Professor
Director, Division of Neuro-Oncology
Department of Neurology, Columbia University
Monday, July 19, 2010 - 4:30 PM
UWMC, Genome Sciences Building, Foege Auditorium
Faculty Sponsor: Thomas Montine, M.D., Ph.D.
Metabolic Remodeling and Dysregulation of Lipid Dynamics in Diseased Hearts
E. Douglas Lewandowski, PhD
Professor, Physiology & Biophysics, and Medicine
Director, Program in Integrative Cardiac Metabolism
University of Illinois at Chicago
Tuesday, July 13, 2010 - 8:30 AM
SLU, 815 Mercer Street, Brotman Auditorium
Faculty Sponsor: Rong Tian
.
E. Douglas Lewandowski, PhD
Professor, Physiology & Biophysics, and Medicine
Director, Program in Integrative Cardiac Metabolism
University of Illinois at Chicago
Tuesday, July 13, 2010 - 8:30 AM
SLU, 815 Mercer Street, Brotman Auditorium
Faculty Sponsor: Rong Tian
.
Regulation of Neointimal Hyperplasia by Sphingosine-1-phosphate in Mice
Guenter Daum, Ph.D.
Research Associate Professor
UW Medicine Surgery
University of Washington
Wednesday, June 30, 2010 - 4:30 PM
Health Sciences Center, Turner Auditorium, Rm. D-209
Faculty Sponsor: Chuck Murry, M.D., Ph.D.
Why Attend
Intimal hyperplasia is a severe complication of surgical interventions to restore blood flow. In various models of arterial injury, smooth muscle cell (SMC) proliferation correlates with loss of expression of contractile proteins including smooth muscle alpha actin (SMA). Sphingosine-1-phosphate (S1P) is a phospholipid produced by platelets and other cells in response to injury. In this lecture I will present genetic and biochemical data linking S1P, and its receptors, to the control of smooth muscle migration and proliferation during neointimal formation.
Speaker is a candidate for an adjunct faculty appointment with UW Medicine Pathology
Guenter Daum, Ph.D.
Research Associate Professor
UW Medicine Surgery
University of Washington
Wednesday, June 30, 2010 - 4:30 PM
Health Sciences Center, Turner Auditorium, Rm. D-209
Faculty Sponsor: Chuck Murry, M.D., Ph.D.
Why Attend
Intimal hyperplasia is a severe complication of surgical interventions to restore blood flow. In various models of arterial injury, smooth muscle cell (SMC) proliferation correlates with loss of expression of contractile proteins including smooth muscle alpha actin (SMA). Sphingosine-1-phosphate (S1P) is a phospholipid produced by platelets and other cells in response to injury. In this lecture I will present genetic and biochemical data linking S1P, and its receptors, to the control of smooth muscle migration and proliferation during neointimal formation.
Speaker is a candidate for an adjunct faculty appointment with UW Medicine Pathology
How to Make a Heart: The Islet Heart Progenitor Story and 'Pregenerative' Medicine
Kenneth R. Chien, M.D., Ph.D.
Director, MGH Cardiovascular Research Center
Department of Cell Biology and Harvard Stem Cell Institute
Harvard University Medical School
Wednesday, June 23, 2010 - 4:30 PM
Health Sciences Center, Turner Auditorium, Rm. D-209
Faculty Sponsor: Chuck Murry
Kenneth R. Chien, M.D., Ph.D.
Director, MGH Cardiovascular Research Center
Department of Cell Biology and Harvard Stem Cell Institute
Harvard University Medical School
Wednesday, June 23, 2010 - 4:30 PM
Health Sciences Center, Turner Auditorium, Rm. D-209
Faculty Sponsor: Chuck Murry
Extending Lifespan by promoting proliferative homeostasis in Drosophila
Heinrich Jasper, Ph.D.
Assistant Professor
Biology
University of Rochester, New York
Tuesday, June 22, 2010 - 12:30 PM
HSB, K-069
Faculty Sponsor: Peter Rabinovitch
Seminar is now RE-SCHEDULED
Heinrich Jasper, Ph.D.
Assistant Professor
Biology
University of Rochester, New York
Tuesday, June 22, 2010 - 12:30 PM
HSB, K-069
Faculty Sponsor: Peter Rabinovitch
Seminar is now RE-SCHEDULED
Mapping gene expression subsets in systemic sclerosis to molecular pathways and concordant mouse models
Michael L. Whitfield, PhD
Assistant Professor
Genetics
Dartmouth Medical School
Tuesday, June 22, 2010 - 8:30 AM
SLU, 815 Mercer St, Brotman Auditorium
Faculty Sponsor: Stephen M. Schwartz, MD, PhD
Michael L. Whitfield, PhD
Assistant Professor
Genetics
Dartmouth Medical School
Tuesday, June 22, 2010 - 8:30 AM
SLU, 815 Mercer St, Brotman Auditorium
Faculty Sponsor: Stephen M. Schwartz, MD, PhD
Mitochondrial signaling in Disease and Aging
Gerald Shadel, Ph.D.
Professor,
Medicine and Molecular Genetics
Yale School of Medicine
Tuesday, June 15, 2010 - 12:30 PM
HSB, K-069
Faculty Sponsor: Peter Rabinovitch
Gerald Shadel, Ph.D.
Professor,
Medicine and Molecular Genetics
Yale School of Medicine
Tuesday, June 15, 2010 - 12:30 PM
HSB, K-069
Faculty Sponsor: Peter Rabinovitch
Of Old Mice and Men: Lessons in Comparative Pathology from a Mouse Model of Healthy Aging
Piper M. Treuting, D.V.M., M.S., DACVP
Assistant Professor, UW Comparative Medicine
Chief of UW Comparative Pathology Services
University of Washington
Wednesday, June 9, 2010 - 4:30 PM
Health Sciences Center, K-069
Faculty Sponsor: Suzanne Dintzis, M.D., Ph.D.
Why Attend,
Biomedical research institutions worldwide are literally over run with mice. The majority of extramural NIH funded grants use animals and the overwhelming majority of the research animals are mice. Mouse model development and validation is often performed by a team of scientists including comparative pathologists who understand how research may be impacted by mouse pathobiology such as the interplay of the mouse background strain with genetic manipulations, husbandry, age or commensal organisms. In this seminar, I will present the data generated by the end-of-life pathological analysis of old mice overexpressing mitochondrial-targeted catalase (mCAT) to highlight some of the unique features of mice and mouse-based research including species-specific anatomy and disease spectrum that make mice such useful, yet challenging, human disease models.
Piper M. Treuting, D.V.M., M.S., DACVP
Assistant Professor, UW Comparative Medicine
Chief of UW Comparative Pathology Services
University of Washington
Wednesday, June 9, 2010 - 4:30 PM
Health Sciences Center, K-069
Faculty Sponsor: Suzanne Dintzis, M.D., Ph.D.
Why Attend,
Biomedical research institutions worldwide are literally over run with mice. The majority of extramural NIH funded grants use animals and the overwhelming majority of the research animals are mice. Mouse model development and validation is often performed by a team of scientists including comparative pathologists who understand how research may be impacted by mouse pathobiology such as the interplay of the mouse background strain with genetic manipulations, husbandry, age or commensal organisms. In this seminar, I will present the data generated by the end-of-life pathological analysis of old mice overexpressing mitochondrial-targeted catalase (mCAT) to highlight some of the unique features of mice and mouse-based research including species-specific anatomy and disease spectrum that make mice such useful, yet challenging, human disease models.
Adenylyl cyclase type 5 (AC5), cardiac stress and longevity
Stephen Vatner, M.D.
Chair
Dept. of Cell Biology & Molecular Medicine
UMDNJ, New Jersey Medical School
Tuesday, June 8, 2010 - 12:30 PM
HSB, K-069
Faculty Sponsor: Peter Rabinovitch
Stephen Vatner, M.D.
Chair
Dept. of Cell Biology & Molecular Medicine
UMDNJ, New Jersey Medical School
Tuesday, June 8, 2010 - 12:30 PM
HSB, K-069
Faculty Sponsor: Peter Rabinovitch
The Adventitia: A Novel Hedgehog Signaling Domain and Progenitor Cell Niche in the Vessel Wall
Mark Majesky, Ph.D.
Professor, UW Medicine Pediatrics
Seattle Children's Research Institute
University of Washington
Wednesday, June 2, 2010 - 4:30 PM
Health Sciences Center, K-069
Faculty Sponsor: Stephen M. Schwartz, M.D., Ph.D.
Why Attend
An adventitia surrounds most blood vessels where it functions as a dynamic compartment for cell trafficking into and out of the vessel wall. Adventitial cells regulate vascular growth, remodeling, angiogenesis and defense against infection. Recent studies report unexpected roles for the adventitia insofar as it provides a niche environment for resident vascular stem and progenitor cells. Since all organs contain blood vessels, adventitial stem cells may be important for morphogenesis, repair and disease involving many different tissues and cell types. The roles of sonic hedgehog signaling in vascular development and the origins and fates of vascular progenitor cells will be discussed.
Mark Majesky, Ph.D.
Professor, UW Medicine Pediatrics
Seattle Children's Research Institute
University of Washington
Wednesday, June 2, 2010 - 4:30 PM
Health Sciences Center, K-069
Faculty Sponsor: Stephen M. Schwartz, M.D., Ph.D.
Why Attend
An adventitia surrounds most blood vessels where it functions as a dynamic compartment for cell trafficking into and out of the vessel wall. Adventitial cells regulate vascular growth, remodeling, angiogenesis and defense against infection. Recent studies report unexpected roles for the adventitia insofar as it provides a niche environment for resident vascular stem and progenitor cells. Since all organs contain blood vessels, adventitial stem cells may be important for morphogenesis, repair and disease involving many different tissues and cell types. The roles of sonic hedgehog signaling in vascular development and the origins and fates of vascular progenitor cells will be discussed.
Aortic Dissections, Vascular Diseases and ACTA2 Mutations
Dianna M. Milewicz, MD, PhD
Professor and Director
Medical Genetics
University of Texas medical School at Houston
Tuesday, June 1, 2010 - 8:30 AM
SLU, 815 Mercer St., Admin Bldg. C, Orin Smith Auditorium
Faculty Sponsor: Stephen M. Schwartz, MD, PhD
WEBINAR
Dianna M. Milewicz, MD, PhD
Professor and Director
Medical Genetics
University of Texas medical School at Houston
Tuesday, June 1, 2010 - 8:30 AM
SLU, 815 Mercer St., Admin Bldg. C, Orin Smith Auditorium
Faculty Sponsor: Stephen M. Schwartz, MD, PhD
WEBINAR
Window of Opportunity: Artificial Cornea Development for Treatable Blindness Worldwide
Tueng Shen
Associate Professor
University of Washington Eye Institute
Wednesday, May 26, 2010 - 4:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Chuck Murry
Why Attend
Treatable blindness, such as cataract and corneal blindness, are already a significant burden on global health and this burden is increasing. The majority of patients with treatable blindness live in the developing world. Common treatments used in developed countries are not viable options in the developing nations due to large discrepancy of health care infrastructure. The research in our laboratory aims to develop innovative solutions that can be applied for the developing world, leveraging cutting edge technology in material science, microelectronics and through collaborations while as the same time, addressing the cost and implementation constraints of the global market. The most recent results of artificial cornea development and drug delivery systems will be presented.
Tueng Shen
Associate Professor
University of Washington Eye Institute
Wednesday, May 26, 2010 - 4:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Chuck Murry
Why Attend
Treatable blindness, such as cataract and corneal blindness, are already a significant burden on global health and this burden is increasing. The majority of patients with treatable blindness live in the developing world. Common treatments used in developed countries are not viable options in the developing nations due to large discrepancy of health care infrastructure. The research in our laboratory aims to develop innovative solutions that can be applied for the developing world, leveraging cutting edge technology in material science, microelectronics and through collaborations while as the same time, addressing the cost and implementation constraints of the global market. The most recent results of artificial cornea development and drug delivery systems will be presented.
Toggling among pluripotent states in embryonic stem cells
Carol Ware, PhD
Professor
Comparative Medicine
Institute for Stem Cell and Regenerative Medicine
Tuesday, May 25, 2010 - 8:30 AM
SLU, 815 Mercer St., Admin Bldg C, Orin Smith Auditorium
Carol Ware, PhD
Professor
Comparative Medicine
Institute for Stem Cell and Regenerative Medicine
Tuesday, May 25, 2010 - 8:30 AM
SLU, 815 Mercer St., Admin Bldg C, Orin Smith Auditorium
Pyroptosis: Coordinated Inflammatory Response
Brad Cookson
Professor
Laboratory Medicine & Microbiology
University of Washington
Wednesday, May 19, 2010 - 4:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Chuck Murry
Why Attend
Eukaryotic cell death is an important and regulated host response, and one outcome is inflammation. We use microbial pathogens as biological probes to query the operation and function(s) of pyroptosis, a caspase-1-dependent pathway of programmed inflammatory cell death. The Greek roots pyro relates to fire or fever and ptosis (to-sis) denotes "a falling" or cell death. Pyroptosis results from the activation of a conserved effector pathway in response to diverse stimuli, with relevance to a variety of diseases in humans in which inflammation plays a central role.
Brad Cookson
Professor
Laboratory Medicine & Microbiology
University of Washington
Wednesday, May 19, 2010 - 4:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Chuck Murry
Why Attend
Eukaryotic cell death is an important and regulated host response, and one outcome is inflammation. We use microbial pathogens as biological probes to query the operation and function(s) of pyroptosis, a caspase-1-dependent pathway of programmed inflammatory cell death. The Greek roots pyro relates to fire or fever and ptosis (to-sis) denotes "a falling" or cell death. Pyroptosis results from the activation of a conserved effector pathway in response to diverse stimuli, with relevance to a variety of diseases in humans in which inflammation plays a central role.
Transcriptional Control of Stroma Dependent Apoptosis in MDS
Mario Marcondes
Graduate Student
Department of Pathology
University of Washington School of Medicine
Wednesday, May 19, 2010 - 2:00 PM
Fred Hutchinson Cancer Research Center, Pelton Auditorium
Faculty Sponsor: H. Joachim Deeg, M.D. and Dan Bowen-Pope, Ph.D.
Mario Marcondes
Graduate Student
Department of Pathology
University of Washington School of Medicine
Wednesday, May 19, 2010 - 2:00 PM
Fred Hutchinson Cancer Research Center, Pelton Auditorium
Faculty Sponsor: H. Joachim Deeg, M.D. and Dan Bowen-Pope, Ph.D.
Weird Animal Genomes and Sex
Jenny Graves, Ph.D.
Professor, Comparative Genomics
Research School of Biological Sciences
Australian National University, Canberra
Wednesday, May 19, 2010 - 1:30 PM
Genome Sciences Building, Foege Auditorium
Faculty Sponsor: Christine Disteche, Ph.D.
Dr. Graves' research focuses on the understanding of mammalian genome organization and evolution, exploiting the genetic diversity of Australia's unique mammals as a source of genetic variation to study highly conserved genetic structures and processes. This strategy is used to shed light on the organization, function and evolution of mammalian genomes, leading to new theories of the origin and evolution of human sex chromosomes and sex determining genes.
Jenny Graves, Ph.D.
Professor, Comparative Genomics
Research School of Biological Sciences
Australian National University, Canberra
Wednesday, May 19, 2010 - 1:30 PM
Genome Sciences Building, Foege Auditorium
Faculty Sponsor: Christine Disteche, Ph.D.
Dr. Graves' research focuses on the understanding of mammalian genome organization and evolution, exploiting the genetic diversity of Australia's unique mammals as a source of genetic variation to study highly conserved genetic structures and processes. This strategy is used to shed light on the organization, function and evolution of mammalian genomes, leading to new theories of the origin and evolution of human sex chromosomes and sex determining genes.
Quantifying Flow-induced Mechanical Stresses to Understand their Role in Vascular Disease
Alberto Aliseda, PhD
Assistant Professor
Mechanical Engineering
UW
Tuesday, May 18, 2010 - 8:30 AM
SLU, 815 Mercer St., Admin Bldg C, Orin Smith Auditorium
Alberto Aliseda, PhD
Assistant Professor
Mechanical Engineering
UW
Tuesday, May 18, 2010 - 8:30 AM
SLU, 815 Mercer St., Admin Bldg C, Orin Smith Auditorium
Cellular and Humoral Immune Responses to the Polyomavirus-linked Merkel Cell Carcinoma: Implications for Pathogenesis, Prognosis and Therapy
Kelly Paulson
Medical Scientist Training Program
Department of Pathology Graduate Student
University of Washington School of Medicine
Thursday, May 13, 2010 - 1:00 PM
Fred Hutchinson Cancer Research Center, Pelton Auditorium
Faculty Sponsor: Paul Nghiem, M.D., Ph.D.
Kelly Paulson
Medical Scientist Training Program
Department of Pathology Graduate Student
University of Washington School of Medicine
Thursday, May 13, 2010 - 1:00 PM
Fred Hutchinson Cancer Research Center, Pelton Auditorium
Faculty Sponsor: Paul Nghiem, M.D., Ph.D.
Mechanics and Mechanical Factors in the Structure-Function Relations of Endothelials and Platelets
Nathan J. Sniadecki, PhD
Assistant Professor
Mechanical Engineering
UW
Tuesday, May 11, 2010 - 8:30 AM
SLU, 815 Mercer St., Admin Bldg C, Orin Smith Auditorium
Nathan J. Sniadecki, PhD
Assistant Professor
Mechanical Engineering
UW
Tuesday, May 11, 2010 - 8:30 AM
SLU, 815 Mercer St., Admin Bldg C, Orin Smith Auditorium
Long-Chain Acyl-CoA Synthesis at the Crossroads Between Glucose and Fatty Acid-Enhanced Inflammation and Atherosclerosis in Diabetes
Jenny Kanter
Graduate Student
Department of Pathology
University of Washington School of Medicine
Monday, May 10, 2010 - 10:00 AM
UW Medicine at 815 Mercer, Orin Smith Auditorium
Faculty Sponsor: Karin Bornfeldt, Ph.D.
Jenny Kanter
Graduate Student
Department of Pathology
University of Washington School of Medicine
Monday, May 10, 2010 - 10:00 AM
UW Medicine at 815 Mercer, Orin Smith Auditorium
Faculty Sponsor: Karin Bornfeldt, Ph.D.
Annual Alvord Lecture in Neuropathology
Alexander R.A. Anderson, PhD
H. Lee Moffitt Cancer Center & Research Institute
Co-Director of Integrated Mathematical Oncology
Lee Moffitt Cancer Center & Research Institute
Wednesday, May 5, 2010 - 4:00 PM
University of Washinton, Genome Sciences Building, Foege Auditorium
Faculty Sponsor: Drs. T. Montine and K. Swanson
8th Annual Alvord Lecture in Neuropathology
The Alvord Lecture honors the scientific and clinical legacy of Professor Emeritus Ellsworth "Buster" Alvord, M.D., as an important pioneer in the field of neuropathology. Dr. Alvord served as Chief of Neoropathology at the University of Washington from 1960 to 2002. A special remembrance in honor of Dr. Alvord will precede the lecture. Reception to immediately follow the lecture at the Vista Cafe & Patio
Alexander R.A. Anderson, PhD
H. Lee Moffitt Cancer Center & Research Institute
Co-Director of Integrated Mathematical Oncology
Lee Moffitt Cancer Center & Research Institute
Wednesday, May 5, 2010 - 4:00 PM
University of Washinton, Genome Sciences Building, Foege Auditorium
Faculty Sponsor: Drs. T. Montine and K. Swanson
8th Annual Alvord Lecture in Neuropathology
The Alvord Lecture honors the scientific and clinical legacy of Professor Emeritus Ellsworth "Buster" Alvord, M.D., as an important pioneer in the field of neuropathology. Dr. Alvord served as Chief of Neoropathology at the University of Washington from 1960 to 2002. A special remembrance in honor of Dr. Alvord will precede the lecture. Reception to immediately follow the lecture at the Vista Cafe & Patio
Genetic Variation in Aging and Longevity
Yousin Suh, Ph.D.
Associate Professor
Medicine and Molecular Genetics
Albert Einstein College of Medicine, New York
Tuesday, May 4, 2010 - 12:30 PM
HSB, K-069
Faculty Sponsor: Peter Rabinovitch
Yousin Suh, Ph.D.
Associate Professor
Medicine and Molecular Genetics
Albert Einstein College of Medicine, New York
Tuesday, May 4, 2010 - 12:30 PM
HSB, K-069
Faculty Sponsor: Peter Rabinovitch
Mechanistic studies of myofilament protein phosphorylation modulating striated muscle contraction
Vijay S. Rao, PhD
Senior Fellow
Heart and Muscle Mechanics Laboratory, Bioengineering
UW
Tuesday, May 4, 2010 - 8:30 AM
SLU, 815 Mercer St., Admin Bldg C, Orin Smith Auditorium
Vijay S. Rao, PhD
Senior Fellow
Heart and Muscle Mechanics Laboratory, Bioengineering
UW
Tuesday, May 4, 2010 - 8:30 AM
SLU, 815 Mercer St., Admin Bldg C, Orin Smith Auditorium
Molecular Mechanisms of c-Myc-induced Immortalization of Human Fibroblasts
Myra Wang
Graduate Student
Department of Pathology
University of Washington School of Medicine
Monday, May 3, 2010 - 3:00 PM
Fred Hutchinson Cancer Research Center, Pelton Auditorium
Faculty Sponsor: Denise Galloway, Ph.D.
Myra Wang
Graduate Student
Department of Pathology
University of Washington School of Medicine
Monday, May 3, 2010 - 3:00 PM
Fred Hutchinson Cancer Research Center, Pelton Auditorium
Faculty Sponsor: Denise Galloway, Ph.D.
We Are What We Eat: Food and Water-borne Infectious Diseases of the Gastrointestinal Tract
Laura Lamps, M.D.
Professor
Department of Pathology
University of Arkansas for Medical Sciences
Friday, April 30, 2010 - 4:30 PM
Health Sciences Center, Turner Auditorium, Rm. D-209
Faculty Sponsor: Melissa Upton, M.D.
Laura Lamps, M.D.
Professor
Department of Pathology
University of Arkansas for Medical Sciences
Friday, April 30, 2010 - 4:30 PM
Health Sciences Center, Turner Auditorium, Rm. D-209
Faculty Sponsor: Melissa Upton, M.D.
Magnetic resonance imaging - a non-invasive method to study atherosclerosis progression and risk assessment
Chun Yuan, PhD
Professor of Radiology
Vascular Imaging Lab
UW
Tuesday, April 27, 2010 - 8:30 AM
SLU, 815 Mercer St., Admin Bldg C, Orin Smith Auditorium
Chun Yuan, PhD
Professor of Radiology
Vascular Imaging Lab
UW
Tuesday, April 27, 2010 - 8:30 AM
SLU, 815 Mercer St., Admin Bldg C, Orin Smith Auditorium
Apoptosis and Autophagy: Neuropathology in the Balance
Kevin Roth, M.D., Ph.D.
Professor and Chair
Department of Pathology
University of Alabama at Birmingham
Wednesday, April 21, 2010 - 4:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Dirk Keene
Why Attend?
Research in my laboratory is focused on the molecular regulation of neuronal cell death. Neuronal cell death occurs both during normal nervous system development and in a variety of neuropathological processes. The two major types of regulated cell death are apoptosis and autophagic cell death. While the processes controlling apoptotic cell death are fairly well characterized, the cellular and molecular regulation of autophagic cell death is poorly understood. We use a variety of in vivo and in vitro model systems to define the key molecules and cellular processes that regulate both apoptotic and autophagic cell death in neural stem cells, neurons and nervous system neoplasms. The long-term goals of my laboratory are to define the interactions between apoptotic and autophagic cell death pathways in the nervous system and to use this information to develop effective neuroprotective strategies to inhibit pathological neuron death and identify novel cell death-inducing compounds for the treatment of malignant glial neoplasms.
Kevin Roth, M.D., Ph.D.
Professor and Chair
Department of Pathology
University of Alabama at Birmingham
Wednesday, April 21, 2010 - 4:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Dirk Keene
Why Attend?
Research in my laboratory is focused on the molecular regulation of neuronal cell death. Neuronal cell death occurs both during normal nervous system development and in a variety of neuropathological processes. The two major types of regulated cell death are apoptosis and autophagic cell death. While the processes controlling apoptotic cell death are fairly well characterized, the cellular and molecular regulation of autophagic cell death is poorly understood. We use a variety of in vivo and in vitro model systems to define the key molecules and cellular processes that regulate both apoptotic and autophagic cell death in neural stem cells, neurons and nervous system neoplasms. The long-term goals of my laboratory are to define the interactions between apoptotic and autophagic cell death pathways in the nervous system and to use this information to develop effective neuroprotective strategies to inhibit pathological neuron death and identify novel cell death-inducing compounds for the treatment of malignant glial neoplasms.
Chemical Modifications of Proteins during Aging
John Baynes, Ph.D.
Carolina Distinguished Professor Emeritus
Dept. of Chemistry & Biochemistry
University of South Carolina
Tuesday, April 20, 2010 - 12:30 PM
HSB, K-069
Faculty Sponsor: Peter Rabinovitch
John Baynes, Ph.D.
Carolina Distinguished Professor Emeritus
Dept. of Chemistry & Biochemistry
University of South Carolina
Tuesday, April 20, 2010 - 12:30 PM
HSB, K-069
Faculty Sponsor: Peter Rabinovitch
Vascular gene therapy: a vector and a transgene that work!
David A. Dichek, MD
Professor of Medicine, Adjunct Professor of Pathology, John L. Locke, Jr. Family Endowed Chair in Medicine Associate Director for Research
Medicine/Cardiology
UW
Tuesday, April 20, 2010 - 8:30 AM
SLU, 815 Mercer St., Admin Bldg C, Orin Smith Auditorium
David A. Dichek, MD
Professor of Medicine, Adjunct Professor of Pathology, John L. Locke, Jr. Family Endowed Chair in Medicine Associate Director for Research
Medicine/Cardiology
UW
Tuesday, April 20, 2010 - 8:30 AM
SLU, 815 Mercer St., Admin Bldg C, Orin Smith Auditorium
Microbe Hunting in the 21st Century
Ian Lipkin, M.D.
Professor
Departments of Epidemiology, Neurology and Pathology
Columbia University Medical Center
Wednesday, April 14, 2010 - 3:30 PM
Health Sciences Center, Turner Auditorium, Room D-209
Faculty Sponsor: Michael Linden
This is a special Path Presents/Grand Rounds hosted by the Departments of Pathology and Laboratory Medicine.
Please note time and location change.
Ian Lipkin, M.D.
Professor
Departments of Epidemiology, Neurology and Pathology
Columbia University Medical Center
Wednesday, April 14, 2010 - 3:30 PM
Health Sciences Center, Turner Auditorium, Room D-209
Faculty Sponsor: Michael Linden
This is a special Path Presents/Grand Rounds hosted by the Departments of Pathology and Laboratory Medicine.
Please note time and location change.
S100A9 Has Disparate Affects in Neutrophils and Dendritic Cells, but Myeloid S100A9-Deficiency Does Not Affect Atherosclerosis and Insulin Resistance
Michelle Averill, PhD
Senior Fellow, Karin Bornfeldt Lab
Pathology
UW
Tuesday, April 13, 2010 - 8:30 AM
SLU, 815 Mercer St., Admin Bldg C, Orin Smith Auditorium
Michelle Averill, PhD
Senior Fellow, Karin Bornfeldt Lab
Pathology
UW
Tuesday, April 13, 2010 - 8:30 AM
SLU, 815 Mercer St., Admin Bldg C, Orin Smith Auditorium
Severe Gastrointestinal Motility Disorders: Understanding the Underlying Pathology of the Neuromuscular Apparatus of the Gut
Michael Schuffler
Professor
UW Medicine Gastroenterology
University of Washington
Wednesday, April 7, 2010 - 4:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Melissa Upton
Why Attend
Gastrointestinal motility disorders are common and responsible for much pain and suffering. Until relatively recently, little was known about the pathology of these disorders. The experimental approach in humans has consisted mainly of physiologic studies to the exclusion of structure. Because of methodologic limitations and relative lack of interest in the morphology of the human muscularis propria and enteric nervous system, the pathology of these structures has received scant attention. My research focused on the pathology of the enteric nervous system and smooth muscles in patients with motility disorders. My lecture will provide an understanding of this pathology and will suggest an approach that conceivably, could be used in the general pathology department to diagnose these disorders.
Michael Schuffler
Professor
UW Medicine Gastroenterology
University of Washington
Wednesday, April 7, 2010 - 4:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Melissa Upton
Why Attend
Gastrointestinal motility disorders are common and responsible for much pain and suffering. Until relatively recently, little was known about the pathology of these disorders. The experimental approach in humans has consisted mainly of physiologic studies to the exclusion of structure. Because of methodologic limitations and relative lack of interest in the morphology of the human muscularis propria and enteric nervous system, the pathology of these structures has received scant attention. My research focused on the pathology of the enteric nervous system and smooth muscles in patients with motility disorders. My lecture will provide an understanding of this pathology and will suggest an approach that conceivably, could be used in the general pathology department to diagnose these disorders.
Engineering Vascularized Human Cardiac Tissue for Heart Repair
Kareen L. Kreutziger, PhD
Postdoctoral Fellow
Pathology
UW
Tuesday, April 6, 2010 - 8:30 AM
SLU, 815 Mercer St., Admin Bldg C, Orin Smith Auditorium
Kareen L. Kreutziger, PhD
Postdoctoral Fellow
Pathology
UW
Tuesday, April 6, 2010 - 8:30 AM
SLU, 815 Mercer St., Admin Bldg C, Orin Smith Auditorium
Diagnosis and Management of Barrett's Esophagus and its Neoplastic Complications
Robert Odze, M.D., F.R.C.P.C
Professor, Harvard Medical School
Department of Pathology
Brigham and Women's Hospital
Wednesday, March 31, 2010 - 4:30 PM
Health Sciences Center, K-069
Faculty Sponsor: Melissa Upton, M.D.
Why Attend
Adenocarcinoma of the esophagus is rapidly rising in incidence in the Western world, and is caused by Barrett's esophagus. Cancer develops in Barrett's through a metaplasia-dysplasia-carcinoma sequence. There are controversies regarding establishing a diagnosis of Barrett's. The pathogenesis, pathology, natural history, and management of its neoplastic complications are also a subject of controversy. This lecture will focus on new insights, and the pathologic and molecular mechanisms involved, in the development of columnar metaplasia, dysplasia, and carcinoma of the esophagus. This lecture will provide guidelines for pathologists and clinicians who treat patients with this disorder.
Robert Odze, M.D., F.R.C.P.C
Professor, Harvard Medical School
Department of Pathology
Brigham and Women's Hospital
Wednesday, March 31, 2010 - 4:30 PM
Health Sciences Center, K-069
Faculty Sponsor: Melissa Upton, M.D.
Why Attend
Adenocarcinoma of the esophagus is rapidly rising in incidence in the Western world, and is caused by Barrett's esophagus. Cancer develops in Barrett's through a metaplasia-dysplasia-carcinoma sequence. There are controversies regarding establishing a diagnosis of Barrett's. The pathogenesis, pathology, natural history, and management of its neoplastic complications are also a subject of controversy. This lecture will focus on new insights, and the pathologic and molecular mechanisms involved, in the development of columnar metaplasia, dysplasia, and carcinoma of the esophagus. This lecture will provide guidelines for pathologists and clinicians who treat patients with this disorder.
Using simulation methods to address biomedical problems
Valerie Daggett, PhD
Professor
Bioengineering
UW
Tuesday, March 30, 2010 - 8:30 AM
SLU, 815 Mercer St., Admin Bldg C, Orin Smith Auditorium
Valerie Daggett, PhD
Professor
Bioengineering
UW
Tuesday, March 30, 2010 - 8:30 AM
SLU, 815 Mercer St., Admin Bldg C, Orin Smith Auditorium
Non-Cell Autonomous Neurodegeneration: A Tale of Two Glia
Gwenn Garden
Associate Professor
UW Medicine Neurology
University of Washington
Wednesday, March 24, 2010 - 4:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Tom Montine
Why Attend
The extra-cellular environment is a critical contributor to the pathogenesis if neurodegenerative diseases. Our laboratory is studying the role of the neural environment in a number of specific neurological diseases including HIV Associated Neurocognitive Disorders (HAND), Alzheimer's disease (AD) and Spinocerebellar Ataxia Type 7 (SCA7). Our overarching hypothesis is that altered regulation of normal glial cell function contributes both actively and passively to eventual neurodegeneration in these diseases. We are evaluating the role of specific molecular regulators of the microglia inflammatory response in HAND and AD with the long term goal of identifying molecular pathways that could serve as therapeutic targets that could develop into disease modifying therapies. In SCA7, a disease caused by inheriting a CAG repeat expansion in the ataxin 7 gene, we have discovered an important role for a specialized cerebellar glial cell, the Bergmann glia. The SCA7 disease gene causes altered Bergmann glia functions that contribute to the eventual degeneration of cerebellar neurons and the neurological symptoms of SCA7.
Gwenn Garden
Associate Professor
UW Medicine Neurology
University of Washington
Wednesday, March 24, 2010 - 4:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Tom Montine
Why Attend
The extra-cellular environment is a critical contributor to the pathogenesis if neurodegenerative diseases. Our laboratory is studying the role of the neural environment in a number of specific neurological diseases including HIV Associated Neurocognitive Disorders (HAND), Alzheimer's disease (AD) and Spinocerebellar Ataxia Type 7 (SCA7). Our overarching hypothesis is that altered regulation of normal glial cell function contributes both actively and passively to eventual neurodegeneration in these diseases. We are evaluating the role of specific molecular regulators of the microglia inflammatory response in HAND and AD with the long term goal of identifying molecular pathways that could serve as therapeutic targets that could develop into disease modifying therapies. In SCA7, a disease caused by inheriting a CAG repeat expansion in the ataxin 7 gene, we have discovered an important role for a specialized cerebellar glial cell, the Bergmann glia. The SCA7 disease gene causes altered Bergmann glia functions that contribute to the eventual degeneration of cerebellar neurons and the neurological symptoms of SCA7.
Natural and Artificial Extra-visual Ocular Photoreception
Russ Van Gelder, M.D., Ph.D.
Professor and Chair
UW Medicine Ophthalmology
University of Washington
Wednesday, March 17, 2010 - 4:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Chuck Murry
Why Attend
In the past ten years, we have come to the realization that the vertebrate eye serves as more than the organ of sight. Additional photoreceptor pathways exist in vertebrate eyes, controlling circadian rhythms, sleep, pupillary light responses, and likely seasonal behavior patterns. These pathways are mediated by novel photopigments including melanopsin and cryptochromes. Examples of recent work in chemically conferring photosensitivity on non-natively photoreceptive cells in the eye will also be discussed.
Russ Van Gelder, M.D., Ph.D.
Professor and Chair
UW Medicine Ophthalmology
University of Washington
Wednesday, March 17, 2010 - 4:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Chuck Murry
Why Attend
In the past ten years, we have come to the realization that the vertebrate eye serves as more than the organ of sight. Additional photoreceptor pathways exist in vertebrate eyes, controlling circadian rhythms, sleep, pupillary light responses, and likely seasonal behavior patterns. These pathways are mediated by novel photopigments including melanopsin and cryptochromes. Examples of recent work in chemically conferring photosensitivity on non-natively photoreceptive cells in the eye will also be discussed.
Machine learning approaches for understanding the genetic basis of complex traits
Su-In Lee, PhD
Assistant Professor
Computer Science & Engineering; and Genome Sciences
UW
Tuesday, March 9, 2010 - 8:30 AM
Health Sciences Building, K-069
Su-In Lee, PhD
Assistant Professor
Computer Science & Engineering; and Genome Sciences
UW
Tuesday, March 9, 2010 - 8:30 AM
Health Sciences Building, K-069
Microfluidics-assisted Display of Genomic DNA for Analysis of DNA Replication and Repair in Vivo
Julia Sidorova, Ph.D.
Acting Assistant Professor
UW Medicine Pathology
University of Washington
Wednesday, March 3, 2010 - 4:30 PM
Health Sciences Center, K-069
Faculty Sponsor: Ray Monnat
Why Attend?
DNA damage and enzymatic malfunction during DNA replication can be major sources of genomic instability. We focus on the functional analysis of DNA replication and repair under conditions of genotoxic stress as it unravels in living cells. Towards this end we have adapted a microfluidics-assisted approach to displaying individual molecules of genomic DNA on glass surfaces suitable for staining and microscopy. This technology allows us to measure DNA replication and repair in different genetic backgrounds and under different environmental stresses. We will discuss the novel insights we derived into the response of replication to blockage caused by nucleotide starvation, and the roles of the human RecQ helicases, WRN and BLM, in this process.
Julia Sidorova, Ph.D.
Acting Assistant Professor
UW Medicine Pathology
University of Washington
Wednesday, March 3, 2010 - 4:30 PM
Health Sciences Center, K-069
Faculty Sponsor: Ray Monnat
Why Attend?
DNA damage and enzymatic malfunction during DNA replication can be major sources of genomic instability. We focus on the functional analysis of DNA replication and repair under conditions of genotoxic stress as it unravels in living cells. Towards this end we have adapted a microfluidics-assisted approach to displaying individual molecules of genomic DNA on glass surfaces suitable for staining and microscopy. This technology allows us to measure DNA replication and repair in different genetic backgrounds and under different environmental stresses. We will discuss the novel insights we derived into the response of replication to blockage caused by nucleotide starvation, and the roles of the human RecQ helicases, WRN and BLM, in this process.
Neuregulin Signaling and Subtype Specialization in Stem Cell Derived Cardiomyocytes
Michael Laflamme, MD, PhD
Assistant Professor
Pathology, Center for Cardiovascular Biology Institute for Stem Cell & Regenerative Medicine
UW
Tuesday, March 2, 2010 - 8:30 AM
Health Sciences Building , K-069
Michael Laflamme, MD, PhD
Assistant Professor
Pathology, Center for Cardiovascular Biology Institute for Stem Cell & Regenerative Medicine
UW
Tuesday, March 2, 2010 - 8:30 AM
Health Sciences Building , K-069
Similarities and Differences of Diabetic Nephropathy in Type 1 vs. Type 2 Diabetic Patients
Behzad Najafian, M.D.
Assistant Professor
Laboratory Medicine and Pathology
University of Minnesota
Thursday, February 25, 2010 - 3:30 PM
University of Washington Medical Center, NE-110 Conference Room
Faculty Sponsor: Charles Alpers, M.D.
Speaker is a candidate for a clinical faculty position in the Department of Pathology Light refreshments will be served
Behzad Najafian, M.D.
Assistant Professor
Laboratory Medicine and Pathology
University of Minnesota
Thursday, February 25, 2010 - 3:30 PM
University of Washington Medical Center, NE-110 Conference Room
Faculty Sponsor: Charles Alpers, M.D.
Speaker is a candidate for a clinical faculty position in the Department of Pathology Light refreshments will be served
Mapping Gene Expression in the CNS: Tools and Data from the Allen Institute for Brain Science
Allan Jones, Ph.D.
Chief Scientific Officer
Allen Institute for Brain Science
Wednesday, February 24, 2010 - 4:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Ray Monnat, M.D.
Why Attend?
The Allen Institute for Brain Science is a non-profit research organization dedicated to providing tools and data for the larger research community. Since 2003, the Allen Institute has created a suite of large-scale data efforts along with a web portal to view and analyze the data. These efforts include gene expression atlases of the developing and adult mouse brain and spinal cord, and developing and adult human and non-human primate gene expression studies. The presentation will cover an overview of the Allen Institute, its projects and infrastructure, a look at a few specific examples of gene expression in the mouse and human as they relate to genetic diversity, and introduce some of the new projects on the horizon for the Institute.
Allan Jones, Ph.D.
Chief Scientific Officer
Allen Institute for Brain Science
Wednesday, February 24, 2010 - 4:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Ray Monnat, M.D.
Why Attend?
The Allen Institute for Brain Science is a non-profit research organization dedicated to providing tools and data for the larger research community. Since 2003, the Allen Institute has created a suite of large-scale data efforts along with a web portal to view and analyze the data. These efforts include gene expression atlases of the developing and adult mouse brain and spinal cord, and developing and adult human and non-human primate gene expression studies. The presentation will cover an overview of the Allen Institute, its projects and infrastructure, a look at a few specific examples of gene expression in the mouse and human as they relate to genetic diversity, and introduce some of the new projects on the horizon for the Institute.
Use of the Mouse Conditional and Null Alleles of the Type III Sodium-Dependent Phosphate Cotransporter PiT-1
Maria Festing, PhD
Senior Fellow, Ceci Giachelli Lab
Bioengineering
UW
Tuesday, February 23, 2010 - 8:30 AM
Health Sciences Building , K-069
Maria Festing, PhD
Senior Fellow, Ceci Giachelli Lab
Bioengineering
UW
Tuesday, February 23, 2010 - 8:30 AM
Health Sciences Building , K-069
Regulation of Neointimal Hyperplasia by Sphingosine-1-Phosphate in Mice
Guenter Daum, PhD
Research Associate Professor
Surgery
UW
Tuesday, February 16, 2010 - 8:30 AM
Health Sciences Building , K-069
Guenter Daum, PhD
Research Associate Professor
Surgery
UW
Tuesday, February 16, 2010 - 8:30 AM
Health Sciences Building , K-069
Common Disease - Multiple Rare Alleles: Understanding the Genetic Basis of Complex Human Traits
Mary-Claire King
Professor
Medicine & Genome Sciences
University of Washington
Wednesday, February 10, 2010 - 4:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Chuck Murry
Why Attend?
Human disease is characterized by marked genetic heterogeneity, far greater than previously appreciated. Converging evidence for a wide range of common diseases indicates that heterogeneity is important at multiple levels of causation: (1) individually rare mutations collectively play a substantial role in causing complex illnesses; (2) the same gene may harbor many different rare severe mutations (hundreds or even thousands) in unrelated affected individuals; (3) the same mutation may have different effects in different individuals; and (4) mutations in different genes in the same or related pathways may all lead to the same disorder. This degree of allelic, locus, and phenotypic heterogeneity has important implications for gene discovery and for development of molecular treatments and their appropriate use by individual patients.
Mary-Claire King
Professor
Medicine & Genome Sciences
University of Washington
Wednesday, February 10, 2010 - 4:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Chuck Murry
Why Attend?
Human disease is characterized by marked genetic heterogeneity, far greater than previously appreciated. Converging evidence for a wide range of common diseases indicates that heterogeneity is important at multiple levels of causation: (1) individually rare mutations collectively play a substantial role in causing complex illnesses; (2) the same gene may harbor many different rare severe mutations (hundreds or even thousands) in unrelated affected individuals; (3) the same mutation may have different effects in different individuals; and (4) mutations in different genes in the same or related pathways may all lead to the same disorder. This degree of allelic, locus, and phenotypic heterogeneity has important implications for gene discovery and for development of molecular treatments and their appropriate use by individual patients.
Biomechanics in carotid atherosclerosis and abdominal aortic aneurysms
Gador Canton, PhD
Senior Fellow
Radiology, Vascular Imaging Laboratory
UW
Tuesday, February 9, 2010 - 8:30 AM
Health Sciences Building , K-069
Gador Canton, PhD
Senior Fellow
Radiology, Vascular Imaging Laboratory
UW
Tuesday, February 9, 2010 - 8:30 AM
Health Sciences Building , K-069
RNA-based Molecular Circuitry for Conditional Gene Regulation
Georg Seelig, Ph.D.
Assistant Professor
Electrical Engineering, Computer Science & Engineering
University of Washington
Wednesday, February 3, 2010 - 4:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Ray Monnat
Why Attend?
In the first part of this talk I will review my recent work on DNA nanotechnology. Together with collaborators, I have advanced a general mechanism for implementing molecular computation using nucleic acids. Using DNA strand-displacement reactions as a molecular primitive we have been able to implement feed-forward digital logic circuits and, more recently, have proposed a method for implementing arbitrary chemical reaction kinetics in actual DNA-based chemistry. The circuit design principles that helped to make this circuitry robust and reliable will be useful to the construction of reliable circuitry for gene regulation control. In the second part of this talk I want to review work currently ongoing in my lab. We are interested in building nucleic acid-based sensors, logic gates and actuators that can detect cellular RNA inside living cells and, in response to varying expression patterns, can differentially and autonomously regulate gene expression. These synthetic regulatory elements are in part based on our in vitro DNA circuitry but also take advantage of existing RNA-based regulatory pathways, in particular the microRNA (miRNA) pathway and the RNA interference (RNAi) pathway.
Georg Seelig, Ph.D.
Assistant Professor
Electrical Engineering, Computer Science & Engineering
University of Washington
Wednesday, February 3, 2010 - 4:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Ray Monnat
Why Attend?
In the first part of this talk I will review my recent work on DNA nanotechnology. Together with collaborators, I have advanced a general mechanism for implementing molecular computation using nucleic acids. Using DNA strand-displacement reactions as a molecular primitive we have been able to implement feed-forward digital logic circuits and, more recently, have proposed a method for implementing arbitrary chemical reaction kinetics in actual DNA-based chemistry. The circuit design principles that helped to make this circuitry robust and reliable will be useful to the construction of reliable circuitry for gene regulation control. In the second part of this talk I want to review work currently ongoing in my lab. We are interested in building nucleic acid-based sensors, logic gates and actuators that can detect cellular RNA inside living cells and, in response to varying expression patterns, can differentially and autonomously regulate gene expression. These synthetic regulatory elements are in part based on our in vitro DNA circuitry but also take advantage of existing RNA-based regulatory pathways, in particular the microRNA (miRNA) pathway and the RNA interference (RNAi) pathway.
Using BAC Recombineering for the Analysis of Cardiac Progenitors
John L. Mignone, MD, PhD
Cardiology Fellow, Murry Lab
Pathology
UW
Tuesday, February 2, 2010 - 8:30 AM
Health Sciences Building , K-069
John L. Mignone, MD, PhD
Cardiology Fellow, Murry Lab
Pathology
UW
Tuesday, February 2, 2010 - 8:30 AM
Health Sciences Building , K-069
Imaging Circuit Assembly in the Developing Retina
Rachel Wong
Professor
Department of Biological Structure
University of Washington
Wednesday, January 27, 2010 - 4:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Suzy Dintzis
Why Attend?
Proper functioning of the nervous system requires the formation and maintenance of precise connectivity patterns between neurons. Our laboratory focuses on developmental mechanisms that regulate precision in circuit assembly of retinal neurons. Using live-cell imaging approaches to visualize retinal synaptogenesis under normal or perturbed developmental conditions, we have uncovered unexpected strategies by which neurons establish their mature connectivity patterns.
Rachel Wong
Professor
Department of Biological Structure
University of Washington
Wednesday, January 27, 2010 - 4:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Suzy Dintzis
Why Attend?
Proper functioning of the nervous system requires the formation and maintenance of precise connectivity patterns between neurons. Our laboratory focuses on developmental mechanisms that regulate precision in circuit assembly of retinal neurons. Using live-cell imaging approaches to visualize retinal synaptogenesis under normal or perturbed developmental conditions, we have uncovered unexpected strategies by which neurons establish their mature connectivity patterns.
When Muscle Runs Out of Gas: nNOS Function in Skeletal and Cardiac Muscle
Justin Percival, PhD
Research Assistant Professor
Physiology and Biophysics
UW
Tuesday, January 26, 2010 - 8:30 AM
Health Sciences Building , K-069
Justin Percival, PhD
Research Assistant Professor
Physiology and Biophysics
UW
Tuesday, January 26, 2010 - 8:30 AM
Health Sciences Building , K-069
High Throughput Screening at the UW: RNA Interference and Small Molecule Screens
Carla Grandori and Tom Martins
Research Associate Professors
Quellos High Throughput Screening Core, ISCRM
UW Medicine Pharmacology
Wednesday, January 20, 2010 - 4:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Ray Monnat
Why Attend?
High Throughput Screening (HTS) has revolutionized the way biomedical research can be conducted. Utilizing laboratory automation and robotics, HTS enables scientists to study complex biological systems and identify therapeutic drug candidates in reasonable timeframes that previously were improbable. The Quellos High Throughput Screening Core, located within the UW's Institute for Stem Cell and Regenerative Medicine at the UW School of Medicine campus in the South Lake Union area now provides HTS technology to both the Seattle academic community as well as its Biotech industry. This facility enables both genomic scale RNA interference screens as well as screening of large compound libraries for drug discoveries.
Further Information
Website: www.depts.washington.edu/uwhts/
Contact Info
General Core Facility Contact:
uwhts@uw.edu
For RNA Interference Screening
Carla Grandori; grandc@uw.edu
James Annis; annisj@uw.edu
For Chemical Screening
Tim Martins; tmartins@uw.edu
Carla Grandori and Tom Martins
Research Associate Professors
Quellos High Throughput Screening Core, ISCRM
UW Medicine Pharmacology
Wednesday, January 20, 2010 - 4:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Ray Monnat
Why Attend?
High Throughput Screening (HTS) has revolutionized the way biomedical research can be conducted. Utilizing laboratory automation and robotics, HTS enables scientists to study complex biological systems and identify therapeutic drug candidates in reasonable timeframes that previously were improbable. The Quellos High Throughput Screening Core, located within the UW's Institute for Stem Cell and Regenerative Medicine at the UW School of Medicine campus in the South Lake Union area now provides HTS technology to both the Seattle academic community as well as its Biotech industry. This facility enables both genomic scale RNA interference screens as well as screening of large compound libraries for drug discoveries.
Further Information
Website: www.depts.washington.edu/uwhts/
Contact Info
General Core Facility Contact:
uwhts@uw.edu
For RNA Interference Screening
Carla Grandori; grandc@uw.edu
James Annis; annisj@uw.edu
For Chemical Screening
Tim Martins; tmartins@uw.edu
Role of microRNA-155 in inflammatory/immune responses
John M. Harlan, MD
Professor of Medicine
Division of Hematology
UW
Tuesday, January 19, 2010 - 8:30 AM
Health Sciences Building , K-069
John M. Harlan, MD
Professor of Medicine
Division of Hematology
UW
Tuesday, January 19, 2010 - 8:30 AM
Health Sciences Building , K-069
Functional Genetic Approaches in In Vitro Stem Cell Systems Using RNAi
Patrick Paddison, Ph.D.
Assistant Member
Human Biology Division
Fred Hutchinson Cancer Research Center
Wednesday, January 13, 2010 - 4:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Ray Monnat
Why Attend?
While RNA interference (RNAi) first emerged as a peculiarity of nematodes, the molecular machinery that underlies RNAi is found in virtually every experimental eukaryotic system and has been co-opted in most to trigger gene silencing. RNAi has become a methodology of choice for knocking down gene expression in cultured mammalian cells has delivered new insights into a host of disease-related processes, including concrete information on potential drug targets. Its use has been expanded to in vivo applications in model rodent systems, including the ex vivo manipulation and transplantation of hematopoietic stem cells. Dr. Paddison's group focuses on applications of genome-scale RNAi libraries in embryonic, adult and cancer stem cell systems to reveal genes responsible for self-renewal, differentiation, and cancer homeostasis.
Patrick Paddison, Ph.D.
Assistant Member
Human Biology Division
Fred Hutchinson Cancer Research Center
Wednesday, January 13, 2010 - 4:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Ray Monnat
Why Attend?
While RNA interference (RNAi) first emerged as a peculiarity of nematodes, the molecular machinery that underlies RNAi is found in virtually every experimental eukaryotic system and has been co-opted in most to trigger gene silencing. RNAi has become a methodology of choice for knocking down gene expression in cultured mammalian cells has delivered new insights into a host of disease-related processes, including concrete information on potential drug targets. Its use has been expanded to in vivo applications in model rodent systems, including the ex vivo manipulation and transplantation of hematopoietic stem cells. Dr. Paddison's group focuses on applications of genome-scale RNAi libraries in embryonic, adult and cancer stem cell systems to reveal genes responsible for self-renewal, differentiation, and cancer homeostasis.
Proteolytic Pathways in Immunity
William C. Parks, Ph.D.
Professor of Medicine
Center for Lung Biology
UW
Tuesday, January 12, 2010 - 8:30 AM
Health Sciences Building , K-069
William C. Parks, Ph.D.
Professor of Medicine
Center for Lung Biology
UW
Tuesday, January 12, 2010 - 8:30 AM
Health Sciences Building , K-069
PET Imaging Tumor Phenotype in Sarcomas
Janet Eary, M.D.
Associate Professor
Department of Nuclear Medicine
University of Washington
Wednesday, January 6, 2010 - 4:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Ray Monnat
Why Attend?
Molecular Imaging techniques have made significant advances in ability to determine tissue specific biological characteristics quantitatively and non-invasively. PET Imaging is among the most sophisticated of these imaging techniques. PET Imaging uses imaging agents labeled with positron emitters and a special positron imaging device. Our UW group has pioneered development and imaging with new agents that report on tissue perfusion, hypoxia, cell proliferation, multiple drug resistance, receptor status, and many others for applications in cancer and several diseases. Sarcoma is a complex malignancy with a wide range of presentations and clinical behavior. In this seminar, molecular imaging in the example of sarcomas will be presented to highlight basic ideas in understanding the disease process in translational clinical studies.
Janet Eary is a Professor of Radiology in the Division of Nuclear Medicine. She has a joint appointment in Orthopedics and has an adjunct appointment in Pathology. She has pioneered a number of translational studies in Molecular Imaging, high dose radionuclide therapy, and is an expert in imaging clinical trials. Her current research is focused on the use of molecular imaging to stratify outcome risk in cancer patients, and advanced image analysis algorithm development and validation. She enjoys collaborations with investigators from many different disciplines.
Janet Eary, M.D.
Associate Professor
Department of Nuclear Medicine
University of Washington
Wednesday, January 6, 2010 - 4:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Ray Monnat
Why Attend?
Molecular Imaging techniques have made significant advances in ability to determine tissue specific biological characteristics quantitatively and non-invasively. PET Imaging is among the most sophisticated of these imaging techniques. PET Imaging uses imaging agents labeled with positron emitters and a special positron imaging device. Our UW group has pioneered development and imaging with new agents that report on tissue perfusion, hypoxia, cell proliferation, multiple drug resistance, receptor status, and many others for applications in cancer and several diseases. Sarcoma is a complex malignancy with a wide range of presentations and clinical behavior. In this seminar, molecular imaging in the example of sarcomas will be presented to highlight basic ideas in understanding the disease process in translational clinical studies.
Janet Eary is a Professor of Radiology in the Division of Nuclear Medicine. She has a joint appointment in Orthopedics and has an adjunct appointment in Pathology. She has pioneered a number of translational studies in Molecular Imaging, high dose radionuclide therapy, and is an expert in imaging clinical trials. Her current research is focused on the use of molecular imaging to stratify outcome risk in cancer patients, and advanced image analysis algorithm development and validation. She enjoys collaborations with investigators from many different disciplines.
The State of Seattle’s Biotech Industry
Luke Timmerman
National Biotechnology Editor
Xconomy
Tuesday, January 5, 2010 - 8:30 AM
Health Sciences Building, K-069
Luke Timmerman
National Biotechnology Editor
Xconomy
Tuesday, January 5, 2010 - 8:30 AM
Health Sciences Building, K-069
Stimulating Myocardial Regeneration with Cardiomyocyte Proliferation Factors
Bernhard Kuhn, M.D.
Associate Professor
Department of Cardiology
Children's Hospital Boston
Wednesday, December 16, 2009 - 4:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Chuck Murry
Why Attend?
Dr. Bernhard Kuhn is a physician-scientist with special interests in cardiac regeneration. He received his medical and graduate degrees from the Freie Universitat in Berlin, Germany, in 1999. Dr. Kuhn completed a residency in pediatrics at Yale in 2002 and a clinical and research fellowship in pediatric cardiology at Children's Hospital Boston in 2007. He is Assistant Professor of Pediatrics at Harvard Medical School. Dr. Kuhn's honors include the Young Investigator Award of the American College of Cardiology (Pathology and Physiology) in 2007.
Dr. Kuhn's laboratory at Children's Hospital Boston studies the mechanisms of heart muscle cell proliferation during development and in adult life with the goal of stimulating this process for treating heart failure. Researchers in Dr. Kuhn's laboratory have extensively studied two extracellular factors that stimulate heart muscle cell proliferation and promote heart muscle regeneration: a peptide of periostin, a component of the extracellular matrix, and neuregulin1, a growth factor. Dr. Kuhn's research may provide new regenerative strategies for the treatment of heart failure.
Bernhard Kuhn, M.D.
Associate Professor
Department of Cardiology
Children's Hospital Boston
Wednesday, December 16, 2009 - 4:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Chuck Murry
Why Attend?
Dr. Bernhard Kuhn is a physician-scientist with special interests in cardiac regeneration. He received his medical and graduate degrees from the Freie Universitat in Berlin, Germany, in 1999. Dr. Kuhn completed a residency in pediatrics at Yale in 2002 and a clinical and research fellowship in pediatric cardiology at Children's Hospital Boston in 2007. He is Assistant Professor of Pediatrics at Harvard Medical School. Dr. Kuhn's honors include the Young Investigator Award of the American College of Cardiology (Pathology and Physiology) in 2007.
Dr. Kuhn's laboratory at Children's Hospital Boston studies the mechanisms of heart muscle cell proliferation during development and in adult life with the goal of stimulating this process for treating heart failure. Researchers in Dr. Kuhn's laboratory have extensively studied two extracellular factors that stimulate heart muscle cell proliferation and promote heart muscle regeneration: a peptide of periostin, a component of the extracellular matrix, and neuregulin1, a growth factor. Dr. Kuhn's research may provide new regenerative strategies for the treatment of heart failure.
Exome Sequencing & Human Disease
Jay Shendure, MD, PhD
Assistant Professor
Dept. of Genome Sciences
UW
Tuesday, December 15, 2009 - 8:30 AM
SLU, 815 Mercer St., Admin Bldg C, Orin Smith Auditorium
Jay Shendure, MD, PhD
Assistant Professor
Dept. of Genome Sciences
UW
Tuesday, December 15, 2009 - 8:30 AM
SLU, 815 Mercer St., Admin Bldg C, Orin Smith Auditorium
Fibrillar Collagens and Their Chaperones in Disease: A Tale of Kinky Tails and Brittle Bones
Helena Christiansen
Graduate Student
Molecular and Cellular Biology
University of Washington School of Medicine
Thursday, December 10, 2009 - 12:00 PM
Health Sciences Center, T-739
Faculty Sponsor: Peter Byers, M.D.
Helena Christiansen
Graduate Student
Molecular and Cellular Biology
University of Washington School of Medicine
Thursday, December 10, 2009 - 12:00 PM
Health Sciences Center, T-739
Faculty Sponsor: Peter Byers, M.D.
Nuclear Architecture and Aging
Tom Misteli, Ph.D.
Senior Investigator
Cell Biology of Genomes
National Cancer Institute, NIH
Wednesday, December 9, 2009 - 4:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Chuck Murry
Why Attend?
Who doesn't care, and at times worry, about aging? Yet, the molecular basis of human aging is one of the least understood fundamental biological processes. A multitude of diverse mechanisms and pathways have been suggested to cause aging. While aging can be readily experimentally studied using animal models, the mechanisms of human aging are more difficult to ascertain. A promising approach is the molecular and cellular interrogation of naturally occurring human pre-mature aging disorders. The most severe premature aging disease is Hutchinson-Gilford Progeria Syndrome. Remarkably, this disease is caused by mutations in a gene encoding major architectural proteins of the cell nucleus. We have analyzed the causes of cellular and organismal defects in this disease and shown that the HGPS mechanisms are also relevant for normal aging. The insights form this rare human disease reveals an intricate interplay between nuclear architecture, stem cell biology and aging.
Tom Misteli is a Senior Investigator at the National Cancer Institute, NIH. He has pioneered the field of genome cell biology by developing imaging approaches to study genomes and gene expression in living cells. His laboratory aims to uncover fundamental principles of higher order genome organization and to apply this knowledge to the development of novel diagnostic and therapeutic strategies for cancer and aging. He has received numerous international awards. He is the Editor-in-Chief of The Journal of Cell Biology and of Current Opinion in Cell Biology.
Tom Misteli, Ph.D.
Senior Investigator
Cell Biology of Genomes
National Cancer Institute, NIH
Wednesday, December 9, 2009 - 4:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Chuck Murry
Why Attend?
Who doesn't care, and at times worry, about aging? Yet, the molecular basis of human aging is one of the least understood fundamental biological processes. A multitude of diverse mechanisms and pathways have been suggested to cause aging. While aging can be readily experimentally studied using animal models, the mechanisms of human aging are more difficult to ascertain. A promising approach is the molecular and cellular interrogation of naturally occurring human pre-mature aging disorders. The most severe premature aging disease is Hutchinson-Gilford Progeria Syndrome. Remarkably, this disease is caused by mutations in a gene encoding major architectural proteins of the cell nucleus. We have analyzed the causes of cellular and organismal defects in this disease and shown that the HGPS mechanisms are also relevant for normal aging. The insights form this rare human disease reveals an intricate interplay between nuclear architecture, stem cell biology and aging.
Tom Misteli is a Senior Investigator at the National Cancer Institute, NIH. He has pioneered the field of genome cell biology by developing imaging approaches to study genomes and gene expression in living cells. His laboratory aims to uncover fundamental principles of higher order genome organization and to apply this knowledge to the development of novel diagnostic and therapeutic strategies for cancer and aging. He has received numerous international awards. He is the Editor-in-Chief of The Journal of Cell Biology and of Current Opinion in Cell Biology.
Evidence Based Management of Liver Cancer: Integration of Research and Clinical Decision Making
Jordi Bruix, M.D.
Associate Professor
Director, Liver Cancer Group
University of Barcelona
Wednesday, December 2, 2009 - 4:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Jean Campbell
Why Attend?
Hepatocellular Carcinoma (HCC) is one of the major causes of cancer related death and its incidence is growing worldwide. Treatment of HCC, particularly, the advanced stage disease, is limited and not curative. The combination of these factors has fueled a growing interest in this disease priming research in both its pathogenesis and clinical management. Dr. Jordi Bruix, leader of the Barcelona Clinic Liver Cancer (BCLC) group at the University of Barcelona, has made key contributions in both areas, with a major emphasis on the development of criteria that allow an evidence-based management from diagnosis to therapy. In addition, Dr. Bruix's group through several international collaborations has provided new insight into the molecular profiling of this neoplasm.
Dr. Bruix will discuss his recent work with the phase 3 sorafenib "SHARP" trial, the first successful treatment of advanced-stage HCC and share his critical insight on the implications of recent studies translational studies on the future of HCC research and clinical practice.
Jordi Bruix, M.D.
Associate Professor
Director, Liver Cancer Group
University of Barcelona
Wednesday, December 2, 2009 - 4:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Jean Campbell
Why Attend?
Hepatocellular Carcinoma (HCC) is one of the major causes of cancer related death and its incidence is growing worldwide. Treatment of HCC, particularly, the advanced stage disease, is limited and not curative. The combination of these factors has fueled a growing interest in this disease priming research in both its pathogenesis and clinical management. Dr. Jordi Bruix, leader of the Barcelona Clinic Liver Cancer (BCLC) group at the University of Barcelona, has made key contributions in both areas, with a major emphasis on the development of criteria that allow an evidence-based management from diagnosis to therapy. In addition, Dr. Bruix's group through several international collaborations has provided new insight into the molecular profiling of this neoplasm.
Dr. Bruix will discuss his recent work with the phase 3 sorafenib "SHARP" trial, the first successful treatment of advanced-stage HCC and share his critical insight on the implications of recent studies translational studies on the future of HCC research and clinical practice.
The what, why, and where of perivascular cells
Morayma Reyes, MD, PhD
Assistant Professor
Pathology and Lab Medicine
UW
Tuesday, December 1, 2009 - 8:30 AM
SLU, 815 Mercer St., Admin Bldg C, Orin Smith Auditorium
Morayma Reyes, MD, PhD
Assistant Professor
Pathology and Lab Medicine
UW
Tuesday, December 1, 2009 - 8:30 AM
SLU, 815 Mercer St., Admin Bldg C, Orin Smith Auditorium
Metabolic spectroscopy: New insights into mitochondrial adaptation to stress and disease
David Marcinek, PhD
Research Assistant Professor
Dept. of Radiology
UW
Tuesday, November 24, 2009 - 8:30 AM
SLU, 815 Mercer St., Admin Bldg C, Orin Smith Auditorium
The ability of mitochondria to adapt to physiological stress is a key component of normal cell function. My talk will focus on new insights from in vivo metabolic spectroscopy in understanding the adaptive response of mitochondria and cell metabolism to oxidative and energetic stress. I will present results from multiple disease models illustrating how the coupling of oxidative phosphorylation, mitochondrial biogenesis, and glycolysis form an integrated system and how breakdown of this integration may underlie dysfunction in disease and aging.
David Marcinek, PhD
Research Assistant Professor
Dept. of Radiology
UW
Tuesday, November 24, 2009 - 8:30 AM
SLU, 815 Mercer St., Admin Bldg C, Orin Smith Auditorium
The ability of mitochondria to adapt to physiological stress is a key component of normal cell function. My talk will focus on new insights from in vivo metabolic spectroscopy in understanding the adaptive response of mitochondria and cell metabolism to oxidative and energetic stress. I will present results from multiple disease models illustrating how the coupling of oxidative phosphorylation, mitochondrial biogenesis, and glycolysis form an integrated system and how breakdown of this integration may underlie dysfunction in disease and aging.
Alpha-catenin in Tissue Morphogenesis, Organ Maintenance and Cancer
Valera Vasioukhin
Associate Member
Fred Hutchinson Cancer Research Center
Wednesday, November 18, 2009 - 4:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Ray Monnat
Why Attend?
Cadherin-catenin-mediated intercellular adhesion is necessary for the assembly of individual cells into multicellular organisms. Intriguingly, in addition to maintaining intercellular adhesion, cadherin-catenin proteins are also linked to several major developmental signaling pathways. This seminar will discuss our findings on the role and mechanisms of alpha-catenin in mammalian tissue morphogenesis, organ maintenance and cancer.
Valera Vasioukhin
Associate Member
Fred Hutchinson Cancer Research Center
Wednesday, November 18, 2009 - 4:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Ray Monnat
Why Attend?
Cadherin-catenin-mediated intercellular adhesion is necessary for the assembly of individual cells into multicellular organisms. Intriguingly, in addition to maintaining intercellular adhesion, cadherin-catenin proteins are also linked to several major developmental signaling pathways. This seminar will discuss our findings on the role and mechanisms of alpha-catenin in mammalian tissue morphogenesis, organ maintenance and cancer.
Muscle Gene Regulation & Regulatory Cassettes for Gene Therapy
Stephen D. Hauschka, PhD
Professor
Dept. of Biochemistry
UIW
Tuesday, November 17, 2009 - 8:30 AM
SLU, 815 Mercer St., Admin Bldg C, Orin Smith Auditorium
Detailed analysis of the M-creatine kinase gene has provided many useful insights regarding the DNA control elements and transcription factors involved in the regulation of structural gene expression in skeletal and cardiac muscle. I will discuss recent studies based on quantitative proteomic strategies that have identified factors with no previously reported transcriptional function in striated muscle gene regulation, such as the Myc-associated zinc finger factor MAZ, and the Kruppel-like factor KLF3. Interestingly, MAZ expression increases >4-fold and KLF3 expression is initiated during skeletal muscle terminal differentiation – suggesting that both play functional roles during this transition. Many of the factors interact with control elements containing very similar conserved sequences that are not necessarily found in the transcription factor databases. Thus despite the presence of these sequence motifs in the regulatory regions of diverse muscle genes, these putative control elements have not previously been recognized as playing regulatory roles in muscle gene expression. For example, MAZ binds sequences such as CTCCTCCC and CTCCACCC that are quite divergent from the “database” binding site GGGAGGG, and control elements of the divergent sequence types have now been identified in the promoters of critical muscle regulatory genes such as: Myogenin, MEF2C, and Six4, as well as in more than a dozen structural genes such as: skeletal alpha-actin, desmin, and alpha-myosin heavy chain. Analogous studies with KLF3 have disclosed multiple KLF3 binding sites in the MCK promoter, and have identified two KLF3 isoforms within skeletal muscle nuclear extracts. Interestingly, the KLF3 protein does not appear to contain a transcriptional activation domain, thus in order to play a positive transcriptional role KLF3 must interact with one or more transcription factors that contain such domains. A search for KLF3 binding partners disclosed that it interacts with serum response factor (SRF), and a KLF3-SRF synergism can be demonstrated in COS cell transactivation studies. Interestingly, the KLF3-SRF synergism can occur with reporter gene constructs that contain KLF3 but no SRF DNA binding motifs. These studies suggest the novel regulatory concept that signal transduction pathways impinging on SRF can mediate the transcriptional control of genes lacking SRF binding sites via the interaction of SRF with KLF3, and association of the complex with KLF3 control elements such as C[A/C]CACCC. Since KLF3 motifs are present in many muscle genes and since SRF is expressed during early embryogenesis, the initiation of KLF3 expression during terminal differentiation could have important developmental consequences during myogenesis. If time permits, I will also discuss the design and evaluation of muscle-specific regulatory gene cassettes for the expression of therapeutic proteins in diseased striated muscles.
Stephen D. Hauschka, PhD
Professor
Dept. of Biochemistry
UIW
Tuesday, November 17, 2009 - 8:30 AM
SLU, 815 Mercer St., Admin Bldg C, Orin Smith Auditorium
Detailed analysis of the M-creatine kinase gene has provided many useful insights regarding the DNA control elements and transcription factors involved in the regulation of structural gene expression in skeletal and cardiac muscle. I will discuss recent studies based on quantitative proteomic strategies that have identified factors with no previously reported transcriptional function in striated muscle gene regulation, such as the Myc-associated zinc finger factor MAZ, and the Kruppel-like factor KLF3. Interestingly, MAZ expression increases >4-fold and KLF3 expression is initiated during skeletal muscle terminal differentiation – suggesting that both play functional roles during this transition. Many of the factors interact with control elements containing very similar conserved sequences that are not necessarily found in the transcription factor databases. Thus despite the presence of these sequence motifs in the regulatory regions of diverse muscle genes, these putative control elements have not previously been recognized as playing regulatory roles in muscle gene expression. For example, MAZ binds sequences such as CTCCTCCC and CTCCACCC that are quite divergent from the “database” binding site GGGAGGG, and control elements of the divergent sequence types have now been identified in the promoters of critical muscle regulatory genes such as: Myogenin, MEF2C, and Six4, as well as in more than a dozen structural genes such as: skeletal alpha-actin, desmin, and alpha-myosin heavy chain. Analogous studies with KLF3 have disclosed multiple KLF3 binding sites in the MCK promoter, and have identified two KLF3 isoforms within skeletal muscle nuclear extracts. Interestingly, the KLF3 protein does not appear to contain a transcriptional activation domain, thus in order to play a positive transcriptional role KLF3 must interact with one or more transcription factors that contain such domains. A search for KLF3 binding partners disclosed that it interacts with serum response factor (SRF), and a KLF3-SRF synergism can be demonstrated in COS cell transactivation studies. Interestingly, the KLF3-SRF synergism can occur with reporter gene constructs that contain KLF3 but no SRF DNA binding motifs. These studies suggest the novel regulatory concept that signal transduction pathways impinging on SRF can mediate the transcriptional control of genes lacking SRF binding sites via the interaction of SRF with KLF3, and association of the complex with KLF3 control elements such as C[A/C]CACCC. Since KLF3 motifs are present in many muscle genes and since SRF is expressed during early embryogenesis, the initiation of KLF3 expression during terminal differentiation could have important developmental consequences during myogenesis. If time permits, I will also discuss the design and evaluation of muscle-specific regulatory gene cassettes for the expression of therapeutic proteins in diseased striated muscles.
Exploring the extraordinary regenerative potential of the mammalian fetal heart
Timothy Cox, PhD
Research Associate Professor
Pediatrics, Division of Craniofacial Medicine
UW
Tuesday, November 10, 2009 - 8:30 AM
SLU, 815 Mercer St., Admin Bldg C, Orin Smith Auditorium
Timothy Cox, PhD
Research Associate Professor
Pediatrics, Division of Craniofacial Medicine
UW
Tuesday, November 10, 2009 - 8:30 AM
SLU, 815 Mercer St., Admin Bldg C, Orin Smith Auditorium
Diet, Death and Demography
Linda Partridge, Ph.D.
Director, The Institute of Healthy Ageing University College, London
Group Leader, Max Planck Institute for Biology of Ageing, Cologne, Germany
Monday, November 9, 2009 - 11:00 AM
Health Sciences Center, Room K-069
Faculty Sponsor: Peter Rabinovitch
Linda Partridge, Ph.D.
Director, The Institute of Healthy Ageing University College, London
Group Leader, Max Planck Institute for Biology of Ageing, Cologne, Germany
Monday, November 9, 2009 - 11:00 AM
Health Sciences Center, Room K-069
Faculty Sponsor: Peter Rabinovitch
Merkel Cell Carcinoma and a New Polyomavirus: Mechanisms of Immune Escape by an Often-lethal Skin Malignancy
Paul Nghiem, M.D., Ph.D.
Associate Professor
UW Medicine Dermatology and Pathology
Wednesday, November 4, 2009 - 4:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Suzy Dintzis
Why Attend?
Merkel cell carcinoma (MCC) is a neuroendocrine skin cancer associated with advanced age, UV exposure and a new human polyomavirus (integrated in 80% of MCCs). Although 10% of MCC patients are profoundly immune suppressed, 90% have apparently normal immunity. Using genome-wide studies of MCC tumors, we found clues as to immune evasion mechanisms in use by this cancer and associated with outcomes. Using IHC studies on validation sets, we have found evidence of profound intra-tumoral immune suppression in many cases associated with poor outcomes. In contrast, outcomes are excellent in cases with evidence of immune recognition of this tumor. These insights are leading to potential new prognostic tests and translational studies designed to activate immune recognition of this highly antigenic tumor that is currently lethal in about 40% of cases.
Paul Nghiem received his undergraduate degree from Harvard, MD & PhD from Stanford, trained in medicine (Brigham & Women's), dermatology (MGH) and post-doctoral fellowship (Stuart Schreiber's lab in Harvard Chemistry). He moved to Seattle in 2006 and is an Associate Professor of Medicine/Dermatology and Pathology (Adjunct) at UW, and Affiliate Investigator at Fred Hutchinson. He sees patients at the Seattle Cancer Care Alliance and his research lab is at SLU.
Paul Nghiem, M.D., Ph.D.
Associate Professor
UW Medicine Dermatology and Pathology
Wednesday, November 4, 2009 - 4:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Suzy Dintzis
Why Attend?
Merkel cell carcinoma (MCC) is a neuroendocrine skin cancer associated with advanced age, UV exposure and a new human polyomavirus (integrated in 80% of MCCs). Although 10% of MCC patients are profoundly immune suppressed, 90% have apparently normal immunity. Using genome-wide studies of MCC tumors, we found clues as to immune evasion mechanisms in use by this cancer and associated with outcomes. Using IHC studies on validation sets, we have found evidence of profound intra-tumoral immune suppression in many cases associated with poor outcomes. In contrast, outcomes are excellent in cases with evidence of immune recognition of this tumor. These insights are leading to potential new prognostic tests and translational studies designed to activate immune recognition of this highly antigenic tumor that is currently lethal in about 40% of cases.
Paul Nghiem received his undergraduate degree from Harvard, MD & PhD from Stanford, trained in medicine (Brigham & Women's), dermatology (MGH) and post-doctoral fellowship (Stuart Schreiber's lab in Harvard Chemistry). He moved to Seattle in 2006 and is an Associate Professor of Medicine/Dermatology and Pathology (Adjunct) at UW, and Affiliate Investigator at Fred Hutchinson. He sees patients at the Seattle Cancer Care Alliance and his research lab is at SLU.
Skeletal muscle stem cells: from classic to eclectic
Zipora Yablonka-Reuveni, PhD
Professor
Dept. of Biological Structure
UW
Tuesday, October 27, 2009 - 8:30 AM
SLU, 815 Mercer St., Admin Bldg C, Orin Smith Auditorium
Background: Satellite cells are recognized as the main source of myogenic progeny in adult skeletal muscle. These cells are located underneath the myofiber basal lamina and are typically quiescent, but upon injury they can be rapidly recruited to provide myogenic progeny. It is yet unclear if satellite cells represent a uniform population of muscle stem cells, all of which are able to contribute differentiating progeny and self-renew, or if only some satellite cells possess self-renewal potential. It is also unclear if satellite cells are the sole source of myogenic progenitors in adult muscles. It has recently been shown that perivascular cells, grown ex-vivo, are able to contribute to adult myogenesis when delivered to host animal. This phenomenon may reflect a natural process occurring in vivo or may be initiated in culture, but is of potential importance to cell-based muscle therapy strategies. Our lab has been interested in defining the features of satellite and non-satellite cell myogenic sources in different muscle groups. Specifically, we focus on bona fide satellite cells and pericytes (contractile cells engulfing the endothelium in the microvasculature) from limb, diaphragm and extraocular muscles. Limb and diaphragm muscles are somite-derived and deteriorate in a range of muscular dystrophy diseases, whereas extrocular muscles derived from head mesenchyme and are not impacted in muscular dystrophy. Based on our recent data, we suggest the following hierarchy of proliferative performance and self-renewal capacity of myogenic stem cells: extraocular>diaphragm>limb. We are also interested in understanding the origin of pre-adipogenic progenitors in skeletal muscle and the balance between myogenic and adipogenic cell fates through the lifespan. Health relevance: Better understanding the regulation and distinctions of myogenic stem cells from different muscle groups, and the nature of cells contributing to intramuscular fibrosis and fat accumulation will provide important insights into therapies for combating muscle wasting disorders associated with aging (i.e., sarcopenia) and disease. Current support: National Institutes of Health (AG021566, AG013798, AG035377); Muscular Dystrophy Association (135908).
Zipora Yablonka-Reuveni, PhD
Professor
Dept. of Biological Structure
UW
Tuesday, October 27, 2009 - 8:30 AM
SLU, 815 Mercer St., Admin Bldg C, Orin Smith Auditorium
Background: Satellite cells are recognized as the main source of myogenic progeny in adult skeletal muscle. These cells are located underneath the myofiber basal lamina and are typically quiescent, but upon injury they can be rapidly recruited to provide myogenic progeny. It is yet unclear if satellite cells represent a uniform population of muscle stem cells, all of which are able to contribute differentiating progeny and self-renew, or if only some satellite cells possess self-renewal potential. It is also unclear if satellite cells are the sole source of myogenic progenitors in adult muscles. It has recently been shown that perivascular cells, grown ex-vivo, are able to contribute to adult myogenesis when delivered to host animal. This phenomenon may reflect a natural process occurring in vivo or may be initiated in culture, but is of potential importance to cell-based muscle therapy strategies. Our lab has been interested in defining the features of satellite and non-satellite cell myogenic sources in different muscle groups. Specifically, we focus on bona fide satellite cells and pericytes (contractile cells engulfing the endothelium in the microvasculature) from limb, diaphragm and extraocular muscles. Limb and diaphragm muscles are somite-derived and deteriorate in a range of muscular dystrophy diseases, whereas extrocular muscles derived from head mesenchyme and are not impacted in muscular dystrophy. Based on our recent data, we suggest the following hierarchy of proliferative performance and self-renewal capacity of myogenic stem cells: extraocular>diaphragm>limb. We are also interested in understanding the origin of pre-adipogenic progenitors in skeletal muscle and the balance between myogenic and adipogenic cell fates through the lifespan. Health relevance: Better understanding the regulation and distinctions of myogenic stem cells from different muscle groups, and the nature of cells contributing to intramuscular fibrosis and fat accumulation will provide important insights into therapies for combating muscle wasting disorders associated with aging (i.e., sarcopenia) and disease. Current support: National Institutes of Health (AG021566, AG013798, AG035377); Muscular Dystrophy Association (135908).
The Amazing Liver: New Perspectives on Regeneration and Cancer
Nelson Fausto, M.D.
Professor and Chair
UW Medicine Pathology
Wednesday, October 21, 2009 - 4:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Chuck Murry
Why Attend?
Most amphibians and fish can regenerate body parts, but mammals have lost this capacity. A question to be asked is "if they can do it, why cant we." Although we do not have clear answers to this question, the liver is a "yes we can" exception. The mechanisms of liver regeneration in mice and humans are complex and involve an initial priming phase in which hepatocytes respond to components of the innate immune system, enter the cell cycle and become sensitive to the effect of growth factors. In a second phase, hepatocytes progress through the cell cycle under growth factor stimulation, and after passing a restriction point, no longer require external proliferative stimuli. Understanding the cellular and molecular mechanisms of liver regeneration is important both because of its scientific interest but also because it has direct applicability to clinical practice, particularly in liver transplantation. Remarkably, liver regeneration even if repeated does not lead to carcinogenesis. New findings on liver cancer show that the liver stroma plays an essential role in the development of liver tumors, through the regulation of angiogenesis and the production of growth factors required for hepatocyte replication. Cancer development involves the close interaction between the stroma and hepatocytes.
Nelson Fausto, M.D.
Professor and Chair
UW Medicine Pathology
Wednesday, October 21, 2009 - 4:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Chuck Murry
Why Attend?
Most amphibians and fish can regenerate body parts, but mammals have lost this capacity. A question to be asked is "if they can do it, why cant we." Although we do not have clear answers to this question, the liver is a "yes we can" exception. The mechanisms of liver regeneration in mice and humans are complex and involve an initial priming phase in which hepatocytes respond to components of the innate immune system, enter the cell cycle and become sensitive to the effect of growth factors. In a second phase, hepatocytes progress through the cell cycle under growth factor stimulation, and after passing a restriction point, no longer require external proliferative stimuli. Understanding the cellular and molecular mechanisms of liver regeneration is important both because of its scientific interest but also because it has direct applicability to clinical practice, particularly in liver transplantation. Remarkably, liver regeneration even if repeated does not lead to carcinogenesis. New findings on liver cancer show that the liver stroma plays an essential role in the development of liver tumors, through the regulation of angiogenesis and the production of growth factors required for hepatocyte replication. Cancer development involves the close interaction between the stroma and hepatocytes.
Platelet-Derived Growth Factor-C induces Fibrosis and Hepatocellular Carcinoma
Jean Campbell, PhD
Research Assistant Professor
Dept. of Pathology
UW
Tuesday, October 20, 2009 - 8:30 AM
SLU, 815 Mercer St., Admin Bldg C, Orin Smith Auditorium
Jean Campbell, PhD
Research Assistant Professor
Dept. of Pathology
UW
Tuesday, October 20, 2009 - 8:30 AM
SLU, 815 Mercer St., Admin Bldg C, Orin Smith Auditorium
Mechanisms of enhanced lung injury in febrile hyperthermia
Anne Lipke, MD
Senior Fellow
Division of Pulmonary and Critical Care Medicine
UW
Tuesday, October 13, 2009 - 8:30 AM
SLU, 815 Mercer St., Admin Bldg C, Orin Smith Auditorium
Faculty Sponsor: Lynn Schnapp, MD
Anne Lipke, MD
Senior Fellow
Division of Pulmonary and Critical Care Medicine
UW
Tuesday, October 13, 2009 - 8:30 AM
SLU, 815 Mercer St., Admin Bldg C, Orin Smith Auditorium
Faculty Sponsor: Lynn Schnapp, MD
Transcriptional Regulation of Vascular Development
Elisabetta Dejana
Italian Foundation for Cancer Research
Institute of Molecular Oncology
Milan, Italy
Tuesday, October 6, 2009 - 4:00 PM
Health Sciences Center, Turner Auditorium, D-209
Faculty Sponsor: Elaine Raines
Elisabetta Dejana
Italian Foundation for Cancer Research
Institute of Molecular Oncology
Milan, Italy
Tuesday, October 6, 2009 - 4:00 PM
Health Sciences Center, Turner Auditorium, D-209
Faculty Sponsor: Elaine Raines
CD40 and IFNα: Common Targets for Regulation of Autoimmune Disease and Atherosclerosis
Jeffrey A. Ledbetter, PhD
Research Professor
Division of Rheumatology
UW
Tuesday, October 6, 2009 - 8:30 AM
SLU, 815 Mercer St., Admin Bldg C, Orin Smith Auditorium
Jeffrey A. Ledbetter is a Research Professor of Rheumatology in the Dept. of Medicine at the University of Washington. He received his Ph.D. from the McArdle Laboratories for Cancer Research at the University of Wisconsin in 1978 and then did his postdoctoral training in Immunology at Stanford University with Dr. Leonard Herzenberg. Dr. Ledbetter spent much of his career in the biotech industry in Seattle, including 17 years with Bristol-Myers Squibb. He worked at Pacific Northwest Research Institute in Seattle for 5 years, then launched Trubion Pharmaceuticals in Seattle in 2001. Dr. Ledbetter joined the University of Washington in 2008 in the division of Rheumatology, Dept. of Medicine. Dr. Ledbetter has over 300 publications and is an inventor of over 40 issued patents. His most notable contributions include the discovery of CTLA4-Ig (Orencia), now approved by the FDA for therapy of patients with rheumatoid arthritis, and the first construction of chimeric anti-CD20 antibodies, now approved for therapy of B cell lymphoma and rheumatoid arthritis (Rituximab).
Jeffrey A. Ledbetter, PhD
Research Professor
Division of Rheumatology
UW
Tuesday, October 6, 2009 - 8:30 AM
SLU, 815 Mercer St., Admin Bldg C, Orin Smith Auditorium
Jeffrey A. Ledbetter is a Research Professor of Rheumatology in the Dept. of Medicine at the University of Washington. He received his Ph.D. from the McArdle Laboratories for Cancer Research at the University of Wisconsin in 1978 and then did his postdoctoral training in Immunology at Stanford University with Dr. Leonard Herzenberg. Dr. Ledbetter spent much of his career in the biotech industry in Seattle, including 17 years with Bristol-Myers Squibb. He worked at Pacific Northwest Research Institute in Seattle for 5 years, then launched Trubion Pharmaceuticals in Seattle in 2001. Dr. Ledbetter joined the University of Washington in 2008 in the division of Rheumatology, Dept. of Medicine. Dr. Ledbetter has over 300 publications and is an inventor of over 40 issued patents. His most notable contributions include the discovery of CTLA4-Ig (Orencia), now approved by the FDA for therapy of patients with rheumatoid arthritis, and the first construction of chimeric anti-CD20 antibodies, now approved for therapy of B cell lymphoma and rheumatoid arthritis (Rituximab).
The role of cardiac metabolism in heart diseases
Rong Tian, MD, PhD
Professor and Director
Mitochondria and Metabolism Center
UW
Tuesday, September 29, 2009 - 8:30 AM
SLU, 815 Mercer St., Admin Bldg C, Orin Smith Auditorium
Rong Tian, MD, PhD
Professor and Director
Mitochondria and Metabolism Center
UW
Tuesday, September 29, 2009 - 8:30 AM
SLU, 815 Mercer St., Admin Bldg C, Orin Smith Auditorium
Disruption of the interaction between delta protein kinase C and the 'd' subunit of F1Fo ATPase: Implications for cardiac ischemia/reperfusion injury
Tiffany Nguyen
Graduate Student
Pharmacology and Toxicology Department
Medical College of Georgia, Augusta, GA
Tuesday, September 22, 2009 - 8:30 AM
SLU, 815 Mercer St., Admin Bldg C, Orin Smith Auditorium
Faculty Sponsor: Rong Tian, MD, PhD
Tiffany Nguyen
Graduate Student
Pharmacology and Toxicology Department
Medical College of Georgia, Augusta, GA
Tuesday, September 22, 2009 - 8:30 AM
SLU, 815 Mercer St., Admin Bldg C, Orin Smith Auditorium
Faculty Sponsor: Rong Tian, MD, PhD
Cell Signaling in Space and Time
John D. Scott, PhD
Edwin G. Krebs-Hilma Speights Professor
Dept. of Pharmacology
UW
Tuesday, September 15, 2009 - 8:30 AM
SLU, 815 Mercer St., Admin Bldg C, Orin Smith Auditorium
John D. Scott, PhD
Edwin G. Krebs-Hilma Speights Professor
Dept. of Pharmacology
UW
Tuesday, September 15, 2009 - 8:30 AM
SLU, 815 Mercer St., Admin Bldg C, Orin Smith Auditorium
Can We Image a Plaque at Risk?
Mat J.A.P. Daemen, MD, PhD
Scientific Director of the Cardiovascular Research Institute Maastricht
Professor and Head of Pathology
University of Maastricht, The Netherlands
Tuesday, September 8, 2009 - 8:30 AM
SLU, 815 Mercer St., Admin Bldg C, Orin Smith Auditorium
Faculty Sponsor: Chun Yuan
Mat J. Daemen received his medical degree in 1983 at the University of Maastricht. After receiving his PhD in Pharmacology in 1987 and a post-doctoral fellowship at the dept of Pathology, University of Washington, Seattle, Wa, USA he started his residency in Pathology in 1989 and became a certified pathologist/ staff member at the dept. of Pathology at the University of Maastricht, professor of Pathology in 1997 and chairman of the department in 2001. He subsequently was vice dean (Research), director of the Clinical Laboratories and chairman of the Scientific Research Council in the Maastricht University Medical Center. In 2006 he was program director of the VIIth International Vascular Biology Meeting in the Netherlands and became Scientific Director of CARIM, the Cardiovascular Research Institute Maastricht (annual budget 23x106 €; 250 fte). He was one of the founding fathers of the Center for Translational Molecular Medicine (budget 400x106 €) and is a member of the scientific committee of the High Risk Plaque consortium, an international public private initiative (budget >30x106$) and co-founder of the small biotech company ACS Biomarker in 2007. He was (co)organiser of the Royal Netherlands Academy of Arts and Sciences Colloquium on “Plaque instability: from molecular regulation to diagnosis and therapy” held in Amsterdam from 27 to 29 Sept 2007. He is one of the co-founders of the Dutch Atherosclerosis Society and an expert in the molecular regulation of plaque (in)stability. He is program leader and member of the executive committee of the European Vascular Genomics Network, sponsored by the EU (FP6) and workpackage leader of the FP7 sponsored EU program Cardiorisk. He is co- spokesman of the recently established international graduate school EUCAR, a collaboration with the cardiovascular research Institute IMCAR in Aachen, He is coprincipal investigator of the CTMM project Circulating Cells and principal investigator of the CTMM project ParisK. He became President of the Dutch Society of Pathologists in 2009. His main research topic is the molecular regulation and imaging of atherosclerotic plaque (in)stability. He has published more than 180 scientific publications and supervised more than 30 PhD theses.
Mat J.A.P. Daemen, MD, PhD
Scientific Director of the Cardiovascular Research Institute Maastricht
Professor and Head of Pathology
University of Maastricht, The Netherlands
Tuesday, September 8, 2009 - 8:30 AM
SLU, 815 Mercer St., Admin Bldg C, Orin Smith Auditorium
Faculty Sponsor: Chun Yuan
Mat J. Daemen received his medical degree in 1983 at the University of Maastricht. After receiving his PhD in Pharmacology in 1987 and a post-doctoral fellowship at the dept of Pathology, University of Washington, Seattle, Wa, USA he started his residency in Pathology in 1989 and became a certified pathologist/ staff member at the dept. of Pathology at the University of Maastricht, professor of Pathology in 1997 and chairman of the department in 2001. He subsequently was vice dean (Research), director of the Clinical Laboratories and chairman of the Scientific Research Council in the Maastricht University Medical Center. In 2006 he was program director of the VIIth International Vascular Biology Meeting in the Netherlands and became Scientific Director of CARIM, the Cardiovascular Research Institute Maastricht (annual budget 23x106 €; 250 fte). He was one of the founding fathers of the Center for Translational Molecular Medicine (budget 400x106 €) and is a member of the scientific committee of the High Risk Plaque consortium, an international public private initiative (budget >30x106$) and co-founder of the small biotech company ACS Biomarker in 2007. He was (co)organiser of the Royal Netherlands Academy of Arts and Sciences Colloquium on “Plaque instability: from molecular regulation to diagnosis and therapy” held in Amsterdam from 27 to 29 Sept 2007. He is one of the co-founders of the Dutch Atherosclerosis Society and an expert in the molecular regulation of plaque (in)stability. He is program leader and member of the executive committee of the European Vascular Genomics Network, sponsored by the EU (FP6) and workpackage leader of the FP7 sponsored EU program Cardiorisk. He is co- spokesman of the recently established international graduate school EUCAR, a collaboration with the cardiovascular research Institute IMCAR in Aachen, He is coprincipal investigator of the CTMM project Circulating Cells and principal investigator of the CTMM project ParisK. He became President of the Dutch Society of Pathologists in 2009. His main research topic is the molecular regulation and imaging of atherosclerotic plaque (in)stability. He has published more than 180 scientific publications and supervised more than 30 PhD theses.
The Neurosecretory Vesicle Protein Phogrin Has Phosphatidylinositol Phosphatase Activity That Regulates Insulin Secretion
Leslie Ann Caromile
Graduate Student
Department of Pathology
University of Washington School of Medicine
Friday, August 14, 2009 - 10:00 AM
UW Medicine at 815 Mercer, Orin Smith Auditorium
Faculty Sponsor: Dan Bown-Pope, Ph.D.
Leslie Ann Caromile
Graduate Student
Department of Pathology
University of Washington School of Medicine
Friday, August 14, 2009 - 10:00 AM
UW Medicine at 815 Mercer, Orin Smith Auditorium
Faculty Sponsor: Dan Bown-Pope, Ph.D.
Long-chain acyl-CoA Synthetase Isoforms 1 and 4 Exhibit Differences in Fatty Acid Preference and Functions in Human Arterial Smooth Muscle Cells
Deidre Golej
MCB Graduate Student
University of Washington School of Medicine
Wednesday, August 12, 2009 - 2:00 PM
UW Medicine at 815 Mercer, Orin Smith Auditorium
Faculty Sponsor: Karin Bornfeldt, Ph.D.
Deidre Golej
MCB Graduate Student
University of Washington School of Medicine
Wednesday, August 12, 2009 - 2:00 PM
UW Medicine at 815 Mercer, Orin Smith Auditorium
Faculty Sponsor: Karin Bornfeldt, Ph.D.
Mitochondria, Age and the Heart
Charles L. Hoppel, M.D.
Professor
Departments of Pharmacology and Medicine
Case Western Reserve University
Tuesday, July 28, 2009 - 4:00 PM
Health Sciences Center, K-069
Faculty Sponsor: Peter Rabinovitch, M.D., Ph.D
Charles L. Hoppel, M.D.
Professor
Departments of Pharmacology and Medicine
Case Western Reserve University
Tuesday, July 28, 2009 - 4:00 PM
Health Sciences Center, K-069
Faculty Sponsor: Peter Rabinovitch, M.D., Ph.D
Targeted Proteomics Using Multiple Reaction Monitoring Mass Spectrometry
Daniel Martin, M.D.
Institute for Systems Biology
Tuesday, June 16, 2009 - 8:30 AM
SLU, 815 Mercer St., Admin Bldg C, Orin Smith Auditorium
Daniel Martin, M.D.
Institute for Systems Biology
Tuesday, June 16, 2009 - 8:30 AM
SLU, 815 Mercer St., Admin Bldg C, Orin Smith Auditorium
Loss of DNA Polymerase Proofreading Leads to Cancer and Tumor Acceleration in MIce
Tina M. Albertson
Graduate Student
UW Medicine Pathology
University of Washington School of Medicine
Tuesday, June 9, 2009 - 2:00 PM
Health Sciences Center, K-069
Faculty Sponsor: Brad Preston, Ph.D.
Tina M. Albertson
Graduate Student
UW Medicine Pathology
University of Washington School of Medicine
Tuesday, June 9, 2009 - 2:00 PM
Health Sciences Center, K-069
Faculty Sponsor: Brad Preston, Ph.D.
.
talk cancelled
UW School of Medicine
Tuesday, June 9, 2009 - 8:30 AM
HSC, NE110
Mechanism of Disease Series: A case-oriented introduction to the study of human diseases.
talk cancelled
UW School of Medicine
Tuesday, June 9, 2009 - 8:30 AM
HSC, NE110
Mechanism of Disease Series: A case-oriented introduction to the study of human diseases.
Nitric Oxide and the Development of Insulin Resistance
Francis Kim, MD
Associate Professor of Medicine
Division of Cardiology
Harborview Medical Center
Tuesday, June 9, 2009 - 8:30 AM
SLU, 815 Mercer St., Admin Bldg C, Orin Smith Auditorium
Francis Kim, MD
Associate Professor of Medicine
Division of Cardiology
Harborview Medical Center
Tuesday, June 9, 2009 - 8:30 AM
SLU, 815 Mercer St., Admin Bldg C, Orin Smith Auditorium
MicroRNAs as Blood-based Cancer Biomarkers
Muneesh Tewari, MD, PhD
Assistant Member
Human Biology
Fred Hutchinson Cancer Research Center
Wednesday, June 3, 2009 - 4:30 PM
Health Sciences Center, K-069
Faculty Sponsor: Ray Monnat, M.D.
Why Attend?
MicroRNAs are small (~22 nt) non-protein-encoding RNAs that regulate target messenger RNAs via sequence-specific base-pairing interactions. MicroRNAs play important roles in diverse biological contexts and disease states. In cancer tissues, alterations in microRNA expression have been shown to be useful biomarkers for disease classification and prognosis. Recently, microRNAs were found to be released by tumor cells into the blood in a cell-free form where they may be useful as blood-based biomarkers for cancer and potentially other diseases. Dr. Tewari will discuss these results and ongoing work in his lab on circulating microRNAs as potential blood-based biomarkers for human cancer.
Dr. Tewari earned a B.A. in Biochemistry from Case Western Reserve University and M.D. and Ph.D. degrees from the University of Michigan. After completing clinical training in Internal Medicine and Medical Oncology, he pursued postdoctoral training in systems biology of genetic and protein interaction networks at Dana-Farber Cancer Institute and Harvard Medical School. Since 2005 he has been on the faculty at the Fred Hutchinson Cancer Research Center, where he is currently an Assistant Member in the Human Biology and Clinical Research Divisions.
Muneesh Tewari, MD, PhD
Assistant Member
Human Biology
Fred Hutchinson Cancer Research Center
Wednesday, June 3, 2009 - 4:30 PM
Health Sciences Center, K-069
Faculty Sponsor: Ray Monnat, M.D.
Why Attend?
MicroRNAs are small (~22 nt) non-protein-encoding RNAs that regulate target messenger RNAs via sequence-specific base-pairing interactions. MicroRNAs play important roles in diverse biological contexts and disease states. In cancer tissues, alterations in microRNA expression have been shown to be useful biomarkers for disease classification and prognosis. Recently, microRNAs were found to be released by tumor cells into the blood in a cell-free form where they may be useful as blood-based biomarkers for cancer and potentially other diseases. Dr. Tewari will discuss these results and ongoing work in his lab on circulating microRNAs as potential blood-based biomarkers for human cancer.
Dr. Tewari earned a B.A. in Biochemistry from Case Western Reserve University and M.D. and Ph.D. degrees from the University of Michigan. After completing clinical training in Internal Medicine and Medical Oncology, he pursued postdoctoral training in systems biology of genetic and protein interaction networks at Dana-Farber Cancer Institute and Harvard Medical School. Since 2005 he has been on the faculty at the Fred Hutchinson Cancer Research Center, where he is currently an Assistant Member in the Human Biology and Clinical Research Divisions.
Genes and Vascular Disease
Gail P. Jarvik, MD, PhD
Professor of Medicine and Head
Division of Medical Genetics
UW
Tuesday, June 2, 2009 - 8:30 AM
SLU, 815 Mercer St., Admin Bldg C, Orin Smith Auditorium
Gail P. Jarvik, MD, PhD
Professor of Medicine and Head
Division of Medical Genetics
UW
Tuesday, June 2, 2009 - 8:30 AM
SLU, 815 Mercer St., Admin Bldg C, Orin Smith Auditorium
Pancreatic Cancer: Genes to Patients
Ralph Hruban, MD
Professor
Pathology/Oncology
John Hopkins University
Wednesday, May 27, 2009 - 4:30 PM
Health Science Center, K-069
Faculty Sponsor: Ray Monnat, M.D.
Why Attend?
Pancreatic cancer is the 4th leading cause of cancer deaths in the United States. Dr. Hruban has been a leader in integrating clinico-pathologic and molecular analyses of human cancer with a special interest in pancreatic carcinoma. Dr. Hruban's research over the past decade has focused on identifying specific genes, mutations and epigenetic profiles that may be determinants of pancreatic cancer risk and progression, and may provide novel insights to improve cancer diagnosis and therapy. His talk will focus on integrating these new data to improve the care of individuals with pancreatic cancer and their families.
Ralph H. Hruban is a Professor of Pathology and Oncology at The Johns Hopkins University School of Medicine. He received his M.D. and completed Residency training at Johns Hopkins, did Fellowship training at Memorial Sloan-Kettering Cancer Center in New York and then returned to Baltimore to join the Johns Hopkins faculty in 1990. Dr. Hruban is currently the Director of The Sol Goldman Pancreatic Cancer Research Center, and Director of the Division of Gastrointestinal/Liver Pathology at Johns Hopkins. In addition to his research Dr. Hruban helped create the Johns Hopkins Pancreatic Cancer Web site (http://pathology.jhu.edu/pancreas), serves on the Scientific Advisory Board of PanCAN and is a Board member or Director at the Monastra, Rolfe and Lustgarten Foundations that are all focused on pancreatic cancer.
Ralph Hruban, MD
Professor
Pathology/Oncology
John Hopkins University
Wednesday, May 27, 2009 - 4:30 PM
Health Science Center, K-069
Faculty Sponsor: Ray Monnat, M.D.
Why Attend?
Pancreatic cancer is the 4th leading cause of cancer deaths in the United States. Dr. Hruban has been a leader in integrating clinico-pathologic and molecular analyses of human cancer with a special interest in pancreatic carcinoma. Dr. Hruban's research over the past decade has focused on identifying specific genes, mutations and epigenetic profiles that may be determinants of pancreatic cancer risk and progression, and may provide novel insights to improve cancer diagnosis and therapy. His talk will focus on integrating these new data to improve the care of individuals with pancreatic cancer and their families.
Ralph H. Hruban is a Professor of Pathology and Oncology at The Johns Hopkins University School of Medicine. He received his M.D. and completed Residency training at Johns Hopkins, did Fellowship training at Memorial Sloan-Kettering Cancer Center in New York and then returned to Baltimore to join the Johns Hopkins faculty in 1990. Dr. Hruban is currently the Director of The Sol Goldman Pancreatic Cancer Research Center, and Director of the Division of Gastrointestinal/Liver Pathology at Johns Hopkins. In addition to his research Dr. Hruban helped create the Johns Hopkins Pancreatic Cancer Web site (http://pathology.jhu.edu/pancreas), serves on the Scientific Advisory Board of PanCAN and is a Board member or Director at the Monastra, Rolfe and Lustgarten Foundations that are all focused on pancreatic cancer.
Critical Role of Intracellular Calcium in Mediating Insulin Secretion (But What Does It Actually Do?)
Ian R. Sweet, PhD
Research Assitant Professor
Division of Metabolism, Endocrinology and Nutrition
UW
Tuesday, May 26, 2009 - 8:30 AM
SLU, 815 Mercer St., Admin Bldg C, Orin Smith Auditorium
Ian R. Sweet, PhD
Research Assitant Professor
Division of Metabolism, Endocrinology and Nutrition
UW
Tuesday, May 26, 2009 - 8:30 AM
SLU, 815 Mercer St., Admin Bldg C, Orin Smith Auditorium
Improving Cancer Gene Therapy: Molecular Evolution and the Search for Super Suicide Genes
Margaret Black, Ph.D.
Associate Professor
Pharmaceutical Sciences
Washington State University
Wednesday, May 20, 2009 - 4:30 PM
Health Sciences Center, K-069
Faculty Sponsor: Larry Loeb, M.D., Ph.D.
Why Attend?
Suicide gene therapy employs nucleotide metabolizing enzymes to convert prodrugs to cytotoxic agents as a means to localize toxicity to tumors. Several enzymes involved in pyrimidine and purine anabolism are being exploited as suicide enzymes in combination with pharmacologically relevant analogs. The poor activity the enzymes display towards their respective prodrugs limits the overall therapeutic potential of suicide gene therapy. Dr. Black will discuss molecular engineering methods her lab is using to achieve a more potent cancer cell killing effect.
Dr. Black earned a B.A. in Biology from the University of California, Santa Cruz, and a M.A. in Microbiology from the University of California, Davis and a Ph.D. in Microbiology from Oregon State University. After completion of a postdoctoral fellowship at the University of Washington, she worked at Darwin Molecular Corp. for several years. Since 1998 she has been on the faculty at Washington State University (WSU) in the Department of Pharmaceutical Sciences. Dr. Black is currently the J. Roberts and Marcia Fosberg Distinguished Professor of Pharmacy and is Director of the Pharmacology/Toxicology Graduate Program at WSU.
Margaret Black, Ph.D.
Associate Professor
Pharmaceutical Sciences
Washington State University
Wednesday, May 20, 2009 - 4:30 PM
Health Sciences Center, K-069
Faculty Sponsor: Larry Loeb, M.D., Ph.D.
Why Attend?
Suicide gene therapy employs nucleotide metabolizing enzymes to convert prodrugs to cytotoxic agents as a means to localize toxicity to tumors. Several enzymes involved in pyrimidine and purine anabolism are being exploited as suicide enzymes in combination with pharmacologically relevant analogs. The poor activity the enzymes display towards their respective prodrugs limits the overall therapeutic potential of suicide gene therapy. Dr. Black will discuss molecular engineering methods her lab is using to achieve a more potent cancer cell killing effect.
Dr. Black earned a B.A. in Biology from the University of California, Santa Cruz, and a M.A. in Microbiology from the University of California, Davis and a Ph.D. in Microbiology from Oregon State University. After completion of a postdoctoral fellowship at the University of Washington, she worked at Darwin Molecular Corp. for several years. Since 1998 she has been on the faculty at Washington State University (WSU) in the Department of Pharmaceutical Sciences. Dr. Black is currently the J. Roberts and Marcia Fosberg Distinguished Professor of Pharmacy and is Director of the Pharmacology/Toxicology Graduate Program at WSU.
Sterol regulation of the macrophage immune response
Jay W. Heinecke, MD
Professor of Medicine
Division of Metabolism, Endocrinology and Nutrition
UW
Tuesday, May 19, 2009 - 8:30 AM
SLU, 815 Mercer St., Admin Bldg C, SLU, 815 Mercer St., Admin Bld
Jay W. Heinecke, MD
Professor of Medicine
Division of Metabolism, Endocrinology and Nutrition
UW
Tuesday, May 19, 2009 - 8:30 AM
SLU, 815 Mercer St., Admin Bldg C, SLU, 815 Mercer St., Admin Bld
Signaling Networks in Vascular Morphogenesis and Homeostasis
Luisa Iruela-Arispe, PhD
Professor
Molecular, Cell and Developmental Biology
UCLA
Wednesday, May 13, 2009 - 4:30 PM
Health Sciences Center, K-069
Faculty Sponsor: Charles Murry, M.D., Ph.D.
Why Attend?
Our understanding of vascular fibrosis is limited, particularly at the molecular level. This seminar will discuss how specific molecular alterations in the tunica media result in progressive loss of smooth muscle, expansion of the tunica adventitia and vascular fibrosis. Luisa Iruela-Arispe is currently Professor in the Department of Molecular, Cell and Developmental Biology. She earned her Ph.D. in 1989 from the University of Sao Paulo in Brazil in 1989, but performed her thesis in Dr. Helene Sage at the University of Washington (Dept. of Biological Structure). She continued with Dr. Sage to complete post-doctoral training for four additional years. In 1994, she became Assistant Professor in the Department of Pathology at Harvard Medical School in 1994 and four years later she moved to UCLA, where she is today. Her research focuses on vascular development and pathology.
Luisa Iruela-Arispe, PhD
Professor
Molecular, Cell and Developmental Biology
UCLA
Wednesday, May 13, 2009 - 4:30 PM
Health Sciences Center, K-069
Faculty Sponsor: Charles Murry, M.D., Ph.D.
Why Attend?
Our understanding of vascular fibrosis is limited, particularly at the molecular level. This seminar will discuss how specific molecular alterations in the tunica media result in progressive loss of smooth muscle, expansion of the tunica adventitia and vascular fibrosis. Luisa Iruela-Arispe is currently Professor in the Department of Molecular, Cell and Developmental Biology. She earned her Ph.D. in 1989 from the University of Sao Paulo in Brazil in 1989, but performed her thesis in Dr. Helene Sage at the University of Washington (Dept. of Biological Structure). She continued with Dr. Sage to complete post-doctoral training for four additional years. In 1994, she became Assistant Professor in the Department of Pathology at Harvard Medical School in 1994 and four years later she moved to UCLA, where she is today. Her research focuses on vascular development and pathology.
Anti-Aging Genes, DNA Damage and Cancer
Valter Longo, Ph.D.
Assistant Professor
Department of Gerontology/Alzheimer's Research
University of Southern California
Tuesday, May 12, 2009 - 12:30 PM
Health Sciences Center, K-069
Faculty Sponsor: Peter Rabinovitch, M.D., Ph.D.
Dr. Longo's presentation is brought to you by the Nathan Shock Center for Excellence
Valter Longo, Ph.D.
Assistant Professor
Department of Gerontology/Alzheimer's Research
University of Southern California
Tuesday, May 12, 2009 - 12:30 PM
Health Sciences Center, K-069
Faculty Sponsor: Peter Rabinovitch, M.D., Ph.D.
Dr. Longo's presentation is brought to you by the Nathan Shock Center for Excellence
Cell Cycle Regulation in Hematopoietic Disorders
Keith Loeb, M.D., Ph.D.
Assistant Professor
Pathology
UW School of Medicine
Tuesday, May 12, 2009 - 8:30 AM
UWMC, NE-110 Conference Room
Faculty Sponsor: Thomas Montine, MD, PhD
Keith Loeb, M.D., Ph.D.
Assistant Professor
Pathology
UW School of Medicine
Tuesday, May 12, 2009 - 8:30 AM
UWMC, NE-110 Conference Room
Faculty Sponsor: Thomas Montine, MD, PhD
Versican: A Matrix Molecule With Some Clout!
Thomas N. Wight, Ph.D.
Member and Director, Hope Heart Program
Benaroya Research Institute at Virginia Mason
Affiliate Professor, Pathology, UW
Tuesday, May 12, 2009 - 8:30 AM
SLU, 815 Mercer St., Admin Bldg C, Orin Smith Auditorium
Thomas N. Wight, Ph.D.
Member and Director, Hope Heart Program
Benaroya Research Institute at Virginia Mason
Affiliate Professor, Pathology, UW
Tuesday, May 12, 2009 - 8:30 AM
SLU, 815 Mercer St., Admin Bldg C, Orin Smith Auditorium
Mitochondrial Signaling and Dynamics in Health and Disease
Gyorgy Hajnoczky, PhD
Professor
Pathology, Anatomy & Cell Biology
Jefferson Medical University
Wednesday, May 6, 2009 - 4:30 PM
Health Sciences Center , K-069
Faculty Sponsor: Charles Murry, M.D., Ph.D.
Why Attend?
Emerging evidence supports the broad involvement of mitochondria in cell signaling and dynamics. These functions often depend on mitochondrial sensing and responding to calcium. Mitochondrial calcium uptake controls mitochondrial function and cell signaling, while excessive mitochondrial calcium accumulation has been implicated in various diseases.
Gyorgy Hajnoczky is currently a Professor in the Department of Pathology and Cell Biology at Thomas Jefferson University. He earned his M.D. (1987) and Ph.D. (1993) from Semmelweis Medical University in Hungary. In 1991, he joined the lab of Dr. Andrew Thomas at Thomas Jefferson University as a postdoc. He became an independent investigator and was appointed to Assistant Professor in 1995 and to full Professor in 2002. His research focuses on calcium and mitochondrial biology.
Gyorgy Hajnoczky, PhD
Professor
Pathology, Anatomy & Cell Biology
Jefferson Medical University
Wednesday, May 6, 2009 - 4:30 PM
Health Sciences Center , K-069
Faculty Sponsor: Charles Murry, M.D., Ph.D.
Why Attend?
Emerging evidence supports the broad involvement of mitochondria in cell signaling and dynamics. These functions often depend on mitochondrial sensing and responding to calcium. Mitochondrial calcium uptake controls mitochondrial function and cell signaling, while excessive mitochondrial calcium accumulation has been implicated in various diseases.
Gyorgy Hajnoczky is currently a Professor in the Department of Pathology and Cell Biology at Thomas Jefferson University. He earned his M.D. (1987) and Ph.D. (1993) from Semmelweis Medical University in Hungary. In 1991, he joined the lab of Dr. Andrew Thomas at Thomas Jefferson University as a postdoc. He became an independent investigator and was appointed to Assistant Professor in 1995 and to full Professor in 2002. His research focuses on calcium and mitochondrial biology.
Tumor Cell Metabolism: How is it different?
David M. Hockenbery, MD
Professor of Medicine, UWMC
Member, FHCRC
Tuesday, May 5, 2009 - 8:30 AM
SLU, 815 Mercer St., Admin Bldg C, Orin Smith Auditorium
David M. Hockenbery, MD
Professor of Medicine, UWMC
Member, FHCRC
Tuesday, May 5, 2009 - 8:30 AM
SLU, 815 Mercer St., Admin Bldg C, Orin Smith Auditorium
Prognostic & Predictive Factors in Surgical Patholgy - - A Critical Assessment
Mark Wick, MD
Professor
Pathology
Univeristy of Virginia
Friday, May 1, 2009 - 4:30 PM
Health Sciences Center, T-639
Faculty Sponsor: Matthew Yeh, M.D., Ph.D.
Why Attend?
Anatomic pathologists are increasingly being asked to evaluate tissue specimens for a growing number of biologically-relevant genes and gene products. These markers are thought to have importance in either prognosis or choice of therapy. However, relatively little attention has been given to the laboratory control mechanisms for assuring the validity of such analyses, and misconceptions also exist as to how they should be applied. This talk considers those issues.
Mark Wick, MD
Professor
Pathology
Univeristy of Virginia
Friday, May 1, 2009 - 4:30 PM
Health Sciences Center, T-639
Faculty Sponsor: Matthew Yeh, M.D., Ph.D.
Why Attend?
Anatomic pathologists are increasingly being asked to evaluate tissue specimens for a growing number of biologically-relevant genes and gene products. These markers are thought to have importance in either prognosis or choice of therapy. However, relatively little attention has been given to the laboratory control mechanisms for assuring the validity of such analyses, and misconceptions also exist as to how they should be applied. This talk considers those issues.
Mechanisms of Cell Fate Acquisition in the Differentiation of Pluripotent Stem Cells
Jonathan Golob
Graduate Student
UW Medicine Pathology
University of Washington School of Medicine
Wednesday, April 29, 2009 - 10:00 AM
UW Medicine at 815 Mercer, Orin Smith Auditorium
Faculty Sponsor: Chuck Murry, M.D., Ph.D.
Jonathan Golob
Graduate Student
UW Medicine Pathology
University of Washington School of Medicine
Wednesday, April 29, 2009 - 10:00 AM
UW Medicine at 815 Mercer, Orin Smith Auditorium
Faculty Sponsor: Chuck Murry, M.D., Ph.D.
Mapping Cell Fate through Somatic Mutations
Marshall Horwitz, MD, PhD
Professor of Pathology
Institute for Stem Cell and Regenerative Medicine
UW
Tuesday, April 28, 2009 - 8:30 AM
SLU, 815 Mercer St., Admin Bldg C, Orin Smith Auditorium
Marshall Horwitz, MD, PhD
Professor of Pathology
Institute for Stem Cell and Regenerative Medicine
UW
Tuesday, April 28, 2009 - 8:30 AM
SLU, 815 Mercer St., Admin Bldg C, Orin Smith Auditorium
Deciphering the Hereditary Prion Protein Amyloidoses
Bernardino Ghetti, MD
Professor
Pathology & Lab Medicine
Indiana University
Wednesday, April 22, 2009 - 4:30 PM
Health Science Center, K-069
Faculty Sponsor: Montine
7th Annual Alvord Lecture in Neuropathology
The Alvord Lecture honors the scientific and clinical legacy of Professor Emeritus Ellsworth "Buster" Alvord, M.D., as an important pioneer in the field of neuropathology. Dr. Alvord served as Chief of Neoropathology at the University of Washington from 1960 to 2002.
Bernardino Ghetti, MD
Professor
Pathology & Lab Medicine
Indiana University
Wednesday, April 22, 2009 - 4:30 PM
Health Science Center, K-069
Faculty Sponsor: Montine
7th Annual Alvord Lecture in Neuropathology
The Alvord Lecture honors the scientific and clinical legacy of Professor Emeritus Ellsworth "Buster" Alvord, M.D., as an important pioneer in the field of neuropathology. Dr. Alvord served as Chief of Neoropathology at the University of Washington from 1960 to 2002.
Shaping the vertebrate body: cell migration in development and disease
Douglas C. Weiser, PhD
Postdoctoral fellow
Department of Biochemistry
UW
Tuesday, April 21, 2009 - 8:30 AM
SLU, 815 Mercer St., Admin Bldg C, Orin Smith Auditorium
Douglas C. Weiser, PhD
Postdoctoral fellow
Department of Biochemistry
UW
Tuesday, April 21, 2009 - 8:30 AM
SLU, 815 Mercer St., Admin Bldg C, Orin Smith Auditorium
Cellular and Molecular Biology of Natural Killer Cells: From Basic Science to Clinical Implications. A Personal Perspective
Vinay Kumar, MD, PhD
Professor and Chairman
Pathology
University of Chicago Medical School
Wednesday, April 15, 2009 - 4:30 PM
Health Sciences Center, K-069
Faculty Sponsor: UW Medicine Pathology Residents
Why Attend?
Dr Vinay Kumar is the Alice Hogge and Arthur Baer Professor, Chairman of the department of Pathology, and the Executive Vice Dean of the Biologic Sciences Division and Pritzker School of Medicine at the University of Chicago. After completing his medical training in India he completed a combined residency-PhD program at The All India Institute Medical Sciences, New Delhi. Soon thereafter, in 1972, he joined the department of pathology at Boston University School of Medicine, then chaired by Dr Stanley Robbins. In 1982, he moved to UT Southwestern Medical School in Dallas where he was appointed Vernie Stembridge Professor of Pathology in 1992. In 2000 he moved to the University of Chicago to chair the department of Pathology and was named the Executive Vice Dean in 2007.
Dr Kumar has devoted his career to medical education and basic research in immunology. He is the coauthor of Robbins and Cotran Pathologic Basis of Disease and Robbins Basic Pathology, and is currently the senior editor/author of both. These two texts with dozens of translations are the most widely used texts of Pathology worldwide. In 1974, two years after he joined Boston University, he and his colleagues discovered a new class of lymphocytes, later called NK cells, as mediators of resistance to acute leukemia in mice. Since then his laboratory has discovered and defined several NK cell receptors and the pathway of NK cell differentiation from stem cell. These studies have impacted clinical bone marrow transplantation and immunotherapy of tumors.
Vinay Kumar, MD, PhD
Professor and Chairman
Pathology
University of Chicago Medical School
Wednesday, April 15, 2009 - 4:30 PM
Health Sciences Center, K-069
Faculty Sponsor: UW Medicine Pathology Residents
Why Attend?
Dr Vinay Kumar is the Alice Hogge and Arthur Baer Professor, Chairman of the department of Pathology, and the Executive Vice Dean of the Biologic Sciences Division and Pritzker School of Medicine at the University of Chicago. After completing his medical training in India he completed a combined residency-PhD program at The All India Institute Medical Sciences, New Delhi. Soon thereafter, in 1972, he joined the department of pathology at Boston University School of Medicine, then chaired by Dr Stanley Robbins. In 1982, he moved to UT Southwestern Medical School in Dallas where he was appointed Vernie Stembridge Professor of Pathology in 1992. In 2000 he moved to the University of Chicago to chair the department of Pathology and was named the Executive Vice Dean in 2007.
Dr Kumar has devoted his career to medical education and basic research in immunology. He is the coauthor of Robbins and Cotran Pathologic Basis of Disease and Robbins Basic Pathology, and is currently the senior editor/author of both. These two texts with dozens of translations are the most widely used texts of Pathology worldwide. In 1974, two years after he joined Boston University, he and his colleagues discovered a new class of lymphocytes, later called NK cells, as mediators of resistance to acute leukemia in mice. Since then his laboratory has discovered and defined several NK cell receptors and the pathway of NK cell differentiation from stem cell. These studies have impacted clinical bone marrow transplantation and immunotherapy of tumors.
Mitochondrial Oxidative Stress in Cardiac Aging, Pressure-Overload Induced Cardiac Hypertrophy and Failure
Dao-Fu Dai
Graduate Student
UW Medicine Department of Pathology
University of Washington
Tuesday, April 14, 2009 - 1:00 PM
UW Medicine at 815 Mercer - South Lake Union, Orin Smith Auditorium
Faculty Sponsor: Peter Rabinovitch, M.D., Ph.D.
Doctoral Dissertation
Dao-Fu Dai
Graduate Student
UW Medicine Department of Pathology
University of Washington
Tuesday, April 14, 2009 - 1:00 PM
UW Medicine at 815 Mercer - South Lake Union, Orin Smith Auditorium
Faculty Sponsor: Peter Rabinovitch, M.D., Ph.D.
Doctoral Dissertation
Chordoma
Benjamin Hoch, MD
Associate Professor, Pathology
UW School of Medicine
Tuesday, April 14, 2009 - 8:30 AM
HSC, NE110
Faculty Sponsor: Thomas Montine, MD, PhD
Mechanism of Disease Series: A case-oriented introduction to the study of human diseases.
Benjamin Hoch, MD
Associate Professor, Pathology
UW School of Medicine
Tuesday, April 14, 2009 - 8:30 AM
HSC, NE110
Faculty Sponsor: Thomas Montine, MD, PhD
Mechanism of Disease Series: A case-oriented introduction to the study of human diseases.
Matrix remodeling during lung injury and repair
Lynn M. Schnapp, MD
Associate Professor of Medicine
Pulmonary and Critical Care Medicine
UW
Tuesday, April 14, 2009 - 8:30 AM
SLU, 815 Mercer St., Admin Bldg C, Orin Smith Auditorium
Lynn M. Schnapp, MD
Associate Professor of Medicine
Pulmonary and Critical Care Medicine
UW
Tuesday, April 14, 2009 - 8:30 AM
SLU, 815 Mercer St., Admin Bldg C, Orin Smith Auditorium
Genomic Dosage Disorders: Diagnostic Insights and Challenges
Nancy Spinner, PhD
Professor
Genetics in Pediatrics
University of Pennsylvania School of Medicine
Wednesday, April 8, 2009 - 4:30 PM
Health Science Center, K-069
Faculty Sponsor: Christine Disteche, Ph.D.
Why Attend?
Cytogenetics is experiencing a Renaissance, lead by the introduction of array based technology. We've been using high density SNP arrays in the both our clinical Cytogenetics (now CytoGenomics) and research laboratories. The combination of genotyping and intensity data in this platform has revealed a new view of the genome in patients with congenital abnormalities. We've identified new mechanisms of disease, shed light on meiotic and mitotic origins of several types of abnormalities, and diagnosed single gene disorders (dominant and recessive), which contribute to the construction of a gene dosage map. Dr. Spinner received her BS from Brandeis University, PhD in Genetics from UC Berkeley and Fellowship training in Genetics and Cytogenetics at The University of Pennsylvania. She is currently on the Faculty at Penn, in the Departments of Pediatrics and Genetics and she is the Director of the Clinical CytoGenomics Laboratory at The Children's Hospital of Philadelphia.
Nancy Spinner, PhD
Professor
Genetics in Pediatrics
University of Pennsylvania School of Medicine
Wednesday, April 8, 2009 - 4:30 PM
Health Science Center, K-069
Faculty Sponsor: Christine Disteche, Ph.D.
Why Attend?
Cytogenetics is experiencing a Renaissance, lead by the introduction of array based technology. We've been using high density SNP arrays in the both our clinical Cytogenetics (now CytoGenomics) and research laboratories. The combination of genotyping and intensity data in this platform has revealed a new view of the genome in patients with congenital abnormalities. We've identified new mechanisms of disease, shed light on meiotic and mitotic origins of several types of abnormalities, and diagnosed single gene disorders (dominant and recessive), which contribute to the construction of a gene dosage map. Dr. Spinner received her BS from Brandeis University, PhD in Genetics from UC Berkeley and Fellowship training in Genetics and Cytogenetics at The University of Pennsylvania. She is currently on the Faculty at Penn, in the Departments of Pediatrics and Genetics and she is the Director of the Clinical CytoGenomics Laboratory at The Children's Hospital of Philadelphia.
Translational control during monocyte/macrophage adherence
David Pritchard, PhD
Acting Instructor
Department of Pathology
UW
Tuesday, April 7, 2009 - 8:30 AM
SLU, 815 Mercer St., Admin Bldg C, Orin Smith Auditorium
David Pritchard, PhD
Acting Instructor
Department of Pathology
UW
Tuesday, April 7, 2009 - 8:30 AM
SLU, 815 Mercer St., Admin Bldg C, Orin Smith Auditorium
Gene Networks as Sensors and Drivers of Disease
Eric Schadt, PhD
Executive Scientific Director
Genetics
Rosetta Inpharmatics LLC
Wednesday, April 1, 2009 - 4:30 PM
Health Sciences Center, K-069
Faculty Sponsor: Ray Monnat, M.D.
Why Attend?
Molecular biology has been remarkably successful at revealing mechanisms and interactions between DNA, RNA, and protein biosynthesis, and is beginning to reveal the inner workings of cells. The genomics revolution has extended this approach by providing new tools to take comprehensive 'snapshots' of the molecular states of cells. These data-rich snapshots have allowed us, in turn, to begin to build whole gene networks that define physiological states, and that link and predict how changes in molecular states alter physiology. Dr. Schadt's talk will describe how whole gene networks are constructed, and how they are being used to gain new insights into the origin of human disease, especially the common diseases that are important causes of premature disability and death.
Dr. Schadt received his B.S. in Applied Mathematics/Computer Science from California Polytechnic State University, his M.A. in Pure Mathematics from UCD, and his Ph.D. in Bio-mathematics from UCLA (requiring Ph.D. candidacy in molecular biology and mathematics). He joined Rosetta in 1999, and formed the Genetics/Systems Biology department at Merck when Rosetta was acquired by Merck in 2001. Dr. Schadt is also a UW Affiliate Associate Professor of Biostatistics, and was recently elected a Fellow to the Institute of Systems and Synthetic Biology at Imperial College, London.
Eric Schadt, PhD
Executive Scientific Director
Genetics
Rosetta Inpharmatics LLC
Wednesday, April 1, 2009 - 4:30 PM
Health Sciences Center, K-069
Faculty Sponsor: Ray Monnat, M.D.
Why Attend?
Molecular biology has been remarkably successful at revealing mechanisms and interactions between DNA, RNA, and protein biosynthesis, and is beginning to reveal the inner workings of cells. The genomics revolution has extended this approach by providing new tools to take comprehensive 'snapshots' of the molecular states of cells. These data-rich snapshots have allowed us, in turn, to begin to build whole gene networks that define physiological states, and that link and predict how changes in molecular states alter physiology. Dr. Schadt's talk will describe how whole gene networks are constructed, and how they are being used to gain new insights into the origin of human disease, especially the common diseases that are important causes of premature disability and death.
Dr. Schadt received his B.S. in Applied Mathematics/Computer Science from California Polytechnic State University, his M.A. in Pure Mathematics from UCD, and his Ph.D. in Bio-mathematics from UCLA (requiring Ph.D. candidacy in molecular biology and mathematics). He joined Rosetta in 1999, and formed the Genetics/Systems Biology department at Merck when Rosetta was acquired by Merck in 2001. Dr. Schadt is also a UW Affiliate Associate Professor of Biostatistics, and was recently elected a Fellow to the Institute of Systems and Synthetic Biology at Imperial College, London.
Water, Energy and Life: Fresh Views from the Water’s Edge
Gerald H. Pollack, PhD
Professor
Department of Bioengineering
UW
Tuesday, March 31, 2009 - 8:30 AM
SLU, 815 Mercer St., Admin Bldg C, Orin Smith Auditorium
Gerald H. Pollack, PhD
Professor
Department of Bioengineering
UW
Tuesday, March 31, 2009 - 8:30 AM
SLU, 815 Mercer St., Admin Bldg C, Orin Smith Auditorium
In situ genetic analysis of cellular chimerism: who's who in gender- matched scenarios?
David Wu, MD, PhD
Assistant Professor
Laboratory medicine
UW
Tuesday, March 24, 2009 - 8:30 AM
SLU, 815 Mercer St., Admin Bldg C, Orin Smith Auditorium
David Wu, MD, PhD
Assistant Professor
Laboratory medicine
UW
Tuesday, March 24, 2009 - 8:30 AM
SLU, 815 Mercer St., Admin Bldg C, Orin Smith Auditorium
In situ genetic analysis of cellular chimerism: who's who in gender- matched scenarios?
David Wu, MD, PhD
Assistant Professor
Dept. of Laboratory Medicine
UW
Tuesday, March 24, 2009 - 8:30 AM
SLU, 815 Mercer St., Admin Bldg C, Orin Smith Auditorium
David Wu, MD, PhD
Assistant Professor
Dept. of Laboratory Medicine
UW
Tuesday, March 24, 2009 - 8:30 AM
SLU, 815 Mercer St., Admin Bldg C, Orin Smith Auditorium
Genetic and Epigenetic Regulation of Gene Expression in Normal Development and Diseases of Skeletal Muscle
Stephen Tapscott
Member
Divisions of Human Biology and Clinical Research
Fred Hutchinson Cancer Research Center
Wednesday, March 11, 2009 - 4:30 PM
Health Sciences Center, K-069
Faculty Sponsor: Ray Monnat, M.D.
Why Attend?
Skeletal myogenesis is a model system for defining the molecular mechanisms of regulating a complex program of gene expression in a dynamic system. MyoD is a central factor in this program and has been used to elucidate general rules for how complex cellular programs might evolve and achieve predictable complex behaviors. Dr. Tapscott will discuss his work on the regulation of gene expression in normal myogenesis and in rhabdomyosarcomas.
Dr. Tapscott earned his BA at Hampshire College and MD/PhD from the University of Pennsylvania, where he also completed medical inter,ship and neurology residency. He completed postdoctoral training in molecular biology at the Fred Hutchinson Cancer Research Center and has been a faculty member there since 1991.
Stephen Tapscott
Member
Divisions of Human Biology and Clinical Research
Fred Hutchinson Cancer Research Center
Wednesday, March 11, 2009 - 4:30 PM
Health Sciences Center, K-069
Faculty Sponsor: Ray Monnat, M.D.
Why Attend?
Skeletal myogenesis is a model system for defining the molecular mechanisms of regulating a complex program of gene expression in a dynamic system. MyoD is a central factor in this program and has been used to elucidate general rules for how complex cellular programs might evolve and achieve predictable complex behaviors. Dr. Tapscott will discuss his work on the regulation of gene expression in normal myogenesis and in rhabdomyosarcomas.
Dr. Tapscott earned his BA at Hampshire College and MD/PhD from the University of Pennsylvania, where he also completed medical inter,ship and neurology residency. He completed postdoctoral training in molecular biology at the Fred Hutchinson Cancer Research Center and has been a faculty member there since 1991.
Metabolic Stability and the Evolution of Life Span
Lloyd Demetrius, PhD
Department of Evolutionary & Organismic Biology
Harvard University
Tuesday, March 10, 2009 - 3:30 PM
Health Sciences Center, K-069
Faculty Sponsor: Peter Rabinovitch, M.D., Ph.D.
Sponsored by the Nathan Shock Center Of Excellence in the Basic Biology Of Aging, and the Genetic Approaches To Aging Training Grant
Lloyd Demetrius, PhD
Department of Evolutionary & Organismic Biology
Harvard University
Tuesday, March 10, 2009 - 3:30 PM
Health Sciences Center, K-069
Faculty Sponsor: Peter Rabinovitch, M.D., Ph.D.
Sponsored by the Nathan Shock Center Of Excellence in the Basic Biology Of Aging, and the Genetic Approaches To Aging Training Grant
Human Pluripotent Stem Cells for Myocardial Repair
Michael LaFlamme, MD, PhD
Assistant Professor, Pathology
UW School of Medicine
Tuesday, March 10, 2009 - 8:30 AM
HSC, NE110
Faculty Sponsor: Thomas Montine, MD, PhD
Mechanism of Disease Series: A case-oriented introduction to the study of human diseases.
Michael LaFlamme, MD, PhD
Assistant Professor, Pathology
UW School of Medicine
Tuesday, March 10, 2009 - 8:30 AM
HSC, NE110
Faculty Sponsor: Thomas Montine, MD, PhD
Mechanism of Disease Series: A case-oriented introduction to the study of human diseases.
Local Control of Excitation-Transcription Coupling in Smooth Muscle
Luis Fernando Santana, Ph.D.
Associate Professor
Physiology and Biophysics
UW
Tuesday, March 10, 2009 - 8:30 AM
Health Sciences Building, K-069
Luis Fernando Santana, Ph.D.
Associate Professor
Physiology and Biophysics
UW
Tuesday, March 10, 2009 - 8:30 AM
Health Sciences Building, K-069
Chromatin and G-quadruplex Functions at Telomeres and Beyond
Brad Johnson, MD, PhD
Assistant Professor
Pathology/Lab Medicine
University of Pennsylvania
Wednesday, March 4, 2009 - 4:30 PM
Health Sciences Center, K-069
Faculty Sponsor: Ray Monnat, M.D.
Why Attend?
Telomeres are the physical and functional 'caps' on the ends of chromosomes. Telomere defects are now known to contribute to several degenerative diseases as well as cancer. Dr. Johnson's talk will describe how telomeres are maintained by a combination of chromatin and helicase-dependent recombination pathways. He will also present new evidence for the role of G-quadruplex structures formed by G-rich telomeric DNA in telomere capping and the regulation of transcription.
Dr. Johnson received his BS from Yale, and MD and PhD from Stanford. He did residency training in Clinical Pathology at Brigham and Women's Hospital, and postdoctoral research at MIT before joining the faculty at Penn. Dr. Johnson is currently Assistant Professor of Pathology and Assistant Director of the Clinical Immunology Laboratory at the Hospital of the University of Pennsylvania.
Brad Johnson, MD, PhD
Assistant Professor
Pathology/Lab Medicine
University of Pennsylvania
Wednesday, March 4, 2009 - 4:30 PM
Health Sciences Center, K-069
Faculty Sponsor: Ray Monnat, M.D.
Why Attend?
Telomeres are the physical and functional 'caps' on the ends of chromosomes. Telomere defects are now known to contribute to several degenerative diseases as well as cancer. Dr. Johnson's talk will describe how telomeres are maintained by a combination of chromatin and helicase-dependent recombination pathways. He will also present new evidence for the role of G-quadruplex structures formed by G-rich telomeric DNA in telomere capping and the regulation of transcription.
Dr. Johnson received his BS from Yale, and MD and PhD from Stanford. He did residency training in Clinical Pathology at Brigham and Women's Hospital, and postdoctoral research at MIT before joining the faculty at Penn. Dr. Johnson is currently Assistant Professor of Pathology and Assistant Director of the Clinical Immunology Laboratory at the Hospital of the University of Pennsylvania.
uPA-accelerated atherosclerosis and plaque rupture: searching for mechanisms
Jie Hong Hu, Ph.D.
Senior Fellow
Division of Cardiology
UW
Tuesday, March 3, 2009 - 8:30 AM
Health Sciences Building, K-069
Jie Hong Hu, Ph.D.
Senior Fellow
Division of Cardiology
UW
Tuesday, March 3, 2009 - 8:30 AM
Health Sciences Building, K-069
Lost in Translation: Ribosomes in Hematopoiesis
Akiko Shimamura, MD, PhD
Associate Member
Division of Pediatric Hematology/Oncology
Fred Hutchinson Cancer Research Center
Wednesday, February 25, 2009 - 4:30 PM
Health Sciences Center, K-069
Faculty Sponsor: Ray Monnat, M.D.
Why Attend?
Ribosomes have long been considered "housekeeping" organelles whose chief-or sole-function is to translate the information contained in mRNAs into cellular proteins. A surprising recent twist in this story was the identification of ribosomal gene mutations in a group of hematologic disorders characterized by marrow failure and leukemia predisposition. Dr. Shimamura will review the emerging field of ribosomal diseases, and discuss models for disease that arise from ribosomal abnormalities or dysfunction.
Dr. Shimamura received her B.A. from Princeton University and did her M.D. and Ph.D. training at the University of Rochester. She joined the faculty at Harvard after Internship and Residency training at Johns Hopkins, and a Fellowship at the Dana-Farber and Children's Hospital in Boston. She was recruited to the UW in 2007, and is an Associate Member at the Fred Hutchinson in 2008. She directs a research lab at the FHCRC, and is head of the Marrow Failure Clinic at Seattle Children's Hospital.
Akiko Shimamura, MD, PhD
Associate Member
Division of Pediatric Hematology/Oncology
Fred Hutchinson Cancer Research Center
Wednesday, February 25, 2009 - 4:30 PM
Health Sciences Center, K-069
Faculty Sponsor: Ray Monnat, M.D.
Why Attend?
Ribosomes have long been considered "housekeeping" organelles whose chief-or sole-function is to translate the information contained in mRNAs into cellular proteins. A surprising recent twist in this story was the identification of ribosomal gene mutations in a group of hematologic disorders characterized by marrow failure and leukemia predisposition. Dr. Shimamura will review the emerging field of ribosomal diseases, and discuss models for disease that arise from ribosomal abnormalities or dysfunction.
Dr. Shimamura received her B.A. from Princeton University and did her M.D. and Ph.D. training at the University of Rochester. She joined the faculty at Harvard after Internship and Residency training at Johns Hopkins, and a Fellowship at the Dana-Farber and Children's Hospital in Boston. She was recruited to the UW in 2007, and is an Associate Member at the Fred Hutchinson in 2008. She directs a research lab at the FHCRC, and is head of the Marrow Failure Clinic at Seattle Children's Hospital.
TLR in Lung Ischemia Reperfusion InjuryTLR in Lung Ischemia Reperfusion Injury
John C. Keech, M.D.
Postdoctoral Fellow
Surgery
UW
Tuesday, February 24, 2009 - 8:30 AM
Health Sciences Building, K-069
John C. Keech, M.D.
Postdoctoral Fellow
Surgery
UW
Tuesday, February 24, 2009 - 8:30 AM
Health Sciences Building, K-069
Translating Pathways to Pancreatic Cancer
Sunil Hingorani, MD, PhD
Assistant Member
Clinical Research and Public Health Sciences Division
Fred Hutchinson Cancer Research Center
Wednesday, February 18, 2009 - 4:30 PM
Health Sciences Center, K-069
Faculty Sponsor: Ray Monnat, M.D.
Why Attend?
Pancreatic cancer is the 4th leading cause of cancer deaths in the U.S. Recent genomic analyses of this common killer have revealed core signaling pathways that are altered in nearly all pancreatic cancers, and thus are new targets for pancreatic cancer diagnosis and therapy. Dr. Hingorani will discuss these findings, and how mouse models can be used to explore the clinical translation of these exciting new results.
Dr. Hingorani received his B.A., M.D. and Ph.D. from Yale. He did internship, residency and fellowship training in Boston at the Brigham & Women's Hospital, Dana-Farber and M.I.T. before joining the faculty at Penn. He was recruited to the Fred Hutchinson and UW in 2005, where he has a research lab and directs the Pancreatic Cancer Specialty Clinic at the Seattle Cancer Care Alliance.
Sunil Hingorani, MD, PhD
Assistant Member
Clinical Research and Public Health Sciences Division
Fred Hutchinson Cancer Research Center
Wednesday, February 18, 2009 - 4:30 PM
Health Sciences Center, K-069
Faculty Sponsor: Ray Monnat, M.D.
Why Attend?
Pancreatic cancer is the 4th leading cause of cancer deaths in the U.S. Recent genomic analyses of this common killer have revealed core signaling pathways that are altered in nearly all pancreatic cancers, and thus are new targets for pancreatic cancer diagnosis and therapy. Dr. Hingorani will discuss these findings, and how mouse models can be used to explore the clinical translation of these exciting new results.
Dr. Hingorani received his B.A., M.D. and Ph.D. from Yale. He did internship, residency and fellowship training in Boston at the Brigham & Women's Hospital, Dana-Farber and M.I.T. before joining the faculty at Penn. He was recruited to the Fred Hutchinson and UW in 2005, where he has a research lab and directs the Pancreatic Cancer Specialty Clinic at the Seattle Cancer Care Alliance.
Mitochondrial-targeted Peptides: Novel Cardio-, Neuro- and Renal-protective Agents
Hazel H. Szeto, M.D., Ph.D.
Professor
Department of Pharmacology
Weill Cornell Medical College
Tuesday, February 17, 2009 - 3:30 PM
Health Sciences Center, K-069
Faculty Sponsor: Peter Rabinovitch, M.D., Ph.D.
Presented by the Nathan Shock Center of Excellence in the Basic Biology of Aging and the Genetic Approaches to Aging Training Grant
Hazel H. Szeto, M.D., Ph.D.
Professor
Department of Pharmacology
Weill Cornell Medical College
Tuesday, February 17, 2009 - 3:30 PM
Health Sciences Center, K-069
Faculty Sponsor: Peter Rabinovitch, M.D., Ph.D.
Presented by the Nathan Shock Center of Excellence in the Basic Biology of Aging and the Genetic Approaches to Aging Training Grant
Myofilament Regulation of the Frank-Starling Law of the Heart
F. Steven Korte, Ph.D.
Senior Fellow
Bioengineering
UW
Tuesday, February 17, 2009 - 8:30 AM
Health Sciences Building, K-069
F. Steven Korte, Ph.D.
Senior Fellow
Bioengineering
UW
Tuesday, February 17, 2009 - 8:30 AM
Health Sciences Building, K-069
Patient-Specific Models of Glioma Growth and Invasion: Predictive Capability and Clinical Utility
Kristin Swanson, PhD
Research Associate Professor, UW Medicine Pathology
Adjunct Associate Research Professor, Applied Mathematics
University of Washington
Wednesday, February 11, 2009 - 4:30 PM
Health Sciences Center, K-069
Faculty Sponsor: Monnat
Kristin Swanson, PhD
Research Associate Professor, UW Medicine Pathology
Adjunct Associate Research Professor, Applied Mathematics
University of Washington
Wednesday, February 11, 2009 - 4:30 PM
Health Sciences Center, K-069
Faculty Sponsor: Monnat
The FGF Axis: New Therapeutic Opportunities
Norman M. Greenberg, Ph.D.
Member, Clinical Research Division, Fred Hutchinson Cancer Research Center; Professor of Pharmacology, University of Washington
FHCRC and UW
Tuesday, February 10, 2009 - 8:30 AM
Health Sciences Building, K-069
Norman M. Greenberg, Ph.D.
Member, Clinical Research Division, Fred Hutchinson Cancer Research Center; Professor of Pharmacology, University of Washington
FHCRC and UW
Tuesday, February 10, 2009 - 8:30 AM
Health Sciences Building, K-069
Water
Gerald Pollack, PhD
Professor, Bioengineering
Department of Engineering, Bioengineering Division
UW School of Medicine
Monday, February 9, 2009 - 8:30 AM
HSC, NE110
Faculty Sponsor: Thomas Montine, MD, PhD
Mechanism of Disease Series: A case-oriented introduction to the study of human diseases. www.i-sis.org.uk/liquidCrystallineWater.php
Gerald Pollack, PhD
Professor, Bioengineering
Department of Engineering, Bioengineering Division
UW School of Medicine
Monday, February 9, 2009 - 8:30 AM
HSC, NE110
Faculty Sponsor: Thomas Montine, MD, PhD
Mechanism of Disease Series: A case-oriented introduction to the study of human diseases. www.i-sis.org.uk/liquidCrystallineWater.php
Archaeoctyes: Monocytes as Universal Probes for Disease
Stephen Schwartz, MD, PhD
Professor
Pathology
University of Washington
Wednesday, February 4, 2009 - 4:30 PM
Health Sciences Center, K-069
Faculty Sponsor: Monnat
Stephen Schwartz, MD, PhD
Professor
Pathology
University of Washington
Wednesday, February 4, 2009 - 4:30 PM
Health Sciences Center, K-069
Faculty Sponsor: Monnat
Tracking the Human Kineome and Phosphoproteins for Biomarker Discovery with Protein Microarrays
Steven Pelech, Ph.D.
President and Chief Scientific Officer, Kinexus Bioinformatics Corporation; Professor, Division of Neurology, Dept. of Medicine, University of British Columbia
Kinexus Bioinformatics Corp. and Univ. of British Columbia
Tuesday, February 3, 2009 - 8:30 AM
Health Sciences Building, K-069
Steven Pelech, Ph.D.
President and Chief Scientific Officer, Kinexus Bioinformatics Corporation; Professor, Division of Neurology, Dept. of Medicine, University of British Columbia
Kinexus Bioinformatics Corp. and Univ. of British Columbia
Tuesday, February 3, 2009 - 8:30 AM
Health Sciences Building, K-069
Roles of Transcription in Genomic Stability or Instability
Philip Hanawalt, PhD
Professor
Biological Sciences
Stanford University
Wednesday, January 28, 2009 - 4:30 PM
Health Sciences Center, K-069
Faculty Sponsor: Loeb
Philip Hanawalt, PhD
Professor
Biological Sciences
Stanford University
Wednesday, January 28, 2009 - 4:30 PM
Health Sciences Center, K-069
Faculty Sponsor: Loeb
SMC plasticity and reprogramming in calcifying vasculature
Yanfeng (Mei) Speer, Ph.D.
Research Assistant Professor
Bioengineering
UW
Tuesday, January 27, 2009 - 8:30 AM
Health Sciences Building, K-069
Yanfeng (Mei) Speer, Ph.D.
Research Assistant Professor
Bioengineering
UW
Tuesday, January 27, 2009 - 8:30 AM
Health Sciences Building, K-069
Studying Hematopoietic Disease with Genetics & Genomics
Yajuan Liu, PhD
Senior Fellow
Medical Genetics
University of Washington
Wednesday, January 21, 2009 - 4:30 PM
Health Science Bldg, K-069
Faculty Sponsor: Dr. Monnat
Yajuan Liu, PhD
Senior Fellow
Medical Genetics
University of Washington
Wednesday, January 21, 2009 - 4:30 PM
Health Science Bldg, K-069
Faculty Sponsor: Dr. Monnat
Genetic & epigenetic control of aging
George Martin, MD
Emeritus Professor (active), Pathology
UW School of Medicine
Tuesday, January 13, 2009 - 8:30 AM
HSC, NE110
Faculty Sponsor: Thomas Montine, MD, PhD
Mechanism of Disease Series: A case-oriented introduction to the study of human diseases. Laboratory of Molecular Genetics Alzheimer's Disease Research Center University of Washington. www.pathology.washington.edu/research/labs/Martin/
George Martin, MD
Emeritus Professor (active), Pathology
UW School of Medicine
Tuesday, January 13, 2009 - 8:30 AM
HSC, NE110
Faculty Sponsor: Thomas Montine, MD, PhD
Mechanism of Disease Series: A case-oriented introduction to the study of human diseases. Laboratory of Molecular Genetics Alzheimer's Disease Research Center University of Washington. www.pathology.washington.edu/research/labs/Martin/
Genome Regulation During Cardiac Mesoderm Directed Differentiation of Human Embryonic Stem Cells
Jonathan Golob
Graduate Student
Pathology
UW
Tuesday, January 13, 2009 - 8:30 AM
Health Sciences Building, K-069
Jonathan Golob
Graduate Student
Pathology
UW
Tuesday, January 13, 2009 - 8:30 AM
Health Sciences Building, K-069
Inights Into Vascular Diseases and Their Treatments from Human Genetics
Richard Lifton, M.D., Ph.D.
Professor and Chair
Department of Genetics
Yale University
Wednesday, January 7, 2009 - 5:00 PM
Health Sciences Center, Turner Auditorium, Rm. D-209
Faculty Sponsor: Stephen Schwartz
Please visit the Benditt Lectureship website for more information about Dr. Lifton: http://pathology.washington.edu/PathNews/news/?id=222
Richard Lifton, M.D., Ph.D.
Professor and Chair
Department of Genetics
Yale University
Wednesday, January 7, 2009 - 5:00 PM
Health Sciences Center, Turner Auditorium, Rm. D-209
Faculty Sponsor: Stephen Schwartz
Please visit the Benditt Lectureship website for more information about Dr. Lifton: http://pathology.washington.edu/PathNews/news/?id=222
AAV vectors: biology and utility for gene addition and gene correction
David Russell, MD, PhD
Professor of Medicine
Div. of Hematology
UW
Tuesday, January 6, 2009 - 8:30 AM
Health Sciences Building, K-069
David Russell, MD, PhD
Professor of Medicine
Div. of Hematology
UW
Tuesday, January 6, 2009 - 8:30 AM
Health Sciences Building, K-069
Cockayne syndrome, chromosome fragility, and piggyBac transposons that are good for you
Alan Weiner, PhD
Professor and ZymoGenetics Chair
Biochemistry
UW
Tuesday, December 16, 2008 - 8:30 AM
South Lake Union, 815 Mercer Street, Orin Smith Auditorium
Alan Weiner, PhD
Professor and ZymoGenetics Chair
Biochemistry
UW
Tuesday, December 16, 2008 - 8:30 AM
South Lake Union, 815 Mercer Street, Orin Smith Auditorium
"Mitotic Reduction Divisions (Somatic Meiosis) in polyploid Hepatocytes"
Markus Grompe, MD
Professor
Molecular & Medical Genetics and Pediatrics
Oregon Health & Science University
Wednesday, December 10, 2008 - 4:30 PM
Health Science Center, K-069
Faculty Sponsor: Dr. Monnat
Markus Grompe, MD
Professor
Molecular & Medical Genetics and Pediatrics
Oregon Health & Science University
Wednesday, December 10, 2008 - 4:30 PM
Health Science Center, K-069
Faculty Sponsor: Dr. Monnat
Climb High, Sleep Low
Lawrence True, MD
Professor, Pathology
UW School of Medicine
Tuesday, December 9, 2008 - 8:30 AM
HSC, NE110
Faculty Sponsor: Thomas Montine, MD, PhD
Mechanism of Disease Series: A case-oriented introduction to the study of human diseases.
Lawrence True, MD
Professor, Pathology
UW School of Medicine
Tuesday, December 9, 2008 - 8:30 AM
HSC, NE110
Faculty Sponsor: Thomas Montine, MD, PhD
Mechanism of Disease Series: A case-oriented introduction to the study of human diseases.
A-type nuclear lamins in aging and disease
Brian Kennedy, PhD
Associate Professor
Biochemistry
UW
Tuesday, December 9, 2008 - 8:30 AM
South Lake Union, 815 Mercer Street, Orin Smith Auditorium
Brian Kennedy, PhD
Associate Professor
Biochemistry
UW
Tuesday, December 9, 2008 - 8:30 AM
South Lake Union, 815 Mercer Street, Orin Smith Auditorium
FEN1 Mutations Result in Autoimmunity, Chronic Inflammation and Cancers
Binghui Shen, PhD
Professor
Radiation Biology
City of Hope
Wednesday, December 3, 2008 - 4:30 PM
Health Sciences Center, K-069
Faculty Sponsor: Dr. Loeb
Binghui Shen, PhD
Professor
Radiation Biology
City of Hope
Wednesday, December 3, 2008 - 4:30 PM
Health Sciences Center, K-069
Faculty Sponsor: Dr. Loeb
Delta 1: A Notch up on cord blood stem cell transplantation
Irwin Bernstein, MD
Hartmann Professor and Head, Division of Pediatric Hematology/Oncology, University of Washington; Member and Head, Pediatric Oncology Program, Fred Hutchinson Cancer Research Center; Clinical Research Professor, American Cancer Society
UW and FHCRC
Tuesday, November 25, 2008 - 8:30 AM
South Lake Union, 815 Mercer Street, Orin Smith Auditorium
Irwin Bernstein, MD
Hartmann Professor and Head, Division of Pediatric Hematology/Oncology, University of Washington; Member and Head, Pediatric Oncology Program, Fred Hutchinson Cancer Research Center; Clinical Research Professor, American Cancer Society
UW and FHCRC
Tuesday, November 25, 2008 - 8:30 AM
South Lake Union, 815 Mercer Street, Orin Smith Auditorium
“Quantum Dots for Cancer Imaging and Therapeutics”
Xiaohu Gao, PhD
Assistant Professor
Bioengineering
University of Washington
Wednesday, November 19, 2008 - 4:30 PM
Health Science Center, K-069
Faculty Sponsor: Dr. Monnat
Xiaohu Gao, PhD
Assistant Professor
Bioengineering
University of Washington
Wednesday, November 19, 2008 - 4:30 PM
Health Science Center, K-069
Faculty Sponsor: Dr. Monnat
Dissection, disruption, and death--aortic dissection and its causes
Peter Byers, MD
Professor, Pathology and Medicine
UW School of Medicine
Tuesday, November 18, 2008 - 8:30 AM
HSC, NE110
Faculty Sponsor: Thomas Montine, MD, PhD
Mechanism of Disease Series: A case-oriented introduction to the study of human diseases.
Peter Byers, MD
Professor, Pathology and Medicine
UW School of Medicine
Tuesday, November 18, 2008 - 8:30 AM
HSC, NE110
Faculty Sponsor: Thomas Montine, MD, PhD
Mechanism of Disease Series: A case-oriented introduction to the study of human diseases.
Oncogene-induced inflammation: A pathway linking autoimmune disease with cancer
Jay Rothstein, PhD
Director
Inflammation Research
Amgen, Inc., Seattle, WA
Tuesday, November 18, 2008 - 8:30 AM
South Lake Union, 815 Mercer Street, Orin Smith Auditorium
Jay Rothstein, PhD
Director
Inflammation Research
Amgen, Inc., Seattle, WA
Tuesday, November 18, 2008 - 8:30 AM
South Lake Union, 815 Mercer Street, Orin Smith Auditorium
Induction of Cardiac Pacemaker by Neuregulin Blockade and electrophysiological properties of cardios derived from hESCs
Wei-Zhong Zhu, PhD
Postdoctoral Fellow
Pathology
UW
Tuesday, November 18, 2008 - 8:30 AM
South Lake Union, 815 Mercer Street, Orin Smith Auditorium
Faculty Sponsor: Michael Laflamme
Wei-Zhong Zhu, PhD
Postdoctoral Fellow
Pathology
UW
Tuesday, November 18, 2008 - 8:30 AM
South Lake Union, 815 Mercer Street, Orin Smith Auditorium
Faculty Sponsor: Michael Laflamme
Neuroregeneration in the Cerebral Cortex: Impossible and Crazy?
Robert Hevner, M.D., Ph.D.
Professor
Neurological Surgery, Seattle Children's Hospital; and UW Medicine Pathology
University of Washington
Wednesday, November 12, 2008 - 4:30 PM
Health Science Center, K-069
Faculty Sponsor: Dr. Monnat
Robert Hevner, M.D., Ph.D.
Professor
Neurological Surgery, Seattle Children's Hospital; and UW Medicine Pathology
University of Washington
Wednesday, November 12, 2008 - 4:30 PM
Health Science Center, K-069
Faculty Sponsor: Dr. Monnat
"Structural and Functional Characterizations of Alternative Gene Products of an Adaptor Protein (FE65) and an Orphan G-Protein Coupled Receptor (Gprc5b) in Learning- and Memory-Impaired Mice with a Selective Knockout of p97FE65"
Bethany Cool
Graduate Student
Pathology
University of Washington
Monday, November 10, 2008 - 2:30 PM
Health Science Center, K-0690
Faculty Sponsor: Dr. Martin
Bethany Cool
Graduate Student
Pathology
University of Washington
Monday, November 10, 2008 - 2:30 PM
Health Science Center, K-0690
Faculty Sponsor: Dr. Martin
"Pathogenesis of NASH: new insights from mice with metabolic syndrome"
Geoffrey Farrell, MD
Director/Professor
Gastroenterology and Hepatology
Australian National University
Wednesday, November 5, 2008 - 4:30 PM
Health Sciences Center, K-069
Faculty Sponsor: Dr. Matthew Yeh
Geoffrey Farrell, MD
Director/Professor
Gastroenterology and Hepatology
Australian National University
Wednesday, November 5, 2008 - 4:30 PM
Health Sciences Center, K-069
Faculty Sponsor: Dr. Matthew Yeh
"The Instability of Genetic Instability: Pathways Suppressing Mutator Phenotypes in Yeast"
Alan Herr, PhD
Senior Fellow
Pathology
University of Washington
Wednesday, October 29, 2008 - 4:30 PM
Health Sciences Center, K-069
Faculty Sponsor: Dr. Brad Preston
Alan Herr, PhD
Senior Fellow
Pathology
University of Washington
Wednesday, October 29, 2008 - 4:30 PM
Health Sciences Center, K-069
Faculty Sponsor: Dr. Brad Preston
"Control of Cardiovascular Signaling by RGS Proteins"
William Mahoney, PhD
Senior Fellow
Pathology
University of Washington
Wednesday, October 22, 2008 - 4:30 PM
Health Sciences Center, K-069
Faculty Sponsor: Dr. Monnat
William Mahoney, PhD
Senior Fellow
Pathology
University of Washington
Wednesday, October 22, 2008 - 4:30 PM
Health Sciences Center, K-069
Faculty Sponsor: Dr. Monnat
Epigenetic programming of mesenchymal stem cells
Philippe Collas, PhD
Professor
Institute of Basic Medical Sciences, Dept. of Biochemistry
University of Oslo, Norway
Tuesday, October 21, 2008 - 8:30 AM
South Lake Union, 815 Mercer Street, Orin Smith Auditorium
Faculty Sponsor: Karol Bomsztyk
Philippe Collas, PhD
Professor
Institute of Basic Medical Sciences, Dept. of Biochemistry
University of Oslo, Norway
Tuesday, October 21, 2008 - 8:30 AM
South Lake Union, 815 Mercer Street, Orin Smith Auditorium
Faculty Sponsor: Karol Bomsztyk
Exploring the Interface Between Glial Progenitors and Gliomas
Peter Canoll, MD, PhD
Assistant Professor
Department of Clinical Pathology
Columbia University
Wednesday, October 15, 2008 - 4:30 PM
Health Sciences Center, K-069
Faculty Sponsor: Dr. Tom Montine
Peter Canoll, MD, PhD
Assistant Professor
Department of Clinical Pathology
Columbia University
Wednesday, October 15, 2008 - 4:30 PM
Health Sciences Center, K-069
Faculty Sponsor: Dr. Tom Montine
Regulation of Nodal Signaling by microRNAs
Wen-Yee Choi
Graduate Researcher
Molecular and Cellular Biology
Harvard University
Tuesday, October 14, 2008 - 8:30 AM
South Lake Union, 815 Mercer Street, Orin Smith Auditorium
Faculty Sponsor: Charles Murry
Wen-Yee Choi
Graduate Researcher
Molecular and Cellular Biology
Harvard University
Tuesday, October 14, 2008 - 8:30 AM
South Lake Union, 815 Mercer Street, Orin Smith Auditorium
Faculty Sponsor: Charles Murry
Contribution of interstitial valve cells to valve calcification
Marcello Rattazzi, MD
Clinical and Experimental Medicine
University of Padua, Italy
Wednesday, October 8, 2008 - 8:30 AM
South Lake Union, 815 Mercer Street, Orin Smith Auditorium
Marcello Rattazzi, MD
Clinical and Experimental Medicine
University of Padua, Italy
Wednesday, October 8, 2008 - 8:30 AM
South Lake Union, 815 Mercer Street, Orin Smith Auditorium
Molecular mechanisms of aging: What can we learn from yeast and worms?
Matt Kaeberlein, PhD
Assistant Professor
Pathology
UW
Tuesday, October 7, 2008 - 8:30 AM
South Lake Union, 815 Mercer Street, Orin Smith Auditorium
Matt Kaeberlein, PhD
Assistant Professor
Pathology
UW
Tuesday, October 7, 2008 - 8:30 AM
South Lake Union, 815 Mercer Street, Orin Smith Auditorium
Pancreatic Cancer: Emerging Ideas About How the Cancer Forms
Teri Brentnall, MD
Professor
Departments of Medicine and Pathology
University of Washington
Wednesday, October 1, 2008 - 4:30 PM
Health Sciences Center, K-069
Faculty Sponsor: Dr. Rabinovitch
Teri Brentnall, MD
Professor
Departments of Medicine and Pathology
University of Washington
Wednesday, October 1, 2008 - 4:30 PM
Health Sciences Center, K-069
Faculty Sponsor: Dr. Rabinovitch
PSGL-1 Mediated Signal Transduction and Translational Control Mechanisms During Adherence of Macrophages
Richard Fox
Graduate Student
UW Medicine Pathology
University of Washington
Thursday, August 14, 2008 - 1:00 PM
South Lake Union Auditorium, K-111
Faculty Sponsor: Dr. Schwartz
Richard Fox
Graduate Student
UW Medicine Pathology
University of Washington
Thursday, August 14, 2008 - 1:00 PM
South Lake Union Auditorium, K-111
Faculty Sponsor: Dr. Schwartz
“Magnetic Resonance Imaging of Gene Expression"
Anna Naumova, Ph.D.
Senior Fellow
Radiology
UW
Tuesday, June 24, 2008 - 8:30 AM
SLU Brotman Building, Blue Flame Auditorium
815 Mercer Street
Anna Naumova, Ph.D.
Senior Fellow
Radiology
UW
Tuesday, June 24, 2008 - 8:30 AM
SLU Brotman Building, Blue Flame Auditorium
815 Mercer Street
“Directly targeting myofibrillar proteins to improve cardiomyocyte contraction"
F. Steven Korte, PhD
Senior fellow
Bioengineering
UW
Tuesday, June 17, 2008 - 8:30 AM
SLU Brotman Building, Blue Flame Auditorium
815 Mercer Street
F. Steven Korte, PhD
Senior fellow
Bioengineering
UW
Tuesday, June 17, 2008 - 8:30 AM
SLU Brotman Building, Blue Flame Auditorium
815 Mercer Street
“Fatty Acids and the Renal Complications of Type 2 Diabetes Mellitus”
Bardia Askari, Ph.D.
Acting Instructor
Pathology
UW
Tuesday, June 10, 2008 - 8:30 AM
SLU Brotman Building, Blue Flame Auditorium
815 Mercer Street
Bardia Askari, Ph.D.
Acting Instructor
Pathology
UW
Tuesday, June 10, 2008 - 8:30 AM
SLU Brotman Building, Blue Flame Auditorium
815 Mercer Street
Understanding aging through conserved longevity pathways
Matt Kaeberlein, PhD
Assistant Professor, Pathology
UW School of Medicine
Tuesday, June 10, 2008 - 8:30 AM
HSC, NE110
Faculty Sponsor: Dr. Thomas Montine
Matt Kaeberlein, PhD
Assistant Professor, Pathology
UW School of Medicine
Tuesday, June 10, 2008 - 8:30 AM
HSC, NE110
Faculty Sponsor: Dr. Thomas Montine
“Acceleration of atherosclerosis by type 1 diabetes: Evidence from a mouse model”
Karin E. Bornfeldt, Ph.D.
Professor
Pathology
Medicine
Tuesday, June 3, 2008 - 8:30 AM
SLU Brotman Building, Blue Flame Auditorium
815 Mercer
Karin E. Bornfeldt, Ph.D.
Professor
Pathology
Medicine
Tuesday, June 3, 2008 - 8:30 AM
SLU Brotman Building, Blue Flame Auditorium
815 Mercer
“Quantitative proteomic identification of MAZ as a transcriptional regulator of muscle-specific genes”
Charis L. Himeda, Ph.D.
Senior fellow
Biochemistry
UW
Tuesday, May 20, 2008 - 8:30 AM
SLU Brotman Building, Blue Flame Auditorium
815 Mercer Street
Charis L. Himeda, Ph.D.
Senior fellow
Biochemistry
UW
Tuesday, May 20, 2008 - 8:30 AM
SLU Brotman Building, Blue Flame Auditorium
815 Mercer Street
“Ex Vivo/In Vivo MRI-based Mechanical Analysis of Human Carotid Atherosclerotic Plaque Vulnerability Assessment”
Dalin Tang, Ph.D.
Professor
Mathematics and Biomedical Engineering
Worcester Polytechnic Institute
Tuesday, May 13, 2008 - 8:30 AM
SLU Brotman Building, Blue Flame Auditorium
Faculty Sponsor: Chun Yuan, Ph.D.
815 Mercer Street
Dalin Tang, Ph.D.
Professor
Mathematics and Biomedical Engineering
Worcester Polytechnic Institute
Tuesday, May 13, 2008 - 8:30 AM
SLU Brotman Building, Blue Flame Auditorium
Faculty Sponsor: Chun Yuan, Ph.D.
815 Mercer Street
“Why are there so many isoforms of long-chain acyl-CoA synthetases in arterial smooth muscle cells? Do they have different functions?”
Deidre Golej
Graduate Student, Molecular and Cellular Biology
Pathology
UW
Tuesday, May 6, 2008 - 8:30 AM
SLU Brotman Building, Blue Flame Auditorium
815 Mercer Street
Deidre Golej
Graduate Student, Molecular and Cellular Biology
Pathology
UW
Tuesday, May 6, 2008 - 8:30 AM
SLU Brotman Building, Blue Flame Auditorium
815 Mercer Street
Why Do Biopsies of Ulcerative Colitis Seem to Look More and More Like Crohn’s Disease? And Whatever Happened to the Old Ulcerative Colitis That We Knew and Loved
Henry Appelman, M.D.
Professor
Department of Pathology
University of Michigan Health System
Thursday, May 1, 2008 - 4:30 PM
Health Sciences Center, Turner Auditorium, Room D-209
Faculty Sponsor: Dr. Melissa Upton
A special lecture in memory of Dr. Rodger C. Haggitt, Professor and Chief, UWMC Anatomic Pathology, 1984-2000.
Henry Appelman, M.D.
Professor
Department of Pathology
University of Michigan Health System
Thursday, May 1, 2008 - 4:30 PM
Health Sciences Center, Turner Auditorium, Room D-209
Faculty Sponsor: Dr. Melissa Upton
A special lecture in memory of Dr. Rodger C. Haggitt, Professor and Chief, UWMC Anatomic Pathology, 1984-2000.
“Diabetic vascular disease: Hitting below the belt”
Kanchan Chitaley, Ph.D.
Research Assistant Professor
Urology
UW
Tuesday, April 29, 2008 - 8:30 AM
SLU Brotman Building, Blue Flame Auditorium
815 Mercer Street
Kanchan Chitaley, Ph.D.
Research Assistant Professor
Urology
UW
Tuesday, April 29, 2008 - 8:30 AM
SLU Brotman Building, Blue Flame Auditorium
815 Mercer Street
6th Annual Alvord Lecture in Neuropathology
Arie Perry, MD
Associate Professor
Pathology, Division of Neuropathology
Washington University, St. Louis
Wednesday, April 23, 2008 - 4:30 PM
Health Sciences Center, K-069
Faculty Sponsor: Dr. Montine
Arie Perry, M.D. Associate Professor Pathology, Division of Neuropathology Washington University School of Medicine, St. Louis, MO Editor-in-Chief, Brain Pathology Molecular Diagnostics of Gliomas Wednesday, April 23, 2008 - 4:30 PM Health Sciences Center, Room K-069 The recognition over the last decade that chromosome 1p and 19q codeletions in gliomas are highly associated with oligodendroglial histopathology, improved overall patient survival, and enhanced therapeutic responsiveness provided the impetus for the first widely utilized molecular diagnostic assay in clinical neuro-oncology. As one of the first neuropathologists to investigate the use of FISH for 1p/19q deletion testing and to make it clinically available, Dr. Perry has amassed extensive experience with this technique and will address the practical issues and most common questions posed by both patients and the physicians involved in their care. Additional biomarkers that are either in common use or clinically promising for the diagnostic workup of gliomas will also be discussed.
Arie Perry, MD
Associate Professor
Pathology, Division of Neuropathology
Washington University, St. Louis
Wednesday, April 23, 2008 - 4:30 PM
Health Sciences Center, K-069
Faculty Sponsor: Dr. Montine
Arie Perry, M.D. Associate Professor Pathology, Division of Neuropathology Washington University School of Medicine, St. Louis, MO Editor-in-Chief, Brain Pathology Molecular Diagnostics of Gliomas Wednesday, April 23, 2008 - 4:30 PM Health Sciences Center, Room K-069 The recognition over the last decade that chromosome 1p and 19q codeletions in gliomas are highly associated with oligodendroglial histopathology, improved overall patient survival, and enhanced therapeutic responsiveness provided the impetus for the first widely utilized molecular diagnostic assay in clinical neuro-oncology. As one of the first neuropathologists to investigate the use of FISH for 1p/19q deletion testing and to make it clinically available, Dr. Perry has amassed extensive experience with this technique and will address the practical issues and most common questions posed by both patients and the physicians involved in their care. Additional biomarkers that are either in common use or clinically promising for the diagnostic workup of gliomas will also be discussed.
“FLT1 is a malaria resistance gene: hypertension, inflammation and natural selection in utero”
Atis Muehlenbachs
MSTP and Incoming Resident
Pathology
UW
Tuesday, April 22, 2008 - 8:30 AM
SLU Brotman Building, Blue Flame Auditorium
815 Mercer Street
Atis Muehlenbachs
MSTP and Incoming Resident
Pathology
UW
Tuesday, April 22, 2008 - 8:30 AM
SLU Brotman Building, Blue Flame Auditorium
815 Mercer Street
"Transcriptional regulation of thrombin receptors by vasodilator prostaglandins"
Karsten Schror, M.D.
Professor and Chair
Pharmacology and Clinical Pharmacology
Heinrich-Heine-Universitat Dusseldorf
Tuesday, April 15, 2008 - 8:30 AM
SLU Brotman Building, Blue Flame Auditorium
Faculty Sponsor: Alexander W. Clowes, MD
815 Mercer Street
Karsten Schror, M.D.
Professor and Chair
Pharmacology and Clinical Pharmacology
Heinrich-Heine-Universitat Dusseldorf
Tuesday, April 15, 2008 - 8:30 AM
SLU Brotman Building, Blue Flame Auditorium
Faculty Sponsor: Alexander W. Clowes, MD
815 Mercer Street
A Recurrent Mutation, p.R961W, in the MED12/TRAP/HOPA Gene Causes Opitz-Kaveggia (FG) Syndrome
Hiba Risheg, Ph.D.
Director
Clinical Ctyogenetics Laboratory
Genecare Medical Genetics Center
Monday, April 14, 2008 - 3:00 PM
Health Sciences Center, T-747
Faculty Sponsor: Dr. Christine Disteche
Dr. Risheg is a candidate for a Cytogenetics faculty position with UW Medicine Pathology
Hiba Risheg, Ph.D.
Director
Clinical Ctyogenetics Laboratory
Genecare Medical Genetics Center
Monday, April 14, 2008 - 3:00 PM
Health Sciences Center, T-747
Faculty Sponsor: Dr. Christine Disteche
Dr. Risheg is a candidate for a Cytogenetics faculty position with UW Medicine Pathology
Untangling Mitochondrial Mutagenesis and Aging in Mice
Marc Vermulst
Graduate Student
UW Medicine Pathology
University of Washington
Friday, April 11, 2008 - 3:30 PM
Health Sciences Center, K-069
Faculty Sponsor: Dr. Larry Loeb
Marc Vermulst
Graduate Student
UW Medicine Pathology
University of Washington
Friday, April 11, 2008 - 3:30 PM
Health Sciences Center, K-069
Faculty Sponsor: Dr. Larry Loeb
“A-type nuclear lamins: insights into the striated muscle phenotypes of Lmna-/- mice”
Richard Frock
PhD Candidate
Biochemistry
UW
Tuesday, April 8, 2008 - 8:30 AM
Health Sciences Building, K-069
Richard Frock
PhD Candidate
Biochemistry
UW
Tuesday, April 8, 2008 - 8:30 AM
Health Sciences Building, K-069
"I get by with a little help from my friends: The alpha1D-adrenergic receptor/dystrophin signalosome regulates blood pressure"
Chris Hague, Ph.D.
Assistant Professor
Pharmacology
UW
Tuesday, April 1, 2008 - 8:30 AM
SLU Brotman Building, Blue Flame Auditorium
815 Mercer Street
Chris Hague, Ph.D.
Assistant Professor
Pharmacology
UW
Tuesday, April 1, 2008 - 8:30 AM
SLU Brotman Building, Blue Flame Auditorium
815 Mercer Street
Glioma Invasion: Interactions with the Microenvironment
Joanna Phillips, MD, PhD
UW Medicine, Neuropathology Faculty Candidate
Department of Pathology, Division of Neuropathology, Research Fellow
University of California, San Francisco
Wednesday, March 26, 2008 - 9:30 AM
R&T Building, 300 Ninth Ave, auditorium
Faculty Sponsor: Montine
Joanna Phillips, MD, PhD
UW Medicine, Neuropathology Faculty Candidate
Department of Pathology, Division of Neuropathology, Research Fellow
University of California, San Francisco
Wednesday, March 26, 2008 - 9:30 AM
R&T Building, 300 Ninth Ave, auditorium
Faculty Sponsor: Montine
"Beyond Transcription: Translational Regulation During Embryonic Stem Cell Differentiation"
Prabha Sampath, Ph.D.
Postdoctoral Fellow
Pathology
UW
Tuesday, March 25, 2008 - 8:30 AM
SLU Brotman Building, Blue Flame Auditorium
815 Mercer Street
Prabha Sampath, Ph.D.
Postdoctoral Fellow
Pathology
UW
Tuesday, March 25, 2008 - 8:30 AM
SLU Brotman Building, Blue Flame Auditorium
815 Mercer Street
“Functional correction of muscles and extension of lifespan in dystrophic mice via AAV gene transfer”
Jeffrey S. Chamberlain, Ph.D.
Professor
Depts. of Neurology, Medicine and Biochemistry
UW
Tuesday, March 18, 2008 - 8:30 AM
HSB, T-635
Jeffrey S. Chamberlain, Ph.D.
Professor
Depts. of Neurology, Medicine and Biochemistry
UW
Tuesday, March 18, 2008 - 8:30 AM
HSB, T-635
“Human RecQ helicases: new roles in biology and disease”
Raymond Monnat, MD
Professor of Pathology
Pathology
UW School of Medicine
Tuesday, March 11, 2008 - 8:30 AM
HSC, NE110
Faculty Sponsor: Dr. Thomas Montine
Three examples of current research will be presented that use new technology to examine clinically important processes at the molecular level.
Raymond Monnat, MD
Professor of Pathology
Pathology
UW School of Medicine
Tuesday, March 11, 2008 - 8:30 AM
HSC, NE110
Faculty Sponsor: Dr. Thomas Montine
Three examples of current research will be presented that use new technology to examine clinically important processes at the molecular level.
"The Road to Resolution: Role of IGF Pathway in Lung Injury and Repair"
Lynn M. Schnapp, M.D.
Associate Professor of Medicine
Pulmonary and Critical Care Medicine
UW
Tuesday, March 4, 2008 - 8:30 AM
SLU Brotman Building, Blue Flame Auditorium
815 Mercer Street
Lynn M. Schnapp, M.D.
Associate Professor of Medicine
Pulmonary and Critical Care Medicine
UW
Tuesday, March 4, 2008 - 8:30 AM
SLU Brotman Building, Blue Flame Auditorium
815 Mercer Street
The Blood Brain Barrier in Parkinson's disease: Old Foe or New Friend
Dr. Paul Carvey
Dean
Rush Medical School
Wednesday, February 20, 2008 - 4:30 AM
Health Sciences Building, T639
Faculty Sponsor: Dr. Zhang
Dr. Paul Carvey
Dean
Rush Medical School
Wednesday, February 20, 2008 - 4:30 AM
Health Sciences Building, T639
Faculty Sponsor: Dr. Zhang
"Proteolytic shedding of cell surface proteins as a gatekeeper for leukocyte trafficking to and from inflammatory sites"
Elaine W. Raines
Research Professor
Pathology
UW
Tuesday, February 12, 2008 - 8:30 AM
HSB, K-069
Elaine W. Raines
Research Professor
Pathology
UW
Tuesday, February 12, 2008 - 8:30 AM
HSB, K-069
The Genetic Basis of Fanconi Anemia and Other Heritable Chromosome Instability Syndromes
Dr. Holger Hoehn
Professor
Humangenetik Institute
University of Wurzburg
Thursday, February 7, 2008 - 3:30 PM
Health Sciences Center, T-747
Faculty Sponsor: Peter Rabinovitch
Dr. Holger Hoehn
Professor
Humangenetik Institute
University of Wurzburg
Thursday, February 7, 2008 - 3:30 PM
Health Sciences Center, T-747
Faculty Sponsor: Peter Rabinovitch
“The Role of Filamin in Transcriptional Control of Laminin Expression”
Christine K. Abrass, MD, FACP
Professor of Medicine
Division of Gerontology and Geriatric Medicine
UW
Tuesday, February 5, 2008 - 8:30 AM
SLU Brotman Building, Blue Flame Auditorium
815 Mercer Street
Christine K. Abrass, MD, FACP
Professor of Medicine
Division of Gerontology and Geriatric Medicine
UW
Tuesday, February 5, 2008 - 8:30 AM
SLU Brotman Building, Blue Flame Auditorium
815 Mercer Street
"Encapsulated vascular smooth muscle cells to treat rat models of diabetes"
William Osborne, PhD
Research Professor
Pediatrics
UW
Tuesday, January 29, 2008 - 8:30 AM
HSB, K-069
William Osborne, PhD
Research Professor
Pediatrics
UW
Tuesday, January 29, 2008 - 8:30 AM
HSB, K-069
“Stabilizing the atherosclerotic plaque: taming the CD40-CD40L system”
Esther Lutgens, MD, PhD
Associate Professor
Pathology
CardioVascular Research Institute Maastricht (CARIM), University of Maastricht, The Netherlands
Tuesday, January 22, 2008 - 8:30 AM
SLU Brotman Building, Blue Flame Auditorium
Faculty Sponsor: Michael Rosenfeld, PhD
815 Mercer Street
Esther Lutgens, MD, PhD
Associate Professor
Pathology
CardioVascular Research Institute Maastricht (CARIM), University of Maastricht, The Netherlands
Tuesday, January 22, 2008 - 8:30 AM
SLU Brotman Building, Blue Flame Auditorium
Faculty Sponsor: Michael Rosenfeld, PhD
815 Mercer Street
"Cre-loxP Technology: a Lineage Tracing Study of Osteochondrogenic Cells in Calcifying Vasculature"
Yanfeng (Mei) Speer, PhD
Research Assistant Professor
Bioengineering
UW
Tuesday, January 15, 2008 - 8:30 AM
HSB, K-069
Yanfeng (Mei) Speer, PhD
Research Assistant Professor
Bioengineering
UW
Tuesday, January 15, 2008 - 8:30 AM
HSB, K-069
TBA
Roger E. Bumgarner, PhD
Associate Professor
Microbiology
UW
Tuesday, December 18, 2007 - 8:30 AM
SLU Brotman Building, Blue Flame Auditorium
815 Mercer Street
Roger E. Bumgarner, PhD
Associate Professor
Microbiology
UW
Tuesday, December 18, 2007 - 8:30 AM
SLU Brotman Building, Blue Flame Auditorium
815 Mercer Street
Secondary Mutations as a Mechanism of Cisplatin Resistance in BRCA1/2-Mutated Cancers: Lessons Learned from Studies on a Rare Genetic Disease, Fanconi Anemia
Toshiyasu Taniguchi, M.D., Ph.D.
Assistant Member
Divisions of Human Biology and Public Health Sciences
Fred Hutchinson Cancer Research Center
Monday, December 17, 2007 - 3:00 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Ray Monnat
Speaker is a candidate for an affiliate faculty appointment with UW Medicine Pathology
Toshiyasu Taniguchi, M.D., Ph.D.
Assistant Member
Divisions of Human Biology and Public Health Sciences
Fred Hutchinson Cancer Research Center
Monday, December 17, 2007 - 3:00 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Ray Monnat
Speaker is a candidate for an affiliate faculty appointment with UW Medicine Pathology
Physiological Functions of Activated Caspases in Macrophages
Thomas Nhan
Graduate Student
UW Medicine Pathology
University of Washington
Thursday, December 13, 2007 - 10:00 AM
South Lake Union, Brotman Building Auditorium
Faculty Sponsor: Stephen Schwartz
Thomas Nhan
Graduate Student
UW Medicine Pathology
University of Washington
Thursday, December 13, 2007 - 10:00 AM
South Lake Union, Brotman Building Auditorium
Faculty Sponsor: Stephen Schwartz
"Innate immune recognition and response to microbial pathogens"
Kelly Smith, MD, PhD
Assistant Professor
Pathology
UW
Tuesday, December 11, 2007 - 8:30 AM
SLU Brotman Building, Blue Flame Auditorium
815 Mercer Street
Kelly Smith, MD, PhD
Assistant Professor
Pathology
UW
Tuesday, December 11, 2007 - 8:30 AM
SLU Brotman Building, Blue Flame Auditorium
815 Mercer Street
Studying Connections between Cancer and Aging
Peter Rabinovitch, M.D., Ph.D.
Professor
UW Medicine Pathology
University of Washington
Tuesday, December 11, 2007 - 8:30 AM
UWMC, NE-110 Conference Room
Faculty Sponsor: Dr. Thomas Montine
Peter Rabinovitch, M.D., Ph.D.
Professor
UW Medicine Pathology
University of Washington
Tuesday, December 11, 2007 - 8:30 AM
UWMC, NE-110 Conference Room
Faculty Sponsor: Dr. Thomas Montine
Macrophage Mediators of Cardiac Fibrosis
April S. Stempien-Otero, MD
Assistant Professor of Medicine
Cardiology
UW
Tuesday, December 4, 2007 - 8:30 AM
SLU Brotman Building, Blue Flame Auditorium
815 Mercer Street
April S. Stempien-Otero, MD
Assistant Professor of Medicine
Cardiology
UW
Tuesday, December 4, 2007 - 8:30 AM
SLU Brotman Building, Blue Flame Auditorium
815 Mercer Street
Where Do the Cells of the Atherosclerotic Plaque Come from and Where Do They Go?
Gwen Randolph, Ph.D.
Associate Professor
Department of Gene and Cell Medicine
Mount Sinai School of Medicine
Friday, November 30, 2007 - 4:00 PM
Health Sciences Center, Turner Auditorium, Room D-209
Faculty Sponsor: Stephen Schwartz
Gwen Randolph, Ph.D.
Associate Professor
Department of Gene and Cell Medicine
Mount Sinai School of Medicine
Friday, November 30, 2007 - 4:00 PM
Health Sciences Center, Turner Auditorium, Room D-209
Faculty Sponsor: Stephen Schwartz
"Lung Injury and Repair: Inflammation, apoptosis and the Fas/FasL system"
Gustavo Matute-Bello, MD
Assistant Professor of Medicine
Pulmonary and Critical Care Medicine
UW
Tuesday, November 27, 2007 - 8:30 AM
SLU Brotman Building, Blue Flame Auditorium
815 Mercer Street
Gustavo Matute-Bello, MD
Assistant Professor of Medicine
Pulmonary and Critical Care Medicine
UW
Tuesday, November 27, 2007 - 8:30 AM
SLU Brotman Building, Blue Flame Auditorium
815 Mercer Street
"Mitochondria, lifespan and the aging heart"
Peter S. Rabinovitch, M.D., Ph.D.
Professor
Pathology
UW
Tuesday, November 20, 2007 - 8:30 AM
SLU Brotman Building, Blue Flame Auditorium
815 Mercer Street
Peter S. Rabinovitch, M.D., Ph.D.
Professor
Pathology
UW
Tuesday, November 20, 2007 - 8:30 AM
SLU Brotman Building, Blue Flame Auditorium
815 Mercer Street
Loss of the Endocytic Protein Sorting Nexin 1 Promotes Colon Cancer Development
Matthew S. Holdren
University of Washington School of Medicine
Department of Pathology Graduate Student
UW Medicine Pathology
Monday, November 19, 2007 - 2:00 PM
Health Sciences Center, K-069
Faculty Sponsor: Dan Bowen-Pope
Matthew S. Holdren
University of Washington School of Medicine
Department of Pathology Graduate Student
UW Medicine Pathology
Monday, November 19, 2007 - 2:00 PM
Health Sciences Center, K-069
Faculty Sponsor: Dan Bowen-Pope
---
Christine Disteche, PhD
Professor of Pathology
UW School of Medicine
Tuesday, November 13, 2007 - 8:30 AM
HSC, NE110
Faculty Sponsor: Dr. Thomas Montine
Christine Disteche, PhD
Professor of Pathology
UW School of Medicine
Tuesday, November 13, 2007 - 8:30 AM
HSC, NE110
Faculty Sponsor: Dr. Thomas Montine
"Human Embryonic Stem Cell Niches?"
C. Anthony Blau, MD
Professor of Medicine
Hematology
UW
Tuesday, November 13, 2007 - 8:30 AM
Brotman Building, 815 Mercer Street, SLU Auditorium
C. Anthony Blau, MD
Professor of Medicine
Hematology
UW
Tuesday, November 13, 2007 - 8:30 AM
Brotman Building, 815 Mercer Street, SLU Auditorium
"Pathology of human graft- versus host disease after hemopoietic cell transplantation: Implications for studies of the vascular system"
Howard M. Shulman, M.D.
Professor
Pathology/Oncology
FHCRC
Tuesday, November 6, 2007 - 8:30 AM
SLU Brotman Building, Blue Flame Auditorium
815 Mercer Street
Howard M. Shulman, M.D.
Professor
Pathology/Oncology
FHCRC
Tuesday, November 6, 2007 - 8:30 AM
SLU Brotman Building, Blue Flame Auditorium
815 Mercer Street
The Role of Epilysin (MMP-28) in Lung Inflammation and Epithelial Cell Survival
Anne Manicone, MD
Pulmonary and Critical Care Medicine
UW - Center for Lung Biology
Thursday, November 1, 2007 - 4:00 PM
SLU Brotman Building, Blue Flame Auditorium
815 Mercer Street - refreshments at 3:45pm
Anne Manicone, MD
Pulmonary and Critical Care Medicine
UW - Center for Lung Biology
Thursday, November 1, 2007 - 4:00 PM
SLU Brotman Building, Blue Flame Auditorium
815 Mercer Street - refreshments at 3:45pm
"Pragmatic Extracellular Matrices for Cell Therapy and Reparative Medicine"
Glenn D. Prestwich, Ph.D.
Presidential Professor of Medicinal Chemistry
Department of Medicinal Chemistry and Center for Therapeutic Biomaterials
The University of Utah
Tuesday, October 30, 2007 - 8:30 AM
SLU - Brotman Bulding, Blue Flame Auditorium
Faculty Sponsor: Thomas N. Wight, Ph.D.
815 Mercer Street
Glenn D. Prestwich, Ph.D.
Presidential Professor of Medicinal Chemistry
Department of Medicinal Chemistry and Center for Therapeutic Biomaterials
The University of Utah
Tuesday, October 30, 2007 - 8:30 AM
SLU - Brotman Bulding, Blue Flame Auditorium
Faculty Sponsor: Thomas N. Wight, Ph.D.
815 Mercer Street
Ribosomes and Spindles in Marrow Failure and Cance Predisposition
Akiko Shimamura, MD
Associate Professor of Pediatrics
Division of Hematology/Oncology
UWSOM
Tuesday, October 16, 2007 - 8:30 AM
SLU - Brotman Building, Blue Flame Auditorium
815 Mercer Street
Akiko Shimamura, MD
Associate Professor of Pediatrics
Division of Hematology/Oncology
UWSOM
Tuesday, October 16, 2007 - 8:30 AM
SLU - Brotman Building, Blue Flame Auditorium
815 Mercer Street
When Opportunities Arise, Be Ready
Raj Kapur, M.D., Ph.D.
Associate Professor
UW Medicine Pathology
University of Washington
Tuesday, October 9, 2007 - 8:30 AM
UWMC Anatomic Pathology, NE-110 Conference Room
Faculty Sponsor: Dr. Thomas Montine
Raj Kapur, M.D., Ph.D.
Associate Professor
UW Medicine Pathology
University of Washington
Tuesday, October 9, 2007 - 8:30 AM
UWMC Anatomic Pathology, NE-110 Conference Room
Faculty Sponsor: Dr. Thomas Montine
Leptin in Cardiovascular Disease
Daniel Eitzman
Assistant Professor
Internal Medicine/Cardiovascular Disease
University of Michigan
Wednesday, September 26, 2007 - 8:30 AM
Brotman Building, SLU, Blue Flame
Faculty Sponsor: Steve Schwartz
815 Mercer Street Reschedule - date tentative
Daniel Eitzman
Assistant Professor
Internal Medicine/Cardiovascular Disease
University of Michigan
Wednesday, September 26, 2007 - 8:30 AM
Brotman Building, SLU, Blue Flame
Faculty Sponsor: Steve Schwartz
815 Mercer Street Reschedule - date tentative
Clinical Experience of High Resolution Oligonucleotide Array:
Ji Yun Lee, Ph.D.
ABMG Training Program Trainee
Department of Human Genetics
Emory University
Monday, September 17, 2007 - 3:00 PM
Health Sciences Center, Turner Auditorium, D-209
Faculty Sponsor: Christine Disteche, Ph.D.
Dr. Lee is a candidate for a Cytogenetics faculty position with the Department of Pathology Refreshments provided
Ji Yun Lee, Ph.D.
ABMG Training Program Trainee
Department of Human Genetics
Emory University
Monday, September 17, 2007 - 3:00 PM
Health Sciences Center, Turner Auditorium, D-209
Faculty Sponsor: Christine Disteche, Ph.D.
Dr. Lee is a candidate for a Cytogenetics faculty position with the Department of Pathology Refreshments provided
Epithelial Differentiation in the Prostate: Insights from a Primary Cell Culture System
Beatrice Knudsen, M.D., Ph.D.
Affiliate Professor
UW Medicine Pathology
Member, FHCRC Division of Public Health Sciences
Tuesday, September 11, 2007 - 8:30 AM
UWMC Anatomic Pathology, NE-110 Conference Room
Faculty Sponsor: Dr. Thomas Montine
Beatrice Knudsen, M.D., Ph.D.
Affiliate Professor
UW Medicine Pathology
Member, FHCRC Division of Public Health Sciences
Tuesday, September 11, 2007 - 8:30 AM
UWMC Anatomic Pathology, NE-110 Conference Room
Faculty Sponsor: Dr. Thomas Montine
Base of Skull Chordoma: The Conundrum of Morphology and Biology
Benjamin Hoch, M.D.
Assistant Professor
Department of Pathology
Mount Sinai School of Medicine
Monday, August 20, 2007 - 1:00 PM
UWMC, NE-110 Conference Room
Faculty Sponsor: Paul Swanson, M.D.
Dr. Hoch is a candidate for a Bone & Soft Tissue faculty position with the Department of Pathology
Benjamin Hoch, M.D.
Assistant Professor
Department of Pathology
Mount Sinai School of Medicine
Monday, August 20, 2007 - 1:00 PM
UWMC, NE-110 Conference Room
Faculty Sponsor: Paul Swanson, M.D.
Dr. Hoch is a candidate for a Bone & Soft Tissue faculty position with the Department of Pathology
Multicolor Karyotyping & Banding in Non-Hodgkin Lymphoma and Bac Array CGH in Chronic Lymphocytic Leukemia
Valia S. Lestou, Ph.D.
Researcher
University of British Columbia Center for Disease Control
Tuesday, July 17, 2007 - 2:00 PM
Health Sciences Center, Turner Auditorium, Room D-209
Faculty Sponsor: Christine Disteche
Dr. Lestou is a candidate for a Cytogenetics faculty position with the Department of Pathology
Refreshments provided
Valia S. Lestou, Ph.D.
Researcher
University of British Columbia Center for Disease Control
Tuesday, July 17, 2007 - 2:00 PM
Health Sciences Center, Turner Auditorium, Room D-209
Faculty Sponsor: Christine Disteche
Dr. Lestou is a candidate for a Cytogenetics faculty position with the Department of Pathology
Refreshments provided
Insulin Modulation of Plasma beta-Amyloid levels
Pattie S. Green, PhD
Research Assistant Professor
Medicine
UWSOM
Tuesday, June 26, 2007 - 8:30 AM
TBA, TBA
Faculty Sponsor: Renee LeBoeuf
Pattie S. Green, PhD
Research Assistant Professor
Medicine
UWSOM
Tuesday, June 26, 2007 - 8:30 AM
TBA, TBA
Faculty Sponsor: Renee LeBoeuf
It's a Small World After All: The MicroRNA Gene Expression Profile of HCV-Associated Hepatocellular Carcinoma
Heike Varnholt, M.D.
Staff Pathologist
Division of Gastrointestinal and Hepatobiliary Pathology
University Hospital of Cologne, Germany
Friday, June 22, 2007 - 12:30 PM
UWMC, NE-110 Conference Room
Faculty Sponsor: Dr. Melissa Upton
Dr. Varnholt is a candidate for a GI faculty position with the Department of Pathology. Refreshments provided.
Heike Varnholt, M.D.
Staff Pathologist
Division of Gastrointestinal and Hepatobiliary Pathology
University Hospital of Cologne, Germany
Friday, June 22, 2007 - 12:30 PM
UWMC, NE-110 Conference Room
Faculty Sponsor: Dr. Melissa Upton
Dr. Varnholt is a candidate for a GI faculty position with the Department of Pathology. Refreshments provided.
TBA
Larry Adams
Senior Research Scientist
Pathology
UWSOM
Tuesday, June 19, 2007 - 8:30 AM
SLU - Brotman Building, Blue Flame Auditorium
815 Mercer Street
Larry Adams
Senior Research Scientist
Pathology
UWSOM
Tuesday, June 19, 2007 - 8:30 AM
SLU - Brotman Building, Blue Flame Auditorium
815 Mercer Street
Finding Genes for Uterine Fibroids
Jennelle Hodge, Ph.D.
Senior Research Fellow
Department of OB-GYN and Reproductive Biology
Brigham and Women's Hospital, Harvard Medical School
Monday, June 11, 2007 - 3:30 PM
Health Sciences Center, Turner Auditorium, D-209
Faculty Sponsor: Christine Disteche
Dr. Hodge is a faculty candidate in Cytogenetics with the Department of Pathology
Jennelle Hodge, Ph.D.
Senior Research Fellow
Department of OB-GYN and Reproductive Biology
Brigham and Women's Hospital, Harvard Medical School
Monday, June 11, 2007 - 3:30 PM
Health Sciences Center, Turner Auditorium, D-209
Faculty Sponsor: Christine Disteche
Dr. Hodge is a faculty candidate in Cytogenetics with the Department of Pathology
Roles of cytokines in regulation of bone mass
Brendan Boyce
Director of Surgical Pathology
Department of Pathology and Laboratory Medicine
University of Rochester Medical Center in New York
Wednesday, June 6, 2007 - 4:30 PM
HSC, K-069
Faculty Sponsor: Dr. Larry True
Brendan Boyce
Director of Surgical Pathology
Department of Pathology and Laboratory Medicine
University of Rochester Medical Center in New York
Wednesday, June 6, 2007 - 4:30 PM
HSC, K-069
Faculty Sponsor: Dr. Larry True
RGS5: Regulating the Regulator
William M. Mahoney Jr.
Postdoctoral Fellow
Pathology
UWSOM
Tuesday, June 5, 2007 - 8:30 AM
SLU - Brotman Building, Blue Flame Auditorium
Faculty Sponsor: Steve Schwartz
815 Mercer Street
William M. Mahoney Jr.
Postdoctoral Fellow
Pathology
UWSOM
Tuesday, June 5, 2007 - 8:30 AM
SLU - Brotman Building, Blue Flame Auditorium
Faculty Sponsor: Steve Schwartz
815 Mercer Street
Erythropoietin and Cancer – A Window of Opportunity for Pharmacologically Regulated Cell Therapy?
C Anthony (Tony) Blau, MD
Professor
Medicine, Hematology
UWSOM
Thursday, May 31, 2007 - 4:00 PM
SLU Brotman Building, Blue Flame Auditorium
Faculty Sponsor: Steve Schwartz
815 Mercer Street Refreshments at 3:45 p.m.
C Anthony (Tony) Blau, MD
Professor
Medicine, Hematology
UWSOM
Thursday, May 31, 2007 - 4:00 PM
SLU Brotman Building, Blue Flame Auditorium
Faculty Sponsor: Steve Schwartz
815 Mercer Street Refreshments at 3:45 p.m.
Membrane Electroporation for Cancer Therapies and Direct Gene Electrotherapy
Dr. Eberhard Neumann
Bielefeld, Germany
Department of Chemistry
University of Bielefeld
Wednesday, May 30, 2007 - 4:30 PM
HSC, K-069
Faculty Sponsor: Dr. Lawrence Loeb
International speaker from Germany
Dr. Eberhard Neumann
Bielefeld, Germany
Department of Chemistry
University of Bielefeld
Wednesday, May 30, 2007 - 4:30 PM
HSC, K-069
Faculty Sponsor: Dr. Lawrence Loeb
International speaker from Germany
How does mechanical force activate adhesion proteins, and what does this have to do with cardiovascular disease?
Wendy Thomas
Assistant Professor
Bioengineering
UWSOM
Tuesday, May 29, 2007 - 8:30 AM
SLU Brotman Building, Blue Flame Auditorium
815 Mercer Street
Wendy Thomas
Assistant Professor
Bioengineering
UWSOM
Tuesday, May 29, 2007 - 8:30 AM
SLU Brotman Building, Blue Flame Auditorium
815 Mercer Street
Chorea vs Parkinsonism: The Search for Primary Centers for Degeneration
Jean Paul Vonsattel, M.D.
Professor
Department of Pathology
Columbia University Medical Center
Wednesday, May 23, 2007 - 4:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Dr. Tom Montine
5th Annual Alvord Lecture in Neuropathology The Alvord Lecture honors the scientific and clinical legacy of Emeritus Professor Ellsworth (Buster) Alvord, M.D., as an important pioneer in the field of neuropathology. Dr. Alvord served as Chief of Neuropathology at the University of Washington from 1960 to 2002.
Jean Paul Vonsattel, M.D.
Professor
Department of Pathology
Columbia University Medical Center
Wednesday, May 23, 2007 - 4:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Dr. Tom Montine
5th Annual Alvord Lecture in Neuropathology The Alvord Lecture honors the scientific and clinical legacy of Emeritus Professor Ellsworth (Buster) Alvord, M.D., as an important pioneer in the field of neuropathology. Dr. Alvord served as Chief of Neuropathology at the University of Washington from 1960 to 2002.
Molecular Mechanisms of Regulation of L-type Calcium Channels
Michelle Emrick
Senior Fellow
Pharmacology
UWSOM
Tuesday, May 22, 2007 - 8:30 AM
Health Sciences, K-069
Michelle Emrick
Senior Fellow
Pharmacology
UWSOM
Tuesday, May 22, 2007 - 8:30 AM
Health Sciences, K-069
TGF-beta signaling in kidney cells
Anne-Christine Poncelet
Acting Instructor
Medicine-Gerontology
UW School of Medicine
Tuesday, May 15, 2007 - 8:30 AM
SLU Brotman Building, Blue Flame Auditorium
815 Mercer Street
Anne-Christine Poncelet
Acting Instructor
Medicine-Gerontology
UW School of Medicine
Tuesday, May 15, 2007 - 8:30 AM
SLU Brotman Building, Blue Flame Auditorium
815 Mercer Street
Chromatin Profiling of the Human Genome: Genomic Distribution and Characterization of Insulator Elements
Anton Krumm PhD
Research Assistant Professor
Radiation Oncology
UW School of Medicine
Thursday, May 10, 2007 - 4:00 PM
SLU Brotman Building, Blue Flame Auditorium
815 Mercer Street Refreshments 3:45 p.m.
Anton Krumm PhD
Research Assistant Professor
Radiation Oncology
UW School of Medicine
Thursday, May 10, 2007 - 4:00 PM
SLU Brotman Building, Blue Flame Auditorium
815 Mercer Street Refreshments 3:45 p.m.
Mortar and Bricks
Melissa Upton, M.D.
Associate Professor, Assistant Chief of Anatomic Pathology
Department of Pathology
University of Washington
Tuesday, May 8, 2007 - 8:30 AM
UWMC, NE-110 Conference Room
Faculty Sponsor: Tom Montine
Melissa Upton, M.D.
Associate Professor, Assistant Chief of Anatomic Pathology
Department of Pathology
University of Washington
Tuesday, May 8, 2007 - 8:30 AM
UWMC, NE-110 Conference Room
Faculty Sponsor: Tom Montine
AAV6-mediated Systemic Expression of alpha-Dystrobrevin-3 Prevents Muscular Dystrophy in alpha-Dystrobrevin Null Mice
Guy Odom
Senior Fellow
Neurology
UWSOM
Tuesday, May 8, 2007 - 8:30 AM
Health Sciences Building, K-069
Faculty Sponsor: David Dichek
Guy Odom
Senior Fellow
Neurology
UWSOM
Tuesday, May 8, 2007 - 8:30 AM
Health Sciences Building, K-069
Faculty Sponsor: David Dichek
To Call or Not to Call: The Challenge of Intraoperative Frozen Section
Gang He, M.D., Ph.D.
Bone and Soft Tissue Fellow
Department of Pathology
University of Chicago
Monday, May 7, 2007 - 1:00 PM
UWMC, NE-110 Conference Room
Faculty Sponsor: Paul Swanson
Dr. He is a clinical faculty candidate for bone and soft tissue pathology.
Gang He, M.D., Ph.D.
Bone and Soft Tissue Fellow
Department of Pathology
University of Chicago
Monday, May 7, 2007 - 1:00 PM
UWMC, NE-110 Conference Room
Faculty Sponsor: Paul Swanson
Dr. He is a clinical faculty candidate for bone and soft tissue pathology.
Diabetes, obesity and the brain
Michael Schwartz
Professor
Metabolism, Endocrinology and Nutrition
UWSOM, Clincal Nutrition, Harborview
Thursday, May 3, 2007 - 4:00 PM
SLU Brotman Building, Blue Flame Auditorium
815 Mercer Street Refreshments 3:45 p.m.
Michael Schwartz
Professor
Metabolism, Endocrinology and Nutrition
UWSOM, Clincal Nutrition, Harborview
Thursday, May 3, 2007 - 4:00 PM
SLU Brotman Building, Blue Flame Auditorium
815 Mercer Street Refreshments 3:45 p.m.
The role of P2X7 and activated caspases in the regulation of macrophage fusion
Thomas Nhan
PhD Candidate
Pathology
UW School of Medicine
Tuesday, May 1, 2007 - 8:30 AM
SLU Brotman Building, Blue Flame Auditorium
Faculty Sponsor: Steve Schwartz
815 Mercer Street
Thomas Nhan
PhD Candidate
Pathology
UW School of Medicine
Tuesday, May 1, 2007 - 8:30 AM
SLU Brotman Building, Blue Flame Auditorium
Faculty Sponsor: Steve Schwartz
815 Mercer Street
Matrilysin (MMP-7) function in acute and chronic lung injury
John K. McGuire, MD
Pediatric Critical Care Medicine
Children's Hospital & Regional Medical Center
UW School of Medicine
Thursday, April 26, 2007 - 4:00 PM
SLU Brotman Building, Blue Flame Auditorium
Faculty Sponsor: Steve Schwartz
815 Mercer Street Refreshments at 3:45 p.m.
John K. McGuire, MD
Pediatric Critical Care Medicine
Children's Hospital & Regional Medical Center
UW School of Medicine
Thursday, April 26, 2007 - 4:00 PM
SLU Brotman Building, Blue Flame Auditorium
Faculty Sponsor: Steve Schwartz
815 Mercer Street Refreshments at 3:45 p.m.
Mechanisms Underlying the Influence of Androgens on Prostate Carcinogenesis
Peter S. Nelson
Associate Professor
Medicine, Oncology
Fred Hutchinson Cancer Research Center
Thursday, April 19, 2007 - 4:00 PM
SLU Brotman Building, Blue Flame Auditorium
Faculty Sponsor: Steve Schwartz
815 Mercer Street Refreshments 3:45 p.m.
Peter S. Nelson
Associate Professor
Medicine, Oncology
Fred Hutchinson Cancer Research Center
Thursday, April 19, 2007 - 4:00 PM
SLU Brotman Building, Blue Flame Auditorium
Faculty Sponsor: Steve Schwartz
815 Mercer Street Refreshments 3:45 p.m.
Using Chemical-Genetics to Reversibly Inhibit Protein Kinase A: Implications for Male Reproduction
Daniel J. Morgan
Senior Fellow
Pharmacology
UWSOM
Tuesday, April 17, 2007 - 8:30 AM
Health Sciences, K-069
Faculty Sponsor: Steve Schwartz
Daniel J. Morgan
Senior Fellow
Pharmacology
UWSOM
Tuesday, April 17, 2007 - 8:30 AM
Health Sciences, K-069
Faculty Sponsor: Steve Schwartz
TBA
Ray Monnat, M.D.
Professor
Department of Pathology
University of Washington
Tuesday, April 10, 2007 - 8:30 AM
UWMC, NE-110 Conference Room
Faculty Sponsor: Tom Montine
Ray Monnat, M.D.
Professor
Department of Pathology
University of Washington
Tuesday, April 10, 2007 - 8:30 AM
UWMC, NE-110 Conference Room
Faculty Sponsor: Tom Montine
Regulation of Angiogenesis by the OPG/RANKL/RANK Molecular Triad
Joseph McGonigle
Research Assistant
Bioengineering
UWSOM
Tuesday, April 10, 2007 - 8:30 AM
SLU Brotman Building, Blue Flame Auditorium
Faculty Sponsor: Cecilia Giachelli
815 Mercer Street
Joseph McGonigle
Research Assistant
Bioengineering
UWSOM
Tuesday, April 10, 2007 - 8:30 AM
SLU Brotman Building, Blue Flame Auditorium
Faculty Sponsor: Cecilia Giachelli
815 Mercer Street
Saving the World from the Next Pandemic: Can Functional Genomics and Computational Biology Save Us?
Michael G. Katze, PhD
Professor of Microbiology
Core Staff Scientist and Associate Director
Washington NPRC
Thursday, April 5, 2007 - 4:00 PM
SLU Brotman Building, Blue Flame Auditorium
Faculty Sponsor: Stephen M. Schwartz
815 Mercer Street Refreshments 4:45 p.m.
Michael G. Katze, PhD
Professor of Microbiology
Core Staff Scientist and Associate Director
Washington NPRC
Thursday, April 5, 2007 - 4:00 PM
SLU Brotman Building, Blue Flame Auditorium
Faculty Sponsor: Stephen M. Schwartz
815 Mercer Street Refreshments 4:45 p.m.
Understanding macrophage foam cell formation using a proteomics-based approach
Lev Becker
Senior Fellow
Medicine, Division of Metabolism, Endocrinology and Nutrition
UWSOM
Tuesday, April 3, 2007 - 8:30 AM
SLU Brotman Building, Blue Flame Auditorium
Faculty Sponsor: Jay Heinecke
815 Mercer Street
Lev Becker
Senior Fellow
Medicine, Division of Metabolism, Endocrinology and Nutrition
UWSOM
Tuesday, April 3, 2007 - 8:30 AM
SLU Brotman Building, Blue Flame Auditorium
Faculty Sponsor: Jay Heinecke
815 Mercer Street
DNA Processing in Autoimmune Disease
Fred Perrino, Ph.D.
Professor
Department of Biochemistry
Wake Forest University Health Sciences
Monday, April 2, 2007 - 11:30 AM
Health Sciences Center, K-069
Faculty Sponsor: Larry Loeb and Brad Preston
Fred Perrino, Ph.D.
Professor
Department of Biochemistry
Wake Forest University Health Sciences
Monday, April 2, 2007 - 11:30 AM
Health Sciences Center, K-069
Faculty Sponsor: Larry Loeb and Brad Preston
Immunomodulation of breast cancer?
Nora Disis, MD
Professor
Medicine
UWSOM, Member Fred Hutchinson Cancer Research Center
Thursday, March 29, 2007 - 4:00 PM
SLU Brotman Building, Blue Flame Auditorium
Faculty Sponsor: Stephen M. Schwartz
815 Mercer Street Refreshments at 3:45 p.m.
Nora Disis, MD
Professor
Medicine
UWSOM, Member Fred Hutchinson Cancer Research Center
Thursday, March 29, 2007 - 4:00 PM
SLU Brotman Building, Blue Flame Auditorium
Faculty Sponsor: Stephen M. Schwartz
815 Mercer Street Refreshments at 3:45 p.m.
Probing chromatin dynamics
Karol Bomsztyk
Professor
Medicine
UWSOM
Tuesday, March 27, 2007 - 8:30 AM
SLU - Brotman Building, Blue Flame Auditorium
815 Mercer Street
Karol Bomsztyk
Professor
Medicine
UWSOM
Tuesday, March 27, 2007 - 8:30 AM
SLU - Brotman Building, Blue Flame Auditorium
815 Mercer Street
Repair of oxidative DNA damage and human disease
Dr. Will Bohr
NIA
Wednesday, March 21, 2007 - 4:30 PM
Health Sciences Building, K-069
Faculty Sponsor: Dr. Monnat
This visit is being co-sponsored by the Werner Program, Gene Action and Genetic Approaches to Aging grants, and the the Seattle Cancer and Aging Program (SCAP).
Dr. Will Bohr
NIA
Wednesday, March 21, 2007 - 4:30 PM
Health Sciences Building, K-069
Faculty Sponsor: Dr. Monnat
This visit is being co-sponsored by the Werner Program, Gene Action and Genetic Approaches to Aging grants, and the the Seattle Cancer and Aging Program (SCAP).
Angiotensin II-induced vascular pathologies - a multitude of mechanisms
Alan Daugherty
Professor
Cardiovascular Medicine
University of Kentucky
Tuesday, March 20, 2007 - 8:30 AM
SLU - Brotman Building, Blue Flame Auditorium
Faculty Sponsor: Mike Rosenfeld
815 Mercer Street
Alan Daugherty
Professor
Cardiovascular Medicine
University of Kentucky
Tuesday, March 20, 2007 - 8:30 AM
SLU - Brotman Building, Blue Flame Auditorium
Faculty Sponsor: Mike Rosenfeld
815 Mercer Street
Haematopoietic stem cell transplantation in the treatment of severe autoimmune disease: Systemic Sclerosis
Richard A Nash, MD
Associate Professor
Medicine, Division of Oncology
Fred Hutchinson Cancer Research Center
Thursday, March 15, 2007 - 4:00 PM
SLU Brotman Building, Blue Flame Auditorium
Faculty Sponsor: Steve Schwartz
815 Mercer Street Refreshments at 3:45 p.m.
Richard A Nash, MD
Associate Professor
Medicine, Division of Oncology
Fred Hutchinson Cancer Research Center
Thursday, March 15, 2007 - 4:00 PM
SLU Brotman Building, Blue Flame Auditorium
Faculty Sponsor: Steve Schwartz
815 Mercer Street Refreshments at 3:45 p.m.
PathPresents: Molecular Diagnosis of Limb-Girdle and Congenital Muscular Dystrophies
Steven A. Moore, M.D., Ph.D.
Co-Director
Wellstone Muscular Dystrophy Research Center
University of Iowa
Wednesday, March 14, 2007 - 4:30 PM
HSC, K-069
Faculty Sponsor: Dr. Hevner
Sponsored by PathPresents.
Steven A. Moore, M.D., Ph.D.
Co-Director
Wellstone Muscular Dystrophy Research Center
University of Iowa
Wednesday, March 14, 2007 - 4:30 PM
HSC, K-069
Faculty Sponsor: Dr. Hevner
Sponsored by PathPresents.
My Adventures in Biomed Research: How You Can Help Us Move Beyond Gleason Grade
Larry True, M.D.
Professor
Department of Pathology
University of Washington
Tuesday, March 13, 2007 - 8:30 AM
UWMC, NE-110 Conference Room
Faculty Sponsor: Tom Montine
Larry True, M.D.
Professor
Department of Pathology
University of Washington
Tuesday, March 13, 2007 - 8:30 AM
UWMC, NE-110 Conference Room
Faculty Sponsor: Tom Montine
A ROCK and Role for Syndecans in Cytoskeletal Regulation
John R. Couchman
Professor
National Heart & Lung Institute
Imperial College, London
Tuesday, March 13, 2007 - 8:30 AM
Brotman Building (SLU), Blue Flame Auditorium
Faculty Sponsor: Bill Parks
815 Mercer Street
John R. Couchman
Professor
National Heart & Lung Institute
Imperial College, London
Tuesday, March 13, 2007 - 8:30 AM
Brotman Building (SLU), Blue Flame Auditorium
Faculty Sponsor: Bill Parks
815 Mercer Street
Chemical Genetics and Translational Research in Skin Cancer
Paul Nghiem, MD PhD
Asst. Professor, UW Dermatology/Medicine
Affiliate Investigator
Fred Hutchinson Cancer Research Center
Thursday, March 8, 2007 - 4:00 PM
SLU Brotman Building, Blue Flame Auditorium
Faculty Sponsor: Steve Schwartz
* Introduction to the discipline of chemical genetics, its diverse research applications, and NIH-sponsored resources available to academia. * Application of chemical genetics to the 'replication checkpoint' involved in the UV-DNA damage response. * Clinical and molecular studies of Merkel cell carcinoma: a recently described and highly lethal skin cancer.
Paul Nghiem, MD PhD
Asst. Professor, UW Dermatology/Medicine
Affiliate Investigator
Fred Hutchinson Cancer Research Center
Thursday, March 8, 2007 - 4:00 PM
SLU Brotman Building, Blue Flame Auditorium
Faculty Sponsor: Steve Schwartz
* Introduction to the discipline of chemical genetics, its diverse research applications, and NIH-sponsored resources available to academia. * Application of chemical genetics to the 'replication checkpoint' involved in the UV-DNA damage response. * Clinical and molecular studies of Merkel cell carcinoma: a recently described and highly lethal skin cancer.
Loss of capillaries and vascular phenotype in Systemic Sclerosis, does autologous stem cell transplant regenerate capillaries?
Jo Fleming
Scleroderma Research Fellow
Pathology
UWSOM
Tuesday, March 6, 2007 - 8:30 AM
SLU - Brotman Building, Blue Flame Auditorium
Faculty Sponsor: Steve Schwartz
815 Mercer Street RESCHEDULED!
Jo Fleming
Scleroderma Research Fellow
Pathology
UWSOM
Tuesday, March 6, 2007 - 8:30 AM
SLU - Brotman Building, Blue Flame Auditorium
Faculty Sponsor: Steve Schwartz
815 Mercer Street RESCHEDULED!
Understanding HSV-2 Reactivations: New Observations, New Surprises
Lawrence Corey, MD
Professor, Laboratory Medicine
Adjunct Professor, Pediatrics
Fred Hutchinson Cancer Research Center
Thursday, March 1, 2007 - 4:00 PM
Brotman Building, SLU, Blue Flame Auditorium
815 Mercer Street Refreshments at 3:45 p.m.
Lawrence Corey, MD
Professor, Laboratory Medicine
Adjunct Professor, Pediatrics
Fred Hutchinson Cancer Research Center
Thursday, March 1, 2007 - 4:00 PM
Brotman Building, SLU, Blue Flame Auditorium
815 Mercer Street Refreshments at 3:45 p.m.
Chromatin Remodeling During Mouse and Human Embryonic Stem Cell Differentiation
Jonathan Golob
Graduate Student
Pathology
UWSOM
Tuesday, February 27, 2007 - 8:30 AM
SLU - Brotman Building, Blue Flame Auditorium
Faculty Sponsor: Chuck Murry
815 Mercer Street
Jonathan Golob
Graduate Student
Pathology
UWSOM
Tuesday, February 27, 2007 - 8:30 AM
SLU - Brotman Building, Blue Flame Auditorium
Faculty Sponsor: Chuck Murry
815 Mercer Street
The Regulation of Long-term Repopulating Hematopoietic Stem Cells (LTR-HSC) by Endogenous Transforming Growth Factor Beta (TGF-beta)
Stephen Bartelmez PhD
BetaStem Therapeutics Inc, San Francisco
Thursday, February 22, 2007 - 4:00 PM
Brotman Building, SLU, Blue Flame Auditorium
815 Mercer Street Refreshments at 3:45 p.m.
Stephen Bartelmez PhD
BetaStem Therapeutics Inc, San Francisco
Thursday, February 22, 2007 - 4:00 PM
Brotman Building, SLU, Blue Flame Auditorium
815 Mercer Street Refreshments at 3:45 p.m.
Pathological Protein in Neurodegenerative Diseases
Tom Montine, M.D., Ph.D.
Professor, Director of Neuropathology
Department of Pathology
University of Washington
Tuesday, February 13, 2007 - 8:30 AM
UWMC, NE-110 Conference Room
Faculty Sponsor: Tom Montine
Tom Montine, M.D., Ph.D.
Professor, Director of Neuropathology
Department of Pathology
University of Washington
Tuesday, February 13, 2007 - 8:30 AM
UWMC, NE-110 Conference Room
Faculty Sponsor: Tom Montine
Adult Stem Cells: Epigenetics, pluripotency and plasticity
Morayma Reyes
Assistant Professor
Pathology and Laboratory Medicine
UWSOM
Tuesday, February 13, 2007 - 8:30 AM
SLU, Brotman Building, Blue Flame Auditorium
Faculty Sponsor: Steve Schwartz
815 Mercer Street
Morayma Reyes
Assistant Professor
Pathology and Laboratory Medicine
UWSOM
Tuesday, February 13, 2007 - 8:30 AM
SLU, Brotman Building, Blue Flame Auditorium
Faculty Sponsor: Steve Schwartz
815 Mercer Street
Immunoexpression of Hypoxia-related Genes in Retroperitoneal Sarcomas
Paul Zhang, M.D.
Associate Professor
Pathology and Lab Medicine
University of Pennsylvania School of Medicine
Monday, February 12, 2007 - 1:00 PM
University of Washington Medical Center, NE-110 Conference Room
Faculty Sponsor: Larry True
Speaker is a candidate for a clinical faculty position with the Department of Pathology
Paul Zhang, M.D.
Associate Professor
Pathology and Lab Medicine
University of Pennsylvania School of Medicine
Monday, February 12, 2007 - 1:00 PM
University of Washington Medical Center, NE-110 Conference Room
Faculty Sponsor: Larry True
Speaker is a candidate for a clinical faculty position with the Department of Pathology
A Trojan Horse Nips at an Achilles Heel: Gallium as an Anti-infective Therapy
Pradeep Singh MD
Associate Professor
Medicine and Microbiology, Pulmonary and Critical Care Medicine
UW School of Medicine
Thursday, February 8, 2007 - 4:00 PM
Brotman Building, SLU, Blue Flame Auditorium
Faculty Sponsor: Steve Schwartz
815 Mercer Street Refreshments: 3:45 p.m.
Pradeep Singh MD
Associate Professor
Medicine and Microbiology, Pulmonary and Critical Care Medicine
UW School of Medicine
Thursday, February 8, 2007 - 4:00 PM
Brotman Building, SLU, Blue Flame Auditorium
Faculty Sponsor: Steve Schwartz
815 Mercer Street Refreshments: 3:45 p.m.
Path Presents: The Isoprostanes and Related Compounds as Markers and Mediators of Oxidant Stress in Human Disease: New Insights and Current Controversies.
Jason D. Morrow
F. Tremaine Billings Professor of Medicine and Pharmacology
Chief, Division of Clinical Pharmacology
Vanderbilt University School of Medicine
Wednesday, February 7, 2007 - 4:30 PM
HSC, K-069
Faculty Sponsor: Dr. Thomas Montine
Jason D. Morrow
F. Tremaine Billings Professor of Medicine and Pharmacology
Chief, Division of Clinical Pharmacology
Vanderbilt University School of Medicine
Wednesday, February 7, 2007 - 4:30 PM
HSC, K-069
Faculty Sponsor: Dr. Thomas Montine
Role of macrophage-expressed urokinase plasminogen activator (uPA) in atherosclerosis
Ranjini M. Krishnan
Fellow
Cardiology
UWSOM
Tuesday, February 6, 2007 - 8:30 AM
Health Sciences, K-069
Faculty Sponsor: David Dichek
Ranjini M. Krishnan
Fellow
Cardiology
UWSOM
Tuesday, February 6, 2007 - 8:30 AM
Health Sciences, K-069
Faculty Sponsor: David Dichek
Subtelomere Dynamics: Why So Many Breaks?
Katie Rudd, Ph.D.
Postdoctoral Fellow
Fred Hutchinson Cancer Research Center
Wednesday, January 31, 2007 - 4:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Christine Disteche
Dr. Rudd is a candidate for a cytogenetic faculty position in the Department of Pathology
Katie Rudd, Ph.D.
Postdoctoral Fellow
Fred Hutchinson Cancer Research Center
Wednesday, January 31, 2007 - 4:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Christine Disteche
Dr. Rudd is a candidate for a cytogenetic faculty position in the Department of Pathology
Monocytes, Dendritic Cells, and Atherosclerosis
Gwen Randollph
Associate Professor
Gene & Cell Medicine
Mt. Sinai School of Medicine
Tuesday, January 30, 2007 - 10:00 AM
Health Sciences, K-069
Faculty Sponsor: Elaine Raines/Stephen Schwartz
Jointly Sponsored by Breakfast Club and Biology of the Artery Wall Program Project
Gwen Randollph
Associate Professor
Gene & Cell Medicine
Mt. Sinai School of Medicine
Tuesday, January 30, 2007 - 10:00 AM
Health Sciences, K-069
Faculty Sponsor: Elaine Raines/Stephen Schwartz
Jointly Sponsored by Breakfast Club and Biology of the Artery Wall Program Project
Genome of Weird Australian Mammals
Jenny Graves, Ph.D.
Professor
Comparative Genomics
Australian National University
Monday, January 29, 2007 - 4:30 PM
Genome Sciences Building, Foege Auditorium
Faculty Sponsor: Christine Disteche
Jenny Graves, Ph.D.
Professor
Comparative Genomics
Australian National University
Monday, January 29, 2007 - 4:30 PM
Genome Sciences Building, Foege Auditorium
Faculty Sponsor: Christine Disteche
Gene Action in the Pathobiology of Aging
George M. Martin
Director Emeritus, Alzheimer’s Disease Research Center (ADRC)
Professor Emeritus (Active), Department of Pathology
UW School of Medicine
Thursday, January 25, 2007 - 4:00 PM
Brotman Building (SLU), Blue Flame Auditorium
815 Mercer Street
George M. Martin
Director Emeritus, Alzheimer’s Disease Research Center (ADRC)
Professor Emeritus (Active), Department of Pathology
UW School of Medicine
Thursday, January 25, 2007 - 4:00 PM
Brotman Building (SLU), Blue Flame Auditorium
815 Mercer Street
Magnetic Resonance Imaging of Atherosclerosis
Hunter R. Underhill
Fellow
Vascular Imaging Lab
UWSOM
Tuesday, January 23, 2007 - 8:30 AM
SLU - Brotman Building, Blue Flame Auditorium
815 Mercer Street
Hunter R. Underhill
Fellow
Vascular Imaging Lab
UWSOM
Tuesday, January 23, 2007 - 8:30 AM
SLU - Brotman Building, Blue Flame Auditorium
815 Mercer Street
Caspase regulation of macrophage functions
Thomas Q. Nhan
PhD Candidate
Pathology
UWSOM
Tuesday, January 16, 2007 - 8:30 AM
SLU - Brotman Building, Blue Flame Auditorium
Faculty Sponsor: Steve Schwartz
815 Mercer Street
Thomas Q. Nhan
PhD Candidate
Pathology
UWSOM
Tuesday, January 16, 2007 - 8:30 AM
SLU - Brotman Building, Blue Flame Auditorium
Faculty Sponsor: Steve Schwartz
815 Mercer Street
How Autopsies Have Expedited Research on Human Progeroid Syndromes, With Comments on the Viability and Cryopreservation of Postmortem Tissues
George Martin, M.D.
Professor
Department of Pathology
University of Washington
Tuesday, January 9, 2007 - 8:30 AM
UWMC, NE-110 Conference Room
Faculty Sponsor: Tom Montine
George Martin, M.D.
Professor
Department of Pathology
University of Washington
Tuesday, January 9, 2007 - 8:30 AM
UWMC, NE-110 Conference Room
Faculty Sponsor: Tom Montine
Tissue voxelation with a high-speed transverse microtome
John Welsh, PhD
Associate Professor
Molecular and Cancer Biology Program
Sidney Kimmel Cancer Center, San Diego, California
Tuesday, January 9, 2007 - 8:30 AM
SLU Brotman Building, Blue Flame Auditorium
Faculty Sponsor: Marshall Horwitz
815 Mercer Street
John Welsh, PhD
Associate Professor
Molecular and Cancer Biology Program
Sidney Kimmel Cancer Center, San Diego, California
Tuesday, January 9, 2007 - 8:30 AM
SLU Brotman Building, Blue Flame Auditorium
Faculty Sponsor: Marshall Horwitz
815 Mercer Street
Molecular Profiling of Circulating Monocytes in Carotid Artery Atherosclerotic Disease
Hangjun Duan
Senior Fellow
Pathology
UWSOM
Tuesday, December 19, 2006 - 8:30 AM
SLU - Brotman Building, Blue Flame Auditorium
Faculty Sponsor: Steve Schwartz
815 Mercer Street
Hangjun Duan
Senior Fellow
Pathology
UWSOM
Tuesday, December 19, 2006 - 8:30 AM
SLU - Brotman Building, Blue Flame Auditorium
Faculty Sponsor: Steve Schwartz
815 Mercer Street
Neurogenesis and Malformations of Cortical Development
Robert Hevner, M.D., Ph.D.
Associate Professor
Department of Pathology
University of Washington
Tuesday, December 12, 2006 - 8:30 AM
UWMC, NE-110 Conference Room
Faculty Sponsor: Tom Montine
Robert Hevner, M.D., Ph.D.
Associate Professor
Department of Pathology
University of Washington
Tuesday, December 12, 2006 - 8:30 AM
UWMC, NE-110 Conference Room
Faculty Sponsor: Tom Montine
BTNL2, a novel B7 family member and regulator of T cell activation
Heather Arnett
Scientist
Amgen, Inc.
Tuesday, December 5, 2006 - 8:30 AM
SLU - Brotman Building, Blue Flame Auditorium
Faculty Sponsor: Steve Schwartz
815 Mercer Street
Heather Arnett
Scientist
Amgen, Inc.
Tuesday, December 5, 2006 - 8:30 AM
SLU - Brotman Building, Blue Flame Auditorium
Faculty Sponsor: Steve Schwartz
815 Mercer Street
The Ins and Outs of Bcl-2 in Cell Death
John M. Harlan, MD
Chief
Clement A. Finch Professor of Hematology, Adjunct Professor of Pathology
University of Washington
Tuesday, November 21, 2006 - 8:30 AM
Health Sciences Building, K-069
John M. Harlan, MD
Chief
Clement A. Finch Professor of Hematology, Adjunct Professor of Pathology
University of Washington
Tuesday, November 21, 2006 - 8:30 AM
Health Sciences Building, K-069
Update of Cervical Cancer Control
Nancy Kiviat MD
Professor, Chief of HMC Pathology
Pathology
UWSOM, Harborview
Thursday, November 16, 2006 - 4:00 PM
Brotman Building, Blue Flame Auditorium
815 Mercer Street Refreshments at 3:45 p.m.
Nancy Kiviat MD
Professor, Chief of HMC Pathology
Pathology
UWSOM, Harborview
Thursday, November 16, 2006 - 4:00 PM
Brotman Building, Blue Flame Auditorium
815 Mercer Street Refreshments at 3:45 p.m.
Updates on Cervical Cytology
Nancy Kiviat, M.D.
Professor, Chief of HMC Pathology
Department of Pathology
University of Washington
Tuesday, November 14, 2006 - 8:30 AM
UWMC, NE-110 Conference Room
Faculty Sponsor: Tom Montine
Nancy Kiviat, M.D.
Professor, Chief of HMC Pathology
Department of Pathology
University of Washington
Tuesday, November 14, 2006 - 8:30 AM
UWMC, NE-110 Conference Room
Faculty Sponsor: Tom Montine
TSLP and Th2-mediated inflammation
Steven F. Ziegler, PhD
Director
Immunology Program
Benaroya Research Institute
Tuesday, November 14, 2006 - 8:30 AM
SLU - Brotman Building, Blue Flame Auditorium
Faculty Sponsor: Steve Schwartz
815 Mercer Street
Steven F. Ziegler, PhD
Director
Immunology Program
Benaroya Research Institute
Tuesday, November 14, 2006 - 8:30 AM
SLU - Brotman Building, Blue Flame Auditorium
Faculty Sponsor: Steve Schwartz
815 Mercer Street
Towards Targeted Therapy in Sarcoma: Somatostatin Type-2 Receptor Expression in Bone and Soft Tissue Tumors
William Ahrens
Senior Fellow
Surgical Pathology - Bone and Soft Tissue
Mayo Clinic
Tuesday, November 7, 2006 - 11:00 AM
UWMC, NE-110 Conference Room
Faculty Sponsor: Paul Swanson
Dr. Ahrens is a clinical faculty candidate for bone and soft tissue pathology in the Department of Pathology
William Ahrens
Senior Fellow
Surgical Pathology - Bone and Soft Tissue
Mayo Clinic
Tuesday, November 7, 2006 - 11:00 AM
UWMC, NE-110 Conference Room
Faculty Sponsor: Paul Swanson
Dr. Ahrens is a clinical faculty candidate for bone and soft tissue pathology in the Department of Pathology
Differentiation of Endothelium from Human Embryonic Stem Cells
Marilyn Nourse
PhD Candidate
Pathology
UWSOM
Tuesday, November 7, 2006 - 8:30 AM
SLU - Brotman Building, Blue Flame Auditorium
Faculty Sponsor: Chuck Murry
815 Mercer Street
Marilyn Nourse
PhD Candidate
Pathology
UWSOM
Tuesday, November 7, 2006 - 8:30 AM
SLU - Brotman Building, Blue Flame Auditorium
Faculty Sponsor: Chuck Murry
815 Mercer Street
Type 1 diabetes promotes inflammation and disruption of advanced atherosclerotic lesions in LDL receptor-deficient mice
Fredrik Johansson
Postdoctoral Fellow
Pathology
UWSOM
Tuesday, October 31, 2006 - 8:30 AM
Health Sciences, K-069
Faculty Sponsor: Karin Bornfeldt
Fredrik Johansson
Postdoctoral Fellow
Pathology
UWSOM
Tuesday, October 31, 2006 - 8:30 AM
Health Sciences, K-069
Faculty Sponsor: Karin Bornfeldt
Calcium Sparklets in Vascular Smooth Muscle
Manuel F. Navedo
Senior Fellow
Physiology and Biophysics
UWSOM
Tuesday, October 24, 2006 - 8:30 AM
Health Sciences Building, K-069
Manuel F. Navedo
Senior Fellow
Physiology and Biophysics
UWSOM
Tuesday, October 24, 2006 - 8:30 AM
Health Sciences Building, K-069
Mutation avoidance, disease, and error catastrophy: The great escape
Bradley D. Preston
Professor
Pathology
UWSOM
Thursday, October 19, 2006 - 3:45 PM
Brotman Building, SLU, Blue Flame Auditorium
815 Mercer Street
Bradley D. Preston
Professor
Pathology
UWSOM
Thursday, October 19, 2006 - 3:45 PM
Brotman Building, SLU, Blue Flame Auditorium
815 Mercer Street
Cancelled will reschedule for spring
David Lovett - postponed
Professor in Residence
Medicine, Division of Nephrology, Fort Miley Veterans Admin Hospital
University of California, San Francisco
Tuesday, October 17, 2006 - 8:30 AM
TBA, TBA
David Lovett - postponed
Professor in Residence
Medicine, Division of Nephrology, Fort Miley Veterans Admin Hospital
University of California, San Francisco
Tuesday, October 17, 2006 - 8:30 AM
TBA, TBA
Hepatitis C Associated Cryoglobulinemia and Glomerulonephritis: A Tale of Mice and Men
Charles Alpers, M.D.
Professor
Department of Pathology
University of Washington
Tuesday, October 10, 2006 - 8:30 AM
UWMC, NE-110 Conference Room
Faculty Sponsor: Tom Montine
Charles Alpers, M.D.
Professor
Department of Pathology
University of Washington
Tuesday, October 10, 2006 - 8:30 AM
UWMC, NE-110 Conference Room
Faculty Sponsor: Tom Montine
PSGL-1 Adherence and mTOR Modulate Translation in Macrophages
Richard Fox
PhD Candidate
Pathology
UW School of Medicine
Tuesday, October 10, 2006 - 8:30 AM
Brotman Building (SLU), Blue Flame Auditorium
Faculty Sponsor: Stephen M. Schwartz
815 Mercer Street
Richard Fox
PhD Candidate
Pathology
UW School of Medicine
Tuesday, October 10, 2006 - 8:30 AM
Brotman Building (SLU), Blue Flame Auditorium
Faculty Sponsor: Stephen M. Schwartz
815 Mercer Street
cFLIP Regulates Fas-induced Apoptosis and Pro-inflammatory Gene Expression in Human Vascular Smooth Muscle Cells
Monja Dishmon
Pathology
UW School of Medicine
Thursday, October 5, 2006 - 1:00 PM
815 Mercer Bldg, Room 111
Faculty Sponsor: Bowen-Pope
Monja Dishmon
Pathology
UW School of Medicine
Thursday, October 5, 2006 - 1:00 PM
815 Mercer Bldg, Room 111
Faculty Sponsor: Bowen-Pope
An unexpected role for the tissue factor pathway in atherosclerosis
Robert D. Simari
Professor
Cardiovascular Diseases
Mayo Clinic
Tuesday, October 3, 2006 - 8:30 AM
Health Sciences Building, K-069
Faculty Sponsor: David Dichek
Robert D. Simari
Professor
Cardiovascular Diseases
Mayo Clinic
Tuesday, October 3, 2006 - 8:30 AM
Health Sciences Building, K-069
Faculty Sponsor: David Dichek
Of mice and mice; why some do and some don't develop arterial lesions
Michael A Reidy PhD
Professor
Pathology
UWSOM
Tuesday, September 26, 2006 - 8:30 AM
Brotman Building, SLU, Blue Flame Auditorium
815 Mercer Street
Michael A Reidy PhD
Professor
Pathology
UWSOM
Tuesday, September 26, 2006 - 8:30 AM
Brotman Building, SLU, Blue Flame Auditorium
815 Mercer Street
Interventional imaging of vascular gene delivery and expression
Xiaoming Yang, MD, PhD
Professor, Director, Image-Guided Bio-Molecular Interventions Research
Radiology
University of Washington School of Medicine
Thursday, September 21, 2006 - 4:00 PM
Brotman Building (SLU), 815 Mercer Street, Blue Flame Auditorium
Faculty Sponsor: Stephen M. Schwartz
Xiaoming Yang, MD, PhD
Professor, Director, Image-Guided Bio-Molecular Interventions Research
Radiology
University of Washington School of Medicine
Thursday, September 21, 2006 - 4:00 PM
Brotman Building (SLU), 815 Mercer Street, Blue Flame Auditorium
Faculty Sponsor: Stephen M. Schwartz
Thyroid Dysfunction in Heart Failure
A. Martin Gerdes
Professor, Medicine and Director
South Dakota Cardiovascular Research Institute, Sioux Falls
University of South Dakota
Thursday, September 14, 2006 - 8:30 AM
Brotman Building, 815 Mercer Street, Room 111, Auditorium
Faculty Sponsor: Chuck Murry
Dr. Gerdes has a longstanding interest in cardiac growth and how the heart remodels under pathological conditions. He has studied hypertension, myocardial ischemia/infarction, diabetic cardiomyopathy and, most recently, how the thyroid hormone axis regulates cardiac structure and function. Please attend his seminar if you are able.
A. Martin Gerdes
Professor, Medicine and Director
South Dakota Cardiovascular Research Institute, Sioux Falls
University of South Dakota
Thursday, September 14, 2006 - 8:30 AM
Brotman Building, 815 Mercer Street, Room 111, Auditorium
Faculty Sponsor: Chuck Murry
Dr. Gerdes has a longstanding interest in cardiac growth and how the heart remodels under pathological conditions. He has studied hypertension, myocardial ischemia/infarction, diabetic cardiomyopathy and, most recently, how the thyroid hormone axis regulates cardiac structure and function. Please attend his seminar if you are able.
Arterial Rupture--Pathology and Genetics
Peter Byers, M.D.
Professor
Department of Pathology
University of Washington
Tuesday, September 12, 2006 - 8:00 AM
UWMC, NE-110 Conference Room
Faculty Sponsor: Tom Montine
Peter Byers, M.D.
Professor
Department of Pathology
University of Washington
Tuesday, September 12, 2006 - 8:00 AM
UWMC, NE-110 Conference Room
Faculty Sponsor: Tom Montine
Electrophysiological Cortical Imaging of Brain Electrical Activity
Yuan Lai, PhD
Fellow Candidate
Electrical Engineering
University of Illinois, Chicago
Thursday, August 31, 2006 - 1:30 PM
Brotman Building (SLU), 110
Faculty Sponsor: Chun Yuan
815 Mercer Street Vascular Imaging Labororatory Seminar
Yuan Lai, PhD
Fellow Candidate
Electrical Engineering
University of Illinois, Chicago
Thursday, August 31, 2006 - 1:30 PM
Brotman Building (SLU), 110
Faculty Sponsor: Chun Yuan
815 Mercer Street Vascular Imaging Labororatory Seminar
Mechanism of Endocytosis of CD33/Siglec-3:Role of ITIMs, Tyrosine Phosphorylation, and Monoubiquitylation
Roland Walter
Pathology
UWSOM
Wednesday, August 9, 2006 - 4:30 PM
Fred Hutchinson Cancer Research Center, Pelton Auditorium
Faculty Sponsor: Dr. Steve Collins
Roland Walter
Pathology
UWSOM
Wednesday, August 9, 2006 - 4:30 PM
Fred Hutchinson Cancer Research Center, Pelton Auditorium
Faculty Sponsor: Dr. Steve Collins
Toxicogenomics of Endemic Nephropathy: A Multinational Disease
Arthur Grollman, M.D.
Distinguished Professor of Pharmacological Sciences and Medicine
State University of New York at Stony Brook
Wednesday, August 2, 2006 - 3:30 PM
Health Sciencs Center, K-069
Faculty Sponsor: Dr. Larry Loeb
Arthur Grollman, M.D.
Distinguished Professor of Pharmacological Sciences and Medicine
State University of New York at Stony Brook
Wednesday, August 2, 2006 - 3:30 PM
Health Sciencs Center, K-069
Faculty Sponsor: Dr. Larry Loeb
“Functional genomics and liver regeneration”
Jiangning Li
Doctoral Dissertation
Pathology
Medicine
Tuesday, August 1, 2006 - 8:30 AM
HSB, T-473
Faculty Sponsor: Dr. Bumgarner
Jiangning Li
Doctoral Dissertation
Pathology
Medicine
Tuesday, August 1, 2006 - 8:30 AM
HSB, T-473
Faculty Sponsor: Dr. Bumgarner
Role of CHF1/Hey2 in Cardiovascular Development
Michael T. Chin, MD/Phd
Assistant Professor
Medicine
Harvard Medical School
Thursday, July 27, 2006 - 4:15 AM
SLU 815 Mercer Street, 111, Auditorium
SLUGs Present Tapas
Michael T. Chin, MD/Phd
Assistant Professor
Medicine
Harvard Medical School
Thursday, July 27, 2006 - 4:15 AM
SLU 815 Mercer Street, 111, Auditorium
SLUGs Present Tapas
The rupture-prone human plaque: how to define and detect it
Erling Falk
Professor
Department of Cardiology
Skejby University Hospital, Aarhus, Denmark
Tuesday, June 27, 2006 - 8:30 AM
SLU 815 Mercer Street, 111
Faculty Sponsor: Steve Schwartz
Erling Falk
Professor
Department of Cardiology
Skejby University Hospital, Aarhus, Denmark
Tuesday, June 27, 2006 - 8:30 AM
SLU 815 Mercer Street, 111
Faculty Sponsor: Steve Schwartz
Protection of cardiovascular stem cells by cholesterol-lowering therapy
Yong-Jian Geng, MD PhD
Professor & Director Center for Cardiovascular Biology and Atherosclerosis Research
Dept. of Internal Medicine, Cardiology Division
University of Texas School of Medicine, Houston, TX
Tuesday, June 20, 2006 - 8:30 AM
SLU 815 Mercer Street, 111
Faculty Sponsor: Chuck Murry
Yong-Jian Geng, MD PhD
Professor & Director Center for Cardiovascular Biology and Atherosclerosis Research
Dept. of Internal Medicine, Cardiology Division
University of Texas School of Medicine, Houston, TX
Tuesday, June 20, 2006 - 8:30 AM
SLU 815 Mercer Street, 111
Faculty Sponsor: Chuck Murry
Proteomics-Based Strategies to Study Hepatitis C Virus-Related Hepatocellular Carcinoma
Laura Beretta
Associate Member, FHCRC, Affiliate Associate Professor, UW
Pathology
UW - Pathology
Wednesday, June 7, 2006 - 4:00 AM
HSB, K-069
Laura Beretta
Associate Member, FHCRC, Affiliate Associate Professor, UW
Pathology
UW - Pathology
Wednesday, June 7, 2006 - 4:00 AM
HSB, K-069
"X Chromosome Upregulation and its Biological Significance in Mammals"
Di Kim Nguyen
Doctoral Dissertation
Pathology
UWSOM
Wednesday, May 31, 2006 - 10:30 AM
HSB, T-435
Faculty Sponsor: Christine Disteche
Di Kim Nguyen
Doctoral Dissertation
Pathology
UWSOM
Wednesday, May 31, 2006 - 10:30 AM
HSB, T-435
Faculty Sponsor: Christine Disteche
Distinct Wnt signaling pathways play opposing roles during organ regeneration
Cristi Stoick-Cooper
CVP Graduate Student
Neurobiology & Behavior
UWSOM
Tuesday, May 30, 2006 - 8:30 AM
HSB, K-069
Cristi Stoick-Cooper
CVP Graduate Student
Neurobiology & Behavior
UWSOM
Tuesday, May 30, 2006 - 8:30 AM
HSB, K-069
Therapeutic use of the endogenous metalloprotease inhibitor TIMP-3
Roy A. Black, Ph.D.
Associate Director of Research
Department of Inflammation
Amgen Inc.
Thursday, May 25, 2006 - 4:00 PM
815 Mercer Street, Blue Flame Auditorium
Faculty Sponsor: Bill Parks
Roy A. Black, Ph.D.
Associate Director of Research
Department of Inflammation
Amgen Inc.
Thursday, May 25, 2006 - 4:00 PM
815 Mercer Street, Blue Flame Auditorium
Faculty Sponsor: Bill Parks
Using Kinase Chemical Genetics as a Novel Tool to Investigate Heart Disease
Daniel J Morgan
Senior Fellow
Pharmacology
UWSOM
Tuesday, May 23, 2006 - 8:30 AM
Health Sciences, K-069
Faculty Sponsor: Stephen M Schwartz
Daniel J Morgan
Senior Fellow
Pharmacology
UWSOM
Tuesday, May 23, 2006 - 8:30 AM
Health Sciences, K-069
Faculty Sponsor: Stephen M Schwartz
Matrix Revisited
Thomas N. Wight, Ph.D.
Benaroya Research Institute
Chair, Vascular Biologoy, The Hope Heart Institute; Affiliate Professor, UW Pathology
School of Medicine
Thursday, May 18, 2006 - 4:00 PM
815 Mercer Street, Blue Flame Auditorium
Faculty Sponsor: Bill Parks
Thomas N. Wight, Ph.D.
Benaroya Research Institute
Chair, Vascular Biologoy, The Hope Heart Institute; Affiliate Professor, UW Pathology
School of Medicine
Thursday, May 18, 2006 - 4:00 PM
815 Mercer Street, Blue Flame Auditorium
Faculty Sponsor: Bill Parks
“Global analysis of X chromosome dosage compensation"
Brian Oliver
Section Chief of Developmental Genomics
National Institutes of Health, Bethesda, MD
Wednesday, May 10, 2006 - 4:30 PM
HSB, K-069
Faculty Sponsor: Christine Disteche
Brian Oliver
Section Chief of Developmental Genomics
National Institutes of Health, Bethesda, MD
Wednesday, May 10, 2006 - 4:30 PM
HSB, K-069
Faculty Sponsor: Christine Disteche
Cardiac applications for human embryonic stem cells
Michael Laflamme
Acting Instructor
Pathology
Center for Cardiovascular Biology & Regenerative Medicine, UWSOM
Tuesday, May 2, 2006 - 8:30 AM
SLU 815 Mercer St, 111
Faculty Sponsor: Chuck Murry
Michael Laflamme
Acting Instructor
Pathology
Center for Cardiovascular Biology & Regenerative Medicine, UWSOM
Tuesday, May 2, 2006 - 8:30 AM
SLU 815 Mercer St, 111
Faculty Sponsor: Chuck Murry
Wnt Signaling in Regeneration and Regenerative Medicine
Randall T. Moon, Ph.D.
Professor and Director, Institute for Stem Cell and Regenerative Medicine
Department of Pharmacology
School of Medicine
Thursday, April 27, 2006 - 4:00 PM
815 Mercer Street, Blue Flame Auditorium
Faculty Sponsor: BIll Parks
Randall T. Moon, Ph.D.
Professor and Director, Institute for Stem Cell and Regenerative Medicine
Department of Pharmacology
School of Medicine
Thursday, April 27, 2006 - 4:00 PM
815 Mercer Street, Blue Flame Auditorium
Faculty Sponsor: BIll Parks
Neurovascular Dementia: How Abnormalities of Cerebral Blood Vessels and Brain Parenchyma Compete
Harry Vinters, M.D.
Professor and Chief, Neuropathology
Departments of Pathology and Laboratory Medicine
University of California, Los Angeles
Wednesday, April 26, 2006 - 4:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Dr. Tom Montine
Harry Vinters, M.D.
Professor and Chief, Neuropathology
Departments of Pathology and Laboratory Medicine
University of California, Los Angeles
Wednesday, April 26, 2006 - 4:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Dr. Tom Montine
**NOTE SPECIAL TIME 1:30PM** "Zebrafish as a model for Cancer, Pigmentation, and Systems Biology"
Keith Cheng
Jake Gittlen Cancer Research Foundation
Penn State College of Medicine
Wednesday, April 26, 2006 - 1:30 PM
HSB, K-069
Faculty Sponsor: Dr. Loeb
Keith Cheng
Jake Gittlen Cancer Research Foundation
Penn State College of Medicine
Wednesday, April 26, 2006 - 1:30 PM
HSB, K-069
Faculty Sponsor: Dr. Loeb
Inflammation loci and carotid artery disease
Gail Jarvik MD
Professor
Medicine, Medical Genetics
UWSOM
Tuesday, April 25, 2006 - 8:30 AM
SLU 815 Mercer, 111 Auditorium
Faculty Sponsor: Stephen M Schwartz
Gail Jarvik MD
Professor
Medicine, Medical Genetics
UWSOM
Tuesday, April 25, 2006 - 8:30 AM
SLU 815 Mercer, 111 Auditorium
Faculty Sponsor: Stephen M Schwartz
Proteomic Analysis of the Cardiac Calcium Channel
Michelle Emrick PhD
Senior Fellow
Pharmacology
UWSOM
Tuesday, April 18, 2006 - 8:30 AM
HSB, K-069
Faculty Sponsor: Stephen M Schwartz
Michelle Emrick PhD
Senior Fellow
Pharmacology
UWSOM
Tuesday, April 18, 2006 - 8:30 AM
HSB, K-069
Faculty Sponsor: Stephen M Schwartz
The role of estrogens in maintaining brain function after injury: Views of a basic scientist and provost
Phyllis M. Wise, Ph.D.
Provost and Vice President for Academic Affairs
University of Washington
Friday, April 14, 2006 - 12:00 PM
815 Mercer Street, Blue Flame Auditorium
Faculty Sponsor: Chuck Murry
Phyllis M. Wise, Ph.D.
Provost and Vice President for Academic Affairs
University of Washington
Friday, April 14, 2006 - 12:00 PM
815 Mercer Street, Blue Flame Auditorium
Faculty Sponsor: Chuck Murry
Diabetic Macrovascular Disease in Mice: What the &#@*'s going on?
Renee C. LeBoeuf, Ph.D.
Research Professor of Medicine
Division of Metabolism, Endocrinology and Nutrition
School of Medicine
Thursday, April 13, 2006 - 4:00 PM
815 Mercer Street, Blue Flame Auditorium
Faculty Sponsor: Bill Parks
Renee C. LeBoeuf, Ph.D.
Research Professor of Medicine
Division of Metabolism, Endocrinology and Nutrition
School of Medicine
Thursday, April 13, 2006 - 4:00 PM
815 Mercer Street, Blue Flame Auditorium
Faculty Sponsor: Bill Parks
The Role of Pattern Recognition Receptors in Macrophage Death
Ira Tabas, MD/PhD
Professor, Medicine and Anatomy & Cell Biology
Deputy Editor - Journal of Clinical Investigation
Columbia University
Tuesday, April 11, 2006 - 8:30 AM
SLU 815 Mercer Street, 111
Faculty Sponsor: Michael Rosenfeld
Ira Tabas, MD/PhD
Professor, Medicine and Anatomy & Cell Biology
Deputy Editor - Journal of Clinical Investigation
Columbia University
Tuesday, April 11, 2006 - 8:30 AM
SLU 815 Mercer Street, 111
Faculty Sponsor: Michael Rosenfeld
Defining a Functional Role for Discoidin Domain Receptors in Vascular Biology
Michelle Bendeck, Ph.D.
Associate Professor
Department of Laboratory Medicine and Pathobiology
University of Toronto
Friday, April 7, 2006 - 10:00 AM
815 Mercer, Blue Flame Auditorium
Faculty Sponsor: Michael Reidy
Michelle Bendeck, Ph.D.
Associate Professor
Department of Laboratory Medicine and Pathobiology
University of Toronto
Friday, April 7, 2006 - 10:00 AM
815 Mercer, Blue Flame Auditorium
Faculty Sponsor: Michael Reidy
Evolutionary genetics, genomics, and genetic networks: How should we approach the genetic foundations of the evolution of development/morphology?
Adam S. Wilkins
Editor, BioEssays
Company of Biologists, Ltd.
Cambridge, UK
Tuesday, April 4, 2006 - 8:30 AM
SLU 815 Mercer Street, 111
Faculty Sponsor: Karol Bomsztyk
Adam S. Wilkins
Editor, BioEssays
Company of Biologists, Ltd.
Cambridge, UK
Tuesday, April 4, 2006 - 8:30 AM
SLU 815 Mercer Street, 111
Faculty Sponsor: Karol Bomsztyk
A Systems Approach to Dissecting Immunity
Alan Aderem, Ph.D.
Institute for Systems Biology, and Affiliate Professor
UW Department of Immunology
Institute for Systems Biology
Thursday, March 30, 2006 - 4:00 AM
815 Mercer St., SLU, Blue Flame Auditorium
Faculty Sponsor: Bill Parks
Alan Aderem, Ph.D.
Institute for Systems Biology, and Affiliate Professor
UW Department of Immunology
Institute for Systems Biology
Thursday, March 30, 2006 - 4:00 AM
815 Mercer St., SLU, Blue Flame Auditorium
Faculty Sponsor: Bill Parks
"Effects of Regulated Expression of Hepatitis C Virus Proteins on HH4 Human Hepatocytes"
Weiliang Tang
Pathology
University of Washington
Tuesday, March 28, 2006 - 1:30 PM
HSB, K-069
Faculty Sponsor: Dr. Fausto
Weiliang Tang
Pathology
University of Washington
Tuesday, March 28, 2006 - 1:30 PM
HSB, K-069
Faculty Sponsor: Dr. Fausto
Regulatory T cells, TGF-beta and atherosclerosis
Goran K. Hansson
Professor
Cardiovascular Research, Molecular Medicine
Karolinska Institutet, Stockhom, Sweden
Tuesday, March 28, 2006 - 8:30 AM
SLU 815 Mercer Street, 111
Faculty Sponsor: Stephen M. Schwartz
Goran K. Hansson
Professor
Cardiovascular Research, Molecular Medicine
Karolinska Institutet, Stockhom, Sweden
Tuesday, March 28, 2006 - 8:30 AM
SLU 815 Mercer Street, 111
Faculty Sponsor: Stephen M. Schwartz
Structure Biology of Ubiquitin Ligase Machinery
Ning Zheng
Assistant Professor
Pharmacology
UWSOM
Tuesday, March 21, 2006 - 8:30 AM
Health Sciences Building, K-069
Ning Zheng
Assistant Professor
Pharmacology
UWSOM
Tuesday, March 21, 2006 - 8:30 AM
Health Sciences Building, K-069
Atheroprotective Effects of Transforming Growth Factor Beta-1
Andrew D. Frutkin, MD
Acting Instructor/Senior Fellow
Cardiology Division
UWSOM
Tuesday, March 14, 2006 - 8:30 AM
SLU 815 Mercer Street, 111
Faculty Sponsor: David Dichek
Please note change of venue
Andrew D. Frutkin, MD
Acting Instructor/Senior Fellow
Cardiology Division
UWSOM
Tuesday, March 14, 2006 - 8:30 AM
SLU 815 Mercer Street, 111
Faculty Sponsor: David Dichek
Please note change of venue
Mechanism of the Cerebral Cortex Malformation Caused by FGFR3 Mutations
Tomoko Iwata, Ph.D.
Beatson Laboratories for Cancer Research
University of Glasgow
Scotland, UK
Friday, March 10, 2006 - 9:30 AM
Harborview Medical Center, R&T Building, Room 109
Faculty Sponsor: Robert Hevner
Dr. Iwata has made mouse models of several fibroblast growth factor receptor 3 (FGFR3) mutations. In humans, the mutations cause dwarfism (achondroplasia, thanatophoric dysplasia) and associated anomalies. Dr. Iwata and Dr. Hevner are collaborating to study cerebral cortex malformations in mice with the K644E kinase domain mutation in FGFR3. The malformation includes increased cortical thickness, hippocampal dysplasia, and abnormal cortical patterning.
The lecture is free and open to the public.
Tomoko Iwata, Ph.D.
Beatson Laboratories for Cancer Research
University of Glasgow
Scotland, UK
Friday, March 10, 2006 - 9:30 AM
Harborview Medical Center, R&T Building, Room 109
Faculty Sponsor: Robert Hevner
Dr. Iwata has made mouse models of several fibroblast growth factor receptor 3 (FGFR3) mutations. In humans, the mutations cause dwarfism (achondroplasia, thanatophoric dysplasia) and associated anomalies. Dr. Iwata and Dr. Hevner are collaborating to study cerebral cortex malformations in mice with the K644E kinase domain mutation in FGFR3. The malformation includes increased cortical thickness, hippocampal dysplasia, and abnormal cortical patterning.
The lecture is free and open to the public.
Cell Therapy for Cardiac Arrhythmias and Myocardial Regeneration
Lior Gepstein, M.D., Ph.D.
Associate Professor, Faculty of Medicine
Department of Physiology and Biophysics
Technion-Israel Institute of Technology
Thursday, March 9, 2006 - 4:00 AM
815 Mercer Street, SLU, Blue Flame Auditorium
Faculty Sponsor: Chuck Murry
Lior Gepstein, M.D., Ph.D.
Associate Professor, Faculty of Medicine
Department of Physiology and Biophysics
Technion-Israel Institute of Technology
Thursday, March 9, 2006 - 4:00 AM
815 Mercer Street, SLU, Blue Flame Auditorium
Faculty Sponsor: Chuck Murry
The CD4+ autoreactive T cell: chance or necessity?
Gerald T. Nepom, MD/PhD
Director
Benaroya Research Institute at Virginia Mason
Tuesday, March 7, 2006 - 8:30 AM
SLU 815 Mercer Street, 111
Gerald T. Nepom, MD/PhD
Director
Benaroya Research Institute at Virginia Mason
Tuesday, March 7, 2006 - 8:30 AM
SLU 815 Mercer Street, 111
Distinguished Faculty Lecture
"Vintage Mice: Modeling the Clinically Relevant Stages of Cardiovascular Disease in Older Apolipoprotein E-deficient Mice"
Michael Rosenfeld, Ph.D.
Professor
Department of Pathobiology
University of Washington
Thursday, March 2, 2006 - 3:30 PM
Health Sciences Center, Room T-625
Faculty Sponsor: Terrance Kavanagh
For more information, please contact Billie Grace at 206.543.1144
"Vintage Mice: Modeling the Clinically Relevant Stages of Cardiovascular Disease in Older Apolipoprotein E-deficient Mice"
Michael Rosenfeld, Ph.D.
Professor
Department of Pathobiology
University of Washington
Thursday, March 2, 2006 - 3:30 PM
Health Sciences Center, Room T-625
Faculty Sponsor: Terrance Kavanagh
For more information, please contact Billie Grace at 206.543.1144
C-reactive protein and cardiovascular risk: a population genomics approach
Alex Reiner, MD MSc
Research Associate Professor
Epidemioloy & Laboratory Medicine
UWSOM
Tuesday, February 28, 2006 - 8:30 AM
SLU 815 Mercer, 111
Faculty Sponsor: Stephen M. Schwartz
Alex Reiner, MD MSc
Research Associate Professor
Epidemioloy & Laboratory Medicine
UWSOM
Tuesday, February 28, 2006 - 8:30 AM
SLU 815 Mercer, 111
Faculty Sponsor: Stephen M. Schwartz
VEGF: From Bench to Bedside
Napoleone Ferrara
Genentech Fellow
Molecular Oncology
Genentech, Inc
Wednesday, February 22, 2006 - 4:00 PM
Health Sciences Center, Room T-739
Faculty Sponsor: Stephen Schwartz
Dr. Ferrara is the discoverer of VEGF, the critical molecule behind tumor angiogenesis and the basis for recent therapeutic advances in treatment of cancer.
The lecture is free and open to the public.
Napoleone Ferrara
Genentech Fellow
Molecular Oncology
Genentech, Inc
Wednesday, February 22, 2006 - 4:00 PM
Health Sciences Center, Room T-739
Faculty Sponsor: Stephen Schwartz
Dr. Ferrara is the discoverer of VEGF, the critical molecule behind tumor angiogenesis and the basis for recent therapeutic advances in treatment of cancer.
The lecture is free and open to the public.
Clinical Genetics and Genomics of Type I Collagen
Peter Byers, MD
Professor
Pathology & Medicine
UWSOM
Tuesday, February 21, 2006 - 8:30 AM
Health Sciences, K-069
Peter Byers, MD
Professor
Pathology & Medicine
UWSOM
Tuesday, February 21, 2006 - 8:30 AM
Health Sciences, K-069
Wnt pathways can control cardiogenesis in mouse embryonic stem cells
Shuichi Ueno, MD/PhD
Senior Fellow
Pathology
UWSOM
Tuesday, February 14, 2006 - 8:30 AM
Health Sciences, K-069
Faculty Sponsor: Chuck Murry
Shuichi Ueno, MD/PhD
Senior Fellow
Pathology
UWSOM
Tuesday, February 14, 2006 - 8:30 AM
Health Sciences, K-069
Faculty Sponsor: Chuck Murry
ABC cholesterol transporters as rescuers from cardiovascular disease
John F. Oram
Research Professor
Medicine
UWSOM
Thursday, February 9, 2006 - 4:00 PM
SLU 815 Mercer Street, 111
South Lake Union Seminar Series
John F. Oram
Research Professor
Medicine
UWSOM
Thursday, February 9, 2006 - 4:00 PM
SLU 815 Mercer Street, 111
South Lake Union Seminar Series
The TGF-beta/Smad Pathway and its Implications in Regulating Fibroblast and Malignant Melanocyte Functions
Alain Mauviel, PhD
Director
INSERM U697
Hospital Saint-Louis, Paris, France
Tuesday, February 7, 2006 - 8:30 AM
South Lake Union, 111
Faculty Sponsor: Bill Parks
Alain Mauviel, PhD
Director
INSERM U697
Hospital Saint-Louis, Paris, France
Tuesday, February 7, 2006 - 8:30 AM
South Lake Union, 111
Faculty Sponsor: Bill Parks
HnRNP K: Gene expression, hubs and scale-free networks
Karol Bomsztyk
Professor
Medicine
UWSOM
Tuesday, January 31, 2006 - 8:30 AM
Health Sciences Building, K-069
Karol Bomsztyk
Professor
Medicine
UWSOM
Tuesday, January 31, 2006 - 8:30 AM
Health Sciences Building, K-069
Molecular Basis of Information
Daniel Storm
Professor
Pharmacology
UWSOM
Tuesday, January 24, 2006 - 8:30 AM
HSB, K-069
Faculty Sponsor: Stephen M Schwartz
Daniel Storm
Professor
Pharmacology
UWSOM
Tuesday, January 24, 2006 - 8:30 AM
HSB, K-069
Faculty Sponsor: Stephen M Schwartz
Metalloproteinases: Effectors of Repair or Conspirators of Disease?
William Parks
Director
Center for Lung Biology
UWSOM
Thursday, January 19, 2006 - 4:00 AM
SLU South Lake Union, 111 (Auditorium)
Faculty Sponsor: Stephen M. Schwartz
Special Tapas. Refreshments 3:45 p.m.
William Parks
Director
Center for Lung Biology
UWSOM
Thursday, January 19, 2006 - 4:00 AM
SLU South Lake Union, 111 (Auditorium)
Faculty Sponsor: Stephen M. Schwartz
Special Tapas. Refreshments 3:45 p.m.
Retrograde Signaling by Leukemia Inhibitory Factor in Sympathetic Neurons
Jennifer O'Brien
Senior Fellow
Pharmacology
UWSOM
Tuesday, January 17, 2006 - 8:30 AM
HSB, K-069
Faculty Sponsor: Stephen M. Schwartz
Jennifer O'Brien
Senior Fellow
Pharmacology
UWSOM
Tuesday, January 17, 2006 - 8:30 AM
HSB, K-069
Faculty Sponsor: Stephen M. Schwartz
Regulation of Nitric Oxide Synthase by Shear Stress
David G. Harrison MD
Professor, Medicine
Director, Division of Cardiology
Emory University School of Medicine
Tuesday, January 10, 2006 - 8:30 AM
South Lake Union (SLU), 111
Faculty Sponsor: Stephen M. Schwartz
David G. Harrison MD
Professor, Medicine
Director, Division of Cardiology
Emory University School of Medicine
Tuesday, January 10, 2006 - 8:30 AM
South Lake Union (SLU), 111
Faculty Sponsor: Stephen M. Schwartz
Current Diagnosis of Ovarian Mucinous Tumors
Hongxiu Ji, M.D., Ph.D.
Assistant Professor
Departments of Pathology and Obstetrics/Gynecology
The Johns Hopkins University School of Medicine
Tuesday, January 10, 2006 - 8:00 AM
UWMC, NE-110 Conference Room
The special seminar will be presented as part of a didactic session with the residents.
Hongxiu Ji, M.D., Ph.D.
Assistant Professor
Departments of Pathology and Obstetrics/Gynecology
The Johns Hopkins University School of Medicine
Tuesday, January 10, 2006 - 8:00 AM
UWMC, NE-110 Conference Room
The special seminar will be presented as part of a didactic session with the residents.
Apoptosis and Macrophage Inflammation
Keith Elkon, MD
Prof. of Medicine & Adjunct Prof. Immunology
Head, Division of Rheumatology
UWSOM
Tuesday, December 20, 2005 - 8:30 AM
Health Sciences Building, K-069
Faculty Sponsor: Stephen M. Schwartz
Keith Elkon, MD
Prof. of Medicine & Adjunct Prof. Immunology
Head, Division of Rheumatology
UWSOM
Tuesday, December 20, 2005 - 8:30 AM
Health Sciences Building, K-069
Faculty Sponsor: Stephen M. Schwartz
Vaccines Targeting Breast and Ovarian Cancers
Nora Disis MD
Associate Professor
Department of Medicine, Division of Oncology
UWSOM
Thursday, December 15, 2005 - 4:00 PM
SLU 815 Mercer Street, 111
Special Tapas Seminar
Nora Disis MD
Associate Professor
Department of Medicine, Division of Oncology
UWSOM
Thursday, December 15, 2005 - 4:00 PM
SLU 815 Mercer Street, 111
Special Tapas Seminar
Assaying Methylation Markers using Coded Silica Particles
Simon Corrie
Visiting Fellow
Pathology
University of Queensland, Australia
Thursday, December 15, 2005 - 9:30 AM
SLU, 815 Mercer Street, 111
Faculty Sponsor: Nancy Kiviat
SLUG Seminar: A Progress Report
Simon Corrie
Visiting Fellow
Pathology
University of Queensland, Australia
Thursday, December 15, 2005 - 9:30 AM
SLU, 815 Mercer Street, 111
Faculty Sponsor: Nancy Kiviat
SLUG Seminar: A Progress Report
Mechanisms of Arterial Constriction due to Urokinase Overexpression
Philip Massey, MD
Acting Instructor
Medicine/Cardiology
UWSOM
Tuesday, December 13, 2005 - 8:30 AM
Health Sciences Building, K-069
Philip Massey, MD
Acting Instructor
Medicine/Cardiology
UWSOM
Tuesday, December 13, 2005 - 8:30 AM
Health Sciences Building, K-069
"Keeping the Balence: Dosage Compensation of the Active X Chromosome in Mammals"
Christine Disteche
Professor
Department of Pathology
University of Washington
Friday, December 9, 2005 - 12:30 PM
Health Sciences Center, Room K-069
Division of Medical Genetics presents the Markey Molecular Medicine Seminar
Christine Disteche
Professor
Department of Pathology
University of Washington
Friday, December 9, 2005 - 12:30 PM
Health Sciences Center, Room K-069
Division of Medical Genetics presents the Markey Molecular Medicine Seminar
Myosin Binding Protein-C: A Regulator of Contraction through Thick and Thin
Samantha Harris, PhD
Research Assistant Professor
Bioengineering
UWSOM
Tuesday, December 6, 2005 - 8:30 AM
Health Sciences Building, K-069
Faculty Sponsor: Cecilia Giachelli
Samantha Harris, PhD
Research Assistant Professor
Bioengineering
UWSOM
Tuesday, December 6, 2005 - 8:30 AM
Health Sciences Building, K-069
Faculty Sponsor: Cecilia Giachelli
Epigenetic Change in the Differentiating Embryonic Stem Cell
Jonathan Golob PhD
Fellow
Department of Pathology
UWSOM
Thursday, December 1, 2005 - 4:15 PM
South Lake Union, 111
Tapas Seminar
Jonathan Golob PhD
Fellow
Department of Pathology
UWSOM
Thursday, December 1, 2005 - 4:15 PM
South Lake Union, 111
Tapas Seminar
Immunopathogenesis of the Acute Respiratory Distress Syndrome (ARDS) and Multiple Organ Dysfunction Syndrome (MODS)
Conrad Liles
Associate Professor
Medicine, Infectious Diseases
UWSOM
Tuesday, November 29, 2005 - 8:30 AM
SLU 815 Mercer Street, 111
Conrad Liles
Associate Professor
Medicine, Infectious Diseases
UWSOM
Tuesday, November 29, 2005 - 8:30 AM
SLU 815 Mercer Street, 111
What are the roles of glucose and lipids in diabetes-accelerated atherosclerosis in mice?
Karin Bornfeldt PhD
Associate Professor
Pathology
UWSOM
Tuesday, November 22, 2005 - 8:30 AM
Health Sciences Building, K-069
Faculty Sponsor: Stephen M. Schwartz
Karin Bornfeldt PhD
Associate Professor
Pathology
UWSOM
Tuesday, November 22, 2005 - 8:30 AM
Health Sciences Building, K-069
Faculty Sponsor: Stephen M. Schwartz
Developmental Genome Anatomy Project (DGAP): Identification of Genes Critical to Human Development
Azra H. Ligon, Ph.D.
Assistant Professor
Department of Pathology
Harvard Medical School
Thursday, November 17, 2005 - 12:00 PM
Health Sciences Center, Room T-639
Faculty Sponsor: Christine Disteche
Azra H. Ligon, Ph.D.
Assistant Professor
Department of Pathology
Harvard Medical School
Thursday, November 17, 2005 - 12:00 PM
Health Sciences Center, Room T-639
Faculty Sponsor: Christine Disteche
Transcription Factor Regulation of Glial Progenitor Development and Gliomas
Keith L. Ligon, M.D., Ph.D.
Staff Pathologist and Associate Neuropathologist
Department of Pathology
Brigham and Women's Hospital
Wednesday, November 16, 2005 - 4:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Tom Montine
Keith L. Ligon, M.D., Ph.D.
Staff Pathologist and Associate Neuropathologist
Department of Pathology
Brigham and Women's Hospital
Wednesday, November 16, 2005 - 4:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Tom Montine
Vascular Calcification: role of smooth muscle cells and phosphate
Cecilia Giachelli PhD
Professor
Bioengineering
UWSOM
Tuesday, November 15, 2005 - 8:30 AM
Health Sciences Building, K-069
Cecilia Giachelli PhD
Professor
Bioengineering
UWSOM
Tuesday, November 15, 2005 - 8:30 AM
Health Sciences Building, K-069
N-terminus-dependent ubiquitin pathway: its role in cardiovascular and nervous systems
Yong Tae Kwon
Assistant Professor
Pharmaceutical Sciences
University of Pittsburgh
Thursday, November 10, 2005 - 8:30 AM
Health Sciences Building, T-635
Faculty Sponsor: Stephen M. Schwartz
Special Breakfast Club
Yong Tae Kwon
Assistant Professor
Pharmaceutical Sciences
University of Pittsburgh
Thursday, November 10, 2005 - 8:30 AM
Health Sciences Building, T-635
Faculty Sponsor: Stephen M. Schwartz
Special Breakfast Club
Macrophage adherence induces ROCK-1 synthesis via mTOR-mediated translational control
Richard Fox
PhD Candidate
Pathology, Cardiovascular Biology
UWSOM
Tuesday, November 8, 2005 - 8:30 AM
Health Sciences Bldg., K-069
Faculty Sponsor: Stephen M Schwartz
Richard Fox
PhD Candidate
Pathology, Cardiovascular Biology
UWSOM
Tuesday, November 8, 2005 - 8:30 AM
Health Sciences Bldg., K-069
Faculty Sponsor: Stephen M Schwartz
A Genome-wide Hunt for Public Mechanisms of Aging
Matt Kaeberlein, Ph.D.
Senior Fellow
Department of Genome Sciences
University of Washington
Wednesday, November 2, 2005 - 4:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Peter Rabinovitch
Dr. Kaeberlein is being considered for a faculty position in the Department of Pathology
Matt Kaeberlein, Ph.D.
Senior Fellow
Department of Genome Sciences
University of Washington
Wednesday, November 2, 2005 - 4:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Peter Rabinovitch
Dr. Kaeberlein is being considered for a faculty position in the Department of Pathology
Extracellular Matrix as a Framework for the Innate Immune Response in the Lungs
Charles Frevert, DVM, ScD
Research Associate Professor
Medicine/Pulmonary & Critical Care Medicine
VA Medical Center/UWSOM
Tuesday, November 1, 2005 - 8:30 AM
SLU 815 Mercer Street, 111
Faculty Sponsor: Bill Parks
Charles Frevert, DVM, ScD
Research Associate Professor
Medicine/Pulmonary & Critical Care Medicine
VA Medical Center/UWSOM
Tuesday, November 1, 2005 - 8:30 AM
SLU 815 Mercer Street, 111
Faculty Sponsor: Bill Parks
FISHing for Answers in Pediatric Gliomas
Christine Fuller, M.D.
Assistant Member
Department of Pathology
St. Jude Children's Research Hospital
Wednesday, October 26, 2005 - 4:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Tom Montine
Christine Fuller, M.D.
Assistant Member
Department of Pathology
St. Jude Children's Research Hospital
Wednesday, October 26, 2005 - 4:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Tom Montine
Role of PAI-1 in Progressive Renal Disease
Allison Eddy, MD
Professor & Head
Division of Pediatric Nephrology
Children's Hospital & Med Center, UWSOM
Tuesday, October 25, 2005 - 8:30 AM
SLU 815 Mercer Street, 111
Faculty Sponsor: Stephen M. Schwartz
Allison Eddy, MD
Professor & Head
Division of Pediatric Nephrology
Children's Hospital & Med Center, UWSOM
Tuesday, October 25, 2005 - 8:30 AM
SLU 815 Mercer Street, 111
Faculty Sponsor: Stephen M. Schwartz
"Stromal" Tumors of the Prostate
Donna Hansel, M.D., Ph.D.
Resident
Department of Pathology
Johns Hopkins Hospital
Friday, October 21, 2005 - 1:00 PM
UWMC, NE-110 Conference Room
Faculty Sponsor: Larry True
Dr. Hansel is being considered for a faculty position in the Department of Pathology
Donna Hansel, M.D., Ph.D.
Resident
Department of Pathology
Johns Hopkins Hospital
Friday, October 21, 2005 - 1:00 PM
UWMC, NE-110 Conference Room
Faculty Sponsor: Larry True
Dr. Hansel is being considered for a faculty position in the Department of Pathology
Roundtable Discussion: Pathologic implications of vascular developmental biology
Brant Weinstein
Senior Investigator and Head of Section of Vertebrate Organogenesis
Laboratory of Molecular Genetics
NIH National Institute of Child Health & Human Development (NICHD)
Tuesday, October 18, 2005 - 9:30 AM
Health Sciences Building, E-212
Faculty Sponsor: Elaine Raines/Steve Schwartz
Special Breakfast Club. Seating is very limited. RSVP to Sharon at 897-1537 or via e-mail sharon1@u.washington.edu. There will be no refreshments.
Brant Weinstein
Senior Investigator and Head of Section of Vertebrate Organogenesis
Laboratory of Molecular Genetics
NIH National Institute of Child Health & Human Development (NICHD)
Tuesday, October 18, 2005 - 9:30 AM
Health Sciences Building, E-212
Faculty Sponsor: Elaine Raines/Steve Schwartz
Special Breakfast Club. Seating is very limited. RSVP to Sharon at 897-1537 or via e-mail sharon1@u.washington.edu. There will be no refreshments.
Assembly of the Developing Vasculature
Brant M. Weinstein, Ph.D.
Senior Investigator and Head of Section of Vertebrate Organogenesis
Laboratory of Molecular Genetics, National Institute of Child Health and Human Development
National Institutes of Health, Bethesda, MD
Monday, October 17, 2005 - 3:00 PM
Health Sciences Center, Room D-209
Faculty Sponsor: Elaine Raines
Brant M. Weinstein, Ph.D.
Senior Investigator and Head of Section of Vertebrate Organogenesis
Laboratory of Molecular Genetics, National Institute of Child Health and Human Development
National Institutes of Health, Bethesda, MD
Monday, October 17, 2005 - 3:00 PM
Health Sciences Center, Room D-209
Faculty Sponsor: Elaine Raines
Regulation of GPCR Function by RGS
Chris Hague
Assistant Professor
Pharmacology
UWSOM
Tuesday, October 11, 2005 - 8:30 AM
SLU 815 Mercer Street, Auditorium, Rm. 111
Faculty Sponsor: Stephen M. Schwartz
Chris Hague
Assistant Professor
Pharmacology
UWSOM
Tuesday, October 11, 2005 - 8:30 AM
SLU 815 Mercer Street, Auditorium, Rm. 111
Faculty Sponsor: Stephen M. Schwartz
Embracing Complexity, Inching Closer to Reality: Novel Integrative Genomics Strategies to Map Genes for Complex Disease Traits
Eric Schadt, PhD
Senior Scientific Director
Research Genetics
Rosetta Inpharmatics, Inc., Seattle, WA
Tuesday, October 4, 2005 - 8:30 AM
SLU 815 Mercer Street, 111
Faculty Sponsor: Stephen M. Schwartz
Eric Schadt, PhD
Senior Scientific Director
Research Genetics
Rosetta Inpharmatics, Inc., Seattle, WA
Tuesday, October 4, 2005 - 8:30 AM
SLU 815 Mercer Street, 111
Faculty Sponsor: Stephen M. Schwartz
Lifestyle modifications improve vascular dysfunction in a mouse model of Type II Diabetes
Dr. Ismail "Issy" Laher
Associate Professor
Pharmacology & Therapeutics
University of British Columbia
Friday, September 23, 2005 - 1:00 PM
HSB, T-359
Sponsor: Nathan Shock Center and the Gene Action Program Project. Contact Kathy Fawthrop (206.616.4135) or Peter Rabinovitch (206.685.3761) for further information.
Dr. Ismail "Issy" Laher
Associate Professor
Pharmacology & Therapeutics
University of British Columbia
Friday, September 23, 2005 - 1:00 PM
HSB, T-359
Sponsor: Nathan Shock Center and the Gene Action Program Project. Contact Kathy Fawthrop (206.616.4135) or Peter Rabinovitch (206.685.3761) for further information.
Translation control in activated endothelial cells
Larry W. Kraiss MD
Assistant Professor & Chief
Division of Vascular Surgery
University of Utah
Tuesday, September 13, 2005 - 8:30 AM
South Lake Union, 111
Faculty Sponsor: Richard Kenagy
Larry W. Kraiss MD
Assistant Professor & Chief
Division of Vascular Surgery
University of Utah
Tuesday, September 13, 2005 - 8:30 AM
South Lake Union, 111
Faculty Sponsor: Richard Kenagy
"Anchoring Molecular Lifelines: Integrin Mediated Survival Signals"
Julie Rice
Graduate Student
Pathology
University of Washington
Thursday, August 18, 2005 - 11:00 AM
Chem, 102
Faculty Sponsor: Giachelli
Doctoral Dissertation
Julie Rice
Graduate Student
Pathology
University of Washington
Thursday, August 18, 2005 - 11:00 AM
Chem, 102
Faculty Sponsor: Giachelli
Doctoral Dissertation
Oncolytic adenoviruses: Progress and Challenges
Andre Lieber, MD PhD
Research Associate Professor
Medical Genetics
UWSOM
Thursday, August 4, 2005 - 4:00 PM
South Lake Union, 815 Mercer St., 111 Auditorium
Faculty Sponsor: Stephen M. Schwartz
Special Tapas Presentation
Andre Lieber, MD PhD
Research Associate Professor
Medical Genetics
UWSOM
Thursday, August 4, 2005 - 4:00 PM
South Lake Union, 815 Mercer St., 111 Auditorium
Faculty Sponsor: Stephen M. Schwartz
Special Tapas Presentation
Mitochondrial Damage and Biogenesis in Diabetic Heart and Protection by Overexpression of Manganese Superoxide Dismutase (MnSOD)
Xia (Clare) Shen PhD
Postdoc Candidate
Pharmacology & Toxicology
University of Louisville
Tuesday, July 26, 2005 - 8:30 AM
HSB, K-069
Faculty Sponsor: Karin Bornfeldt
Special Breakfast Club
Xia (Clare) Shen PhD
Postdoc Candidate
Pharmacology & Toxicology
University of Louisville
Tuesday, July 26, 2005 - 8:30 AM
HSB, K-069
Faculty Sponsor: Karin Bornfeldt
Special Breakfast Club
Expression Profiling of Human Cavernosal Endothelial Cells: A Role For Claudin-11/OSP in the Endothelium?
Chris Sullivan
Postdoctoral Fellow
Urology
UWSOM
Tuesday, July 19, 2005 - 9:00 AM
South Lake Union, 111
Faculty Sponsor: Hunter Wessells
Chris Sullivan
Postdoctoral Fellow
Urology
UWSOM
Tuesday, July 19, 2005 - 9:00 AM
South Lake Union, 111
Faculty Sponsor: Hunter Wessells
Arrhythmogenic Right Ventricular Cardiomyopathy: From Anatomical Theatre to Double Helix
Gaetano Thiene, M.D., FRCP
Professor, Cardiovascular Patholology
Director, Institute of Pathological Anatomy
University of Padua Medical School
Thursday, June 16, 2005 - 3:30 PM
Health Sciences Center, Room T-435
Faculty Sponsor: Chuck Murry
Gaetano Thiene, M.D., FRCP
Professor, Cardiovascular Patholology
Director, Institute of Pathological Anatomy
University of Padua Medical School
Thursday, June 16, 2005 - 3:30 PM
Health Sciences Center, Room T-435
Faculty Sponsor: Chuck Murry
The role of wnt signaling in zebrafish heart development and regeneration
Cristi Stoick
Graduate Student
Neurobiology & Behavior
UWSOM
Tuesday, June 14, 2005 - 8:30 AM
Health Sciences Building, K-069
Faculty Sponsor: Steve Schwartz
Cristi Stoick
Graduate Student
Neurobiology & Behavior
UWSOM
Tuesday, June 14, 2005 - 8:30 AM
Health Sciences Building, K-069
Faculty Sponsor: Steve Schwartz
Potassium Channel Regulation in Cerebral Arterial Smooth Muscle
Gregory Amberg
Senior Fellow
Physiology & Biophysics
UWSOM
Tuesday, June 7, 2005 - 8:30 AM
Health Sciences Building, K-069
Gregory Amberg
Senior Fellow
Physiology & Biophysics
UWSOM
Tuesday, June 7, 2005 - 8:30 AM
Health Sciences Building, K-069
Physiological and Genomic Consequences of Mitochondrial Oxidative Stress
Simon Melov
Buck Institute
Tuesday, May 31, 2005 - 1:30 PM
HSB, T-747
Faculty Sponsor: The Nathan Shock Center
Simon Melov
Buck Institute
Tuesday, May 31, 2005 - 1:30 PM
HSB, T-747
Faculty Sponsor: The Nathan Shock Center
Aldosterone and cardiovascular disease: past, present and future
Bardia Askari
Acting Instructor
Pathology
UWSOM
Tuesday, May 31, 2005 - 8:30 AM
Health Sciences Building, K-069
Faculty Sponsor: Steve Schwartz
Bardia Askari
Acting Instructor
Pathology
UWSOM
Tuesday, May 31, 2005 - 8:30 AM
Health Sciences Building, K-069
Faculty Sponsor: Steve Schwartz
Searching for Conserved Mechanisms of Eukaryotic Aging
Brian Kennedy
University of Washington
Tuesday, May 24, 2005 - 1:30 PM
HSB, T-747
Faculty Sponsor: The Nathan Shock Center
Brian Kennedy
University of Washington
Tuesday, May 24, 2005 - 1:30 PM
HSB, T-747
Faculty Sponsor: The Nathan Shock Center
Non-invasive, quantitative magnetic resonance perfusion measurements in limb skeletal muscle
Kenneth Marro
Research Assistant Professor
Radiology
UWSOM
Tuesday, May 24, 2005 - 9:00 AM
South Lake Union, 100
Faculty Sponsor: Chun Yuan
Please note change of venue to 815 Mercer Street.
Kenneth Marro
Research Assistant Professor
Radiology
UWSOM
Tuesday, May 24, 2005 - 9:00 AM
South Lake Union, 100
Faculty Sponsor: Chun Yuan
Please note change of venue to 815 Mercer Street.
Role of Renal Biopsy in Renal Transplantion
Robert Colvin, M.D.
Castleman Professor & Chair
Department of Pathology
Massachusetts General Hospital
Monday, May 23, 2005 - 2:00 PM
UWMC, Anatomic Pathology Conference Room, NE-110K
Faculty Sponsor: Charles Alpers
Robert Colvin, M.D.
Castleman Professor & Chair
Department of Pathology
Massachusetts General Hospital
Monday, May 23, 2005 - 2:00 PM
UWMC, Anatomic Pathology Conference Room, NE-110K
Faculty Sponsor: Charles Alpers
Intraepithelial Neoplasia in the Pancrea
David Klimstra
Director, Oncologic Pathology Fellowship Programs
Department of Pathology
Memorial Sloan-Kettering Cancer Center
Thursday, May 19, 2005 - 4:00 PM
Health Sciences Center, Room T-747
Faculty Sponsor: Brian Rubin
David Klimstra
Director, Oncologic Pathology Fellowship Programs
Department of Pathology
Memorial Sloan-Kettering Cancer Center
Thursday, May 19, 2005 - 4:00 PM
Health Sciences Center, Room T-747
Faculty Sponsor: Brian Rubin
New Insights on Mechanisms of Calorie Restriction
Rafael DeCabo
Laboratory of Experimental Gerontology
NIA
Tuesday, May 10, 2005 - 1:30 PM
HSB, T-747
Faculty Sponsor: The Nathan Shock Center
Rafael DeCabo
Laboratory of Experimental Gerontology
NIA
Tuesday, May 10, 2005 - 1:30 PM
HSB, T-747
Faculty Sponsor: The Nathan Shock Center
Selective Control of Endothelial Cell Proliferation with a Synthetic Dimerizer of the FGF Receptor
Marilyn Nourse
Graduate Student
Bioengineering
UWSOM
Tuesday, May 10, 2005 - 8:30 AM
Health Sciences Building, K-069
Marilyn Nourse
Graduate Student
Bioengineering
UWSOM
Tuesday, May 10, 2005 - 8:30 AM
Health Sciences Building, K-069
Tough mice and aging: How to survive with a damaged proteome"
Steve Clarke
Professor
Department of Chemistry and Biochemistry
UCLA
Wednesday, May 4, 2005 - 4:30 PM
health science bldg, K-069
Faculty Sponsor: George Martin
Steve Clarke
Professor
Department of Chemistry and Biochemistry
UCLA
Wednesday, May 4, 2005 - 4:30 PM
health science bldg, K-069
Faculty Sponsor: George Martin
New Roles for Uncoupling Proteins in Protection Against Mitochondrial Radical Production and Aging
Martin Brand
MRC Dunn Human Nutrition Unit, Cambridge, UK
Tuesday, May 3, 2005 - 1:30 PM
HSB, T-747
Faculty Sponsor: The Nathan Shock Center
Martin Brand
MRC Dunn Human Nutrition Unit, Cambridge, UK
Tuesday, May 3, 2005 - 1:30 PM
HSB, T-747
Faculty Sponsor: The Nathan Shock Center
Can Endothelial Cells Transdifferentiate into Cardiomyocytes? HUVECs and Developmental Studies
Robert Welikson
Senior Research Fellow
Biochemistry
UWSOM
Tuesday, May 3, 2005 - 8:30 AM
SLU 815 Mercer Street, 100
Faculty Sponsor: Stephen Schwartz
Please note change of venue.
Robert Welikson
Senior Research Fellow
Biochemistry
UWSOM
Tuesday, May 3, 2005 - 8:30 AM
SLU 815 Mercer Street, 100
Faculty Sponsor: Stephen Schwartz
Please note change of venue.
"Grial Cell Regulated, Apolipoprotein E Isoform-Specific Mechanism of Neuroprotection and Neurodegeneration"
Izumi Maezawa
Doctoral Dissertation
Medicine
Pathology
Monday, May 2, 2005 - 1:00 PM
Health Sciences Center, T-639
Izumi Maezawa
Doctoral Dissertation
Medicine
Pathology
Monday, May 2, 2005 - 1:00 PM
Health Sciences Center, T-639
Coenzyme Q and Aging: Dr. Jekyll or Mr. Hyde?
Catherine Clarke
Professor
Dept Chemistry and Biochemistry
UCLA
Wednesday, April 27, 2005 - 4:30 PM
Health Science Bldg, K-069
Faculty Sponsor: Tony Parks
Catherine Clarke
Professor
Dept Chemistry and Biochemistry
UCLA
Wednesday, April 27, 2005 - 4:30 PM
Health Science Bldg, K-069
Faculty Sponsor: Tony Parks
Age-Related Decline in Base Excision Repair as Mechanism for Decreased Genomic Stability with Age
Ahmad Heydari
Wayne State University
Tuesday, April 26, 2005 - 1:30 PM
HSB, T-747
Faculty Sponsor: The Nathan Shock Center
Ahmad Heydari
Wayne State University
Tuesday, April 26, 2005 - 1:30 PM
HSB, T-747
Faculty Sponsor: The Nathan Shock Center
Uncovering the role of receptor trafficking in disease
Matthew Holdren
Graduate Student
Pathology
UWSOM
Tuesday, April 26, 2005 - 8:30 AM
Health Sciences Building, K-069
Faculty Sponsor: Tony Parks
Matthew Holdren
Graduate Student
Pathology
UWSOM
Tuesday, April 26, 2005 - 8:30 AM
Health Sciences Building, K-069
Faculty Sponsor: Tony Parks
The Role of Protein Tyrosine Phosphatase Receptor Q in Development of Disease
Carmen Jane Booth, D.V.M.
Doctoral Dissertation
Pathology
University of Washington
Friday, April 22, 2005 - 10:00 AM
815 Mercer Building, Room 111
Faculty Sponsor: Dan Bowen-Pope
Carmen Jane Booth, D.V.M.
Doctoral Dissertation
Pathology
University of Washington
Friday, April 22, 2005 - 10:00 AM
815 Mercer Building, Room 111
Faculty Sponsor: Dan Bowen-Pope
Does Oxidative Stress Play an Important Role in Determining Lifespan
Holly Van Remmen
University of Texas, San Antonio
Tuesday, April 19, 2005 - 1:30 PM
HSB, T-747
Faculty Sponsor: The Nathan Shock Center
Holly Van Remmen
University of Texas, San Antonio
Tuesday, April 19, 2005 - 1:30 PM
HSB, T-747
Faculty Sponsor: The Nathan Shock Center
Can bacteria cause blood vessels to calcify?
Michael Rosenfeld
Professor
Pathobiology and Pathology
UWSOM
Tuesday, April 19, 2005 - 8:30 AM
Health Sciences Building, K-069
Michael Rosenfeld
Professor
Pathobiology and Pathology
UWSOM
Tuesday, April 19, 2005 - 8:30 AM
Health Sciences Building, K-069
The Role of GH and IGF-1 in Extension of Lifespan and Resistance to Toxic Challenges in Mice
Andrzej Bartke
Southern Illinois University
Tuesday, April 12, 2005 - 1:30 PM
HSB, T-747
Faculty Sponsor: The Nathan Shock Center
Andrzej Bartke
Southern Illinois University
Tuesday, April 12, 2005 - 1:30 PM
HSB, T-747
Faculty Sponsor: The Nathan Shock Center
Exploring the immunomodulatory action of mechanical ventilation
William A. Altemeier
Assistant Professor
Pulmonary & Critical Care Medicine
UWSOM
Tuesday, April 12, 2005 - 9:00 AM
SLU 815 Mercer Street (Blue Flame), 100
Faculty Sponsor: Conrad Liles
Please note change of venue.
William A. Altemeier
Assistant Professor
Pulmonary & Critical Care Medicine
UWSOM
Tuesday, April 12, 2005 - 9:00 AM
SLU 815 Mercer Street (Blue Flame), 100
Faculty Sponsor: Conrad Liles
Please note change of venue.
Modeling Neurodegeneration in Yeast
Susan Lindquist, Ph.D.
Member, Whtitehead Institute for Biomedical Research
Professor, Department of Biology
Massachusetts Institutute of Technology
Wednesday, April 6, 2005 - 4:00 PM
Health Sciences Center, Hogness Auditorium
Faculty Sponsor: Nelson Fausto
Susan Lindquist, Ph.D.
Member, Whtitehead Institute for Biomedical Research
Professor, Department of Biology
Massachusetts Institutute of Technology
Wednesday, April 6, 2005 - 4:00 PM
Health Sciences Center, Hogness Auditorium
Faculty Sponsor: Nelson Fausto
Why do Big Mice Die Young? Size, Stress, and the Cell Biology of Aging
Rich Miller
University of Michigan
Tuesday, April 5, 2005 - 1:30 PM
HSB, T-747
Faculty Sponsor: The Nathan Shock Center
Rich Miller
University of Michigan
Tuesday, April 5, 2005 - 1:30 PM
HSB, T-747
Faculty Sponsor: The Nathan Shock Center
FDR, April 12, 1945
Karol Bomsztyk
Professor
Medicine, Allergy and Infectious Disease
UWSOM, South Lake Union
Tuesday, April 5, 2005 - 8:30 AM
Health Sciences Building, K-069
Karol Bomsztyk
Professor
Medicine, Allergy and Infectious Disease
UWSOM, South Lake Union
Tuesday, April 5, 2005 - 8:30 AM
Health Sciences Building, K-069
PKA Mutations in Mice Affect Metabolism and Adiposity
Stanley McKnight
University of Washington
Tuesday, March 29, 2005 - 1:30 PM
HSB, T-747
Faculty Sponsor: The Nathan Shock Center
Stanley McKnight
University of Washington
Tuesday, March 29, 2005 - 1:30 PM
HSB, T-747
Faculty Sponsor: The Nathan Shock Center
Integrin Signaling: Grasping the survival mechanisms
Donald Courter
PhD Candidate
Bioengineering
University of Washington
Tuesday, March 29, 2005 - 8:30 AM
Health Sciences Building, K-069
Faculty Sponsor: Cecilia Giachelli
Donald Courter
PhD Candidate
Bioengineering
University of Washington
Tuesday, March 29, 2005 - 8:30 AM
Health Sciences Building, K-069
Faculty Sponsor: Cecilia Giachelli
Hedgehog signaling in angiogenesis
Ronald Heimark PhD
Associate Professor
Surgery, Cell Biology & Anatomy, and Pathology
Arizona Health Sciences Center
Tuesday, March 22, 2005 - 9:00 AM
SLU 815 Mercer Street (Blue Flame), 100
Faculty Sponsor: Stephen M. Schwartz
Please note change of venue.
Ronald Heimark PhD
Associate Professor
Surgery, Cell Biology & Anatomy, and Pathology
Arizona Health Sciences Center
Tuesday, March 22, 2005 - 9:00 AM
SLU 815 Mercer Street (Blue Flame), 100
Faculty Sponsor: Stephen M. Schwartz
Please note change of venue.
Vascular malformations and guidance
Dean Li
Faculty Candidate
Medicine, Division of Cardiology
University of Utah
Tuesday, March 15, 2005 - 8:30 AM
Health Sciences Building, K-069
Faculty Sponsor: David Dichek
Dean Li
Faculty Candidate
Medicine, Division of Cardiology
University of Utah
Tuesday, March 15, 2005 - 8:30 AM
Health Sciences Building, K-069
Faculty Sponsor: David Dichek
Research Training Seminar
Narci Teoh
Department of Pathology
Thursday, March 10, 2005 - 4:00 PM
Health Sciences Center, Room T-473
Faculty Sponsor: Fausto
Pathology 511 Seminar
Narci Teoh
Department of Pathology
Thursday, March 10, 2005 - 4:00 PM
Health Sciences Center, Room T-473
Faculty Sponsor: Fausto
Pathology 511 Seminar
"The liver as a model system for cell growth, proliferation, and carcinogenesis"
Jeffrey Albrecht
Associate Professor
Medicine
University of Minnesota
Wednesday, March 9, 2005 - 4:30 PM
Health Science Bldg, K-069
Faculty Sponsor: Tony Parks
Jeffrey Albrecht
Associate Professor
Medicine
University of Minnesota
Wednesday, March 9, 2005 - 4:30 PM
Health Science Bldg, K-069
Faculty Sponsor: Tony Parks
Recombomice" Shed Light on Homologous Recombination in Mammals
Bevin Engelward, Sc.D.
Associate Professor of Molecular Toxicology
Biological Engineering Division
MIT
Wednesday, March 2, 2005 - 4:30 PM
Health Science Bldg, K-069
Faculty Sponsor: Ray Monnat
Bevin Engelward, Sc.D.
Associate Professor of Molecular Toxicology
Biological Engineering Division
MIT
Wednesday, March 2, 2005 - 4:30 PM
Health Science Bldg, K-069
Faculty Sponsor: Ray Monnat
Adaptation of the Developing Cardiovascular System to Changes in Vessel Wall Extracellular Matrix
Robert Mecham
Alumni Endowed Professor Cell Biology and Physiology
Medicine, Pediatrics and Bioengineering
Washington University, St. Louis MO
Tuesday, March 1, 2005 - 9:00 AM
South Lake Union, 815 Mercer Street, 110
Faculty Sponsor: Bill Parks
Please note change of location.
Robert Mecham
Alumni Endowed Professor Cell Biology and Physiology
Medicine, Pediatrics and Bioengineering
Washington University, St. Louis MO
Tuesday, March 1, 2005 - 9:00 AM
South Lake Union, 815 Mercer Street, 110
Faculty Sponsor: Bill Parks
Please note change of location.
Research Training Seminar
Izumi Maezawa
Department of Pathology
Thursday, February 24, 2005 - 4:00 PM
Health Sciences Center, Room T-473
Faculty Sponsor: Montine
Pathology 511 Seminar
Izumi Maezawa
Department of Pathology
Thursday, February 24, 2005 - 4:00 PM
Health Sciences Center, Room T-473
Faculty Sponsor: Montine
Pathology 511 Seminar
Maternal Cells in Children's Organs: Playing, Working, or Stirring up Trouble
Anne M. Stevens
Acting Assistant Professor
Pediatrics, Division of Immunology/Rheumatology
Children's Hospital and Regional Medical Center
Tuesday, February 22, 2005 - 8:30 AM
Health Sciences Building, K-069
Anne M. Stevens
Acting Assistant Professor
Pediatrics, Division of Immunology/Rheumatology
Children's Hospital and Regional Medical Center
Tuesday, February 22, 2005 - 8:30 AM
Health Sciences Building, K-069
"DNA Repair: Winning the Race with Replication"
Dr. John Heddle
Professor Emeritus & Senior Scholar
Department of Biology
York University, Toronto, Canada
Wednesday, February 16, 2005 - 4:30 PM
Health Science Bldg, K-069
Faculty Sponsor: Dr. Loeb
Dr. John Heddle
Professor Emeritus & Senior Scholar
Department of Biology
York University, Toronto, Canada
Wednesday, February 16, 2005 - 4:30 PM
Health Science Bldg, K-069
Faculty Sponsor: Dr. Loeb
ROCK-1 protein is translationally regulated by mTOR and post-translationally processed in a caspase dependent manner following adherence in macrophage
Richard Fox
Graduate Student
Pathology
University of Washington
Tuesday, February 15, 2005 - 8:30 AM
Health Sciences Building, K-069
Faculty Sponsor: Stephen M. Schwartz
Richard Fox
Graduate Student
Pathology
University of Washington
Tuesday, February 15, 2005 - 8:30 AM
Health Sciences Building, K-069
Faculty Sponsor: Stephen M. Schwartz
Research Training Seminar
Rich Fox
Department of Pathology
Thursday, February 10, 2005 - 4:00 PM
Health Sciences Center, Room T-473
Faculty Sponsor: Schwartz
Pathology 511 Seminar
Rich Fox
Department of Pathology
Thursday, February 10, 2005 - 4:00 PM
Health Sciences Center, Room T-473
Faculty Sponsor: Schwartz
Pathology 511 Seminar
Hepsins: Lethal giant larvae
Valeri Vasioukhin
Assistant Member
Human Biology
Fred Hutchinson Cancer Research Center
Tuesday, February 8, 2005 - 8:30 AM
Health Sciences Building, K-069
Faculty Sponsor: Bill Parks
Valeri Vasioukhin
Assistant Member
Human Biology
Fred Hutchinson Cancer Research Center
Tuesday, February 8, 2005 - 8:30 AM
Health Sciences Building, K-069
Faculty Sponsor: Bill Parks
Placental malaria and maternal blood pressure
Atis Muehlenbachs
Graduate Student, Concurrent Degree
Molecular & Cellular Biology
UWSOM
Tuesday, February 1, 2005 - 8:30 AM
Health Sciences Building, K-069
Faculty Sponsor: Dan Bowen-Pope
Atis Muehlenbachs
Graduate Student, Concurrent Degree
Molecular & Cellular Biology
UWSOM
Tuesday, February 1, 2005 - 8:30 AM
Health Sciences Building, K-069
Faculty Sponsor: Dan Bowen-Pope
Research Training Seminar
Galynn Zitnik
Department of Pathology
Thursday, January 27, 2005 - 4:00 PM
Health Sciences Center, Room T-473
Faculty Sponsor: Martin
Pathology 511 Seminar
Galynn Zitnik
Department of Pathology
Thursday, January 27, 2005 - 4:00 PM
Health Sciences Center, Room T-473
Faculty Sponsor: Martin
Pathology 511 Seminar
The Role of PI-3 Kinase in Cardioprotection
Charles Steenbergen, MD PhD
Faculty Candidate
Pathology
Duke University, Durham, NC
Tuesday, January 25, 2005 - 8:30 AM
Health Sciences Building, K-069
Faculty Sponsor: Chuck Murry
Charles Steenbergen, MD PhD
Faculty Candidate
Pathology
Duke University, Durham, NC
Tuesday, January 25, 2005 - 8:30 AM
Health Sciences Building, K-069
Faculty Sponsor: Chuck Murry
"Females Have Reduced Cardiac Ischemia-Reperfusion Injury and Hypertrophy: A Role for Estrogen Receptor Beta and Nitric Oxide"
Elizabeth Murphy, Ph.D.
Faculty Candidate
Cell Biology Group, Lab of Signal Transduction
Nat'l Inst. of Environmental Health Sciences, Research Triangle Park, NC
Monday, January 24, 2005 - 4:00 PM
HSB Turner Autitorium, Room D-209
Elizabeth Murphy, Ph.D.
Faculty Candidate
Cell Biology Group, Lab of Signal Transduction
Nat'l Inst. of Environmental Health Sciences, Research Triangle Park, NC
Monday, January 24, 2005 - 4:00 PM
HSB Turner Autitorium, Room D-209
Inhibitors of Adipogenesis, Stress and Lipotoxicity: Enough to Drive Aging Preadipocytes Mad?
James Kirkland, M.D., Ph.D.
Associate Professor
Department of Medicine
Boston University School of Medicine
Tuesday, January 18, 2005 - 9:30 AM
Health Sciences Center, Room K-069
Faculty Sponsor: Peter Rabinovitch
The Nathan Shock Center of Excellence in the Basic Biology of Aging and The Genetic Approaches to Aging Training Grant
James Kirkland, M.D., Ph.D.
Associate Professor
Department of Medicine
Boston University School of Medicine
Tuesday, January 18, 2005 - 9:30 AM
Health Sciences Center, Room K-069
Faculty Sponsor: Peter Rabinovitch
The Nathan Shock Center of Excellence in the Basic Biology of Aging and The Genetic Approaches to Aging Training Grant
Metalloproteinases: Effectors of Innate Immunity
William C. Parks
Professor
Pulmonary & Critical Care Medicine
UWSOM, Harborview
Tuesday, January 18, 2005 - 8:30 AM
Health Sciences Building, K-069
William C. Parks
Professor
Pulmonary & Critical Care Medicine
UWSOM, Harborview
Tuesday, January 18, 2005 - 8:30 AM
Health Sciences Building, K-069
Research Training Seminar
Ashwini Kamath-Loeb
Department of Pathology
Thursday, January 13, 2005 - 4:00 PM
Health Sciences Center, Room T-473
Faculty Sponsor: Loeb
Pathology 511 Seminar
Ashwini Kamath-Loeb
Department of Pathology
Thursday, January 13, 2005 - 4:00 PM
Health Sciences Center, Room T-473
Faculty Sponsor: Loeb
Pathology 511 Seminar
Unrepaired G1 DNA breaks can transit S-phase for repair by homologous recombination
Dr Yannick Saintigny
Wednesday, January 12, 2005 - 4:30 PM
Health Sciences Center, T-747
Faculty Sponsor: Dr. Ray Monnat
Dr Yannick Saintigny
Wednesday, January 12, 2005 - 4:30 PM
Health Sciences Center, T-747
Faculty Sponsor: Dr. Ray Monnat
Roles of TGFbeta1 in preventing autoimmune myocarditis and in stimulating cardiac hypertrophy
Tom Doetschman
Professor of Molecular Genetics
Biochemistry & Micorbiology
University of Cincinnati College of Medicine
Tuesday, January 11, 2005 - 8:30 AM
Health Sciences Building, K-069
Faculty Sponsor: David Dichek/Stephen M. Schwartz
Tom Doetschman
Professor of Molecular Genetics
Biochemistry & Micorbiology
University of Cincinnati College of Medicine
Tuesday, January 11, 2005 - 8:30 AM
Health Sciences Building, K-069
Faculty Sponsor: David Dichek/Stephen M. Schwartz
"Genome Maintenance, Telomeres and RecQ Helicases"
Dr. Judith Campisi
Professor
Lawrence Berkeley Laboratory, Center on the Economics and Demography of Aging
University of California, Berkeley
Wednesday, January 5, 2005 - 3:00 PM
HSB, K-069
Faculty Sponsor: Dr. Rabinovitch
Dr. Judith Campisi
Professor
Lawrence Berkeley Laboratory, Center on the Economics and Demography of Aging
University of California, Berkeley
Wednesday, January 5, 2005 - 3:00 PM
HSB, K-069
Faculty Sponsor: Dr. Rabinovitch
Angiogenesis in Prostate Cancer
Norman M. Greenberg
Professor
Clinical Research
Fred Hutchinson Cancer Research Center
Tuesday, December 14, 2004 - 8:30 AM
Health Sciences Building, K-069
Faculty Sponsor: Stephen M. Schwartz
Norman M. Greenberg
Professor
Clinical Research
Fred Hutchinson Cancer Research Center
Tuesday, December 14, 2004 - 8:30 AM
Health Sciences Building, K-069
Faculty Sponsor: Stephen M. Schwartz
Chaos out of Order: Splicing and Mosaicism in Genetic Collagen Disorders
Peter H. Byers, M.D.
Professor, Adjunct Professor of Genome Sciences & Oral Biology
Pathology
University of Washington
Thursday, December 9, 2004 - 12:00 PM
HSB, T-625
http://depts.washington.edu/mednews/sim04_05.html
Peter H. Byers, M.D.
Professor, Adjunct Professor of Genome Sciences & Oral Biology
Pathology
University of Washington
Thursday, December 9, 2004 - 12:00 PM
HSB, T-625
http://depts.washington.edu/mednews/sim04_05.html
Defective DNA Damage Responses and Neurodegeneration and Brain Tumors."
Peter McKinnon, Ph.D.
Dept of Genetics,St. Jude Children's Research Hospital, Memphis, TN
Pathology
University of Washington
Wednesday, December 8, 2004 - 4:30 PM
HSB, K-069
Faculty Sponsor: Ray Monnat
Peter McKinnon, Ph.D.
Dept of Genetics,St. Jude Children's Research Hospital, Memphis, TN
Pathology
University of Washington
Wednesday, December 8, 2004 - 4:30 PM
HSB, K-069
Faculty Sponsor: Ray Monnat
Identification of novel substrates of Matrix Metalloproteinase-9 by proteomics
Tomas Vaisar
Research Scientist
Metabolism, Endocrinology & Nutrition
University of Washington School of Medicine
Tuesday, December 7, 2004 - 8:30 AM
Health Sciences Building, K-069
Faculty Sponsor: Elaine Raines
Tomas Vaisar
Research Scientist
Metabolism, Endocrinology & Nutrition
University of Washington School of Medicine
Tuesday, December 7, 2004 - 8:30 AM
Health Sciences Building, K-069
Faculty Sponsor: Elaine Raines
Angiogenesis and Lymphangiogenesis in Inflammation and Tumor Progression
Sam Dadras, M.D., Ph.D.
candidate for a Pathology Faculty Position
Pathology
University of Washington
Monday, December 6, 2004 - 1:15 PM
UWMC, NE-110K
Sam Dadras, M.D., Ph.D.
candidate for a Pathology Faculty Position
Pathology
University of Washington
Monday, December 6, 2004 - 1:15 PM
UWMC, NE-110K
Patterning of Cortical Regions and Connections
John Rubenstein
Nina Ireland Distinguished Professor in Child Psychiatry
University of California, San Francisco
Wednesday, December 1, 2004 - 4:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Tom Montine
John Rubenstein
Nina Ireland Distinguished Professor in Child Psychiatry
University of California, San Francisco
Wednesday, December 1, 2004 - 4:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Tom Montine
Endothelial Cell Activation and Apoptosis
John M. Harlan
Professor of Medicine
Division of Hematology
University of Washington School of Medicine
Tuesday, November 30, 2004 - 8:30 AM
Health Sciences Building, K-069
John M. Harlan
Professor of Medicine
Division of Hematology
University of Washington School of Medicine
Tuesday, November 30, 2004 - 8:30 AM
Health Sciences Building, K-069
Probing the determinants of inter-individual variability in innate immune inflammatory responses
Mark Wurfel
Acting Instructor
Division of Pulmonary and Critical Care Medicine
University of Washington
Tuesday, November 23, 2004 - 8:30 AM
Health Sciences Building, K-069
Faculty Sponsor: Tom Martin
Mark Wurfel
Acting Instructor
Division of Pulmonary and Critical Care Medicine
University of Washington
Tuesday, November 23, 2004 - 8:30 AM
Health Sciences Building, K-069
Faculty Sponsor: Tom Martin
Characterization of Adenovirus Serotype 35 as a Gene Therapy Vector
Anuj Gaggar
Doctoral Dissertation
Pathology
Dept of Pathology
Thursday, November 18, 2004 - 2:45 PM
UWMC, RR-134
Anuj Gaggar
Doctoral Dissertation
Pathology
Dept of Pathology
Thursday, November 18, 2004 - 2:45 PM
UWMC, RR-134
The collagen VI muscular dystrophies: new insights into their molecular pathology and genetic basis
Shireen Lamande
Departmenet of Pediatrics
University of Melbourne, Australia
Wednesday, November 17, 2004 - 4:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Peter Byers
Shireen Lamande
Departmenet of Pediatrics
University of Melbourne, Australia
Wednesday, November 17, 2004 - 4:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Peter Byers
Magnetic Resonance Imaging: The Coronary Frontier
Won Yong Kim, MD PhD
MR-Center & Department of Cardiology
Skejby University Hospital, Aarhus Denmark
Tuesday, November 16, 2004 - 8:30 AM
Health Sciences Building, K-069
Faculty Sponsor: Stephen M. Schwartz
Won Yong Kim, MD PhD
MR-Center & Department of Cardiology
Skejby University Hospital, Aarhus Denmark
Tuesday, November 16, 2004 - 8:30 AM
Health Sciences Building, K-069
Faculty Sponsor: Stephen M. Schwartz
Hypoxia and Angiogenesis: Why Do Endothelial Cells Move into Growing Tumors?
Randall Johnson
Professor
Molecular Biology Section, Division of Biological Sciences
University of California, San Diego
Monday, November 15, 2004 - 8:30 AM
Health Sciences Center, Turner Auditorium, Room D-209
Faculty Sponsor: Chuck Murry
Dr. Johnson is a faculty candidate for the Department of Pathology and the Center for Cardiovascular Biology and Regenerative Medicine
Randall Johnson
Professor
Molecular Biology Section, Division of Biological Sciences
University of California, San Diego
Monday, November 15, 2004 - 8:30 AM
Health Sciences Center, Turner Auditorium, Room D-209
Faculty Sponsor: Chuck Murry
Dr. Johnson is a faculty candidate for the Department of Pathology and the Center for Cardiovascular Biology and Regenerative Medicine
Pharmacological modulation of medial elastocalcinosis
Pierre Moreau, PhD
Associate Professor
Pharmacology
Universit de Montral
Tuesday, November 9, 2004 - 8:30 AM
Health Sciences Building, K-069
Faculty Sponsor: Cecelia Giachelli
Pierre Moreau, PhD
Associate Professor
Pharmacology
Universit de Montral
Tuesday, November 9, 2004 - 8:30 AM
Health Sciences Building, K-069
Faculty Sponsor: Cecelia Giachelli
Rapid discovery and validation of accessible tumor targets via prefractionated proteomics and molecular imaging in vivo
Jan E. Schnitzer, MD
Professor Cellular & Molecular Biology
Scientific Director
Sidney Kimmel Cancer Center, San Diego, CA
Tuesday, November 2, 2004 - 8:30 AM
Health Sciences Building, K-069
Jan E. Schnitzer, MD
Professor Cellular & Molecular Biology
Scientific Director
Sidney Kimmel Cancer Center, San Diego, CA
Tuesday, November 2, 2004 - 8:30 AM
Health Sciences Building, K-069
Identification and Characterization of Cyclic Nucleotide Phosphodiesterases in Monocytes and Macrophages
Andrew Bender
Senior Fellow
Pharmacology
University of Washington School of Medicine
Tuesday, October 26, 2004 - 8:30 AM
Health Sciences Building, K-069
Andrew Bender
Senior Fellow
Pharmacology
University of Washington School of Medicine
Tuesday, October 26, 2004 - 8:30 AM
Health Sciences Building, K-069
The Molecular Architecture of Signal Transduction Complexes
John D. Scott
Scientist
Oregon Health Sciences University
Wednesday, October 20, 2004 - 4:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Stephen Schwartz
John D. Scott
Scientist
Oregon Health Sciences University
Wednesday, October 20, 2004 - 4:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Stephen Schwartz
LMNA mutations in progeroid syndromes
Junko Oshima
Research Associate Professor
Pathology
University of Washington
Tuesday, October 19, 2004 - 8:30 AM
Health Sciences Building, K-069
Junko Oshima
Research Associate Professor
Pathology
University of Washington
Tuesday, October 19, 2004 - 8:30 AM
Health Sciences Building, K-069
Intersections between apoptosis and inflammation
Gustave Matute-Bello
Assistant Professor
Department of Medicine, Division of Pulmonary & Critical Care
University of Washington
Pulmonary Research Laboratories, VA Puget Sound Health Care System
Tuesday, October 12, 2004 - 8:30 AM
Health Sciences Center, Room K-069
Faculty Sponsor: Tom Martin
Gustave Matute-Bello
Assistant Professor
Department of Medicine, Division of Pulmonary & Critical Care
University of Washington
Pulmonary Research Laboratories, VA Puget Sound Health Care System
Tuesday, October 12, 2004 - 8:30 AM
Health Sciences Center, Room K-069
Faculty Sponsor: Tom Martin
Imaging of Angiogenesis & Lymphangiogenesis in Mouse Models of Disease
Donald McDonald
Professor of Anatomy
University of California, San Francisco
Wednesday, October 6, 2004 - 4:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Stephen Schwartz
Donald McDonald
Professor of Anatomy
University of California, San Francisco
Wednesday, October 6, 2004 - 4:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Stephen Schwartz
Arterial Smooth Muscle Cell Heterogeneity: Role in Atheroma Formation and Restenosis
Giulio Gabbiani
Professor
Departments of Pathology and Immunology
University of Geneva-CMU
Tuesday, October 5, 2004 - 8:30 AM
Health Sciences Center, Room K-069
Faculty Sponsor: Stephen Schwartz
Giulio Gabbiani
Professor
Departments of Pathology and Immunology
University of Geneva-CMU
Tuesday, October 5, 2004 - 8:30 AM
Health Sciences Center, Room K-069
Faculty Sponsor: Stephen Schwartz
Longevity and Stress-resistance: Mapping the Genes Responsible for Natural Variation in C. Elegans
Robert J. Reis
Professor
Departments of Geriatrics, Biochemistry & Molecular Biology, and Pharmacology/Toxicology
University of Arkansas
Friday, October 1, 2004 - 11:30 AM
Health Sciences Center, Room K-069
Faculty Sponsor: Peter Rabinovitch
Robert J. Reis
Professor
Departments of Geriatrics, Biochemistry & Molecular Biology, and Pharmacology/Toxicology
University of Arkansas
Friday, October 1, 2004 - 11:30 AM
Health Sciences Center, Room K-069
Faculty Sponsor: Peter Rabinovitch
What Are the Roles of Mammalian DNA Damage Binding Protein (DDB) Heterodimer and Its Two Individual Subunits
Stuart Linn
Professor
Department of Biochemistry and Molecular Biology
University of California, Berkeley
Monday, September 27, 2004 - 4:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Ray Monnat
Stuart Linn
Professor
Department of Biochemistry and Molecular Biology
University of California, Berkeley
Monday, September 27, 2004 - 4:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Ray Monnat
Genetics of Coronary Heart Disease
Jan L. Breslow, M.D.
Frederick Henry Leonhardt Professor and Director of the Laboratory of Biochemical Genetics & Metabolism
Rockefeller University
Monday, September 27, 2004 - 10:30 AM
Health Sciences Center, T-439
Faculty Sponsor: Elaine Raines
Jan L. Breslow, M.D.
Frederick Henry Leonhardt Professor and Director of the Laboratory of Biochemical Genetics & Metabolism
Rockefeller University
Monday, September 27, 2004 - 10:30 AM
Health Sciences Center, T-439
Faculty Sponsor: Elaine Raines
Evolving Concepts in Soft Tissue Neoplasia
Christopher Fletcher
Professor and Director of Surgical Pathology
Brigham & Women's Hospital
Boston, MA
Wednesday, September 22, 2004 - 4:30 PM
Health Sciences Center, Room T-733
Faculty Sponsor: Dr. Brian Rubin
Christopher Fletcher
Professor and Director of Surgical Pathology
Brigham & Women's Hospital
Boston, MA
Wednesday, September 22, 2004 - 4:30 PM
Health Sciences Center, Room T-733
Faculty Sponsor: Dr. Brian Rubin
Seminar Title: TBA
Paul DiCorleto
Director
Lerner Institute
Cleveland Clinic
Wednesday, July 14, 2004 - 4:30 PM
Health Sciences Center, K-069
Faculty Sponsor: Dr. Dan Bowen-Pope
Paul DiCorleto
Director
Lerner Institute
Cleveland Clinic
Wednesday, July 14, 2004 - 4:30 PM
Health Sciences Center, K-069
Faculty Sponsor: Dr. Dan Bowen-Pope
Cardiomyopathy of Dystrophy: Primary Mechanisms and Experimental Therapeutics
Joseph Metzger
Professor
Departments of Physiology and Internal Medicine
University of Michigan
Tuesday, July 13, 2004 - 4:30 PM
Health Sciences Center, Room K-069
Joseph Metzger
Professor
Departments of Physiology and Internal Medicine
University of Michigan
Tuesday, July 13, 2004 - 4:30 PM
Health Sciences Center, Room K-069
Regulation of Cell Growth and Cell Size by the TSC-mTOR Pathway
Kun-Liang Guan
Professor
Department of Biological Chemistry
University of Michigan
Monday, July 12, 2004 - 4:30 PM
Health Sciences Center, K-069
Kun-Liang Guan
Professor
Department of Biological Chemistry
University of Michigan
Monday, July 12, 2004 - 4:30 PM
Health Sciences Center, K-069
Hepatocellular Carcinoma: A Translational Research Challenge
Jordi Bruix
Director
Liver Cancer Unit
Hospital Clinic, Barcelona, Spain
Friday, July 2, 2004 - 9:00 AM
Health Sciences Center, Room K-069
Faculty Sponsor: Division of Gastroenterology and the Department of
Jordi Bruix
Director
Liver Cancer Unit
Hospital Clinic, Barcelona, Spain
Friday, July 2, 2004 - 9:00 AM
Health Sciences Center, Room K-069
Faculty Sponsor: Division of Gastroenterology and the Department of
Progression vs Regression of Chronic Kidney Disease: Fact or Fantasy
Agnos Fogo
Professor
Department of Pathology
Vanderbilt University
Thursday, June 17, 2004 - 10:30 AM
Health Sciences Center, Room T-747
Faculty Sponsor: Dr. Charles Alpers
Agnos Fogo
Professor
Department of Pathology
Vanderbilt University
Thursday, June 17, 2004 - 10:30 AM
Health Sciences Center, Room T-747
Faculty Sponsor: Dr. Charles Alpers
NFATc3-Induced Reductions in Voltage-gated K+ currents After Myocardial Infarction
Rick Rossow
Senior Fellow
Physiology and Biophysics
University of Washington
Tuesday, June 15, 2004 - 8:30 AM
Health Sciences Building, K-069
Rick Rossow
Senior Fellow
Physiology and Biophysics
University of Washington
Tuesday, June 15, 2004 - 8:30 AM
Health Sciences Building, K-069
Perlecan Heparan Sulfate in the Control of Vascular Smooth Muscle Cell Proliferation During Development and Disease
Mary Wiser-Evans
Assistant Professor
Departments of Pediatrics and Cell and Developmental Biology
University of Colorado
Tuesday, June 8, 2004 - 4:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Michael Reidy
Mary Wiser-Evans
Assistant Professor
Departments of Pediatrics and Cell and Developmental Biology
University of Colorado
Tuesday, June 8, 2004 - 4:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Michael Reidy
Embryonic Stem Cells for Myocardial Infarct Repair
Jeannette Nussbaum
Graduate Student
Department of Pathology
University of Washington
Tuesday, June 8, 2004 - 9:30 AM
Health Sciences Center, Room T-733
Jeannette Nussbaum
Graduate Student
Department of Pathology
University of Washington
Tuesday, June 8, 2004 - 9:30 AM
Health Sciences Center, Room T-733
The Role of Acyl Co-enzyme A Synthetases in Lipid Uptake in Vascular Cells
Bardia Askari
Associate
Howard Hughes Medical Institute
University of Washington
Tuesday, June 8, 2004 - 8:30 AM
Health Sciences Building, K-069
Bardia Askari
Associate
Howard Hughes Medical Institute
University of Washington
Tuesday, June 8, 2004 - 8:30 AM
Health Sciences Building, K-069
Pleiotropic Effects of HDL and Lysophospholipids in the Vasculature and Heart
Bodo Levkau
Professor
Institute of Pathophysiology
University of Essen
Monday, June 7, 2004 - 4:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Elaine Raines
Bodo Levkau
Professor
Institute of Pathophysiology
University of Essen
Monday, June 7, 2004 - 4:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Elaine Raines
Genetics on Embryonic Stem Cells; A Shortcut for Functional Genomics
Andras Nagy
Professor
Department of Molecular and Medical Genetics
University of Toronto
Wednesday, May 26, 2004 - 4:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Dr. Stephen Schwartz
Andras Nagy
Professor
Department of Molecular and Medical Genetics
University of Toronto
Wednesday, May 26, 2004 - 4:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Dr. Stephen Schwartz
Harnessing Adult Stem Cells for Myocardial Repair
Ronglih Liao
Associate Professor
Department of Medicine
Boston University School of Medicine
Wednesday, May 26, 2004 - 10:00 AM
Health Sciences Center, Room K-069
Faculty Sponsor: Chuck Murry
Ronglih Liao
Associate Professor
Department of Medicine
Boston University School of Medicine
Wednesday, May 26, 2004 - 10:00 AM
Health Sciences Center, Room K-069
Faculty Sponsor: Chuck Murry
Mislocalization of Neutrophil Elastase is the Major Cause of Inherited Neutropenia
Richard E. Person
Doctoral Dissertation
Department of Pathology
University of Washington School of Medicine
Tuesday, May 25, 2004 - 11:30 AM
Health Sciences Center, K-069
Richard E. Person
Doctoral Dissertation
Department of Pathology
University of Washington School of Medicine
Tuesday, May 25, 2004 - 11:30 AM
Health Sciences Center, K-069
Cytochomes p450 and Cardiac Ischemia/Reperfusion Injury
David Granville
University of British Columbia
Tuesday, May 25, 2004 - 8:30 AM
HSB, K-069
David Granville
University of British Columbia
Tuesday, May 25, 2004 - 8:30 AM
HSB, K-069
Understanding protein tolerance to random amino acid change through directed evolution
Haiwei H. Guo
Doctoral Dissertation
Department of Pathology
University of Washington School of Medicine
Friday, May 21, 2004 - 12:15 PM
University of Washington Medical Center, RR-134
Haiwei H. Guo
Doctoral Dissertation
Department of Pathology
University of Washington School of Medicine
Friday, May 21, 2004 - 12:15 PM
University of Washington Medical Center, RR-134
Barking Up the Right Vascular Tree with Sphingosine 1-Phosphate
Timothy Hla
Professor of Cell Biology and of Genetics and Developmental Biology
Director, Center for Vascular Biology
University of Connecticut School of Medicine
Thursday, May 20, 2004 - 4:30 PM
Health Sciences Center, Room T-747
Faculty Sponsor: Dr. Michael Reidy
Timothy Hla
Professor of Cell Biology and of Genetics and Developmental Biology
Director, Center for Vascular Biology
University of Connecticut School of Medicine
Thursday, May 20, 2004 - 4:30 PM
Health Sciences Center, Room T-747
Faculty Sponsor: Dr. Michael Reidy
Histone Methyltransferases in Tumor Suppression
Shi Huang
Associate Professor
The Burnham Institute
La Jolla, California
Wednesday, May 19, 2004 - 4:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Dr. Marshall Horwitz
Shi Huang
Associate Professor
The Burnham Institute
La Jolla, California
Wednesday, May 19, 2004 - 4:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Dr. Marshall Horwitz
Discovery and Characterization of Novel BMP-Regulated Genes Involved in Zebrafish Vascular Development
Ujwal Pyati
Graduate Student
Biochemistry
University of Washington
Tuesday, May 18, 2004 - 8:30 AM
HSB, K-069
Ujwal Pyati
Graduate Student
Biochemistry
University of Washington
Tuesday, May 18, 2004 - 8:30 AM
HSB, K-069
Pathway Profiling of Glioblastoma
Paul Mischel
Assistant Professor
Department of Pathology and Laboratory Medicine
UCLA School of Medicine
Thursday, May 13, 2004 - 4:30 PM
Health Sciences Center, Room T-747
Faculty Sponsor: Dr. Tom Montine
Paul Mischel
Assistant Professor
Department of Pathology and Laboratory Medicine
UCLA School of Medicine
Thursday, May 13, 2004 - 4:30 PM
Health Sciences Center, Room T-747
Faculty Sponsor: Dr. Tom Montine
New Entities in Pediatric Renal Neoplasia
Pedram Argani
Assistant Professor
Department of Pathology
Johns Hopkins University School of Medicine
Wednesday, May 12, 2004 - 4:30 PM
Health Sciences Center, K-069
Faculty Sponsor: Dr. Brian Rubin
Pedram Argani
Assistant Professor
Department of Pathology
Johns Hopkins University School of Medicine
Wednesday, May 12, 2004 - 4:30 PM
Health Sciences Center, K-069
Faculty Sponsor: Dr. Brian Rubin
Transplantation of undifferentiated embryonic stem cells leads to teratoma formation in the heart
Jeanette Nussbaum
Graduate Student
Department of Pathology
University of Washington
Tuesday, May 11, 2004 - 8:30 AM
Health Sciences Building, K-069
Jeanette Nussbaum
Graduate Student
Department of Pathology
University of Washington
Tuesday, May 11, 2004 - 8:30 AM
Health Sciences Building, K-069
Identification of Therapeutic Targets in Clinical Practice: Lessons Learned from the HER2 Story
Stuart Schnitt
Professor
Department of Pathology
Harvard Medical School
Wednesday, May 5, 2004 - 4:30 PM
Health Sciences Center, K-069
Faculty Sponsor: Dr. Brian Rubin
Stuart Schnitt
Professor
Department of Pathology
Harvard Medical School
Wednesday, May 5, 2004 - 4:30 PM
Health Sciences Center, K-069
Faculty Sponsor: Dr. Brian Rubin
Greater Potency of Adult Stem Cells: Possible Mechanisms and Uses
Catherine Verfaillie
Director
Stem Cell Institute
University of Minnesota
Tuesday, May 4, 2004 - 10:00 AM
Health Sciences Center, Hogness Auditorium
Faculty Sponsor: Charles Murry
Catherine Verfaillie
Director
Stem Cell Institute
University of Minnesota
Tuesday, May 4, 2004 - 10:00 AM
Health Sciences Center, Hogness Auditorium
Faculty Sponsor: Charles Murry
Genetic Basis of Aortic Aneurysms and Dissections
Dianna Milewicz
Professor
Department of Medical Genetics
University of Texas Medical School
Wednesday, April 28, 2004 - 4:30 PM
Health Sciences Center, K-069
Faculty Sponsor: Dr. Eileen Mulvihill
Dianna Milewicz
Professor
Department of Medical Genetics
University of Texas Medical School
Wednesday, April 28, 2004 - 4:30 PM
Health Sciences Center, K-069
Faculty Sponsor: Dr. Eileen Mulvihill
Modulation of Cerebrovascular Potassium Channel Composition and Function During Hypertension
Gregory C. Amber
Senior Fellow
Physiology and Biophysics
University of Washington
Tuesday, April 27, 2004 - 8:30 AM
HSB, K069
Gregory C. Amber
Senior Fellow
Physiology and Biophysics
University of Washington
Tuesday, April 27, 2004 - 8:30 AM
HSB, K069
Biological Roles of ADAMTS Metalloproteases
Suneel Apte
Associate Professor
Department of Molecular Medicine
CANCELED
Wednesday, April 21, 2004 - 4:30 PM
Health Sciences Center, K-069
Faculty Sponsor: Dr. Ulrike Schwarze
Suneel Apte
Associate Professor
Department of Molecular Medicine
CANCELED
Wednesday, April 21, 2004 - 4:30 PM
Health Sciences Center, K-069
Faculty Sponsor: Dr. Ulrike Schwarze
The role of endothelial cells in erectile function and dysfunction
Hunter Wessells
Associate Professor
Urology
University of Washington
Tuesday, April 20, 2004 - 8:30 AM
HSB, K-069
Hunter Wessells
Associate Professor
Urology
University of Washington
Tuesday, April 20, 2004 - 8:30 AM
HSB, K-069
Smooth Muscle Cells and Disease - Insights from Microarray Studies
Eileen Mulvihill
Research Assistant Professor
Pathology
University of Washington
Tuesday, April 13, 2004 - 8:30 AM
Health Sciences Building, K-069
Eileen Mulvihill
Research Assistant Professor
Pathology
University of Washington
Tuesday, April 13, 2004 - 8:30 AM
Health Sciences Building, K-069
Studies in the Pathology and Pathogenesis of Multiple Sclerosis
Samuel Ludwin
Professor
Department of Neuropathology
Queens University: Kingston, Ontario, Canada
Wednesday, April 7, 2004 - 4:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Dr. Thomas Montine
Samuel Ludwin
Professor
Department of Neuropathology
Queens University: Kingston, Ontario, Canada
Wednesday, April 7, 2004 - 4:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Dr. Thomas Montine
Osteoprotegerin and TRAIL as regulators of endothelial cell survival and angiogenesis
Marta Scatena
Research Assistant Professor
Department of Bioengineering
University of Washington
Tuesday, April 6, 2004 - 8:30 AM
Health Sciences Building, K-069
Marta Scatena
Research Assistant Professor
Department of Bioengineering
University of Washington
Tuesday, April 6, 2004 - 8:30 AM
Health Sciences Building, K-069
Cytologic Diagnosis of Lymphomas
Xiaohua Qian
Clinical Fellow
Department of Pathology
Brigham and Women's Hospital
Friday, April 2, 2004 - 12:30 PM
UWMC, NE-110 Conference Room
Faculty Sponsor: Dr. Brian Rubin
Xiaohua Qian
Clinical Fellow
Department of Pathology
Brigham and Women's Hospital
Friday, April 2, 2004 - 12:30 PM
UWMC, NE-110 Conference Room
Faculty Sponsor: Dr. Brian Rubin
C1Q-TNF Related Protein-1 (CTRP-1), A Novel Approach to Treating Platelet Thrombosis Without Affecting Hemostasis
Joachim Fruebis
Associate Director, ZymoGenetics, Inc.
Tuesday, March 30, 2004 - 8:30 AM
Health Sciences Building, K-069
Joachim Fruebis
Associate Director, ZymoGenetics, Inc.
Tuesday, March 30, 2004 - 8:30 AM
Health Sciences Building, K-069
Phenotypic Modulation of Smooth Muscle Cells in CalcifiedArteries: an On-and-Off Effect Associated with Culture Environment
Mei Speer
Senior Fellow
Bioengineering
University of Washington
Tuesday, March 23, 2004 - 8:30 AM
HSB, K069
Mei Speer
Senior Fellow
Bioengineering
University of Washington
Tuesday, March 23, 2004 - 8:30 AM
HSB, K069
The Fragile X Gene: Distinct Molecular and Neuropathologic Mechanisms Give Rise to Two Separate Syndromes
Paul Hagerman
Professor
Department of Biological Chemistry
University of California, Davis
Monday, March 15, 2004 - 4:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Brad Preston and Charles Laird
Paul Hagerman
Professor
Department of Biological Chemistry
University of California, Davis
Monday, March 15, 2004 - 4:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Brad Preston and Charles Laird
Pathology Reporting of Colorectal Cancer in the Molecular Era - When does research become best clinical practice?
Kieran Sheahan
Consultant Pathologist
Center for Colorectal Disease
St. Vincent's University Hospital: Dublin, Ireland
Friday, March 12, 2004 - 9:00 AM
Health Sciences Center, K-069
Kieran Sheahan
Consultant Pathologist
Center for Colorectal Disease
St. Vincent's University Hospital: Dublin, Ireland
Friday, March 12, 2004 - 9:00 AM
Health Sciences Center, K-069
Development Gone Awry: Genetics and Pathology of Medulloblastoma
Charles Eberhart
Assistant Professor
Department of Pathology
Johns Hopkins University School of Medicine
Wednesday, March 10, 2004 - 4:30 PM
Health Sciences Center, K-069
Faculty Sponsor: Dr. Tom Montine
Charles Eberhart
Assistant Professor
Department of Pathology
Johns Hopkins University School of Medicine
Wednesday, March 10, 2004 - 4:30 PM
Health Sciences Center, K-069
Faculty Sponsor: Dr. Tom Montine
Inflammation and atherosclerosis: Role of serum amyloid A
Alan Chait
Edwin L. Bierman Professor of Medicine
Head, Division of Metabolism,
University of Washington
Tuesday, March 9, 2004 - 8:30 AM
HSB, K069
Alan Chait
Edwin L. Bierman Professor of Medicine
Head, Division of Metabolism,
University of Washington
Tuesday, March 9, 2004 - 8:30 AM
HSB, K069
Vascular Calcification in Chronic Kidney Disease
William G. Goodman
Professor
Department of Medicine
U.C.L.A. School of Medicine
Wednesday, March 3, 2004 - 4:30 PM
Health Sciences Center, K-069
Faculty Sponsor: Dr. Cecilia Giachelli
William G. Goodman
Professor
Department of Medicine
U.C.L.A. School of Medicine
Wednesday, March 3, 2004 - 4:30 PM
Health Sciences Center, K-069
Faculty Sponsor: Dr. Cecilia Giachelli
New Developments in an Integrated Model of Cardiac Function
N.P Smith and P.J. Hunter
Bioengineering Institute
University of Auckland
Tuesday, March 2, 2004 - 8:30 AM
Health Science Building, K069
Faculty Sponsor: James B Bassingthwaighte
N.P Smith and P.J. Hunter
Bioengineering Institute
University of Auckland
Tuesday, March 2, 2004 - 8:30 AM
Health Science Building, K069
Faculty Sponsor: James B Bassingthwaighte
Genes, Lymphocytes and Autoimmunity
Abul K. Abbas, M.D.
Professor & Chair
Department of Pathology
University of California, San Francisco
Friday, February 27, 2004 - 12:00 PM
Health Sciences Center, Room T-733
Abul K. Abbas, M.D.
Professor & Chair
Department of Pathology
University of California, San Francisco
Friday, February 27, 2004 - 12:00 PM
Health Sciences Center, Room T-733
Utilizing Human Genetics to Understand Vascular Development
Dean Li
Associate Professor
Department of Medicine
University of Utah
Wednesday, February 25, 2004 - 4:30 PM
Health Sciences Center, K-069
Faculty Sponsor: Dr. Stephen Schwartz
Dean Li
Associate Professor
Department of Medicine
University of Utah
Wednesday, February 25, 2004 - 4:30 PM
Health Sciences Center, K-069
Faculty Sponsor: Dr. Stephen Schwartz
TGF-B1 and Atherogenesis: Conditional Transgenic Mouse Models
Andrew Frutkin
Senior Fellow
Cardiology
University of Washington
Tuesday, February 24, 2004 - 8:30 AM
HSB, K069
Andrew Frutkin
Senior Fellow
Cardiology
University of Washington
Tuesday, February 24, 2004 - 8:30 AM
HSB, K069
Characterization of Cancer-Associated Mutants of DNA Polymerase Beta
Joann Sweasy
Associate Professor
Departments of Therapeutic Radiology and Genetics
Yale University School of Medicine
Wednesday, February 11, 2004 - 4:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Dr. Larry Loeb
Joann Sweasy
Associate Professor
Departments of Therapeutic Radiology and Genetics
Yale University School of Medicine
Wednesday, February 11, 2004 - 4:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Dr. Larry Loeb
Functional analysis of RGS5 in vascular smooth muscle
Xi Wang
Senior Fellow
Pathology
University of Washington
Tuesday, February 3, 2004 - 8:30 AM
HSB, K069
Xi Wang
Senior Fellow
Pathology
University of Washington
Tuesday, February 3, 2004 - 8:30 AM
HSB, K069
Reduced BRCA1 Expression and Ovarian Tumorigenesis
Rachel M. Gonzalez
Graduate Student
Department of Pathology
University of Washington
Friday, January 30, 2004 - 11:00 AM
Health Sciences Center, Room K-069
Faculty Sponsor: Mary Claire King
Rachel M. Gonzalez
Graduate Student
Department of Pathology
University of Washington
Friday, January 30, 2004 - 11:00 AM
Health Sciences Center, Room K-069
Faculty Sponsor: Mary Claire King
Mechanism of Lung Adenocarcinoma Induction by Jaagsiekte Sheep Retrovirus and Parallels with Human Lung Cancer
Dusty Miller
Member, FHCRC
Affiliate Professor, Department of Pathology
University of Washington
Wednesday, January 28, 2004 - 4:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Dr. Tony Parks
Dusty Miller
Member, FHCRC
Affiliate Professor, Department of Pathology
University of Washington
Wednesday, January 28, 2004 - 4:30 PM
Health Sciences Center, Room K-069
Faculty Sponsor: Dr. Tony Parks
Salmonid Cardiac Troponin C: Structural and Functional Studies of a Protein Evolved to Increase Cardiac Calcium Sensitivity
Todd Gillis
Senior Fellow
Bioengineering
University of Washington
Tuesday, January 27, 2004 - 8:30 AM
HSB, K069
Todd Gillis
Senior Fellow
Bioengineering
University of Washington
Tuesday, January 27, 2004 - 8:30 AM
HSB, K069
Gene transfer to striated muscles using AAV
Jeff Chamberlain
Professor
Neurology
University of Washington
Tuesday, January 20, 2004 - 8:30 AM
HSB, K069
Jeff Chamberlain
Professor
Neurology
University of Washington
Tuesday, January 20, 2004 - 8:30 AM
HSB, K069
Fundamental Issues in Engineered Vessel Development
Laura Niklason
Assistant Professor
Departments of Biomedical Engineering, Anesthesia and Surgery
Duke University
Friday, January 16, 2004 - 3:30 PM
Health Sciences Center, K-069
Faculty Sponsor: Chuck Murry and Thomas Wight
Laura Niklason
Assistant Professor
Departments of Biomedical Engineering, Anesthesia and Surgery
Duke University
Friday, January 16, 2004 - 3:30 PM
Health Sciences Center, K-069
Faculty Sponsor: Chuck Murry and Thomas Wight
Linking Mathmatical Modeling with Clinical Research to Better Understand Brain Cancer (Gliomas)
Kristin R. Swanson
Research Assistant Professor
Departments of Pathology and Applied Mathematics
University of Washington
Tuesday, January 13, 2004 - 2:30 PM
Guggenheim Hall, 317
Kristin R. Swanson
Research Assistant Professor
Departments of Pathology and Applied Mathematics
University of Washington
Tuesday, January 13, 2004 - 2:30 PM
Guggenheim Hall, 317
Myocardial Reperfusion Injury
Tim Pohlman
Professor
Surgery
University of Washington
Tuesday, January 13, 2004 - 8:30 AM
HSB, K069
Tim Pohlman
Professor
Surgery
University of Washington
Tuesday, January 13, 2004 - 8:30 AM
HSB, K069
Prelamin A Processing and Progeria
Stephen Young, M.D.
Senior Investigator
Gladstone Institute of Cardiovascular Disease
University of California, San Francisco
Wednesday, December 17, 2003 - 4:30 PM
Health Sciences Center, K-069
Stephen Young, M.D.
Senior Investigator
Gladstone Institute of Cardiovascular Disease
University of California, San Francisco
Wednesday, December 17, 2003 - 4:30 PM
Health Sciences Center, K-069
The role of Factor XIII in Hemostasis and Wound Healing
Paul Bishop
Distinguished Fellow
ZymoGenetics
Tuesday, December 16, 2003 - 8:30 AM
Health Sciences, K069
Paul Bishop
Distinguished Fellow
ZymoGenetics
Tuesday, December 16, 2003 - 8:30 AM
Health Sciences, K069
The Role of Runt-Related Transcription Factor @ (Runx2) in Arterial Smooth Muscle Cell Mineralization
Gabrielle Mercedes Curinga
Graduate Student
Department of Pathology
University of Washington
Friday, December 12, 2003 - 10:30 AM
Health Sciences Center, Room RR-134
Gabrielle Mercedes Curinga
Graduate Student
Department of Pathology
University of Washington
Friday, December 12, 2003 - 10:30 AM
Health Sciences Center, Room RR-134
Leukocyte Bcl-2 and ischemia-reperfusion injury
Robert K. Winn
Research Professor
Surgery and Physiology-Biophysics
Harborview Medical Center
Tuesday, December 9, 2003 - 8:30 AM
Health Sciences, K069
Robert K. Winn
Research Professor
Surgery and Physiology-Biophysics
Harborview Medical Center
Tuesday, December 9, 2003 - 8:30 AM
Health Sciences, K069
Translational Control in Macrophage Inflammation
Paul L. Fox
Professor of Molecular Medicine
Department of Cell Biology
The Lerner Research Institute, Cleveland Clinic Foundation
Wednesday, December 3, 2003 - 4:30 PM
Health Sciences Center, K-069
Paul L. Fox
Professor of Molecular Medicine
Department of Cell Biology
The Lerner Research Institute, Cleveland Clinic Foundation
Wednesday, December 3, 2003 - 4:30 PM
Health Sciences Center, K-069
Targeting interventions to reduce athero-thrombotic disease: genomics, translational biology and population science
David Siscovick
Professor of Medicine & Epidemiology
Cardiovascular Health Research Unit
University of Washington
Tuesday, December 2, 2003 - 8:30 AM
HSB, K069
David Siscovick
Professor of Medicine & Epidemiology
Cardiovascular Health Research Unit
University of Washington
Tuesday, December 2, 2003 - 8:30 AM
HSB, K069
Improved Vascular Gene Transfer with a Helper-Dependent Adenoviral Vector
Shan Wen
Acting Instructor
Medicine/Division of Cardiology
University of Washington
Tuesday, November 25, 2003 - 8:30 AM
HSB, K069
Shan Wen
Acting Instructor
Medicine/Division of Cardiology
University of Washington
Tuesday, November 25, 2003 - 8:30 AM
HSB, K069
Involvement of IKK Alpha in Rank-Mediated Osteoclastogenesis
Michelle Chaisson
Post-Doctoral Fellow
Amgen, Inc.
Wednesday, November 19, 2003 - 4:30 PM
Health Sciences Center, Room K-069
Michelle Chaisson
Post-Doctoral Fellow
Amgen, Inc.
Wednesday, November 19, 2003 - 4:30 PM
Health Sciences Center, Room K-069
Functional Genomic Approaches Towards the Understanding of the Mouse Circadian Clock
John Hogenesch
Program Manager, Genomics
Genomics Institute
Novartis Research Foundation
Tuesday, November 18, 2003 - 8:30 AM
HSB, K069
John Hogenesch
Program Manager, Genomics
Genomics Institute
Novartis Research Foundation
Tuesday, November 18, 2003 - 8:30 AM
HSB, K069
Parkinson's Disease Caused by Alpha-synuclein Locus Triplication
Lee-Way Jin, M.D., Ph.D.
Assistant Professor
Department of Pathology
University of Washington
Friday, November 7, 2003 - 9:30 AM
Harboview Medical Center, R & T Building, Room 113
Lee-Way Jin, M.D., Ph.D.
Assistant Professor
Department of Pathology
University of Washington
Friday, November 7, 2003 - 9:30 AM
Harboview Medical Center, R & T Building, Room 113
A Murine Model of Intestinal Pseudo-Obstruction
Raj Kapur, M.D., Ph.D.
Associate Professor
Department of Pathology and Department of Laboratories
University of Washington and Children's Hospital and Regional Medical Center
Wednesday, November 5, 2003 - 4:30 PM
Health Sciences Center, Room K-069
Raj Kapur, M.D., Ph.D.
Associate Professor
Department of Pathology and Department of Laboratories
University of Washington and Children's Hospital and Regional Medical Center
Wednesday, November 5, 2003 - 4:30 PM
Health Sciences Center, Room K-069
Impaired Myocardial Insulin Signaling and Cardiac Dysfunction in Diabetes
Dale Abel
Assistant Professor of Medicine and Biochemistry
Division of Endocrinology Diabetes and Metabolism
Investigator: Program in Human Molecular Biology and Genetics, University of Utah School of Medicine
Tuesday, November 4, 2003 - 8:30 AM
HSB, K069
Dale Abel
Assistant Professor of Medicine and Biochemistry
Division of Endocrinology Diabetes and Metabolism
Investigator: Program in Human Molecular Biology and Genetics, University of Utah School of Medicine
Tuesday, November 4, 2003 - 8:30 AM
HSB, K069
Mechanisms of transforming growth factor-beta1-induced neointimal formation
Goro Otsuka
Senior Fellow
Medicine/Cardiology
University of Washington
Tuesday, October 28, 2003 - 8:30 AM
HSB, K069
Goro Otsuka
Senior Fellow
Medicine/Cardiology
University of Washington
Tuesday, October 28, 2003 - 8:30 AM
HSB, K069
Tropomyosin Isoform and the Sensitivity of Contractile Mechanics to Strong Actomyosin Crossbridge Binding
Emilie Clemmens
Graduate Student (Defense date Oct. 7th)
Bioengineering
University of Washington
Tuesday, October 21, 2003 - 8:30 AM
HSB, K069
Emilie Clemmens
Graduate Student (Defense date Oct. 7th)
Bioengineering
University of Washington
Tuesday, October 21, 2003 - 8:30 AM
HSB, K069
Natural antibodies protect against atherogenesis
Gregg Silverman
Professor in Medicine
Dept. of Medicine
UCSD
Tuesday, October 14, 2003 - 8:30 AM
HSB, K069
Gregg Silverman
Professor in Medicine
Dept. of Medicine
UCSD
Tuesday, October 14, 2003 - 8:30 AM
HSB, K069
Many Genes and Many Tumors: Genetics of Uterine Leiomyomata
Cynthia Morton
Professor
Department of Pathology
Brigham and Women's Hospital, Boston, MA
Wednesday, October 8, 2003 - 4:30 PM
Health Sciences Center, Room K-069
Cynthia Morton
Professor
Department of Pathology
Brigham and Women's Hospital, Boston, MA
Wednesday, October 8, 2003 - 4:30 PM
Health Sciences Center, Room K-069
Thyroid Hormone and Cardiac Metabolism
Michael Portman
Professor of Pediatrics
Children's Hospital and Regional Medical Center
University of Washington, Division of Cardiology
Tuesday, October 7, 2003 - 8:30 AM
Health Science Buidling, K069
Michael Portman
Professor of Pediatrics
Children's Hospital and Regional Medical Center
University of Washington, Division of Cardiology
Tuesday, October 7, 2003 - 8:30 AM
Health Science Buidling, K069
The Cell Cycle Phase Specificity of DNA Damage and Repair Induced by Radiation, Oxidation and Anti-Topoisomerase II Chemotherapy Drugs
Alan Potter
Graduate Student
Department of Pathology
University of Washington
Thursday, October 2, 2003 - 10:30 AM
Health Sciences Center, Room D-310
Alan Potter
Graduate Student
Department of Pathology
University of Washington
Thursday, October 2, 2003 - 10:30 AM
Health Sciences Center, Room D-310
"Pituitary Tumor Pathogeneis
M. Beatriz S. Lopes, M.D.
Associate Professor
Department of Pathology
University of Virginia Health Sciences Center
Wednesday, September 17, 2003 - 8:00 AM
Harborview Medical Center, Research and Training Auditori
M. Beatriz S. Lopes, M.D.
Associate Professor
Department of Pathology
University of Virginia Health Sciences Center
Wednesday, September 17, 2003 - 8:00 AM
Harborview Medical Center, Research and Training Auditori
The Role of Hypoxia and Genetics in the Progression of Glioblastoma
Daniel J. Brat
Associate Professor
Department of Pathology and Laboratory Medicine
Emory University School of Medicine
Thursday, September 11, 2003 - 4:30 PM
Health Sciences Center, Room T-739
Daniel J. Brat
Associate Professor
Department of Pathology and Laboratory Medicine
Emory University School of Medicine
Thursday, September 11, 2003 - 4:30 PM
Health Sciences Center, Room T-739
The Functions of FE65 Proteins and Their Roles in Dementias of Alzheimer's Disease
Baiping Wang
Graduate Student
Department of Pathology
University of Washington
Tuesday, August 19, 2003 - 10:00 AM
Health Sciences Center, Room K-069
Baiping Wang
Graduate Student
Department of Pathology
University of Washington
Tuesday, August 19, 2003 - 10:00 AM
Health Sciences Center, Room K-069
"Neurospheres and Neurosphere Forming Cells: Morphological and Ultrastructural Characterization
Alessandra Bez
National Neurologic Institute "C.Besta"
Milan, Italy
Monday, July 28, 2003 - 1:00 PM
VA Medical Center, Building 1, Room 812
Alessandra Bez
National Neurologic Institute "C.Besta"
Milan, Italy
Monday, July 28, 2003 - 1:00 PM
VA Medical Center, Building 1, Room 812
Telomere Length and Chromosomal Instability in the Neoplastic Progression of Barrett's Esophagus
Jennifer C. Finley
Graduate Student
Department of Pathology
University of Washington
Wednesday, July 23, 2003 - 3:00 PM
Health Sciences Center, Room K-069
Jennifer C. Finley
Graduate Student
Department of Pathology
University of Washington
Wednesday, July 23, 2003 - 3:00 PM
Health Sciences Center, Room K-069
Cardiovascular Genomics: Clinical Implications
Gary H. Gibbons, M.D
Cardiovascular Research Institute
Morehouse School of Medicine
Monday, June 23, 2003 - 8:30 AM
Health Sciences Building, K069
Gary H. Gibbons, M.D
Cardiovascular Research Institute
Morehouse School of Medicine
Monday, June 23, 2003 - 8:30 AM
Health Sciences Building, K069
"Links between contractile and electrical dysfunction in heart"
Jeffrey E. Saffitz, M.D., Ph.D.
Lacy Professor of Pathology
Department of Pathology and Immunology
Washington University School of Medicine
Thursday, June 19, 2003 - 10:00 AM
Health Sciences Building, K069
Jeffrey E. Saffitz, M.D., Ph.D.
Lacy Professor of Pathology
Department of Pathology and Immunology
Washington University School of Medicine
Thursday, June 19, 2003 - 10:00 AM
Health Sciences Building, K069
Microscale Systems and Applications for Life-on-a-Chip
Deirdre Meldrum
Professor
Department of Electrical Engineering
University of Washington
Wednesday, June 11, 2003 - 4:30 PM
Health Sciences Center, Room K-069
Deirdre Meldrum
Professor
Department of Electrical Engineering
University of Washington
Wednesday, June 11, 2003 - 4:30 PM
Health Sciences Center, Room K-069
Sheep Retroviral Envelope Glycoprotiens: Mechanisms of Oncogenesis and Incorporation into HIV-1 Lentiviral Vectors
Shan-Lu Liu
Graduate Student
Department of Patholgy
University of Washington
Tuesday, June 10, 2003 - 2:00 PM
Fred Hutchinson Cancer Research Center, Weintraub Building, Pelton Aud
Shan-Lu Liu
Graduate Student
Department of Patholgy
University of Washington
Tuesday, June 10, 2003 - 2:00 PM
Fred Hutchinson Cancer Research Center, Weintraub Building, Pelton Aud
Integrative signaling in angiogenesis
Michael Simons
A. G. Huber Professor of Medicine & Chief of Cardiology
Medical School
Dartmouth
Tuesday, June 10, 2003 - 8:30 AM
Health Sciences Building, T747
Michael Simons
A. G. Huber Professor of Medicine & Chief of Cardiology
Medical School
Dartmouth
Tuesday, June 10, 2003 - 8:30 AM
Health Sciences Building, T747
Biotechnology Drug Discovery in the Post-Human Genome Era
Thomas Bumol, Ph.D.
Vice President
Biotechnology Discovery Research
Lilly Research Laboratories
Thursday, June 5, 2003 - 4:30 PM
Health Sciences Center, T-747
Thomas Bumol, Ph.D.
Vice President
Biotechnology Discovery Research
Lilly Research Laboratories
Thursday, June 5, 2003 - 4:30 PM
Health Sciences Center, T-747
An Informal Career/Research Workshop
Thomas Bumol, Ph.D.
Vice President
Biotechnology Discovery Research
Lilly Research Laboratories
Thursday, June 5, 2003 - 9:30 AM
South Campus Center, Room 303
Thomas Bumol, Ph.D.
Vice President
Biotechnology Discovery Research
Lilly Research Laboratories
Thursday, June 5, 2003 - 9:30 AM
South Campus Center, Room 303
Evolutionary Theories of Aging and How We Test Them
Daniel Promislow
Part of the Methods in Gerontological Research Seminar Series. Discussion to follow 1:30-3:30, HSB T-663. Students may sign up for credit in PATH 511
University of Georgia
Tuesday, June 3, 2003 - 12:30 PM
HSB, T-639
Daniel Promislow
Part of the Methods in Gerontological Research Seminar Series. Discussion to follow 1:30-3:30, HSB T-663. Students may sign up for credit in PATH 511
University of Georgia
Tuesday, June 3, 2003 - 12:30 PM
HSB, T-639
Population Mortality Analyses: A Tool for the Study of Aging
Scott Pletcher
Part of the Methods in Gerontological Research Seminar Series. Discussion to follow 1:30-3:30, HSB T-663. Students may sign up for credit in PATH 511
Baylor College of Medicine
Tuesday, May 27, 2003 - 12:30 PM
HSB, T-639
Scott Pletcher
Part of the Methods in Gerontological Research Seminar Series. Discussion to follow 1:30-3:30, HSB T-663. Students may sign up for credit in PATH 511
Baylor College of Medicine
Tuesday, May 27, 2003 - 12:30 PM
HSB, T-639
Genetic Chemoprotection of Hematopoietic Stem Cells: Implications for the Treatment of Genetic and Malignant Diseases
Hans-Peter Kiem
Associate Member
Fred Hutchinson Cancer Research Center
Wednesday, May 21, 2003 - 4:30 PM
Health Sciences Center, K-069
Hans-Peter Kiem
Associate Member
Fred Hutchinson Cancer Research Center
Wednesday, May 21, 2003 - 4:30 PM
Health Sciences Center, K-069
Design of Human Aging Studies
Norm Wolf
Part of the Methods in Gerontological Research Seminar Series. Discussion to follow 1:30-3:30, HSB T-663. Students may sign up for credit in PATH 511
University of Washington
Tuesday, May 20, 2003 - 12:30 PM
HSB, T-639
Norm Wolf
Part of the Methods in Gerontological Research Seminar Series. Discussion to follow 1:30-3:30, HSB T-663. Students may sign up for credit in PATH 511
University of Washington
Tuesday, May 20, 2003 - 12:30 PM
HSB, T-639
Regional Cardiac Sympathetic Dysfunction in CHF
James Caldwell, MD
Professor
Medicine
VA Medical Center
Tuesday, May 20, 2003 - 8:30 AM
Health Sciences Building, K069
James Caldwell, MD
Professor
Medicine
VA Medical Center
Tuesday, May 20, 2003 - 8:30 AM
Health Sciences Building, K069
Cellular Adaptation to Client Protein Load on the Endoplasmic Reticulum
David Ron, M.D.
Professor
Departments of Medicine and Cell Biology
NYU School of Medicine
Wednesday, May 14, 2003 - 4:30 PM
Health Sciences Center, Room K-069
David Ron, M.D.
Professor
Departments of Medicine and Cell Biology
NYU School of Medicine
Wednesday, May 14, 2003 - 4:30 PM
Health Sciences Center, Room K-069
Oligodendrogliomas and Mixed Gliomas: An Epidemic
Peter Burger, M.D.
Professor
Department of Pathology
Johns Hopkins University
Wednesday, May 14, 2003 - 8:00 AM
Harborview Medical Center, R&T Building Auditorium
Faculty Sponsor: Dr. Tom Montine
Dr. Burger is one of the world's leading experts on tumors of the central nervous system. Among many other achievements, he is co-author of the AFIP Atlas of Tumor Pathology, Tumors of the Central Nervous System, and has authored two major textbooks in central nervous system tumors.
Peter Burger, M.D.
Professor
Department of Pathology
Johns Hopkins University
Wednesday, May 14, 2003 - 8:00 AM
Harborview Medical Center, R&T Building Auditorium
Faculty Sponsor: Dr. Tom Montine
Dr. Burger is one of the world's leading experts on tumors of the central nervous system. Among many other achievements, he is co-author of the AFIP Atlas of Tumor Pathology, Tumors of the Central Nervous System, and has authored two major textbooks in central nervous system tumors.
Design of Human Aging Studies
William Hazzard
Part of the Methods in Gerontological Research Seminar Series. Discussion to follow 1:30-3:30, HSB T-663. Students may sign up for credit in PATH 511
University of Washington
Tuesday, May 13, 2003 - 12:30 PM
HSB, T-639
William Hazzard
Part of the Methods in Gerontological Research Seminar Series. Discussion to follow 1:30-3:30, HSB T-663. Students may sign up for credit in PATH 511
University of Washington
Tuesday, May 13, 2003 - 12:30 PM
HSB, T-639
Yeast and Mouse Models for Exploring Telomere Function in Werner Syndrome
Brad Johnson, M.D., Ph.D.
Assistant Professor
Department of Pathology and Laboratory Medicine
University of Pennsylvania
Wednesday, May 7, 2003 - 4:30 PM
Health Sciences Center, Room K-069
Brad Johnson, M.D., Ph.D.
Assistant Professor
Department of Pathology and Laboratory Medicine
University of Pennsylvania
Wednesday, May 7, 2003 - 4:30 PM
Health Sciences Center, Room K-069
Use of Nonhuman Primates for Studies of Caloric Restriction and Aging
George Roth
Part of the Methods in Gerontological Research Seminar Series. Discussion to follow 1:30-3:30, HSB T-663. Students may sign up for credit in PATH 511
National Institute on Aging
Tuesday, May 6, 2003 - 12:30 PM
HSB, T-639
George Roth
Part of the Methods in Gerontological Research Seminar Series. Discussion to follow 1:30-3:30, HSB T-663. Students may sign up for credit in PATH 511
National Institute on Aging
Tuesday, May 6, 2003 - 12:30 PM
HSB, T-639
Quantitative proteomics: new technology and applications
Reudi Abersold
Professor and Co-founder of the Institutes for Systems Biology
The Institute for Systems Biology
Tuesday, May 6, 2003 - 8:30 AM
HSB, K069
Reudi Abersold
Professor and Co-founder of the Institutes for Systems Biology
The Institute for Systems Biology
Tuesday, May 6, 2003 - 8:30 AM
HSB, K069
Bacteriophages: Natures Self-replicating, Self-limiting Antibiotics
Betty Kutter, Ph.D.
Faculty Member
Department of Biophysics
Evergreen State College
Wednesday, April 30, 2003 - 4:30 PM
HSC, Room K-069
Betty Kutter, Ph.D.
Faculty Member
Department of Biophysics
Evergreen State College
Wednesday, April 30, 2003 - 4:30 PM
HSC, Room K-069
Gene Expression Profile Assays: Strengths and Pitfalls
Richard Miller
Part of the Methods in Gerontological Research Seminar Series. Discussion to follow 1:30-3:30, HSB T-663. Students may sign up for credit in PATH 511
University of Michigan
Tuesday, April 29, 2003 - 12:30 PM
HSB, T-639
Richard Miller
Part of the Methods in Gerontological Research Seminar Series. Discussion to follow 1:30-3:30, HSB T-663. Students may sign up for credit in PATH 511
University of Michigan
Tuesday, April 29, 2003 - 12:30 PM
HSB, T-639
Marrow Derived Stem Cells- What do we really know?
Beverly J Torok-Storb
Member & Associate Program Head Transplantation Biology Program
Fred Hutchinson Cancer Research Center
Tuesday, April 29, 2003 - 8:30 AM
HSB, K069
Beverly J Torok-Storb
Member & Associate Program Head Transplantation Biology Program
Fred Hutchinson Cancer Research Center
Tuesday, April 29, 2003 - 8:30 AM
HSB, K069
Why Is the Gastric Cardia Such a Big Deal When It Is So Small?
Henry Appelman, M.D.
Professor
Pathology
University of Michigan
Wednesday, April 23, 2003 - 4:30 PM
HSC, Room K-069
Henry Appelman, M.D.
Professor
Pathology
University of Michigan
Wednesday, April 23, 2003 - 4:30 PM
HSC, Room K-069
Transgenic Models: Strengths and Pitfalls
Warren Ladiges
Part of the Methods in Gerontological Research Seminar Series. Discussion to follow 1:30-3:30, HSB T-663. Students may sign up for credit in PATH 511
University of Washington
Tuesday, April 22, 2003 - 12:30 PM
HSB, T-639
Warren Ladiges
Part of the Methods in Gerontological Research Seminar Series. Discussion to follow 1:30-3:30, HSB T-663. Students may sign up for credit in PATH 511
University of Washington
Tuesday, April 22, 2003 - 12:30 PM
HSB, T-639
Discoidin Domain Receptors (DDRS) - Novel Collagen Receptors in the Vascular System
Michelle Bendeck, Ph.D.
Associate Professor
Laboratory Medicine and Pathobiology
University of Toronto
Wednesday, April 16, 2003 - 4:30 PM
HSC, Room K-069
Michelle Bendeck, Ph.D.
Associate Professor
Laboratory Medicine and Pathobiology
University of Toronto
Wednesday, April 16, 2003 - 4:30 PM
HSC, Room K-069
Caloric Restriction: A Tool for the Study of Aging
Edward Masoro
Part of the Methods in Gerontological Research Seminar Series. Discussion to follow 1:30-3:30, HSB T-663. Students may sign up for credit in PATH 511
University of Texas at San Antonio
Tuesday, April 15, 2003 - 12:30 PM
HSB, T-639
Edward Masoro
Part of the Methods in Gerontological Research Seminar Series. Discussion to follow 1:30-3:30, HSB T-663. Students may sign up for credit in PATH 511
University of Texas at San Antonio
Tuesday, April 15, 2003 - 12:30 PM
HSB, T-639
Use of Rodent Models in Aging Research
Edward Masoro
Part of the Methods in Gerontological Research Seminar Series. *Note: special day for Dr. Masoro's first lecture, Monday, April 14th. Discussion to follow 1:30-3:30, HSB T-663. Students may sign up for credit in PATH 511
University of Texas at San Antonio
Monday, April 14, 2003 - 12:30 PM
HSB, T-639
Edward Masoro
Part of the Methods in Gerontological Research Seminar Series. *Note: special day for Dr. Masoro's first lecture, Monday, April 14th. Discussion to follow 1:30-3:30, HSB T-663. Students may sign up for credit in PATH 511
University of Texas at San Antonio
Monday, April 14, 2003 - 12:30 PM
HSB, T-639
Pros and Cons of Non-Mammalian Models in Aging Research
Steven Austad
Part of the Methods in Gerontological Research Seminar Series. Discussion to follow 1:30-3:30, HSB T-663. Students may sign up for credit in PATH 511
University of Idaho
Tuesday, April 8, 2003 - 12:30 PM
HSB, T-639
Steven Austad
Part of the Methods in Gerontological Research Seminar Series. Discussion to follow 1:30-3:30, HSB T-663. Students may sign up for credit in PATH 511
University of Idaho
Tuesday, April 8, 2003 - 12:30 PM
HSB, T-639
Sex Chromosome Evolution: A Tale of the Smart, Sexy X Chromosome and the Degenerate Y
Jenny Graves
Professor
Comparative Genomics
Australian National University
Wednesday, April 2, 2003 - 4:30 PM
HSC, Room K-069
Jenny Graves
Professor
Comparative Genomics
Australian National University
Wednesday, April 2, 2003 - 4:30 PM
HSC, Room K-069
Concepts and Theories of Aging
George Martin
Part of the Methods in Gerontological Research Seminar Series. Discussion to follow 1:30-3:30, HSB T-663. Students may sign up for credit in PATH 511
University of Washington
Tuesday, April 1, 2003 - 12:30 PM
HSB, T-639
George Martin
Part of the Methods in Gerontological Research Seminar Series. Discussion to follow 1:30-3:30, HSB T-663. Students may sign up for credit in PATH 511
University of Washington
Tuesday, April 1, 2003 - 12:30 PM
HSB, T-639
The Genetics and Biology of Tumor Suppression by p27/Kipl
Chris Kemp, Ph.D.
Affiliate Associate Professor
Department of Pathology
Fred Hutchinson Cancer Research Center
Wednesday, March 26, 2003 - 4:30 PM
HSC, K-069
Chris Kemp, Ph.D.
Affiliate Associate Professor
Department of Pathology
Fred Hutchinson Cancer Research Center
Wednesday, March 26, 2003 - 4:30 PM
HSC, K-069
X Inactivation: The Role of the XIST RNA in Silencing a Chromosome
Carolyn Brown
Associate Professor
Department of Medical Genetics
University of British Columbia
Friday, March 21, 2003 - 12:30 PM
Health Sciences Center, Room K-069
Carolyn Brown
Associate Professor
Department of Medical Genetics
University of British Columbia
Friday, March 21, 2003 - 12:30 PM
Health Sciences Center, Room K-069
TBA
Marsha Whitney
Graduate Student
Bioengineering
University of Washington
Tuesday, March 18, 2003 - 8:30 AM
HSB, K069
Marsha Whitney
Graduate Student
Bioengineering
University of Washington
Tuesday, March 18, 2003 - 8:30 AM
HSB, K069
TBA
Lisa Tannock
Acting Instructor/Senior Fellow
Division of Metabolism, Endocrinology and Nutrition
University of Washington
Tuesday, March 4, 2003 - 8:30 AM
HSB, K069
Lisa Tannock
Acting Instructor/Senior Fellow
Division of Metabolism, Endocrinology and Nutrition
University of Washington
Tuesday, March 4, 2003 - 8:30 AM
HSB, K069
Biology and Evolution of Cervical Squamous Intraepithelial Lesions: A Hypothesis with Diagnostic/Prognostic Implications
Kumarasen Cooper, MBChB, DPhil, FRC Path
Director of Anatomic Pathology
University of Vermont College of Medicine
Thursday, February 27, 2003 - 4:30 PM
University of Washington Medical Center, BB-204
Kumarasen Cooper, MBChB, DPhil, FRC Path
Director of Anatomic Pathology
University of Vermont College of Medicine
Thursday, February 27, 2003 - 4:30 PM
University of Washington Medical Center, BB-204
Array CGH for High Resolution Analysis of Genomic Aberrations
Dan Pinkel, Ph.D.
Professor
Department of Laboratory Medicine
UCSF
Tuesday, February 25, 2003 - 4:30 PM
Health Sciences Center, Room K-069
Dan Pinkel, Ph.D.
Professor
Department of Laboratory Medicine
UCSF
Tuesday, February 25, 2003 - 4:30 PM
Health Sciences Center, Room K-069
Innate Immune Recognition and Response to Microbial Pathogens
Kelly Smith, Ph.D., M.D.
Department of Pathology
University of Washington
Wednesday, February 19, 2003 - 4:30 PM
Health Sciences Center, Room K-069
Kelly Smith, Ph.D., M.D.
Department of Pathology
University of Washington
Wednesday, February 19, 2003 - 4:30 PM
Health Sciences Center, Room K-069
TBA
Joe Beavo/ Sergei Rybalkin
Professor/ Acting Instructor
Pharmacology
University of Washington
Tuesday, February 18, 2003 - 8:30 AM
HSB, K069
Joe Beavo/ Sergei Rybalkin
Professor/ Acting Instructor
Pharmacology
University of Washington
Tuesday, February 18, 2003 - 8:30 AM
HSB, K069
The Role of Proteolysis in the Pathogenesis of Atherosclerosis
Peter Gough
Research Assistant Professor
Department of Pathology
University of Washington
Wednesday, February 12, 2003 - 4:30 PM
Health Sciences Center, Room K-069
Peter Gough
Research Assistant Professor
Department of Pathology
University of Washington
Wednesday, February 12, 2003 - 4:30 PM
Health Sciences Center, Room K-069
TBA
Joanne Hulme
Senior Fellow
Pharmacology
University of Washington
Tuesday, February 11, 2003 - 8:30 AM
HSB, K069
Joanne Hulme
Senior Fellow
Pharmacology
University of Washington
Tuesday, February 11, 2003 - 8:30 AM
HSB, K069
Cellular and Molecualr Mechanisms of Diabetes-accelerated Atherosclerosis
Karin Bornfeldt, Ph.D.
Associate Professor
Department of Pathology
University of Washington
Wednesday, February 5, 2003 - 4:30 PM
Health Sciences Center, Room K-069
Karin Bornfeldt, Ph.D.
Associate Professor
Department of Pathology
University of Washington
Wednesday, February 5, 2003 - 4:30 PM
Health Sciences Center, Room K-069
Signaling Pathways Regulating Endothelial Cell Survival and Activation
Xianwu (James) Li
Graduate Student
Department of Pathology
University of Washington
Friday, January 31, 2003 - 3:15 PM
Health Sciences Center, Room K-069
Xianwu (James) Li
Graduate Student
Department of Pathology
University of Washington
Friday, January 31, 2003 - 3:15 PM
Health Sciences Center, Room K-069
Protein Interactions
Stan Fields, Ph.D.
Professor
Departments of Genome Sciences and Medicine
University of Washington
Tuesday, January 21, 2003 - 4:30 PM
Health Sciences Center, T-747
Stan Fields, Ph.D.
Professor
Departments of Genome Sciences and Medicine
University of Washington
Tuesday, January 21, 2003 - 4:30 PM
Health Sciences Center, T-747
TBA
Jin-Yong Hwang, M.D. (Visiting Scientist)
Assitant Professor
Department of Medicine
Gyeongsang National University, Republic of South Korea
Tuesday, January 21, 2003 - 8:30 AM
HSB, K069
Jin-Yong Hwang, M.D. (Visiting Scientist)
Assitant Professor
Department of Medicine
Gyeongsang National University, Republic of South Korea
Tuesday, January 21, 2003 - 8:30 AM
HSB, K069
Molecular Medicine in the Post Genome Era
Dr. Richard Klausner
Executive Director, Global Health Program
Gates Foundation
Wednesday, January 15, 2003 - 12:00 PM
Hogness Auditorium,
Dr. Richard Klausner
Executive Director, Global Health Program
Gates Foundation
Wednesday, January 15, 2003 - 12:00 PM
Hogness Auditorium,
TBA
Themis Kyriakides
Research Assistant Professor
Biochemistry
University of Washington
Tuesday, January 14, 2003 - 8:30 AM
HSB, K069
Themis Kyriakides
Research Assistant Professor
Biochemistry
University of Washington
Tuesday, January 14, 2003 - 8:30 AM
HSB, K069
From Gene Expression Patterns to Antibody Diagnostics: A Pharmacogenomics Approach to Cancer Classification and Treatment
Douglas Ross, M.D., Ph.D.
Chief Scientific Officer
Applied Genomics Inc.
Wednesday, December 18, 2002 - 4:30 PM
HSC, K-069
Douglas Ross, M.D., Ph.D.
Chief Scientific Officer
Applied Genomics Inc.
Wednesday, December 18, 2002 - 4:30 PM
HSC, K-069
Delta1: A Notch Up on Hematopoietic Stem Cell Expansion
Irwin Bernstein
Professor
FHCRC
Tuesday, December 17, 2002 - 8:30 AM
HSC, K-069
Irwin Bernstein
Professor
FHCRC
Tuesday, December 17, 2002 - 8:30 AM
HSC, K-069
Development of a Gene Expression Array-Based Diagnostic Tool for Lymphoma
Daniel E. Sabath
Associate Professor
Laboratory Medicine
University of Washington
Wednesday, December 4, 2002 - 4:30 PM
HSC, K-069
Daniel E. Sabath
Associate Professor
Laboratory Medicine
University of Washington
Wednesday, December 4, 2002 - 4:30 PM
HSC, K-069
"A Genetic Approach to Understanding Basement Membrane Assembly"
Mats Paulsson
Professor of Biochemistry
School of Medicine
University of Cologne
Tuesday, December 3, 2002 - 8:30 AM
HSC, K-069
Mats Paulsson
Professor of Biochemistry
School of Medicine
University of Cologne
Tuesday, December 3, 2002 - 8:30 AM
HSC, K-069
"Microarray Analysis in Cancer Research: Progress and Promise"
Paul Meltzer, M.D., Ph.D.
Senior Investigator
Cancer Genetics Branch
NIH, National Human Genome Research Institute
Wednesday, November 20, 2002 - 4:30 PM
Health Sciences Center, K-069
Paul Meltzer, M.D., Ph.D.
Senior Investigator
Cancer Genetics Branch
NIH, National Human Genome Research Institute
Wednesday, November 20, 2002 - 4:30 PM
Health Sciences Center, K-069
Molecular Pathology of the Vascular Form of Ehlers-Danlos Syndrome
Ulrike Schwarze, M.D.
Assistant Professor
Department of Pathology
University of Washington
Wednesday, November 13, 2002 - 4:30 PM
Health Sciences Center, K-069
Ulrike Schwarze, M.D.
Assistant Professor
Department of Pathology
University of Washington
Wednesday, November 13, 2002 - 4:30 PM
Health Sciences Center, K-069
Single Cell Proteomics
Norm Dovichi
Professor
Department of Chemistry
University of Washington
Wednesday, November 6, 2002 - 4:30 PM
HSC, K-069
Norm Dovichi
Professor
Department of Chemistry
University of Washington
Wednesday, November 6, 2002 - 4:30 PM
HSC, K-069
DNA Repair Genes Select Stem Cells in Vivo
Stan Gerson, M.D.
Professor and Chief
Hematology/Oncology
Case Western Reserve University
Wednesday, October 30, 2002 - 4:30 PM
HSC, K-069
Stan Gerson, M.D.
Professor and Chief
Hematology/Oncology
Case Western Reserve University
Wednesday, October 30, 2002 - 4:30 PM
HSC, K-069
Science in Medicine Lecture: Genetic Instability and Human Disease
Raymond J. Monnat, Jr., M.D.
Professor
Department of Pathology
University of Washington
Thursday, October 24, 2002 - 12:00 PM
HSC, Turner Auditorium, D-209
Raymond J. Monnat, Jr., M.D.
Professor
Department of Pathology
University of Washington
Thursday, October 24, 2002 - 12:00 PM
HSC, Turner Auditorium, D-209
Multimodality Phenotyping: A Systematic Approach to Understanding Pathogenetic Mechanisms in Cardiovascular Disease
James Scott
Professor
Genetics and Genomics Research Institute
Imperial College of Science
Wednesday, October 16, 2002 - 4:30 PM
Health Sciences Center, K-069
James Scott
Professor
Genetics and Genomics Research Institute
Imperial College of Science
Wednesday, October 16, 2002 - 4:30 PM
Health Sciences Center, K-069
Mouse Models Unravel the p53 Pathway
Gigi Lozano, Ph.D.
Professor and Geneticist
Department of Molecular Genetics
MD Anderson Cancer Center
University of Texas
Wednesday, October 2, 2002 - 4:30 PM
Health Sciences Center, K-069
Gigi Lozano, Ph.D.
Professor and Geneticist
Department of Molecular Genetics
MD Anderson Cancer Center
University of Texas
Wednesday, October 2, 2002 - 4:30 PM
Health Sciences Center, K-069
Building the Cerebral Cortex: Neuron by Neuron, Layer by Layer
Robert F. Hevner, M.D, Ph.D.
Assistant Professor
Department of Pathology
University of Washington
Thursday, September 26, 2002 - 12:00 PM
Health Sciences Center, D-209
Robert F. Hevner, M.D, Ph.D.
Assistant Professor
Department of Pathology
University of Washington
Thursday, September 26, 2002 - 12:00 PM
Health Sciences Center, D-209
Neurochemical Dynamics of Traumatic Brain Injury
J. Clay Goodman, M.D.
Professor and Neuropathology Program Director
Departments of Pathology, Neurology, and Neurosurgery
Baylor College of Medicine
Thursday, September 19, 2002 - 4:30 PM
HSC, T-747
J. Clay Goodman, M.D.
Professor and Neuropathology Program Director
Departments of Pathology, Neurology, and Neurosurgery
Baylor College of Medicine
Thursday, September 19, 2002 - 4:30 PM
HSC, T-747
Fas/FADD-Mediated Activation of a Specific Program of Inflammatory Gene Expression in Vascular Smooth Muscle Cells
Friedemann J. Schaub
Graduate Student
Department of Pathology
University of Washington
Thursday, September 19, 2002 - 11:00 AM
HSC, K-069
Friedemann J. Schaub
Graduate Student
Department of Pathology
University of Washington
Thursday, September 19, 2002 - 11:00 AM
HSC, K-069
Diagnosis of Minimal Prostate Cancer in Needle Biopsies - When Should You Jump off the Fence?
John Srigley
Professor
Department of Pathology and Molecular Medicine
McMaster University
Monday, August 26, 2002 - 8:00 AM
UWMC, BB-204
John Srigley
Professor
Department of Pathology and Molecular Medicine
McMaster University
Monday, August 26, 2002 - 8:00 AM
UWMC, BB-204
Cohesion proteins SMC1 and SMC3: roles in aneuploidy and in meiotic chromosome dynamics
Rosalina James
Graduate Stdent of Pathology
School of Medicine
University of Washington
Friday, August 23, 2002 - 11:00 AM
HSC, D-209
Rosalina James
Graduate Stdent of Pathology
School of Medicine
University of Washington
Friday, August 23, 2002 - 11:00 AM
HSC, D-209
Characterization of Genomic Instability in Neoplastic Progression of Ulcerative Colitis
Ru Chen
Graduate Student of Pathology
School of Medicine
University of Washington
Tuesday, August 20, 2002 - 1:00 PM
HSC, K-069
Ru Chen
Graduate Student of Pathology
School of Medicine
University of Washington
Tuesday, August 20, 2002 - 1:00 PM
HSC, K-069
Cell Growth Survival and Papillogenesis in Ovarian Epithelial Cancer
Santo Nicosia, M.D.
Professor
Interdisciplinary Oncology Program
Moffitt Cancer Center and Research Institute
University of South Florida
Wednesday, July 31, 2002 - 4:30 PM
Health Sciences Center, Room T-747
Santo Nicosia, M.D.
Professor
Interdisciplinary Oncology Program
Moffitt Cancer Center and Research Institute
University of South Florida
Wednesday, July 31, 2002 - 4:30 PM
Health Sciences Center, Room T-747
In Vitro Modeling of Breast Cancer
Krishna Rao
Graduate Student of Pathology
School of Medicine
University of Washington
Wednesday, July 10, 2002 - 1:00 PM
Doctoral Dissertation, Pelton Auditorium
Day Campu
Krishna Rao
Graduate Student of Pathology
School of Medicine
University of Washington
Wednesday, July 10, 2002 - 1:00 PM
Doctoral Dissertation, Pelton Auditorium
Day Campu
"Regulation of ErbB Ligand Signaling Networks in Cancer and Diabetes - Role of Ligand Trafficking and Processing"
Peter J. Dempsey, Ph.D.
Principal Scientist
Pacific Northwest Research Institute
Seattle, Washington
Wednesday, June 26, 2002 - 4:30 PM
Health Sciences Center, K-069
Peter J. Dempsey, Ph.D.
Principal Scientist
Pacific Northwest Research Institute
Seattle, Washington
Wednesday, June 26, 2002 - 4:30 PM
Health Sciences Center, K-069
"Neurogenesis and Laminar Fate in the Developing Mouse Cerebral Cortex"
Robert Hevner, M.D., Ph.D.
Assistant Professor
Department of Pathology
University of Washington
Wednesday, June 5, 2002 - 4:30 PM
Health Sciences Building, K-069
Robert Hevner, M.D., Ph.D.
Assistant Professor
Department of Pathology
University of Washington
Wednesday, June 5, 2002 - 4:30 PM
Health Sciences Building, K-069
"Immunohistochemistry in Urologic Tumor Pathology"
Mark Wick, M.D.
Associate Director
Surgical Pathology
University of Virgina Health System
Wednesday, May 29, 2002 - 4:30 PM
Health Sciences Building, K-069
Mark Wick, M.D.
Associate Director
Surgical Pathology
University of Virgina Health System
Wednesday, May 29, 2002 - 4:30 PM
Health Sciences Building, K-069
Cell Adhesion in the Vasculature
Richard O. Hynes, Ph.D., F.R.S.
Daniel K. Ludwig Professor for Cancer Research
Department of Biology
Massachusetts Institute of Technology
Friday, May 24, 2002 - 11:00 AM
Health Sciences Center, D-209
Richard O. Hynes, Ph.D., F.R.S.
Daniel K. Ludwig Professor for Cancer Research
Department of Biology
Massachusetts Institute of Technology
Friday, May 24, 2002 - 11:00 AM
Health Sciences Center, D-209
Membranoproliferative/Cryoglobulinemic (Hepatitis C Associcated) Glomerulonephritis: A Disease of Mice and Men
Charles Alpers, M.D.
Professor
Department of Pathology
University of Washington
Wednesday, May 15, 2002 - 4:30 PM
Health Sciences Center,
Charles Alpers, M.D.
Professor
Department of Pathology
University of Washington
Wednesday, May 15, 2002 - 4:30 PM
Health Sciences Center,
Genetics in Everyday Life
David R. Cox, M.D., Ph.D.
Professor and Associate Chair
Department of Genetics
Stanford University
Thursday, January 10, 2002 - 4:30 PM
Health Sciences Center, T-739
David R. Cox, M.D., Ph.D.
Professor and Associate Chair
Department of Genetics
Stanford University
Thursday, January 10, 2002 - 4:30 PM
Health Sciences Center, T-739